lncRNA在动脉粥样硬化病变中的作用研究进展

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Abstract The cardiovascular and cerebrovascular diseases caused by atherosclerosis (AS) is one of the main causes of death. AS is the result of synergistic effect of multiple factors and multiple mechanisms. The endothelial dysfunction, proliferation and migration of vascular smooth muscle cell, lipid metabolism disorders, inflammatory response and autophagy are involved in AS. Because of the complexity of its pathogenesis, it still needs to improve the understanding of its pathogenesis from different perspectives. In recent years, long non-coding RNA is found involving in regulating gene expression, as biomarkers and therapeutic targets for tumors, it has been widely studied and applied. However, lncRNA in atherosclerosis is still in early stage. This article reviews the research progress of lncRNA in the pathogenesis of AS, in order to provide new ideas for prevention and treatment of AS.

Key words： Atherosclerosis Long non-coding RNA Lesions Research progress

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	LI Lijuan1 WANG Qinggao2 HE Yazhou1 LIANG Shan1 HUANG Caiyi1

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LI Lijuan1 WANG Qinggao2 HE Yazhou1 LIANG Shan1 HUANG Caiyi1. Research progress on the effect of lncRNA in atherosclerosis lesions[J]. 中国医药导报, 2018, 15(24): 22-25.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I24/22

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