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2018 Vol. 15, No. 24
Published: 2018-08-25
 
 
4 Toxicity and multipotent differentiation influence of hydroxyapatite/multiwalled carbon nanotube composites on mesenchymal stem cells
SONG Guodong* GUO Xiaoshuang* ZONG Xianlei ZHAO Jingyi LAI Chenzhi JIN Xiaolei
Objective To develop hydroxyapatite functionalized multi-walled carbon nanotubes (HA-MWCNTs), and assess the toxicity of HA-MWCNTs on rat′s BMSCs and its influence on the multipotent differentiation of bone marrow derived mesenchymal stem cells (BMSCs), thereby to provide experimental evidence for its utility in tissue engineering. Methods HA-MWCNTs were synthesized. Transmission electron microscope (TEM), X-ray diffraction (XRD) were used to observe the microstructure; BMSCs were obtained from female SD rats of 4 weeks old which weighted between 100 to 150 grams. After cultured and expanded to the third passage, cells were co-cultured with HA-MWCNTs and unfunctionalized MWCNTs (MWCNTs). MTT and live-dead cell assay were used to appraise the toxicity of MWCNTs on BMSCs. BMSCs were then induced and differentiated into adipocytic and osteoblastic cells and were used to assess the influence of MWCNTs on BMSCs′ multipotent differentiation. Results Compared to control group, BMSCs in MWCNTs group were significantly inhibited (P < 0.05), while in HA-MWCNTs group, BMSCs were slightly inhibited, with no statistical difference (P > 0.05), and the ratio of dead cells was less in HA-MWCNTs group. The mRNA level of osteogenesis (Cbfal/Runx2, BSP and OCN) was increased (P < 0.05) and the mRNA of adipogenesis (aP2 and LPL) was decreased (P < 0.05) in HA-MWCNTs group. Conclusion Compared with MWCNTs, HA-MWCNTs had slight influence on cell proliferation, trivial toxicity and favorable biocompatibility of BMSCs, meanwhile it could promote osteoblastic and inhibit adipocytic differentiation of BMSCs. HA-MWCNTs may supply a novel platform for applications of scaffold in bone tissue engineering.
2018 Vol. 15 (24): 4-8,13 [Abstract] ( 291 ) HTML (1 KB)  PDF (1014 KB)  ( 103 )
9 Experimental study on toxicology related to nanomagnetic beads technology
WANG Xin ZHANG Liming
Objective To study the toxicology of nanomagnetic beads and to understand the distribution of metabolism in rats. Methods Twenty-four healthy adult rats were randomly divided into 8 groups with 3 rats in each group. One group without any treatment as a blank control group, one group was injected with normal saline as positive control group, the other 6 groups were injected with nano-oxidized iron magnetic beads as the experimental group, the growth, behavior and neurological changes of the rats of each group were observed. HE staining and Prussian blue iron staining were used to observe the changes of organ structure and local pathological changes such as inflammatory reaction of rats in the experimental groups, and the distribution of magnetic beads in the main organs of the rats. Ten rats were randomly divided into two groups, and with 5 rats in each group, rats in the two groups were injected with ferromagnetic beads or normal saline respectively, and the cognitive function of rats was observed. Blood of 4 healthy New Zealand rabbits were collected after the injection of iron oxide magnetic beads and changes of related indexes were observed. Results There was no abnormal growth or appearance in the experimental group and the blank control group. The Longa score was 0, no abnormal changes were observed. Water maze experiments of the two groups including the escape latency and the number of crossing platforms were scored, there was no statistically significant (P > 0.05). There were no structural and pathological changes in the organ morphology of the rats in each group. The iron oxide magnetic beads had left the circulatory system and entered various organs of the rats after being injected for 5 minutes. Most of the magnetic beads were distributed in the spleen and liver. The difference in creatinine levels at different time points after injecting iron oxide magnetic beads in rabbits was statistically significant (P < 0.05), but still in the normal range. Other serum biochemical indicators, iron series indicators and blood routine indicators were not statistically significant (P > 0.05). Conclusion There is no obvious toxicological reaction by nanomagnetic beads. The toxicology related to nanomagnetic beads remain to be further explored.
2018 Vol. 15 (24): 9-13 [Abstract] ( 301 ) HTML (1 KB)  PDF (682 KB)  ( 165 )
14 Effects of miR-221 on the inflammatory factor secretion from macrophages after Mycobacterium tuberculosis infection
HE Baoming BAI Ying LI Yanqin
Objective To explore the effects of miR-221 on the inflammatory factor secretion from macrophages after Mycobacterium tuberculosis infection. Methods The expression of miR-221 in macrophages after Mycobacterium tuberculosis infection was detected by real-time quantitative PCR (qRT-PCR). Macrophages were transiently transfected with miR-221 mimic or miR-221 inhibitor. The expression of macrophage inflammatory factor and secretion of NO were detected by enzyme-linked immunosorbent assay (ELISA) and Griess method, respectively. The relationship of miR-221 and Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) was analyzed by dual-luciferase reporter gene assay, qRT-PCR and Western blot. Results Down-regulated miR-221 was observed in macrophages infected with Mycobacterium tuberculosis. The expression of miR-221 in macrophages was up-regulated by miR-221 mimics, but down-regulated by miR-221 inhibitors. The secretions of TNF-α, IL-1β, IL-6 and NO were significantly accelerated in macrophages infected with Mycobacterium tuberculosis, and increased in miR-221 up-regulated macrophages, but suppressed in miR-221 down-regulated macrophages. miR-221 directly binds to the 3′UTR of ROCK1, and negatively regulated its expression. Conclusion miR-221 can regulate the ROCK1 expression and inhibit the secration of inflammatory factors expression in macrophages after Mycobacterium tuberculosis infection.
2018 Vol. 15 (24): 14-17,29 [Abstract] ( 285 ) HTML (1 KB)  PDF (1243 KB)  ( 104 )
18 Changes of renin-angiotensin in rats with cerebral-cardiac syndrome after subarachnoid hemorrhage
PAN Rui1 DU Yeliang2▲ MU Weinan1 LIU Qihui1 ZHAO Yu1
1.Graduate School, Weifang Medical University, Shandong Province, Weifang   261000, China; 2.Department of Neurology, Brain Hospital, Weifang People′s Hospital, Shandong Province, Weifang   261000, China
[Abstract] Objective To investigate the changes of renin-angiotensin in rats with subarachnoid hemorrhage (SAH) complicated by cerebral-cardiac syndrome (CCS). Methods The occipital large pool was injected with autologous arterial blood to replicate the SAH model. Seventy-five healthy male Wistar rats were 6 weeks old and weighed 150-200 g. All rats were connected to a dynamic laboratory system (Power Lab system) to detect ECG, excluding abnormal ECG. The rats were randomly divided into surgery group (50 rats) and sham group (25 rats). The surgical group was divided into SAH group and CCS group according to different electrocardiograms after surgery. Each group had 25 animals (insufficient ones were recruited in the same condition as new rat). Different time periods were randomly divided into five subgroups: 1, 3, 5, 7, 14 d group, with 5 rats in each group. Electrocardiograms were measured with the Power Lab system after modeling, and electrocardiograms were again detected on day 1, 3, 5, 7 and 14. The levels of plasma renin activity (PRA) and angiotensin Ⅱ (AngⅡ) were detected by enzyme-linked immunosorbent assay (ELISA). Results After successful modeling, there was no significant change in electrocardiogram in the sham-operated group. The incidence of cerebral-cardiac syndrome was highest in the surgical group at 2 hours after surgery. The levels of PRA and AngⅡ in SAH group and CCS group were higher than those in sham-operated group at day 1 (P ＜ 0.05), and the CCS group was higher than the SAH group (P ＜ 0.05); PRA and AngⅡ peaked at 3 days in SAH group and CCS group were significantly higher than that in sham operation group (P ＜ 0.05), and CCS group was higher than the SAH group (P ＜ 0.05). The contents of PRA and AngⅡ in SAH group and CCS group decreased gradually after 5 and 7 days, which was still higher than that in sham operation group (P ＜ 0.05). The contents of PRA and AngⅡ gradually decreased to 7 days and then stabilized in the sham operation group. The levels of PRA and AngⅡ in the SAH group and the CCS group reached the peak at 3 days, and then gradually decreased to 14 days afterwards, and the levels of PRA and AngⅡ basically reached the level of the sham operation group (P ＞ 0.05). Conclusion PRA and AngⅡ in SAH complicated with CCS gradually increase and reach a peak, then gradually decrease and tend to be stable. This suggests that PRA and AngⅡ play a certain role in the occurrence and development of SAH concurrent with CCS.
2018 Vol. 15 (24): 18-21 [Abstract] ( 360 ) HTML (1 KB)  PDF (563 KB)  ( 76 )
22 Research progress on the effect of lncRNA in atherosclerosis lesions
LI Lijuan1 WANG Qinggao2 HE Yazhou1 LIANG Shan1 HUANG Caiyi1
The cardiovascular and cerebrovascular diseases caused by atherosclerosis (AS) is one of the main causes of death. AS is the result of synergistic effect of multiple factors and multiple mechanisms. The endothelial dysfunction, proliferation and migration of vascular smooth muscle cell, lipid metabolism disorders, inflammatory response and autophagy are involved in AS. Because of the complexity of its pathogenesis, it still needs to improve the understanding of its pathogenesis from different perspectives. In recent years, long non-coding RNA is found involving in regulating gene expression, as biomarkers and therapeutic targets for tumors, it has been widely studied and applied. However, lncRNA in atherosclerosis is still in early stage. This article reviews the research progress of lncRNA in the pathogenesis of AS, in order to provide new ideas for prevention and treatment of AS.
2018 Vol. 15 (24): 22-25 [Abstract] ( 305 ) HTML (1 KB)  PDF (546 KB)  ( 88 )
26 Diagnosis and treatment strategy of fecal incontinence
DONG Qingjun LIANG Hongtao WANG Chen CAO Yongqing LU Jingen
Fecal incontinence (FI) is a refractory disease, the diagnosis is simple while treatment is very difficult and lack of a recommended standardization. This paper delineates the clinical strategy and multidisciplinary conception of FI. Finally, author makes a clinical chain for FI “nonoperative management → sphincteroplasty → graciloplasty → artificial bowel sphincter → implanting device → colostomy” for reference of clinicians.
2018 Vol. 15 (24): 26-29 [Abstract] ( 231 ) HTML (1 KB)  PDF (582 KB)  ( 164 )
30 Research progress of Amiloride and its derivatives in central nervous system diseases
LIANG Jingjing ZENG Yanping XIAO Zheman LU Zuneng
Amiloride is an oral potassium retaining diuretic, which is always used as antihypertensive drugs in clinic. Information available at present suggests that with the property of being multiple ion channel blockers, Amiloride has tremendous development foreground in the central nervous system diseases, such as epilepsy, migraine, multiple sclerosis and cerebral ischemia injury. This review aims to discuss the mechanisms of Amiloride in the central nervous system diseases, which provide certain theoretical basis in clinical practice, and also makes a prediction focusing on Amiloride and its derivatives in the central nervous system disease.
2018 Vol. 15 (24): 30-33 [Abstract] ( 269 ) HTML (1 KB)  PDF (588 KB)  ( 117 )
34 Research progress in nerve-sparing radical hysterectomy for cervical cancer
GENG Yuning WU Yumei▲
Early stage cervical cancer is mainly treated by radical hysterectomy and pelvic lymph node dissection. Extensive pelvic surgery can damage innervation of the pelvic organs resulting in urinary，rectal and sexual disorders. Nerve-sparing radical hysterectomy (NSRH) was introduced as one of the treatment option for cervical cancer patient suffer from postoperative complains. Substantial progress has been made in understanding the neuroanatomy of the antonomic pelvic plexus. Nerve sparing technique in laparoendoscopic single-site radical hysterectomy, robotic-assisted radical hysterectomy，minilaparoscopic radical hysterectomy and  has made grate progress. Because the nerve fibers of pelvic plexue are distributed in a network，it is difficult to identify with the naked eyes. The inaccuracy of nerve preservation restricts the standardization and promotion of surgery. Intraoperation neurelectrophysiological monitoring may be a new development direction of nerve-sparing hysterectomy.
2018 Vol. 15 (24): 34-37 [Abstract] ( 318 ) HTML (1 KB)  PDF (540 KB)  ( 58 )
38 Research progress of early in-bed rehabilitation of critically ill patients in the intensive care unit
JI Jianhong WANG Fang WU Xiaoli
Early rehabilitation has been confirmed to be effective in prevention and treatment of Intensive Care Unit (ICU) acquired weakness, shorten the duration of mechanical ventilation and ICU stay. However, early rehabilitation, particularly the out-bed rehabilitation, is still not generally accepted by ICU medical staff for various reasons. In-bed rehabilitation is the beginning of the early rehabilitation for ICU patients, which is also the way that ICU medical staff tend to choose. This review summarizes the concept, potential risks, methods and the onset time of the early in-bed rehabilitation, as well as the possible obstacles and countermeasures in the performing procedure. Furthermore, the disadvantages of available research in this field are also presented.
2018 Vol. 15 (24): 38-41 [Abstract] ( 846 ) HTML (1 KB)  PDF (579 KB)  ( 401 )
42 Analysis of the population attributable risk of hyperuricemia on people with diabetes
XUE Bai GAO Ruqin LIU Li DUAN Haiping LIU Yan
Objective To investigate the effect of hyperuricemia on diabetes attack, and provide scientific basis for the work of prevention. Methods Cohort study was conducted in this study. Subjects were selected to participate in the baseline survey in July 2009. A three-year follow-up was conducted for those who met the conditions. The follow-up ended in December 2012. Eventually 2177 people aged 35 to 74 that had lived in Qingdao for years were included in the study. Non-conditional Logistic regression analysis was used to calculate the advantage ratio. The population attributable risk was estimated by using the formula defined by Bruzzi. Results After controlling for confounding factors, the OR value of hyperuricemia was 1.497. The attributional risk of multifactorial population was 6.71%. Conclusion Hyperuricemia is a risk factor for diabetes, and diabetes is caused in part by a history of hyperuricemia in Qingdao.
2018 Vol. 15 (24): 42-44,54 [Abstract] ( 285 ) HTML (1 KB)  PDF (646 KB)  ( 134 )
45 A case control study of gastric cancer risk factors in Lishui City
ZHOU Yuefen WU Minhua XIE Yanru LIU Wujing WANG Yonghui LOU Jian
Objective To investigate the risk factors of gastric cancer in Lishui City. Methods Two hundred and ten cases of gastric cancer diagnosed by pathology, that were treated in hospitals above the country level in Lishui City were enrolled in this study as case group from March 2012 to February 2015. The method, 1∶1 matched case-control study was used, 2010 healthy people in each country and districts in Lishui City were randomly selected as the control group. By means of “Questionnaire of the Survey of Living and Health of the Population”, the correlation factors of gastric cancer patients and control population were investigated and the relationship between these factors and gastric cancer was analyzed. Results Through the one-way ANOVA, it showed that frequent drinking, frequent green tea drinking, impatience, history of stomach disease, eating fast, often eating midnight snacks, often eating out, often eating salted foods, often eating fresh vegetables were found to be statistically different between the case group and the control group (P ＜ 0.05). After controlling and considering other confounding factors, via multiple Logistic analysis method often eating salted food (OR = 19.662, 95%CI:10.000-38.658, P = 0.000), often eating midnight snacks (OR = 2.494, 95%CI:1.297-4.807, P = 0.006), eating fast (OR = 4.329, 95%CI:2.273-8.264, P = 0.000), the history of stomach problems (OR = 2.033, 95%CI:1.004-4.119, P = 0.049) were found to be major risk factors of gastric cancer in Lishui; often drinking green tea (OR = 0.330, 95%CI:0.169-0.647, P = 0.001), often eating fresh vegetables (OR = 0.439, 95%CI:0.213-0.907, P = 0.026) were found to be protective factors. Conclusion The incidence of gastric cancer in Lishui City is closely related to eating habits. Changing unhealthy eating habits is an important way to reduce the incidence of gastric cancer in this area.
2018 Vol. 15 (24): 45-50 [Abstract] ( 251 ) HTML (1 KB)  PDF (434 KB)  ( 139 )
51 Analysis of risk factors of lower extremity arterial disease in elderly patients with type 2 diabetes mellitus
LIU Chang WANG Yingnan WANG Xuze LIN Hong GAO Yu▲
Objective To explore the risk factors of lower extremity arterial disease in elderly patients with type 2 diabetes mellitus, so as to provide the basis for early clinical prevention and treatment of diabetic foot and heart, cerebrovascular disease. Methods From October 2015 to April 2017, 280 cases of elderly patients with type 2 diabetes mellitus in Affiliated Hospital of Chengde Medical College were selected, they were divided into control group and case group according to lower extremity blood vessel color Doppler ultrasonography results, each group of 140 cases. The differences of general, smoking history, prevalence of disease and laboratory indicators between the two groups were compared, the risk factors of lower extremity arterial disease of elderly patients with type 2 diabetes mellitus were analyzed. Results Multivariate Logistic regression analysis showed that: systolic blood pressure (SBP) (OR=2.195, 95%CI: 1.085-3.530), low density lipoprotein cholesterol (LDL-C)(OR=1.900, 95%CI: 1.170-3.129), plasma homocysteine (Hcy) (OR=1.677, 95%CI: 1.178-2.410), triglyceride (TG) (OR=1.510, 95%CI: 1.122-1.950), glycosylated hemoglobin (HbA1c) (OR=1.362, 95%CI: 1.000-1.860) were the risk factors of lower extremity arterial disease of elderly patients with type 2 diabetes mellitus. Conclusion Elderly patients with type 2 diabetes mellitus are more likely to develop lower extremity arterial disease with high SBP, high LDL-C, high Hcy, high TG, and high HbA1c.
2018 Vol. 15 (24): 51-54 [Abstract] ( 309 ) HTML (1 KB)  PDF (380 KB)  ( 88 )
55 Efficacy of simple bladder hydrodistention in treatment for female refractory overactive bladder
SHI Xiaozhi1* QIAO Ximin2 XU Xiaofeng2 DU Quan2* LIU Guoxiong2
Objective To evaluate the efficacy of simple bladder hydrodistention to treat female refractory overactive bladder. Methods Sixty-two female patients with refractory overactive bladder treated in Xianyang Central Hospital from February 2015 to August 2017 were selected and they were divided into simple bladder hydrodistention group (observation group) and Capsaicin (CAP) group (control group), with 31 cases in each group. OABSS scores, daily voiding frequency, urinary frequency in night, quantity of each urination, bladder capacity at first desire, maxima bladder capacity were recorded. Results OABSS scores, daily voiding frequency, urinary frequency in night, average quantity of each urination, bladder capacity at first desire, maxima bladder capacity after treatment in the two groups had difference with those before treatment （P ＜ 0.05）. One 1 week after treatment, urinary frequency in night, average quantity of each urination, bladder capacity at first desire, maxima bladder capacity in the observation group were different from those in the control group （P ＜ 0.05）. Three months treatment after, there were differences in daily voiding frequency and maxima bladder capacity between the two groups, the differences were statistically significant （P ＞ 0.05）. There was no significant difference in clinical treatment efficiency between the two groups (P ＞ 0.05). Conclusion Simple bladder hydrodistention can be used as a supplement treatment for refractory bladder overactivity.
2018 Vol. 15 (24): 55-57,62 [Abstract] ( 216 ) HTML (1 KB)  PDF (521 KB)  ( 162 )
58 Curative effect of combining therapy of Testosterone and Solifenacin for patients with lower urinary tract symptoms after transurethral resection of the prostate
CHEN Shenquan1 SU Jiuxiong2 LI Jianfei2 WU Baozhong1 LIU Mingjian1 YANG Dikuan1
Objective To investigate the clinical efficacy of Testosterone supplement combining with Solifenacin in the treatment for early stage of lower urinary tract symptoms (LUTS) after transurethral resection of the prostate (TUPP) for benign prostatic hyperplasia (BPH) patients. Methods Twenty-six cases with BPH treated in the Second People′s Hospital in Zhaoqing City from January 2017 to September 2017, that serum total testosterone (TT) was lower than normal range, and post TURP for 7 d with LUTS after removal of catheter were selected and they were randomly divided into experimental group and control group, with 13 cases in each group. The experimental group was applicated with Testosterone supplement and Solifenacin,and the control group was only supplemented with Testosterone supplement. The treatment course was 30 days. Prostate specific antigen (PSA), TT, International prostate symptom score-Quality of life (IPSS-QOL) score, overactive bladder symptom score (OABSS), the maximum flow rate (Qmax), residual urine (RU) and digital rectal examination between the two groups were compared before treatment, on 14th day and 30th day after treatment. Results Before treatment, the indices above between the two groups had no statistically significant differences (P ＞ 0.05). There was a statistically significant difference in the IPSS-QOL scores in the two groups before and 14th day after treatment (P ＜ 0.05). There were significant differences in TT, Qmax, IPSS-QOL and OABSS in the two groups before and in 30th day after treatment (P ＜ 0.05). On 14th day after treatment, there was no significant difference between the two groups in the indices above (P ＞ 0.05). On 30th day after treatment, the scores of IPSS-QOL and OABSS in the experimental group were all higher than those in the control group, the differences were statistically significant (P ＜ 0.05). On 14th and 30th day after treatment, both groups were not touched prostatic induration in rectal digital examination. Conclusion M receptor blocker combining with Testosterone supplemen can relieve the symptoms of LUTS after TURP effectively, and for BPH patients with low testosterone levels and LUTS can simultaneously treat with Testosterone supplement and M receptor blocker.
2018 Vol. 15 (24): 58-62 [Abstract] ( 240 ) HTML (1 KB)  PDF (497 KB)  ( 95 )
63 Effect of Western medicine combined with immunosorbent therapy on systemic lupus erythematosus nephritis and its effect on inflammatory cytokines and immune function
LONG Jie1 WANG Tao1 ZHU Changliang2▲
Objective To investigate the effect of Western medicine combined with immunosorbent therapy on systemic lupus erythematosus nephritis (SLEN) and its effect on inflammatory cytokines and immune functions. Methods Forty-eight patients diagnosed by pathology with SLEN in Chengdu Military General Hospital from January 2013 to August 2017 were selected and divided into observation group and control group according to random number table method, with 24 cases in each group. The control group was treated with Glucocorticoid combined with Cyclophosphamide, the observation group was treated with immunosorbent therapy on the basis of the control group treatment. The course of treatment in both groups was 6 months. Before and after treatment, the renal function, serum indices, immune function and inflammatory factors were compared between the two groups. Results There was statistically significant difference in the total effective rate between the two groups, and the observation group was significantly higher than that of the control group (P ＜ 0.05). After treatment, the renal function indices (Scr, BUN, 24 h urine protein) and the serum indices (ANA and ds-DNA antibodies) were lower than those before treatment in the two groups, and the renal function indices and the serum indices of the observation group were lower than those of the control group (P ＜ 0.05). After treatment,  the contents of complement C3 and C4 were higher than those before treatment in the two groups, and the contents of complement C3 and C4 in the observation group were higher than those of the control group (P ＜ 0.05). The levels of interleukin (IL)-6, IL-8, TNF-α and IgA, IgM,  IgG were lower than those before treatment, and the levels of IL-6, IL-8, TNF-α and IgA, IgM, IgG in the observation group were lower than those in the control group (P ＜ 0.05). Conclusion There is better effecacy of Cyclophosphamide and Glucocorticoid combined with immunoadsorption in the treatment of patients with SLEN, thereby scavenging ANA and ds-DNA antibodies of patients, improving renal function and inflammatory response, and it can improve immune function, that is worthy of clinical promotion.
2018 Vol. 15 (24): 63-66 [Abstract] ( 287 ) HTML (1 KB)  PDF (488 KB)  ( 166 )
67 Clinical application of 3D printing technique in treating sacral fracture
HUAN Ke1 SU Fei2 WANG Fei3 LIU Bin3 FAN Yong2 SANG Hongxun4
Objective To disscuss the effect of 3D printing technique in treating sacral fracture. Methods From January 2010 to January 2015, in Department of Orthopaedics, Shaanxi Fourth People′s Hospital, 19 patients with sacral fracture accompanied with sacral nerve injury were selected. According to the Denis classification, 7 cases were type Ⅱ and 12 cases were type Ⅲ. All patients had varying degrees of sacral nerve damage symptoms. According to the three-dimensional reconstruction of CT scan before operation, the degree of fracture displacement and the compression of the sacral nerve were fully understood. According to the three-dimensional reconstruction of the three-dimensional structure and the experience of the operator, the software preposition screw was carried out to measure the relevant indexes (diameter, length and angle) of internal fixation, and to observe the possible effect and whether it was needed, that surgeon expanded the decompression. According to the plan, the surgical treatment was performed. After the operation, the X-ray plain film and CT scan were regularly taken. The pedicle screw and the iliac bone nail had no loosening and the fracture healing. The Gibbons score and the Mjeed curative effect standard score were carried out to evaluate the postoperative nerve function and clinical efficacy, and then the feasibility and effectiveness of the technique were evaluated. Results All patients were treated with the aid of 3D printing model, fracture reduction, bone graft fusion and internal fixation, the operation went well, and there were no incision infection, pressure sore and other complications. And all of them were followed up for more than 1 year. Postoperative X-ray or CT showed that sacral fractures were stable and well healed. The neurological function of all the patients after operation was improved in different degrees. The Gibbons score was recovered from (5.21±0.49) points before operation to (2.18±0.51) points after operation, the difference was statistically significant (P < 0.05). The effective rate of Mjeed was 84.2%. Conclusion Preoperative 3D printing technology is helpful not only on fully understanding the degree of sacral fracture damage, sacral nerve compression area, but also on supervising decompression range and placement of nail segments. These technologies can help surgeons make accurate preoperative design of surgical procedures plan, decrease operation time, improve fracture reduction and nerve decompression accuracy, which will help the recovery of sacral plexus, reduce the incidence of failure of internal fixation. In a word, these technologies have a certain guiding significance for clinical treatment.
2018 Vol. 15 (24): 67-70,83 [Abstract] ( 301 ) HTML (1 KB)  PDF (729 KB)  ( 56 )
71 Effect of limited incision approach locking plate internal fixation in the treatment of complex osteoporotic humeral shaft fractures
ZHANG Zheng ZHAI Sheng LIU Dapeng HAN Xiaoping WANG Wu WU Zhongyan CUI Yong▲
Objective To explore the clinical effect of long proximal humeral locking system (PHILOS) in the treatment of complex osteoporotic humeral shaft fractures. Methods From July 2014 to March 2017, in Fifth Affiliated Hospital of Xinjiang Medical University, 28 patients with humeral shaft fractures (AO type: 9 cases of type B, 19 cases of type C) treated with limited incision and long type PHILOS plate insertion were selected. The fracture healing and internal fixation were evaluated by X-ray, and the function of shoulder and elbow joint was evaluated by University of California at LosAngeles (UCLA) score and Mayo score respectively. Results All fractures healed smoothly. There was no iatrogenic radial nerve injury. The healing time was 12-36 weeks [by an average of (22.5±6.8) weeks]. Abduction of shoulder joint ranged 80°-110° degrees [by an average of (102.2±3.2)°], extending 20°-40° degrees [by an average of (38.0±1.1)°], and flexion 150°-170° [by an average of (165.3±2.1)°]. The elbow joint extends -5°-10° [by an average of (8.0±0.9)°], and the flexion was 120°-140° [by an average of (132.2±2.4)°]. The shoulder joint function, 26 cases were excellent and 2 cases were good according to UCLA criteria. For the elbow joint function, 26 cases were excellent and 2 cases were good according to Mayo criteria. Conclusion Limited open long PHILOS is an effective and safe method for the treatment of complex and osteoporotic humeral shaft fractures.
2018 Vol. 15 (24): 71-74 [Abstract] ( 287 ) HTML (1 KB)  PDF (690 KB)  ( 133 )
75 Effect comparison of lever positioning and chiropractic manipulation in the treatment of lumbar-discherniation
HU Sijin1 GONG Zhaoyang1 JIN Ligui1 HE Xinguo2 XUE Daoyi3 CHEN Zhihui4 JIN Yangjin5 JIN Zenghe6
Objective To compare the curative effect of lever positioning and chiropractic manipulation in the treatment of prolapse of lumbar intervertebral disc. Methods From March 2015 to November 2017, 302 cases of patients with prolapse of lumbar intervertebral disc admitted to Rui′an Hospital of Traditional Chinese Medicine were selected, according to the random number table method, they were divided into treatment group (152 cases) and control group (150 cases), the treatment group was given lever positioning combined with traction, the control group was given traditional chiropractic manipulation traction. The time and number of treatment in two groups were the same, the curative effects between the two groups were compared after treatment. Results After treatment, the scores of visual analogue scale (VAS) in two groups were lower than those before treatment, the Japanese Orthopaedic Association scores (JOA) were higher than those before treatment, the differences were highly statistically significant (P < 0.01); after treatment, the VAS score in treatment group was lower than that of control group, the JOA score was higher than that of control group, the differences were highly statistically significant (P < 0.01). The curative effect of treatment group was better than that of control group, the difference was highly statistically significant (P < 0.01). Conclusion The curative effect of lever positioning for treating prolapse of lumbar intervertebral disc is definite, which is worthy of clinical promotion and application.
2018 Vol. 15 (24): 75-78 [Abstract] ( 422 ) HTML (1 KB)  PDF (576 KB)  ( 166 )
79 Clinical effect of shock wave therapy in meniscal injuries healing after arthroscopic surgery
LOU Yi CHEN Fengmei ZHANG Yinquan▲
Objective To investigate the clinical effect of shock wave treatment after meniscus repair under arthroscopy. Methods From October 2015 to December 2016, in Department of Orthopedics, Shanghai Eastern Hepatobiliary Surgery Hospital, 80 patients with meniscus laceration in the red and white junction area of medial posterior horn of knee joint were analyzed retrospectively, according to different treatment, they were divided into experiment group and control group, with 40 cases in each group. The experiment group was given knee arthroscopic meniscus repair, after the operation 2 weeks, the shock wave treatment was conducted at the affected area until after operation for 6 weeks; the control group was given simple knee arthroscopic meniscus repair. According to Lysholm and Hospital for Spcial Surgery (HSS) scores and imaging data were used to evaluate, the meniscus healing and knee function recovery situation in the two groups before and after operation for 6 weeks were compared. Results After operation for 6 weeks, the Lysholm and HSS scores in the two groups were higher than those before surgery, the differences were statistically significant (P < 0.05); moreover, the Lysholm and HSS scores in experiment group were higher than those in control group, the differences were statistically significant (P < 0.05); the excellent and good rates of Lysholm and HSS scores in the experiment group were all higher than those of control group (P < 0.05). MRI showed that the hyperintense of injured meniscus in experiment group after operation for 6 weeks was significantly lower than that of the control group. Conclusion Shock wave treatment after knee arthroscopic meniscus repair has high safety and less side effects, to some extent, it can promote the repair of meniscus injury and improve joint function.
2018 Vol. 15 (24): 79-83 [Abstract] ( 274 ) HTML (1 KB)  PDF (697 KB)  ( 132 )
84 Comparison of single-row suture anchor technique and suture bridge suture anchor technique in repairing moderate rotator cuff tears
ZONG Longze1 SHI Yongtao1 YANG Mingzhi2▲
Objective To compare the conditions of single-row suture anchor technique and suture bridge suture anchor technique in repairing moderate rotator cuff tears. Methods From January to December 2017, in Yan′an University Affiliated Hospital, 70 patients with moderate rotator cuff tears were selected, they were divided into two groups by random paper method, control group (single-row suture anchor technique) had 35 cases, observation group (suture bridge suture anchor technique) had 35 cases. The shoulder score of University of California at LosAngeles (UCLA), American Shoulder and Elbow Surgeons′ Form (ASES) score, constant-murley score, visual analogue scale (VAS) score, anteflexion angle, abduction angle, body side external rotation angle of the two groups before and after operation were detected, the clinical effect of the two groups was compared. Results The UCLA shoulder score, ASES score, constant-murley score, VAS score, anteflexion angle, abduction angle, body side external rotation angle between the two groups before and after operation were compared, the differences were not statistically significant (P > 0.05). The UCLA shoulder score, ASES score, constant-murley score, anteflexion angle, abduction angle, body side external rotation angle in two groups after operation were higher than those before operation, while the VAS scores were lower than those before operation, the differences were statistically significant (P < 0.05). The excellent and good rate between the two groups had no statistically significant difference (P > 0.05). Conclusion Both single-row suture anchor technique and suture bridge suture anchor technique in repairing moderate rotator cuff tears have good effects, they have no significant difference, they are worthy of clinical promotion and application.
2018 Vol. 15 (24): 84-87 [Abstract] ( 364 ) HTML (1 KB)  PDF (579 KB)  ( 43 )
88 Clinical value of serum pancreatic stone protein in the early diagnosis of early-onset neonatal sepsis
ZHA Li HU Jinhui ZHU Hongli LIU Yingying WU Rong▲
Objective To evaluate the value of serum pancreatic stone protein (PSP) for the early diagnosis of early-onset neonatal sepsis (EONS). Methods Ninety neonatal with infectious risk factors or infectious symptoms admitted to the Huai′an Maternity and Child Healthcare Hospital Affiliated to Yangzhou University Medical Academy within 24 h after birth from January to June 2014 were enrolled. They were divided into sepsis group (33 cases) and non-sepsis group (57 cases) depending on whether the diagnostic standard of early-onset neonatal sepsis was met. Twenty neonatal with good general situations admited at the same time without infection poisoning manifestation were treated as the control group. The blood samples were obtained from children on 1, 3 and 7 d after birth. The levels of serum PSP and IL-6 were measured, and the data was statistical analyzed. Results There were statistically significant among three groups at all time points (all P < 0.01), and the levels of serum PSP on 1, 3 and 7 d after birth in sepsis group were all higher than those of the non-sepsis group, the differences were statistically significant (all P < 0.05). Levels of serum PSP showed upward trend during d1-d3 after birth, and downward trend during d3-d7. Area under the curve (AUC) of ROC of PSP at 1 d after birth in the diagnosis of sepsis was 0.802 [95%CI: 0.70-0.90, P < 0.01], 3 d after birth was 0.836 (95%CI 0.74-0.93, P < 0.01), the AUC of the combination of PSP and IL-6 in the diagnosis of sepsis at 1 d after birth was 0.879 (95%CI: 0.80-0.95, P < 0.01). Conclusion The level of serum PSP of neonatal has certain clinical value in early diagnosis of EONS. Combination detection of serum PSP and IL-6 in the diagnosis of sepsis at 1 d after birth can improve the sensibility to diagnose early-onset neonatal sepsis and reduce the rate of missed diagnosis.
2018 Vol. 15 (24): 88-91 [Abstract] ( 250 ) HTML (1 KB)  PDF (608 KB)  ( 79 )
92 Effect of unilateral salpingectomy on ovarian reserve function and reproductive function in patients with tubal pregnancy
PAN Zhuo1 SU Qing1 SU Jingjing2
Objective To explore the effect of unilateral salpingectomy on ovarian reserve function and reproductive function in patients with tubal pregnancy. Methods A total of 60 patients with tubal pregnancy were selected from Panjin People′s Hospital from January 2015 to January 2017. They were divided into two groups according to operation method, 30 patients with unilateral salpingectomy were selected as experimental group, 30 patients with salpingotomy were selected as control group. Six months post operation, levels of FSH, LH, E2, AFC and AMH were compared in both groups. Pregnancy rate was observed after one year. Results Compared with control group, the levels of FSH, LH and E2 increased in experimental group, but no significant differences were found (P > 0.05), while AFC and AMH levels significantly decreased in experimental group, the differences were statistically significant (P < 0.05). There was no significant difference in pregnancy rate between the two groups at one year after operation (P > 0.05). Conclusion Unilateral salpingectomy can lead to decrease the ovarian reserve function, while it exerts no significant effect on short-term pregnancy rate.
2018 Vol. 15 (24): 92-94 [Abstract] ( 264 ) HTML (1 KB)  PDF (554 KB)  ( 46 )
95 Effect of hyaluronic acid on maternal inflammatory factors and intrauterine adhesions after cesarean section
LIU Jieling LIANG Yuan
Objective To analyze the effect of hyaluronic acid on maternal inflammatory factors and intrauterine adhesions after obstetric cesarean section. Methods A total of 90 pregnant women with cesarean section form May 2016 to May 2017 in Department of Gynaecology and Obstetrics of Haikou Third People′s Hospital were selected and divided into the control group and observation group by random number table method, with 45 cases in each group. Pregnant women in observation group were given the treatment of medical hyaluronic acid after cesarean section, while the control group without any therapy after cesarean section. The incidences of intrauterine adhesion, inflammatory factor levels and pain degree were compared between the two groups. Results The total incidence of postpartum adhesion in observation group was lower than control group, and the difference was significant (P < 0.05). The levels of serum IL-6, IL-10 and pain degree of two groups 3 d after treatment were all higher than those before treatment, the levels of the above indexes, were significantly reduced 7 d after treatment, while those were still higher than those before treatment, and the differences were significant (P < 0.05). The L-6, IL-10, TNF-α and pain degree of the observation group 3 and 7 d after treatment were obviously lower than those of the control group, and the differences were significant (P < 0.05). Conclusion The application of hyaluronic acid can effectively prevent adhesion, improve postoperative inflammatory factors, and relieve pain for pregnant women after cesarean, it is worthy of clinical application.
2018 Vol. 15 (24): 95-98,106 [Abstract] ( 256 ) HTML (1 KB)  PDF (586 KB)  ( 156 )
99 Application of enhanced recovery after surgery in the recovery of ovarian cysts
XIE Chunhong1 ZHAO Enfeng2▲ ZHANG Ningning1 LU Rongqin1 ZHANG Yunfang3 ZHOU Hongrui3 WEI Yongzhi1
Objective To explore the application of enhanced recovery after surgery (ERAS) in patients with laparoscopic ovarian cysts. Methods A total of 110 patients of ovarian cyst in the First Hospital of Shijiazhuang from January 2016 to December 2017 were selected. According to the order of diagnosis, all cases were numbered corresponding to the number in the random number table, and divided into two groups according to the sequence, with 55 cases in each group. Observation group was given the perioperative management of ERAS and control group was given the routine perioperative management. The postoperative rehabilitation related indicators such as postoperative exhaust time, indwelling catheter, activity time, the pain level score, postoperative hospital stay and the cost of hospitalization of two groups, and the satisfaction rate of perioperative management were recorded and compared. Results Compared with the control group, the postoperative exhaust time and the time of indwelling catheter after operation in the observation group were shorter, the activity time was earlier, and the pain level score was lower (P < 0.01). The postoperative hospital stay and the cost of hospitalization in the observation group were less than those in the control group (P < 0.01). The satisfaction rate of perioperative management of the observation group was 92.7%, which was higher than that of the control group (78.2%) (P < 0.05). Conclusion The methods of ERAS can accelerate the rehabilitation process and improve the medical experience of patients with laparoscopic ovarian cysts, worthy of popularization.
2018 Vol. 15 (24): 99-102 [Abstract] ( 252 ) HTML (1 KB)  PDF (596 KB)  ( 99 )
103 Disposable cervical dilation balloon and Dinoprostone suppository for cervical maturation and induction of labor in term pregnant women
WANG Yayun CHEN Huijuan▲ WU Lei
Objective To investigate the effects of single-use cervical dilatation balloon (Aiying balloon) and Dinoprostone suppository (Propess) on cervical ripening and induction of labor. Methods A total of 60 full-term pregnant women induced labour with Propess from December 2015 to August 2016 in Wuxi Maternal and Child Health Hospital, Nanjing Medical University ("our hospital" for short) were selected as control group. Forty-six cases of full-term pregnant women who were induced by the Aiying balloon in our hospital from September 2016 to May 2017 were selected as observation group. The cervical ripening, effect of induced labour and delivery outcomes of two groups were compared. Results The total effective rate of cervical ripening in the observation group was higher than that in the control group, and the difference was statistically significant (P < 0.01). The cesarean section rate in the observation group was lower than that in the control group, the vaginal delivery rate was higher than that in the control group, the differences were statistically significant (P < 0.05). The postpartum hemorrhage of the observation group was less than that of the control group, the total labor was shorter than that of the control group, and the 1 min Apgar score of the newborns was higher than that of the control group, the differences were statistically significant (P < 0.01). Conclusion The Aiying balloon has a significant effect on the use of full-term pregnant women compared with Propess. It can effectively promote cervical ripening, improve induction of labor and the outcome of delivery, it is worthy of promotion.
2018 Vol. 15 (24): 103-106 [Abstract] ( 235 ) HTML (1 KB)  PDF (605 KB)  ( 149 )
107 Clinical diagnostic value of serum procalcitonin, albumin and soluble myeloid cell trigger receptor-1 in children with sepsis
ZHANG Jing YANG Xiangfeng MENG Xianmei GUO Ru LI Fang
Objective To investigate the clinical value of serum procalcitonin (PCT), albumin (Alb) and soluble myeloid cell triggering receptor-1 (sTREM-1) in the diagnosis of children with sepsis. Methods From October 2015 to August 2017, 140 children with sepsis (sepsis group) and 60 cases of non-infectious children with systemic inflammatory response syndrome (control group) in Hu′nan Provincial Maternal and Child Health Care Hospital were selected as the study objects. Levels of serum PCT, Alb, and sTREM-1 were compared between two groups, and according to the condition of illness, children of the sepsis group were divided into general sepsis group (79 cases), severe sepsis group (43 cases) and septic shock group (18 cases) for subgroup analysis. The value of serum PCT, Alb, and sTREM-1 alone or in combination in the diagnosis of sepsis was analyzed by using the subjects′ work curve. Results The levels of serum PCT and sTREM-1 of the sepsis group were significantly higher than those of the control group (P < 0.05); level of serum Alb and PCIS score of the sepsis group were significantly lower than those of the control group (P < 0.05); the differences of serum PCT, sTREM-1 in general sepsis group, severe sepsis group and septic shock group were statistically significant (P < 0.05), without gradual increasing trend; the differences of serum Alb, PCIS score among groups were statistically significant (P < 0.05), without gradual decreasing trend. The sensitivity, specificity and AUC value of PCT+Alb+sTREM-1 were 91.96%, 95.72% and 0.956 respectively in the diagnosis of children with sepsis and inflammatory response syndrome. Conclusion PCT+Alb+sTREM-1 combined diagnosis has higher clinical value in children with sepsis.
2018 Vol. 15 (24): 107-110 [Abstract] ( 235 ) HTML (1 KB)  PDF (648 KB)  ( 141 )
111 Effect of 3D printing guide plate used for titanium mesh pre-forming in orbital surgery
ZHAO Feng1 MA Jingxue2 GAO Yanjun2 GENG Yuxin2 JING Xin2 REN Yanxin2
Objective To discuss the feasibility of 3D printing guide plate used for titanium mesh pre-forming in orbital surgery and observe its preliminary effect. Methods From January 2013 to December 2015, 20 patients (20 eyes) underwent orbital fracture surgery in the Second Hospital of Hebei Medical University were enrolled in the study. Preoperative eyeball invagination was greater than 3 mm. All the patients underwent spiral CT scan before operation. The data were reconstructed by Mimics software, and then the images were repaired by computer aided design. The subtraction operation in the Boolean operation of the software was applied, and the original defect orbital wall data were subtracted from the repaired image. 3D printing guide plate was used for titanium mesh pre-forming in orbital surgery. Visual acuity, exophthalmos and diplopia were observed after operation to evaluate the effect. Results No visual acuity was reduced at 6 months post surgery in the 20 patients, the difference of the protrusion of the eyes were equal to or less than 2 mm in 17 patients, diplopia disappeared in 11 patients at 6 months post operation. The 3D printing guide plate helped to achieve more precise anastomosis between titanium mesh and orbital defect area, and reduced the time required for titanium mesh formation in operation. Conclusion The individualized surgical guide plate can be used for 3D pre-forming of titanium mesh, which is helpful to improve the accuracy of operation and reduce the operation time.
2018 Vol. 15 (24): 111-113 [Abstract] ( 321 ) HTML (1 KB)  PDF (472 KB)  ( 75 )
114 The effect of vidian neurotomy in pulmonary function of allergic rhinosinusitis with nasal polyps
Gulibositan·Maimaitiaili Kayisaier·Kahaer CAI Liang ZHANG Jin
Objective To investigate the effect of vidian neurotomy in pulmonary function of allergic rhinosinusitis with nasal polyps. Methods Sixty-eight cases of allergic rhinosinusitis with nasal polyps, living in Xinjiang for years, hospitalizing at the otorhinolaryngology center of the Xinjiang Uygur Autonomous Region People′s Hospital from February 2015 to May 2017 were selected and were divided into control group and observation group by random number table method, with 34 cases in each group. The two groups were treated with nasal polyp cut and paranasal sinus opening surgery. The observation group was added vidian neurectomy. After a follow-up period for half a year, the clinical efficacy of the two groups was evaluated. The changes of pulmonary function, the postoperative complications and recurrence of the two groups were compared. Results The cure rate in the observation group was significantly higher than that in the control group (P ＜ 0.05), and the levels of VCmax, FEV1, FVC and MMEF in the observation group were significantly higher than those before operation and the corresponding period of the control group (P ＜ 0.05). There were no serious complications and recurrence in the two groups. Conclusion Vidian neurectomy can effectively improve the clinical efficacy of allergic rhinitis sinusitis with nasal polyps, and improve the lung function of patients.
2018 Vol. 15 (24): 114-116,120 [Abstract] ( 296 ) HTML (1 KB)  PDF (518 KB)  ( 151 )
117 The comparison detection of otoendoscope myringoplasty and microscope myringoplasty
LIU Hong FU Baohua▲ WEN Liting ZHOU Min
Objective To compare the effecacy of otoendoscope myringoplasty and microscope myringoplasty. Methods The clinical data of 200 cases of tympanic membrane perforation patients treated in Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, the First Affiliated Hospital of the Fourth Military Medical University of PLA, from January 2016 to December 2017 were analyzed. They were divided into two groups by different operation method, with 100 cases in otoendoscope myringoplasty group and 100 cases in microscope myringoplasty group. The peroperative bleeding, operation time, pain grading post operation, improvement of hearing level post operation and total effective rate, hospital stay and complication incidence of the two groups were compared. Results The peroperative bleeding, operation time, hearing level post operation and total effective rate of the two groups had no significant difference (P ＞ 0.05). The pain grading post operation of otoendoscope myringoplasty group was better than microscope myringoplasty group, the hospital stay was less than microscope myringoplasty group, and complication incidence rate was lower than microscope myringoplasty group, the differences were statistically significant (P ＜ 0.05). Conclusion The otoendoscope myringoplasty treatment for tympanic membrane perforation patient, the pain is little, the recovery is quick, the complication is few, and it is worth to be promoted.
2018 Vol. 15 (24): 117-120 [Abstract] ( 269 ) HTML (1 KB)  PDF (481 KB)  ( 66 )
121 The suitability test of sterility test for Metronidazole and Sodium Chloride Injection
XIA Tian CUI Ying LI Hongduo SHA Miao REN Wenxin
Objective To establish optimized sterility test method of Metronidazole and Sodium Chloride Injection according to the suitability test of sterility test for Metronidazole and Sodium Chloride Injection by the sterility test method (general rule 1101) in Chinese Pharmacopoeia (2015). Methods The test applied membrane filtration method and used 0.1% sterile peptone solution as rinse solution. The rinsing amount of per membrane was increased from 100 mL to the maximum amount of 1000 mL per membrane. Three separate tests were performed. The sample was directly rinsed with the rinse solution for the first time, the rinse solution containing 0.13% and 0.2% polysorbate 80 were used for the second and third time respectively. Results In test one, the Clostridium sporogenes test group did not grow; in test two, the test group grew well when the rinsing amount reached the maximum (1000 mL per membrane); in test three, the antibacterial effect of Metronidazole could be eliminated and the test group grew well when the rinsing amount reached 500 mL per membrane. Conclusion Metronidazole Sodium Chloride Injection (100 mL: Metronidazole 0.5 g and Sodium Chloride 0.8 g) should be sterilized by membrane filtration (10 bottles for each filter cartridge, 0.1% sterile peptone solution containing 0.2% polysorbate 80 as the rinse solution, rinsed for 5 times, 100 mL/time per film), using Clostridium sporogenes as a positive control.
2018 Vol. 15 (24): 121-124,128 [Abstract] ( 276 ) HTML (1 KB)  PDF (583 KB)  ( 58 )
125 Effect of vitamin B12, folic acid combined with Metformin in patients with type 2 diabetes mellitus
GUO Caihong ZHANG Jing
Objective To evaluate the effect of vitamin B12, folic acid combined with Metformin on type 2 diabetes and its effect on homocysteine. Methods From January 2016 to January 2017, 66 newly diagnosed patients with type 2 diabetes, who were diagnosed and treated in Beijing Aerospace Hospital were selected as the subjects. The randomized digital table method was used to divide them into the control group and the observation group, with 33 cases in each group. The control group was treated with Metformin only, while the observation group was treated with vitamin B12 and folic acid combined with Metformin. Vitamin B12, folic acid and homocysteine levels were compared between the two groups after 8 and 12 weeks′ treatment. Results Before treatment, there was no significant difference in the content of folic acid, vitamin B12 and level of homocysteine in these two groups (P > 0.05). After 8 and 12 weeks of treatment, the content of folic acid and the level of homocysteine in the observation group had no obvious change, while the content of vitamin B12 increased obviously. The content of folic acid and vitamin B12 in the control group were more than those of the before treatment, the level of homocysteine was increased, and the differences were statistically significant (P < 0.05). Conclusion Compared with Metformin alone, the treatment of vitamin B12, folic acid and Metformin can effectively stabilize the level of homocysteine in the patients with type 2 diabetes.
2018 Vol. 15 (24): 125-128 [Abstract] ( 393 ) HTML (1 KB)  PDF (361 KB)  ( 57 )
129 Introduction on the experience of Professor Jiang Jian in diagnosing and treating “spleen and stomach disease due to depression syndrome”
ZHOU Dan1 GU Zhijian1 ZHU Leilei1 LI Wei2 CUI Chen1 GEN Qi1 JIANG Jian1
This paper introduces Professor Jiang Jian's clinical experience and academic views on “spleen and stomach disease due to depression syndrome” through experienced cases. The clinical features of spleen and stomach disease due to depression syndrome are as followed: the symptoms of spleen and stomach disease are caused by emotional pathogenic factors, and there are various physical manifestations of emotion, spleen and stomach disease, and beyond spleen and stomach disease; there are no organic gastrointestinal disease or it can not properly explain the patients' symptoms; the symptoms are strange and irrational; it is effective by treatment from depression or by adjuvant treatment from depression. The treatment of spleen-stomach disease due to depression syndrome need follow four principles: the treatment of disease from depression needs combination of medication and non-pharmaceutical approaches; radical treatment for resolving depression need combination with zang-fu location; the treatment of disease from depression needs combination with syndrome differentiation; the treatment of disease from depression needs combination with treatment from phlegm and stasis. The treatment of spleen-stomach disease due to depression syndrome takes depression as root cause and symptom of spleen and stomach disease as manifestation, thus the treatment from depression is to treat the root, the treatment from symptom of spleen and stomach disease is to treat the manifestation.
2018 Vol. 15 (24): 129-132 [Abstract] ( 265 ) HTML (1 KB)  PDF (566 KB)  ( 144 )
133 Effects of Bushen Peiyuan Capsules on the levels of inflammatory factors and heat shock protein in chronic obstructive pulmonary disease patients with syndrome of deficiency of kidney yang
DAI Yong ZENG Qigang DUAN Chenxia LAO Changhui
Objective To study the effect of Bushen Peiyuan Capsules on the levels of inflammatory factors and heat shock protein in chronic obstructive pulmonary disease patients with syndrome of deficiency of kidney yang. Methods Sixty patients with stable chronic obstructive pulmonary disease diagnosed and treated in Guangdong Integrated Traditional Chinese and Western Medicine Hospital from January to December 2017 were selected as research objects. The patients were divided into two groups according to the random number table, with 30 cases in each group. The control group was given Tiotropium Bromide Powder Inhalation to maintain treatment, while the treatment group was added with Bushen Peiyuan Capsules orally. The therapeutic effect between the two groups was observed. Enzyme-linked immunosorbent assay (ELISA) was used to determine the serum levels of tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and interleukin-8 (IL-8). The expression levels of serum heat shock protein-70 (HSP70) were determined by double-antibody sandwich enzyme immunoassay. Results The total effective rate in the treatment group (93.3%) was significantly higher than that in the control group (76.7%) (P ＜ 0.05). After treatment, the expression levels of TNF-α, IL-4 and IL-8 in the two groups were significantly lower than those before treatment (P ＜ 0.05), but the expression levels of inflammatory factors in the treatment group were decreased more significantly (P ＜ 0.05). After treatment, the HSP70 level in the treatment group was significantly higher than that before treatment (P ＜ 0.05), while the control group had no significant improvement (P ＞ 0.05). Conclusion On basis of conventional treatment, Bushen Peiyuan Capsules in the treatment of chronic obstructive pulmonary disease patients with syndrome of deficiency of kidney yang has a significant clinical effect, which can reduce the inflammatory response, improve the expression of heat shock protein, thus protecting the cells from being damaged.
2018 Vol. 15 (24): 133-136,140 [Abstract] ( 259 ) HTML (1 KB)  PDF (622 KB)  ( 65 )
137 Meta analysis of the effect of baduanjin on blood pressure in patients with hypertension
CHEN Xiaoyin1 ZHAO Jingying1 ZHANG Guangqing2 WEI Lin1 LIN Meizhen1 LIN Xiaoli1
Objective To evaluate the effect of baduanjin on blood pressure of patients with hypertension systematically. Methods By searching the recognized Chinese and English database, the randomized controlled trials related to baduanjin in intervention of hypertension were enrolled. Through document screening, data extraction, quality and bias risk assessment, RevMan5.1 software was used to take Meta analysis. Results Finally, total 8 studies were enrolled， the results of meta-analysis showed that no matter when the course was 3 months or 6 months, baduanjin was better than the control group in reducing systolic blood pressure [MD = -4.36, 95%CI (-5.68, -3.04), P ＜ 0.000 01; MD = -8.81, 95%CI (-10.84, -6.78), P ＜ 0.000 01] and diastolic blood pressure [MD = -1.50, 95%CI (-2.58, -0.43), P = 0.006; MD = -4.53, 95%CI (-6.23, -2.83), P ＜ 0.000 01], the differences were statistically significant. Conclusion Baduanjin has certain effects of regulating blood pressure, but whether it can replace drug therapy remains to be verified by prospective randomized controlled studies with high quality and large samples.
2018 Vol. 15 (24): 137-140 [Abstract] ( 264 ) HTML (1 KB)  PDF (1061 KB)  ( 100 )
141 Clinical study of acupuncture combined with Modified Wendan Decoction in the treatment of insomnia with syndrome of phlegm-heat attacking heart
LI Jing
Objective To observe the clinical effect of acupuncture combined with Modified Wendan Decoction in the treatment of insomnia with syndrome of phlegm-heat attacking heart. Methods According to the random number table method, 64 cases of insomnia patients with syndrome of phlegm-heat attacking heart admitted to Department of Psychiatry, Hubei Hospital of Traditional Chinese Medicine from January 2016 to June 2017 were randomly divided into observation group and control group, with 32 cases in each group. The control group was treated with Estazolam Tablets orally. Based on control group, the observation group was treated with acupuncture combined with Modified Wendan Decoction. After 3 weeks of treatment, the changes of main sleep parameters (sleep latency, sleep efficiency, total sleep time), Pittsburgh sleep quality index scale (PSQI) (sleep efficiency, fall-sleep time, sleep time, sleep disorder, daytime function) of the two groups before and after treatment were observed, and the clinical effect of the two groups was compared. Results After treatment, the total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Compared with those before treatment, the sleep latency of the two groups was significantly decreased (P ＜ 0.05), the sleep efficiency and total sleep time were significantly increased, the differences were statistically significant (P ＜ 0.05), and the improvement of the above sleep indexes in the observation group were all significantly better than those of the control group (P ＜ 0.05). The scores of fall-sleep time, sleep time, sleep efficiency, sleep disorder, and daytime function in the two groups after treatment were significantly lower than those before treatment, the differences were statistically significant (P ＜ 0.05), and the scores of PSQI indexes above in the observation group were significantly lower than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Acupuncture combined with Modified Wendan Decoction can improve the sleep quality of insomnia patients with syndrome of phlegm-heat attacking heart, and relieve clinical symptoms.
2018 Vol. 15 (24): 141-144 [Abstract] ( 259 ) HTML (1 KB)  PDF (569 KB)  ( 97 )
145 Report on one case with acute pyelonephritis combined with renal abscess and septicemia
WU Kunzhe1 XU Xiaohua2
Acute pyelonephritis is inflammatory of the upper urinary tract caused by various pathogenic microorganisms in the urinary tract. Renal abscess is one of the common serious complications of pyelonephritis. To further understand the common causes of pyelonephritis combined with renalabscess, this article reports one patient with acute pyelonephritis combined with renal abscess and septicemia admitted to China-Japan Union Hospital, Jilin University, and summarizes the clinical treatment experience of pyelonephritis combined with renal abscess.
2018 Vol. 15 (24): 145-147 [Abstract] ( 283 ) HTML (1 KB)  PDF (483 KB)  ( 88 )
148 Multiple intracerebral calcification: case report and differential diagnosis
LIN Jia1 LIU Jialin2
Pseudohypoparathyroidism is a rare genetic disease, in which, the X chromosome has multiple genes with dominant heredity and is accompanied by autosomal dominant or recessive inheritance in some cases. The clinical manifestations are complex and diverse, especially cases with intracerebral calcification and characteristic manifestations of the nervous system are often misdiagnosed as other diseases. This article reports one patient with head trauma who checked the head CT showed multiple calcifications in the brain. After the consultation of Department of Endocrinology, the patient′s diagnosis was clearly defined, and the patient′s examination results, condition, and treatment process were discussed. Finally, the paper summarizes the clinical differential diagnosis of these diseases.
2018 Vol. 15 (24): 148-151 [Abstract] ( 249 ) HTML (1 KB)  PDF (562 KB)  ( 129 )
152 Discussion on the physical health management system of college students combined with traditional Chinese medicine constitution identification theory
AO Xiang WANG Bin WU Zhikun
This study bases on the traditional Chinese medicine constitution identification theory, via establishing the comprehensive physical tests, personalizing distinguished teaching, and the comprehensive evaluation platform, to form a physical health management system with Chinese characteristics. Current college students′ physical health management is lack of individualization in obtaining health methods, lack of correlation in testing physical health, lack of continuity in paying attention to health management, and lack of effectiveness in choosing physical education courses. The introduction of traditional Chinese medicine constitution identification theory has obvious advantages in physical fitness test， late intervention, physical health management and education function.
2018 Vol. 15 (24): 152-156 [Abstract] ( 258 ) HTML (1 KB)  PDF (809 KB)  ( 172 )
157 Efficacy of Chinese medicine foot-bathing on relieving edema of children primary nephrotic syndrome
CHEN Manni1 LIU Zhuoxun1 CHEN Naiqing1 HUANG Zhenxia1 YANG Jinghua1 ZHOU Chunjiao1
Objective To evaluate the clinical effect of foot-bathing with traditional Chinese medicine on relieving edema of children with primary nephrotic syndrome. Methods Sixty children treated inpatient diagnosed with primary nephrotic syndrome with renal edema in Department of Pediatrics, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine (“our hospital” for short) from October 2015 to June 2017 were selected as subjects. They were divided into control group and treatment group by simple random asignment, with 30 cases in each group. Both groups were given routine treatment and nursing intervention. The treatment group received Chinese herbal (medicine particle prescription in our hospital) foot-bathing treatment for 20 min every day additionally. The course of treatment was 7 days, and both groups were treated for 1 course. Severity of edema, urine volume (24 h), abdominal circumference and the lower limb circumference were compared between the two groups. Results After treatment, the severity of edema in both groups alleviated, and the degree of reduction in the treatment group was better than that in the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the 24 h urine volume increased in both groups, and the increase in the treatment group was higher than that in the control group, the difference was statistically significant (P ＜ 0.05). After treatment, abdominal circumference and lower limb circumference in the two groups had  no significant difference (P ＞ 0.05). Conclusion Chinese medicine foot-bathing was beneficial to alleviate edema. The therapy is simple and convenient that can be applied in clinical practice and promotion.
2018 Vol. 15 (24): 157-160 [Abstract] ( 232 ) HTML (1 KB)  PDF (674 KB)  ( 230 )
161 The risk identification and control of pension program of combined medical and care service in PPP mode
ZHAO Xifeng MO Yingning
In recent years, the state has repeatedly proposed to explore the investment and financing model of public-private partnerships (PPP) in the field of combined medical and care service integration, among these, exploration of PPP project risk management is particularly critical. On the basis of summing up the practice experience of combined medical and care service, this paper decomposes and analyzes the operation flow of PPP project from the perspective of the whole project cycle, it identifies the key risks and risk incentives of the implementation of PPP model for pension programs of combined medical and care service, and proposes to control risks, plays a role in the PPP model, aimed at promoting the healthy development of the pension in our country and providing reference for government decision.
2018 Vol. 15 (24): 161-164 [Abstract] ( 348 ) HTML (1 KB)  PDF (731 KB)  ( 71 )
165 Exploration and practice of higher vocational nursing virtue education based on position competence
TAO Fengyan JI Cheng
Based on the current situation of virtue education, attempts to establish a higher vocational nursing virtue education system based on the position competence, and practice it in order to improve the virtues and qualities of nursing students. Under the common educational mechanism in colleges and hospitals cooperation, nursing virtue education curriculum system covering entire process and all-round is established by construction of the classroom, community and workplace three-in-one virtue education field, which combined the virtues of nursing dominant curriculum and hidden curriculum.
2018 Vol. 15 (24): 165-167,171 [Abstract] ( 298 ) HTML (1 KB)  PDF (743 KB)  ( 133 )
168 Analysis on the prescription comment results of Zhachong Shisanwei Pills in our hospital
CHEN Beirong ZHAO Yun ZHANG Dongmei ZHANG Jianping GUO Cheng
Objective To understand the usage and existing problems of Zhachong Shisanwei Pills in the Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University by reviewing the outpatient prescriptions. Methods Medications reviewed during the research were chosen according to the medication usage evaluation data by using the hospital network. 663 prescriptions from the outpatient pharmacy in May 2017 were randomly selected to be reviewed by using a retrospective method and the results were analyzed statistically. The analysis was conducted based on the rate of irrational prescriptions in different departments, irrational usage and dosage, repeated administration, inappropriate medication use, drug interaction and duration of treatment. Results The overall rate of irrational prescriptions was 15.84%, the most were from Department of Orthopedics. Among the problems in these irrational prescriptions, 67.62% of them were irrational usage and dosage, 33.33% were repeated administration, 0.95% were inappropriate medication use, 2.86% were drug interaction, and 2.86% were duration of treatment. Some prescriptions contained more than one mistake. Conclusion The usage of Zhachong Shisanwei Pills in clinic has some existing problems, the closer drug monitoring is needed, clinical staff need to pay more attention to the use of Chinese patent medicines to make sure patients' safety and to reduce the occurrence of adverse drug reactions.
2018 Vol. 15 (24): 168-171 [Abstract] ( 281 ) HTML (1 KB)  PDF (674 KB)  ( 67 )
172 A study on standardized management paradigm of medical adverse events
WANG Jinyu1 XIAO Longhua1 YAO Xuehan1 LI Qiuyan1 WANG Chuan1 XIE Wenjun2
The paper aim to build up the paradigm of the standardized management of the adverse events, and provide theoretical reference for the management of adverse events in medical institutions. Expert interview and Delphi method have been used, and the ethical principles, objectives and implementation paths of standardized management of adverse events are preliminarily defined, and the paradigm of standardized management of adverse events has been constructed.
2018 Vol. 15 (24): 172-174,181 [Abstract] ( 295 ) HTML (1 KB)  PDF (826 KB)  ( 114 )
175 Current research situation of hospital-school joint program in the cultivation of “dual-qualified” nursing teachers
SHAO Haiyan1 YE Meng2 JIANG Jinxia1
“Practical” and “clinical ability” are the characteristics of higher vocational nursing education. The “dual-qualified” teacher plays an important role in promoting the cultivation of “dual-qualified” teacher for technology applied talents. The school-running orientation and talent training goal of higher vocational nursing education determine the necessity of the requirements for the “dual-qualified” teacher. The hospital-school joint program is a school-running measure for higher vocational colleges to jointly train professional talent by schools and hospitals in order to meet the needs of current development. It is also an effective way to improve teachers′ practical ability and cultivate “dual-qualified” teacher. Strengthening the association of hospitals and universities has great significance for deepening the teaching reform of higher vocational nursing and improving the quality of nursing teaching in China.
2018 Vol. 15 (24): 175-177 [Abstract] ( 316 ) HTML (1 KB)  PDF (667 KB)  ( 112 )
178 Analysis on the rational drug use of Clopidogrel in a hospital of traditional Chinese medicine
FANG Jia XU Bin
Objective To analyze and explore the rationality and potential risk of drug use about Clopidogrel in Wuhu Hospital of Traditional Chinese Medicine ("our hospital" for short). Methods Using our hospital information system, 200 prescriptions containing Clopidogrel in November 2016 were randomly selected. According to content of package insert, results of evidence based medicine and science of drug metabolism, these prescriptions were reviewed for rational use. Results In our hospital, the clinical use of Clopidogrel was generally rational. Only a small number of prescriptions involved irrational drug use like irrational drug indications (n = 20), irrational drug regimen (n = 14) and irrational drug combination (n = 5). Conclusion Doctors should enhance the rationality of drug use about Clopidogrel, clinical pharmacists should establish the relevant standard therapeutic guidline about Clopidogrel to improve the level of rational drug use in the hospital.
2018 Vol. 15 (24): 178-181 [Abstract] ( 240 ) HTML (1 KB)  PDF (884 KB)  ( 95 )
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