通脉化浊汤治疗痰瘀互结型高血压病的效果及对转化生长因子β1、血管内皮生长因子、可溶性细胞间黏附分子-1的影响

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (766 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect of Tongmai Huazhuo Decoction in the treatment of hypertension patients with syndrome of intermin-gled phlegm and blood stasis and its influence on transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1). Methods Seventy hypertension patients with syndrome of intermin-gled phlegm and blood stasis admitted to the Second Department of Cardiology, the Second Hospital Affiliated to Liaoning University of Traditional Chinese Medicine from August 2013 to July 2016 were selected and randomly divided into experimental group and control group, with 35 cases in each group. The control group was treated with Amlodipine Besylate 5 mg, one agent every day. On basis of control group, the experimental group was treated with Chinese medicine Tongmai Huazhuo Decoction, once a day. The course of the two groups was 8 weeks. The clinical efficacy and levels of blood pressure, TGF-β1, VEGF, sICAM-1 before and after treatment between the two groups were compared. Results The total effective rate in the experimental group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, the levels of systolic blood pressure and diastolic blood pressure in the two groups were all lower than those before treatment, and the levels of systolic blood pressure and diastolic blood pressure in the experimental group after treatment were lower than those of control group, the differences were statistically significant (P ＜ 0.05). After treatment, the levels of TGF-β1, VEGF and sICAM-1 in the two groups were all lower than those before treatment, and the levels of TGF-β1, VEGF and sICAM-1 in the experimental group after treatment were lower than those of control group, the differences were statistically significant (P ＜ 0.05). Conclusion Tongmai Huazhuo Decoction in the treatment of hypertension patients with syndrome of intermin-gled phlegm and blood stasis has significant curative effects, which can down-regulate the levels of TGF-β1, VEGF and sICAM-1, it is suitable for clinical promotion and application.

Key words： Tongmai Huazhuo Decoction Syndrome of intermin-gled phlegm and blood stasis Hypertension Transforming growth factor-β1 Vascular endothelial growth factor Soluble intercellular adhesion molecule-1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	RUAN Lin JIAO Xiaomin▲ LI Jia WANG Chunlin LI Ting

Cite this article:

RUAN Lin JIAO Xiaomin▲ LI Jia WANG Chunlin LI Ting. Effect of Tongmai Huazhuo Decoction in the treatment of hypertension patients with syndrome of intermin-gled phlegm and blood stasis and its influence on transforming growth factor-β1, vascular endothelial growth factor, soluble intercellular adhesion molecule-1[J]. 中国医药导报, 2017, 14(16): 74-77.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I16/74

[1] 李亚杰.高血压患者的社区护理管理[J].临床合理用药杂志，2011，4（10）：136-137.
[2] 顾东风，Jiang He，吴锡桂，等.中国成年人高血压患病率、知晓率、治疗和控制状况[J].中华预防医学杂志，2003，37（2）：84-89.
[3] 王勇，靳利艳，王留义，等.不同剂量培哚普利对原发性高血压病患者血管内皮功能及血压变异性的影响研究[J].中国全科医学，2016，19（26）：3160-3164.
[4] 张学明.糖尿病合并高血压的可能机制和降压药选择策略[J].中国当代医药，2010，17（6）：13-15.
[5] Martensson J，Bellomo R. Perioperative renal failure in elderly patients [J]. Curr Opin Anaesthesiol，2015，28（2）：123-130.
[6] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志，2011，39（7）：579-616.
[7] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：112-113.
[8] 朱文锋.现代中医临床诊断学[M].北京：人民卫生出版社，2003：55-56.
[9] 何森，陈晓平，陈小妮，等.成都地区自然人群的高血压患病率及血压水平15年（1992～2007）的变化[J].四川大学学报：医学版，2010，41（3）：494-497.
[10] 王晓冰，李运伦.高血压病痰瘀互结证证治规律[J].湖北中医杂志，2016，38（10）：39-42.
[11] 冉旭，陈立，吕波，等.补肾益心汤对高血压病患者血管内皮功能的影响[J].中国中医急症，2014，23（2）：244-245.
[12] 焦红蕾.化痰通络活血方治疗原发性高血压的临床观察[D].石家庄：河北医科大学，2015.
[13] 崔圆圆.化痰活瘀法干预痰瘀互结型高血压病的机制探讨[D].郑州：河南中医学院，2014.
[14] 李娇娇.化痰活瘀基本方对痰瘀互结型高血压病患者血液流变学的影响[D].郑州：河南中医学院，2014.
[15] Miller CG，Pozzi A，Zent R，et al. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells [J]. Mol Biol Cell，2014，25（16）：2342-2350.
[16] Zhang Y，Liu J，Lin J，et al. The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer [J]. Oncotarget，2016，7（9）：9859-9875.
[17] 张烈元，刘炜枫，赵帅，等.陈伯钧教授中医药治疗高血压临床经验[J].环球中医药，2015，8（3）：350-352.
[18] 张云松，曹志群，朱晓林，等.参芪扶正注射液对高血压并失眠气虚者心率震荡的影响[J].中国现代医生，2015， 53（34）：124-127.
[19] 刘静.中医辨证治疗联合β受体阻滞剂治疗高血压的疗效分析[J].中外医学研究，2015，13（29）：68-69.
[20] 李琛，李璐，陈雪松，等.血管内皮生长因子及C反应蛋白与高血压颈动脉粥样硬化的关系[J].海南医学院学报，2012，18（11）：1565-1567.
[21] 吴建恒.高血压脑出血患者血清血管内皮生长因子（VEGF）和肿瘤坏死因子-α（TNF-α）表达水平的变化及临床意义研究[D].桂林：桂林医学院，2014.
[22] 牛国平.高血压病患者血清IGF-Ⅱ和VEGF检测的临床意义[J].放射免疫学杂志，2006，19（2）：97-98.
[23] 韩琳，秦建国，高誉珊，等.降压通络方对高血压肾损害大鼠肾脏血管紧张素Ⅱ及肾功能的影响[J].环球中医药，2015，8（1）：36-41.
[24] 严亚锋，白海侠，周海哲，等.脑清通颗粒对高血压肝热痰瘀证大鼠血浆ET-1和AngⅡ含量的影响[J].西部中医药，2015，28（9）：10-13.
[25] Andor M，Suciu M，Cristescu C，et al. Relationship between plasmatic sICAM-1，sP-selectin，HS-CRP levels and clinico-biological parameters in hypertensive patients [J]. Atherosclerosis，2015，241（1）：177-178.