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| Research progress of Amiloride and its derivatives in central nervous system diseases |
| LIANG Jingjing ZENG Yanping XIAO Zheman LU Zuneng |
| Department of Neurology, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract Amiloride is an oral potassium retaining diuretic, which is always used as antihypertensive drugs in clinic. Information available at present suggests that with the property of being multiple ion channel blockers, Amiloride has tremendous development foreground in the central nervous system diseases, such as epilepsy, migraine, multiple sclerosis and cerebral ischemia injury. This review aims to discuss the mechanisms of Amiloride in the central nervous system diseases, which provide certain theoretical basis in clinical practice, and also makes a prediction focusing on Amiloride and its derivatives in the central nervous system disease.
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