胰石蛋白对早发型新生儿败血症的早期诊断价值

Abstract
Figure/Table
References (16)
Related Citation (15)

Download: PDF (608 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the value of serum pancreatic stone protein (PSP) for the early diagnosis of early-onset neonatal sepsis (EONS). Methods Ninety neonatal with infectious risk factors or infectious symptoms admitted to the Huai′an Maternity and Child Healthcare Hospital Affiliated to Yangzhou University Medical Academy within 24 h after birth from January to June 2014 were enrolled. They were divided into sepsis group (33 cases) and non-sepsis group (57 cases) depending on whether the diagnostic standard of early-onset neonatal sepsis was met. Twenty neonatal with good general situations admited at the same time without infection poisoning manifestation were treated as the control group. The blood samples were obtained from children on 1, 3 and 7 d after birth. The levels of serum PSP and IL-6 were measured, and the data was statistical analyzed. Results There were statistically significant among three groups at all time points (all P < 0.01), and the levels of serum PSP on 1, 3 and 7 d after birth in sepsis group were all higher than those of the non-sepsis group, the differences were statistically significant (all P < 0.05). Levels of serum PSP showed upward trend during d1-d3 after birth, and downward trend during d3-d7. Area under the curve (AUC) of ROC of PSP at 1 d after birth in the diagnosis of sepsis was 0.802 [95%CI: 0.70-0.90, P < 0.01], 3 d after birth was 0.836 (95%CI 0.74-0.93, P < 0.01), the AUC of the combination of PSP and IL-6 in the diagnosis of sepsis at 1 d after birth was 0.879 (95%CI: 0.80-0.95, P < 0.01). Conclusion The level of serum PSP of neonatal has certain clinical value in early diagnosis of EONS. Combination detection of serum PSP and IL-6 in the diagnosis of sepsis at 1 d after birth can improve the sensibility to diagnose early-onset neonatal sepsis and reduce the rate of missed diagnosis.

Key words： Neonate Sepsis Pancreatic stone protein Interleukin-6

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHA Li HU Jinhui ZHU Hongli LIU Yingying WU Rong▲

Cite this article:

ZHA Li HU Jinhui ZHU Hongli LIU Yingying WU Rong▲. Clinical value of serum pancreatic stone protein in the early diagnosis of early-onset neonatal sepsis[J]. 中国医药导报, 2018, 15(24): 88-91.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I24/88

[1] Santos RP，Tristram D. A practical guide to the diagnosis，treatment，and prevention of neonatal infections [J]. Pediatr Clin North Am，2015，62（2）：491-508.
[2] Simonsen KA，Anderson-Berry AL，Delair SF，et al. Early-onset neonatal sepsis [J]. Clin Microbiol Rev，2014，27（1）：21-47.
[3] Stafford IA，SteStewart RD，heffield JS，et al. Efficacy of maternal and neonatal chemoprophylaxis for early-onset group B streptococcal disease [J]. Obstet Gynecol，2012， 120（1）：123-129.
[4] Schlapbach LJ，Graf R，Woerner A，et al. Pancreatic stone protein as a novel marker for neonatal sepsis [J]. Intensive Care Med，2013，39（4）：754-763. DOI：10.1007/s00133-012-2798-3.
[5] Gukasjan R，Raptis DA，Schulz HU，et al. Pancreatic stone protein predicts outcome in patients with peritonitis in the ICU [J]. Crit Care Med，2013，41（4）：1027-1036. DOI：10.1097/CCM0b013e3182771193.
[6] 邵肖梅，叶鸿瑁，丘小汕.实用新生儿学[M].4版.北京：人民卫生出版社，2011.
[7] Bassler D，Stoll BJ，Schmidt B，et al. Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants：added role of neonatal infection [J]. Pediatrics，2009，123（1）：313-318.
[8] Kermorvant-Duchemin E，Laborie S，Rabilloud M，et al. Outcome and prognostic factors in neonates with septic shock [J]. Pediatr Crit Care，2008，9（2）：186-191.
[9] Cotton CM. Antibiotic stewardship：reassessment of guidelines for managemet of neonatal sepsis [J]. Clin Perinatol，2015，42（1）：195-206.
[10] Soni S，Wadhwa N，Kumar R，et al. Evaluation of CD64 expression on neutrophils as an early indicator of neonatal sepsis [J]. Pediatr Infect Dis J，2013，32（1）：e33-e37.
[11] 张文静.血清CRP、IL-6、PCT的检测在新生儿败血症中的诊断价值[J].国际检验医学杂志，2014，35（6）：786-787.
[12] 戴标.IL-6、CRP和CD64在新生儿感染性疾病诊断中的价值[J].江苏大学学报，2012，22（5）：434-436.
[13] García de Guadiana-Romualdo L，Berger M，Jiménez-Santos E，et al. Pancreatic stone protein and soluble CD25 for infection and sepsis in an emergency department [J]. Eur J Clin Invest，2017，47（4）：297-304.
[14] Palmiere C，Augsburger M. Pancreatic stone protein as a postmortem biochemical marker for the diagnosis of sepsis [J]. Leg Med（Tokyo），2015，17（1）：9-13.
[15] Ji■í Z，Kyr M，Vav?伥ina M，et al. Pancreatic stone protein-possible bio-marker of multior-gan failure and mortality in childrensepsis [J]. Cytokine，2014，66（2）：106-111.
[16] Schlapbach LJ，Graf R，Woerner A，et al. Pancreatic stone protein as a novel marker for neonatal sepsis [J]. Intensive Care Med，2013（S3），39：754-763.