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2020 Vol. 17, No. 3 Published: 2020-01-25

	4	Effect and mechanism of 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid on myocardial inflammatory response in sepsis mice
		WANG Yan1 XIA Lin2 CAI Huazhong3 XIONG Yuyun2
		Objective To investigate the effect and mechanism of 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid (DIDS) on myocardial inflammatory response in sepsis mice. Methods A total of 52 male BALB/c mice were divided into 4 groups by random number table method, namely blank control group, lipopolysaccharide (LPS) group, low dose DIDS group and high dose DIDS group, with 13 mice in each group. For 3 days of pretreatment, the low dose DIDS group and the high dose DIDS group were intraperitoneally injected with 7 and 14 mg/kg DIDS every day, respectively, while the blank control group and the LPS group were given the same amount of phosphate buffer salt solution (PBS) intraperitoneally every day. After 2 h of pretreatment on the third day, PBS was injected intraperitoneally into the blank control group, and LPS 10 mg/kg was injected intraperitoneally into the other three groups to establish a mouse sepsis model. After the model was created successfully, the survival status of 10 mice in each group were observed for 48 h, and the survival rates were calculated. In addition, 3 mice in each group were sacrificed after 4 h, and their heart tissues were taken. The mRNA expression of inflammatory factors [including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6)] and genes related to Notch signaling pathway (including Notch1-4, Dll1 and Jag1) were detected by real-time PCR. Western blot was used to detect the expression of proteins related to the Notch signaling pathway. Results Compared with the LPS group, the survival rate of mice in the high dose DIDS group was significantly improved, with a highly statistically significant difference (P < 0.01). Compared with the blank control group, the mRNA levels of TNF-α,IL-1β and IL-6 in the LPS group were significantly increased, with statistically significant differences (all P ＜ 0.05). Compared with the LPS group, the mRNA levels of TNF-α，IL-1β and IL-6 in the high dose DIDS group were significantly decreased, with statistically significant differences (all P ＜ 0.05). Compared with the LPS group, mRNA expression levels of Notch1, Notch3, Dll 1 and Jag 1 of Notch signaling related genes in the high-dose DIDS group were increased, and protein levels of Dll 1 and Jag 1 were increased, with statistically significant differences (all P < 0.05). Conclusion DIDS can significantly reduce the myocardial inflammatory response in sepsis mice, and its mechanism may be related to the regulation of Notch signaling pathway.
		2020 Vol. 17 (3): 4-7,21 [Abstract] ( 189 ) HTML (1 KB) PDF (677 KB) ( 105 )

	8	Design of bluetooth lung function instrument
		LIANG Rui1 YAO Kainan2 DENG Yingqiang3 CHEN Jianmin3
		Objective To design and develop a bluetooth portable device which can detect common lung function parameters. Methods The data of high precision varistor were collected and processed by single chip microcomputer. And the test data were calculated by calibration parameters and linear interpolation. Standard breathing simulator error and actual measurement error for testing bluetooth lung function meter. Results The bluetooth lung function instrument was designed successfully, which could monitor forced vital capacity (FVC), peak expiratory flow, forced expiratory volume in one second (FEV1) and FEV1/FVC. The requirement was met by the bluetooth pulmonary function. Compared with the yeger pulmonary function tester, the measuring error by the bluetooth pulmonary function tester of six subjects were all within 5%. Conclusion The device is small and convenient, and can meet the application requirements of clinical and home tests.
		2020 Vol. 17 (3): 8-12 [Abstract] ( 145 ) HTML (1 KB) PDF (1318 KB) ( 112 )

	13	Effect of Regesi regeneration silicon and Bio-Oss bone meal on proliferation and osteogenic differentiation of osteoblasts
		JIA Yan1 ZHANG Baorong2
		Objective To observe the growth of mouse osteoblast (MC3T3-E1) on Regesi regeneration silicon and Bio-Oss bone powder, and to analyze the effects of Regesi regeneration silicon materials and Bio-Oss bone powder on mouse osteoblast proliferation and osteogenic differentiation. Methods The experiment was divided into three groups, respectively Regesi regeneration silicon group, Bio-Oss bone powder group and control group. The two materials were placed in 24-well plates, while the control group was blank. Cells were inoculated on 24-well plates in each group, and the cell growth was observed by inverted microscope at 1, 4 days, and 7 days of culture; MTT was used to detect cell proliferation activity at 1, 4 days, and 7 days of culture; OD value of osteoblasts was determined by alkaline phosphatase (ALP) kit at 7 d culture to analyze ALP activity. Rt-PCR method was used to determine Runx2 and Osterix(OSX) gene expression in 3 groups of cells at 7 days of culture. Results Under the microscope, the number of cells in each group increased with time. The proliferation level of cells in Regesi group increased (P ＜ 0.05), and the ALP activity elevated,the expression levels of Runx2 and OSX mRNA increased at 7 days of culture(P ＜ 0.05). The proliferation level of cells in the bio-Oss bone meal group was decreased at 7 days of culture(P ＜ 0.05), and there was no significant difference in the ALP activity, and the expression levels of Runx2 and OSX mRNA (P ＞ 0.05). Conclusion Regesi regenerated silicon can promote the proliferation and differentiation of MC3T3-E1 cells. Bio-Oss bone powder can decrease cell proliferation, while there is no significant difference between osteogenic differentiation ability and osteoblasts alone.
		2020 Vol. 17 (3): 13-16 [Abstract] ( 301 ) HTML (1 KB) PDF (919 KB) ( 95 )

	17	Screening of population with β-thalassemia mutation and analysis of functional mutation of KLF1 in Gaoming District, Foshan City
		CHEN Hanghua1 ZHANG Yu2 LIU Cuixian2 HE Qingrong1
		Objective To analyze the mutation spectrum and carrier frequency of β-thalassemia in Gaoming District, Foshan City, and the relationship between functional mutation carriers of KLF1 gene and increased fetal hemoglobin (HbF) level was also analyzed. Methods From January 2017 to October 2018, peripheral blood of pregnant women in Gaoming District People′s Hospital Affiliated to Guangdong Medical University was collected for prenatal screening of thalassemia. Gene diagnosis and phenotypic- genotype analysis were performed for phenotypic positive samples. All poor carriers were screened for KLF1 mutations. Results A total of 5318 pregnant women were screened and 1387 cases were found to be positive for hematological phenotype. Subsequent molecular diagnosis identified 649 cases of geodesic poor gene carriers, of which 246 cases were geodesic poor carriers, and 4 cases were carrying KLF1 mutations, with significantly higher HbF levels than non-carriers(P ＜ 0.01). 498 of the spouses were recalled for genetic diagnosis, of which 87 cases were positive for destitute gene, of which 32 cases were carriers of destitute mutation. Seven couples were at high risk for children born in moderate and heavy poverty areas. In the prenatal diagnosis of fetal genotype in 7 pregnant women, 3 cases were identified as medium and heavy fetuses. Conclusion In this study, the low-fertility mutation screening and epidemiological investigation were carried out on the pregnant screening population in this area, and the low-fertility carrying rate in Gaoming District counted under a certain sample space, and the phenomenon that KLF1 functional mutation was significantly correlated with the increase of HbF was verified.
		2020 Vol. 17 (3): 17-21 [Abstract] ( 146 ) HTML (1 KB) PDF (837 KB) ( 120 )

	22	Research progress on protective mechanism of Flos Carthami and Astragali Radix on cerebral ischemia injury
		WANG Kai1,2 LEI Lu2 CAO Jinyi2 DUAN Jialin2 WEN Aidong2 QIAO Yi2 YANG Zhifu2
		Flos Carthami is a traditional medicine to promote blood circulation and remove blood stasis, and Astragali Radix is a traditional medicine to replenish qi, they are commonly used in treating ischemic stroke in clinic. Ischemic stroke is an acute cerebrovascular disease, also known as cerebral ischemia, with a higher mortality. After cerebral ischemia, a series of responses occur in the brain, leading to inflammation, apoptosis and brain edema. The mechanism of Flos Carthami and Astragali Radix in the treatment of ischemic stroke is mainly through antioxidant scavenging free radicals, inhibiting apoptosis and inflammatory response, and regulating some signaling pathways to play a role in brain protection. The protective mechanism of Flos Carthami and Astragali Radix is complex and has the characteristics of multiple links, multiple pathways and multiple targets. In this paper, the cerebral protective effects and mechanism of Flos Carthami and Astragali Radix in recent years are reviewed, which will provide theoretical basis for further in-depth research and clinical application.
		2020 Vol. 17 (3): 22-25 [Abstract] ( 240 ) HTML (1 KB) PDF (587 KB) ( 58 )

	26	Research progress in biomarkers and predictors of cognitive impairment after ischemic stroke
		GAO Manman YAN Bingchun
		Cognitive impairment after ischemic stroke is an important part of post-stroke disability, which not only increases the mortality rate of patients, but also seriously affects patients′ daily living ability and social function. A large number of biomarkers such as enzymes, serum, cerebrospinal fluid, inflammatory mediators, hormones, genotypes and RNA profiles have been shown to predict cognitive impairment after ischemic stroke. In addition, neuroimaging, cerebrovascular disease and its risk factors such as blood pressure, blood glucose, renal function and other abnormal indicators are related to cognitive dysfunction. The paper reviews the known biomarkers and predictors to provide a basis for the prediction and diagnosis of cognitive impairment after ischemic stroke.
		2020 Vol. 17 (3): 26-29,37 [Abstract] ( 202 ) HTML (1 KB) PDF (642 KB) ( 397 )

	30	Research progress on the relationship between fusobacterium nucleatum and colorectal cancer
		CHENG Yu1 TAN Shiyun2 LI Ming2 Ma Fengmei1
		Colorectal Cancer (CRC) has high incidence and mortality. Fusobacterium nucaleatum (Fn) is closely related to the occurrence, development and drug resistance of CRC, however, the mechanism is not clear. This paper intends to explore mechanisms from inflammation, immunity, phenotypic inheritance, metabolism, drug resistance and so on. Moreover, Fn can also be used as a new biomarker in the clinical diagnosis of CRC, while fecal test, serological test and electrospray ionization mass spectrometry are of great value in clinical diagnosis. At the same time, antibiotic treatment and vaccine therapy for Fn provide a new direction for the treatment of CRC. This article reviews the mechanism of pathogenesis, drug resistance, the diagnostic value and the treatment of CRC caused by Fn.
		2020 Vol. 17 (3): 30-33 [Abstract] ( 207 ) HTML (1 KB) PDF (578 KB) ( 96 )

	34	Research progress on adjuvant transcatheter arterial chemoembolization in postoperative hepatocellular carcinoma
		LI Jinghe SHI Zhengrong
		Transcatheter arterial chemoembolization (TACE) has become an important adjuvant therapy in postoperat -ive hepatocellular carcinoma, and the effect of TACE has gradually gained the attention of clinicians. The current study suggests that recurrence after hepatocellular carcinoma resection is related to the failure to detect potential microscopic lesions in time. Since the blood supply to liver cancer tissue is mainly derived from the hepatic artery, the adjuvant use of TACE can lead to tumor tissue ischemia and necrosis in the embolization area, which can help eliminate small residual cancer, and theoretically can reduce recurrence and prolong survival. However, the actual clinical efficacy and scope of application are still the focus of current explore and research. In this paper, the application opportunity, the applicable population, the application mode and the research progress of efficacy detection of TACE are described.
		2020 Vol. 17 (3): 34-37 [Abstract] ( 193 ) HTML (1 KB) PDF (580 KB) ( 86 )

	38	Research progress in the role of inflammatory factors in the pathogenesis of pre-diabetes
		ZUO Jiaojiao1 WANG Xiaoxia1 ZHANG Dinghua2 SHI Xiaowei2 QIU Lianli3
		The prevalence of type 2 diabetes and pre-diabetes is increasing year by year. Early detection of risk factors for pre-diabetes and timely diagnosis and intervention to prevent and reduce the occurrence and development of diabetes and its complications are worthy of attention and research. The role of inflammatory factors in the development of pre-diabetes has been one of the research hotspots in the field of endocrine metabolism. CRP, TNF-α, IL-6 and other novel inflammatory factors has also been discovered by more and more researchers. In this paper，the research progress of the role of inflammatory factors in the pathogenesis of pre-diabetes in recent years is reviewed in order to provide new ideas for the intervention of pre-diabetes.
		2020 Vol. 17 (3): 38-40,44 [Abstract] ( 158 ) HTML (1 KB) PDF (593 KB) ( 69 )

	41	Effect of matrix metalloproteinase-9 and vascular endothelial growth factor on ischemic stroke
		XU Yang1 XIONG Yingqiong2▲
		Matrix metalloproteinase 9 (MMP-9) can aggravate the development of ischemic stroke (brain infarction) disease by promoting inflammatory response, which is detrimental to the prognosis of the disease. Vascular endothelial growth factor (VEGF) is beneficial to the establishment of ischemic and penumbra collateral circulation, and plays a relatively beneficial role in the repair of brain infarction injury. However, MMP-9 and VEGF have complex interactions, and the changes in concentration at the time of disease may synergistically aggravate the damage of ischemic brain tissue. In this paper, the role of MMP-9 and VEGF in the development of brain infarction and the interaction between them are reviewed in recent years. It is proposed to reduce the concentration of MMP-9 in time after brain infarction, and timely promotion of VEGF content may be more favorable for prognosis.
		2020 Vol. 17 (3): 41-44 [Abstract] ( 196 ) HTML (1 KB) PDF (577 KB) ( 133 )

	45	Review on relationship between the expression and function of transient receptor potential channels in the lower urinary tract
		REN Jie1 GAO Hongfei2
		Some channels in the transient receptor potential superfamily are widely expressed in the lower urinary tract, such as TRPV1, TRPV4, TRPA1, TRPM4 and TRPM8 channels. These transient receptor potential channels participate in many physiological and pathological activities in the lower urinary tract. It is related to the pathogenesis of lower urinary tract dysfunction, bladder cancer and prostate cancer. For example, TRPV1 channel and overactivity of bladder, TRPV4, TRPA1 and TRPM4 channel with overactivity of detrusor, TRPM4 channel and TRPM8 channel with prostate cancer. Transient receptor potential channel can be used as a new target for clinical treatment of these diseases. For example, the TRPV1 channel agonist capsaicin has been used in the clinical treatment of overactive bladder, but this goal still needs to be achieved through follow-up studies.
		2020 Vol. 17 (3): 45-48 [Abstract] ( 178 ) HTML (1 KB) PDF (576 KB) ( 135 )

	49	Vitamin D nutritional status and the relationship with climatic changes research of minors aged 0-16 in Liuzhou area
		WEI Xiaoni DING Yanling FU Jinjian
		Objective To investigate the levels of 25-hydroxy vitamin D [25-(OH) D] in minors of 0-16 years old in Liuzhou area, and provide scientific reference for reasonable supplement of vitamin D (Vit D). Methods A total of 3441 minors aged 0 to 16 who underwent a health check-up at the Children′s Health Department of Liuzhou Maternal and Child Health Hospital from January to December 2017 were selected. The study subjects were divided into four groups according to age, including 161 children in the group of 0 to 1 year old, 1716 children in the group of 1 to 3 years old, 1184 children in the group of 3 to 6 years old, and 380 children of the > 6 years old group; according to season 1209 minors were divided in the winter and spring group, 2232 in the summer and autumn group. The levels of 25-(OH) D were detected by electrochemical luminescence method, and the relationship between 25-(OH) D and age, sex, and season were analyzed. Results There was no statistically significant difference in the levels of 25-(OH) D among different minors aged 0 to 16 in Liuzhou area (P ＞ 0.05). Among them, the constituent ratios of adequate, insufficient, and lacking Vit D were 77.4%, 19.5% and 3.1% respectively. Comparison of 25-(OH) D levels in each age groups, the differences were highly statistically significant (P ＜ 0.01). The differences of percentage of Vit D deficiency and insufficiency in each age group was highly statistically significant (P ＜ 0.01). The difference of proportion of Vit D deficiency, insufficiency, and adequacy of different genders in the ＞6 years old group was highly statistically significant (P ＜ 0.01). The proportion of deficiency and insufficiency Vit D in the winter and spring group was significantly higher than that in the summer and autumn group, and the difference was highly statistically significant (P ＜ 0.01). Conclusion The reasonable supplement of Vit D should be paid more attention, especially the schoolchildren, adolescents, girls and the supplement of Vit D in winter and spring.
		2020 Vol. 17 (3): 49-52 [Abstract] ( 132 ) HTML (1 KB) PDF (544 KB) ( 51 )

	53	Analysis and discussion on the needs of scientific researchers in a third-class hospital of children′s speciality in Beijing
		ZHAO Qiongshu1,2 WANG Zhiwei1 ZHAO Bo2 LI Zhe2 LIANG Di2 TAI Jun2 XIE Xianghui2 NI Xin2
		Objective To investigate and analyze the current situation of scientific research needs of scientific research personnel in children′s specialist grade A class three hospitals, propose countermeasures, strengthen the effectiveness of scientific research management, and improve the level of pediatric scientific research. Methods According to the basic information, scientific research activities, and the status of scientific research needs of the transferees, they independently designed a questionnaire for “Scientific Research Needs Questionnaire”. A questionnaire survey was conducted on personnel engaged in scientific research at a children′s specialist hospital in Beijing from January to February 2019. Results 400 questionnaires were distributed, 326 questionnaires were collected and 293 questionnaires were valid, with an effective recovery rate of 89.88%. The main reason for the participants to engage in scientific research work was the need for promotion (74.74%). The practical difficulty for most participants in scientific research was lack of time or energy (73.38%). At the same time, scientific researchers need training and academic activities for scientific research design and topic selection ideas. Conclusion Researchers have the most outstanding difficulties and needs in every aspect of scientific research. It is suggested that work out manage countermeasure on giving appropriate off-work time, scientific research topic selection, scientific research bidding document writing, academic paper writing and submission training, improving experimental space and conditions, simplifying the use of funds properly and enhancing the construction of incentive mechanism for scientific research.
		2020 Vol. 17 (3): 53-56,64 [Abstract] ( 255 ) HTML (1 KB) PDF (559 KB) ( 46 )

	57	Analysis on relativity between social support and quality of life of family caregivers of patients with stroke sequelae
		KANG Junming1 CHEN Xiuyan2 CHEN Lei1 WU Chengkai1 DENG Yalin3 LI Wenyuan4
		Objective To analyze the status and correlation of quality of life and social support levels of family caregivers of patients with stroke sequelae. Methods A survey of 148 patients with stroke sequelae and their family caregivers were conducted in Dadong Street Community Health Service Center of Yuexiu District of Guangzhou from April to August 2019 by the MOS 36-item Short Form Health Survey (SF-36) and Social Support Rating Scale (SSRS). The differences in quality of life and social support with norm scores were compared and the correlation was analyzed. Results The quality of life of family caregivers of patients with stroke sequelae was poor. Except for physiological function and mental health, the other dimensions were lower than the norm, and the differences were all statistically significant (all P ＜ 0.05). Overall, the quality of life of family caregivers of patients with stroke sequelae was positively correlated with social support (r = 0.275, P ＜ 0.01). Except for objective support, all other dimensions were significantly correlated with the total score of quality of life (P ＜ 0.05). Conclusion The family caregivers of patients with stroke sequelae have lower quality of life and poor social support. Community medical staff should actively take measures to improve the levels of social support for family caregivers of patients with stroke sequelae, thereby improving the quality of life of patients and family caregivers.
		2020 Vol. 17 (3): 57-60 [Abstract] ( 239 ) HTML (1 KB) PDF (578 KB) ( 133 )

	61	Study on investigation of the current situation of empathy ability of pediatric nurses and the influence factors
		ZHANG Yalin ZHANG Saichun ZHANG Lin YU Yanli
		Objective To investigate the current situation of empathy ability of pediatric nurses and analyze the influence factors. Methods A total of 3488 registered pediatric nurses worked in hospitals of many provinces and municipalities for more than one year from Beijing Children′s Hospital Group were recruited by convenience sampling method. A cross-sectional questionnaire survey was performed on the general information and the Chinese version of the Jefferson Scale of Empathy-Health Professionals (JSE-HP). Results The average empathy ability of pediatric nurses were (82.14±11.01) points, which was in the middle level. There were significant positive correlations between working age, education and empathy ability (P ＜ 0.05). Education and working age were the influencing factors of nurses' empathy ability (P ＜ 0.05). Conclusion The empathy ability of pediatric nurses is at a medium level. Managers must fully consider the effects of various factors in the nurses on empathy ability, while carry out learning and career cognition and developing empathy ability for pediatric nurses with different working years to cultivate. In addition, it is necessary to actively guide nurses to participate in on-the-job education and continuously improve their academic credentials and empathy ability.
		2020 Vol. 17 (3): 61-64 [Abstract] ( 188 ) HTML (1 KB) PDF (570 KB) ( 448 )

	65	Diagnostic value of combined detection of serum NF-κB, TNF-α levels in patients with tPSA gray area prostate cancer
		ZHOU Yi WANG Wei LIU Jie YAO Yuan YANG Jianwen
		Objective To investigate the diagnostic value of tumor necrosis factor-α (TNF-α) and nuclear factor-κB (NF-κB) in serum of prostate cancer (PCa) patients. Methods From January 2015 to January 2018, 100 cases of PCa diagnosed and treated in Liuzhou People′s Hospital Affiliated to Guangxi University of Science and Technology (hereinafter referred to as “our hospital”) were selected as the PCa group. Forty patients with benign prostatic hyperplasia (BPH) diagnosed and treated in our hospital during the same period were selected as the BPH group, 40 healthy subjects who underwent physical examination in our hospital during the same period were selected as the healthy control group. Determination of total PSA (tPSA) in each group by electrochemical luminescence. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum TNF-α and NF-κB in each group, and the differences in the expression of each indicator were statistically analyzed. The receiver operating characteristic curve (ROC) was used to analyze the diagnostic value of each indicator in PCa. Results Comparison of serum tPSA between the BPH group and the PCa group showed statistically significant difference (P ＜ 0.05). The levels of TNF-α and NF-κB in the PCa group were higher than those in the healthy control group and the BPH group, with statistically significant differences (all P ＜ 0.05). The expression of TNF-α and NF-κB in the PCa group was correlated with pathological grade, Gleason score and tumor stage (all P ＜ 0.05), and was independent of age, initial tPSA and the presence of distant metastasis (P ＞ 0.05). Sensitivity and specificity of TNF-α, NF-κB and combined assays were 75.1%, 79.2% and 81.3%, respectively, and 71.5%, 80.1% and 82.4%, respectively. The area under the ROC curve was 0.713, 0.753 and 0.832, respectively. The diagnostic efficiency of joint diagnosis was higher than that of any single indicator. Conclusion The expressions of TNF-α and NF-κB in serum of PCa patients were increased, and the combined detection of TNF-α and NF-κB in serum of PCa patients was of high diagnostic value for PCa in the gray area of diagnosis.
		2020 Vol. 17 (3): 65-68,73 [Abstract] ( 237 ) HTML (1 KB) PDF (760 KB) ( 149 )

	69	Meta analysis of extracorporeal shock wave therapy in the treatment of knee osteoarthritis
		YU Shaoyong1 LIU Jianhang2 ZHOU Hanjing1 WU Haibo1 XIE Guixin1 LI Jinwei3
		Objective To systematically assess the clinical effect of extracorporeal shock wave therapy （ESWT） for knee osteoarthritis (KOA). Methods From the establishment of the database to February 20, 2019, the databases of PubMed, Embase, Web of Science, the Cochrane Library, CNKI, CBM, VIP, WanFang were searched, and the clinical randomized controlled trials of ESWT in the treatment of KOA were searched. According to inclusion and exclusion criteria, the literature were screened with 2 researchers, the data and the quality of the included literature were extracted and evaluated. RevMan 5.3 was used for data analysis. Results A total of 11 articles, 969 cases were included. The results of meta analysis showed that, VAS scores in ESWT group were lower than those in control group, with statistically significant differences (MD = -2.07, 95%CI: -3.83, -0.31, P < 0.05). Western Ontario and Mcmaster University Osteoarthritis index (WOMAC) in ESWT group were significantly lower than those in control group, with statistically significant differences (MD = -9.06, 95%CI: -14.36, -3.76, P < 0.01). There was no significant difference in shedding rate between the two groups (OR = 0.82, 95%CI: 0.28, 2.45, P > 0.05). The results of the subgroup analysis showed that the VAS scores in ESWT group were significantly lower than those in drug group, with statistically significant differences (MD = -1.99, 95%CI: -3.58, -0.41, P < 0.05). VAS scores in ESWT group were significantly lower than those in ultrasonic group, with statistically significant differences (MD = -1.11, 95%CI: -1.98, -0.23, P < 0.05). VAS scores in ESWT group and sodium hyaluronate group showed no significant differences (MD = -2.86, 95%CI: -9.23, -3.51, P > 0.05). Conclution ESWT improves pain, stiffness, and somatic function in the short term.
		2020 Vol. 17 (3): 69-73 [Abstract] ( 199 ) HTML (1 KB) PDF (1377 KB) ( 172 )

	74	Comparative study of modified lower abdominal median incision internal fixation and external fixation in the treatment of anterior pelvic ring fractures
		LU Guoliang PAN Yaocheng ZOU Zeliang▲
		Objective To compare the clinical effect of modified lower abdominal median incision internal fixation and external fixation in the treatment of anterior pelvic ring fractures. Methods From June 2017 to March 2018, 80 cases with anterior pelvic ring fractures who admitted to Guangdong Province, Foshan Hospital of TCM were retrospectively analyzed. According to the different surgical methods, they were divided into group A (n = 36) and group B (n = 44). Group A was treated with external pelvic fixation stent, group B was treated with percutaneous nail-rod system fixation. The clinical effect, operation time, incidence of nerve injury, intraoperative blood loss, incision length, fracture healing time, visual pain analogue score (VAS) and the occurrence of complications were compared betwee two groups. Results The total effective rate of group B was higher than that of group A, and the difference was statistically significant (P < 0.05). VAS scores at 1, 3, 6 months and 12 months after surgery showed a gradually decreasing trend, and group B was lower than group A, with statistically significant differences (all P < 0.05). The operative time and incision length of group B were longer than those of group A, intraoperative blood loss was higher than that of group A, and fracture healing time of group B was shorter than that of group A, the differences were statistically significant (all P < 0.05). There was no significant differences in the rate of nerve injury (P > 0.05). There were no significant differences in the incidence of complications between two groups (P > 0.05). Conclusion Compared with external pelvic fixation stent, the percutaneous nail-rod system fixation has a relatively large wound, but the fracture healing time is shorter and the nerve injury is less, which can effectively reduce the postoperative pain, improve the clinical effect, and do not increase the incidence of complications and the clinical application value is higher.
		2020 Vol. 17 (3): 74-77 [Abstract] ( 272 ) HTML (1 KB) PDF (559 KB) ( 112 )

	78	Experience in the treatment of meniscus defect by allogeneic meniscus transplantation under arthroscopy
		WANG Min1 WANG Wen1 LI Ying2 MENG Qingqi1 YANG Weimin1 LI Siming1
		Objective To investigate the clinical efficacy of arthroscopic allogeneic meniscus transplantation in the treatment of meniscus defects. Methods Fifteen patients with meniscus defects received from the Department of Orthopedics, Guangzhou Red Cross Hospital and the Second People′s Hospital of Shenzhen from January 2016 to March 2017 were selected. All patients underwent the same allogeneic meniscus transplantation under arthroscopy. Postoperative follow-up was conducted, including joint symptoms and signs, knee imaging examination results, and Lysholm knee score. Results All the 15 patients were followed up for 8 to 16 months, with an average of (12.50±0.50) months. 93.33% of the patients had no obvious symptoms of discomfort in the knee joint and were able to take care of themselves, 6.67% of the patients developed effusion in the joint cavity 6 months after the operation, which affected the function of the knee joint. The pain was intense, and the effusion disappeared after repeated drainage, and the pain was relieved. The imaging results showed that there was no change in the postoperative knee joint space in 93.33% patients, no osteophyte formation and necrosis occurred around them, and there was a small amount of effusion in the joint cavity and local uplift in 6.67% patients. Lysholm knee score before and after surgery was compared at different time points, and the difference was statistically significant (F = 6.478 , P ＜ 0.05), and the 3, 6 months and 12 months after the operation were all improved compared with the pre-operation, the difference was statistically significant (P ＜ 0.05). Conclusion The clinical effect of allogeneic meniscus transplantation under arthroscopy for meniscus defect is better, and it has important application value.
		2020 Vol. 17 (3): 78-81 [Abstract] ( 231 ) HTML (1 KB) PDF (768 KB) ( 178 )

	82	Expression changes and clinical significance of TLR-4 and IL-1β in serum and knee joint fluid of patients with knee osteoarthritis
		MAO Honggang1 ZHU Yanli2 LIU Yan1 LIU Guodong1 ZHANG Fei1
		Objective To investigate the expression changes and clinical significance of Toll-like receptor-4 (TLR-4) and interleukin-1β (IL-1β) in serum and knee joint fluid of patients with knee osteoarthritis (KOA). Methods From June 2017 to December 2018, 220 cases with KOA who admitted in Department of Orthopedics, the Third Affiliated Hospital of Inner Mongolia Medical University (“our hospital” for short) were selected as observation group. According to the severity of KOA, they were divided into mild subgroup (n = 98), moderate subgroup (n = 80) and severe subgroup (n = 42). In addition, 60 cases of volunteers were selected for physical examination in our hospital of health center medical as control group. The levels of TLR-4 and IL-1β in serum and knee joint fluid were detected by enzyme-linked immunosorbent assay. The correlation between TLR-4, IL-1β levels and KOA severity were analyzed and their correlation were analyzed. Results The levels of TLR-4 and IL-1β in serum and knee joint fluid of observation group were significantly higher than those of control group, and the differences were statistically significant (all P < 0.05). The levels of TLR-4 and IL-1β in severe subgroup were significantly increased than those of moderate subgroup and mild subgroup, compared with mild subgroup, the levels of TLR-4 and IL-1β in moderate subgroup were significantly increased, and the differences were statistically significant (all P < 0.05). Serum and knee joint fluid TLR-4 and IL-1β levels were positively correlated with KOA severity (r = 0.706, 0.729, 0.741, 0.715, all P < 0.05). Serum TLR-4 level was positively correlated with IL-1β level (r = 0.720, P < 0.05). The level of TLR-4 in knee joint fluid was positively correlated with IL-1 level (r = 0.736, P < 0.05). Conclusion The levels of TLR-4 and IL-1β in serum and knee joint fluid of KOA patients unusually increase, which is closely related with the severity of KOA. It can be used for clinical prediction, diagnosis and treatment of KOA.
		2020 Vol. 17 (3): 82-85 [Abstract] ( 227 ) HTML (1 KB) PDF (562 KB) ( 82 )

	86	Risk factors analysis and prediction model construction of nosocomial infection in elderly hospitalized orthopedic patients
		ZUO Lili XUE Yiwei
		Objective To analyze the risk factors of nosocomial infection in orthopedic hospitalized patients and to construct a predictive model. Methods A total of 2114 patients who were admitted to the Department of Orthopedics of Shanghai Sixth People′s Hospital from January 2015 to December 2018 were selected. The patients were divided into the modeling group and the validation group according to the random number table method, with 1057 patients in each group. Chi-square test and unconditional logistic regression were used to analyze the risk factors affecting nosocomial infection, and the predictive model of nosocomial infection in elderly orthopedic patients was established based on the results. Results Among the 1057 patients in the modeling group, 53 cases had nosocomial infection. Logistic regression analysis showed age, hospital stay, operative time, surgical incision type, catheterization, and osteoporosis were risk factors for nosocomial infection in hospitalized orthopedic patients (P < 0.05). The area under the ROC curve of probability value fitting joint prediction in the constructed prediction model was 0.808, and the sensitivity and specificity were 73.3% and 81.2%, respectively. Based on this, a predictive scoring model was established. The area under the ROC curve of the modeling group and the verification group were 0.801 (95%CI: 0.725-0.852) and 0.721 (95%CI: 0.630-0.812), respectively. Conclusion Age, hospital stay, operative time, surgical incision type, catheterization and osteoporosis of orthopedic patients are risk factors for nosocomial infection. The predictive model constructed by this method has good discriminat validity in both the modeling group and the validation group.
		2020 Vol. 17 (3): 86-89,97 [Abstract] ( 177 ) HTML (1 KB) PDF (1035 KB) ( 100 )

	90	Effect of human luteinizing hormone on clinical outcome during in-vitro fertilization or intracytoplasmic sperm injection-embryo transfer
		XIA Rong YANG Pan LI Jianjun GUO Haichun ZHANG Jianmei XIAO Yaling
		Objective To investigate the effect of human luteinizing hormone (LH) on clinical outcome during in-vitro fertilization or intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). Methods Clinical data of patients with ovulation induced through long follicle stage regimen at the Reproductive Center of Changsha Maternal and Child Health Hospital from January 2017 to August 2018 were analyzed retrospectively, 188 cycles. The patients were divided into four groups based on whether the LH preparation was added during the ovulation promotion or not: Group A [human menopausal gonadotropin (HMG) group, 72 cycles]: HMG was included in addition to follicle-stimulating hormone (FSH), during ovulation]. Group B (r-LH group, 34 cycles): r-LH was added in addition to FSH in the later stage. Group C (HMG+r-LH group, 51 cycles): HMG was added during ovulation promotion and r-LH group was added in the later stage (no LH group, P < 0.05). Group D (31 cycles): no LH preparation was added. Only FSH was used to promote ovulation until the HCG injection day. Thereafter, the number of eggs, normal fertilization rate, high quality embryo rate, clinical pregnancy rate and embryo implantation rate were compared. Results No significant differences were observed in age, infertility years, blood LH level, number of oocytes acquired, normal fertilization rate and embryo rate among all groups (P > 0. 05). There was highly statistically significant difference in total dose of gonadotropin (Gn) among all groups (P < 0.01), and the total doses of Gn of group A, B, and C were higher than that of group D, the differences were statistically significant (P < 0.05). There was highly statistically significant difference in usage days of Gn among all groups (P < 0.01), and the usage days of Gn of group B and C were longer than those of group A and D, the differences were statistically significant (P < 0.05). There was no statistically significant difference in the number of oocytes, normal fertilization rate, high quality embryo rate and implantation rate in each group (P > 0.05). There was statistically significant difference in clinical pregnancy rate among four groups (P > 0.05), the clinical pregnancy rate of group B were higher than that of those group A and D, the differences were statistically significant (P < 0.05). Conclusion For the patients with ovulation induced by long regimen in early follicular phase, the addition of LH, especially r-LH, exhibited a tendency to increase the clinical pregnancy rate. However, it still needs to be verified through a study based on larger sample size.
		2020 Vol. 17 (3): 90-93,109 [Abstract] ( 242 ) HTML (1 KB) PDF (795 KB) ( 71 )

	94	Effect of free position combined with non-invasive delivery on the outcome of primiparas delivery
		RAN Xiuwen1 GUAN Chanchan1 XU Sisi1 LIU Zhijuan1 NIE Cong2
		Objective To investigate the effect of free position combined with non-invasive delivery technique on delivery outcome. Methods A total of 3514 cases of head-position, singleton and primipara in the Department of Obstetrics of Karamay Central Hospital of Xinjiang from January 2013 to December 2017 were divided into two groups according to the time points of free position waiting for delivery and non-invasive delivery technology. A total of 2125 primiparas with free posture and non-invasive delivery technique were used as the observation group from January 2015 to December 2017, 1389 primiparas with traditional bed waiting for delivery combined with traditional delivery technique from January 2013 to December 2014 were used as the control group. The differences in perineal lateral incision rate, degree of perineal laceration, perineal healing, postpartum bleeding volume, labor process time, average hospital stay, incidence of neonatal asphyxia and neonatal injury were compared between the two groups. Results There were highly statistically significant differences in lateral perineal incision rate, perineal healing and perineal laceration between the two groups (P < 0.01). The first and second stages of labor and the average daily hospitalization in the observation group were shorter than those in the control group, the differences were highly statistically significant (P < 0.01). There was no statistically significant difference in postpartum bleeding volume, neonatal birth injury and neonatal asphyxia between the two groups (P > 0.05). Conclusion The free position waiting for labor combined with non-invasive delivery technique can reduce the rate of lateral perineal incision, improve the comfort of perineum, accelerate the process of labor and shorten the average hospitalization days effectively. So, it is worth popularizing and applying widely in clinic.
		2020 Vol. 17 (3): 94-97 [Abstract] ( 136 ) HTML (1 KB) PDF (574 KB) ( 63 )

	98	Clinical effect of phloroglucinol combined with Mifepristone and Rivanol in course of terminating mid-trimester pregnancy on scar uterus
		REN Hongwei1 WANG Yan1 ZHANG Yuxiang1 ZHAO Yuan2 DOU Weina2 LIU Chunli1 ZHANG Limin1 HAN Wenfeng3
		Objective To observe clinic effect of using Phloroglucinol combined with Mifepristone and Ethacridine Lactate Injection (Rivanol) in course of terminating mid-trimester pregnancy on scar uterus. Methods A total of 68 women with scar uterus (16-27 weeks gestation) desiring to terminate mid-trimester pregnancy were selected, and then they were divided into observation group and control group by random number method. In the observation group, 34 women were given Mifepristone and were injected abdominal intra-amniotically with Rivanol, as well given 80 mg of Phloroglucinol Injection intravenously when the cervix dilated 1 cm. In the control group, 34 women only were induced by Mifepristone combined with Rivanol. The time duration, cervical dilatation, suffering of the patients, laceration of cervix, the cervix edema, success rate of terminating pregnancy and adverse reactions of the two groups were observed, and postpartum hemorrhage were taken record. Results Time duration of terminating pregnancy in the observation group was shorter than that in the control group, the difference was statistically significant (P < 0.05). The pain degree in the observation group was significantly lower than that in the control group, the difference was statistically significant (P < 0.05). There were statistically significant differences in the proportion of patients with successful labor induction, cervical dilatation over 3 cm in 2 h, cervix edema, laceration of cervix between the two groups (P < 0.05). There was no statistically significant difference in postpartum hemorrhage and the incidence of adverse reactions (P > 0.05）. Conclusion Phloroglucinol combined with Mifepristone and Rivanol in terminating mid-trimester pregnancy on scar uterus have a good clinical effect. There is no obvious adverse reactions. It is safe and reliable, as well as simple and easy to operate. So it is worth to be widely promoted.
		2020 Vol. 17 (3): 98-101 [Abstract] ( 207 ) HTML (1 KB) PDF (534 KB) ( 119 )

	102	Effect of aerosol inhalation of Broncho-Vaxom combined with beClomethasone Propionate Aerosol in the treatment of children with acute attack of bronchial asthma
		WU Xiaoxu
		Objective To explore the effect of Broncho-Vaxom combined with inhalation of valproate on serum levels of galectin-3 (Gal-3) and serum amyloid A (SAA) in treating children with acute attack of bronchial asthma. Methods From January 2014 to September 2017, 120 children with bronchial asthma treated by paediatrics in West China-Guang′an Hospital, Sichuan University were selected as subjects. According to the random number table method, they were divided into the study group and the control group, with 60 children in each group. The control group was given Beclomethasone Propionate Aerosol inhalation treatment, while the study group was given Broncho-Vaxom combined treatment on the basis of the control group. The clinical efficacy, pulmonary function, serum inflammatory factors and levels of Gal-3, SAA and adverse reactions were analyzed. Results The total effective rate of treatment in the study group was higher than that in the control group, the difference was highly statistically significant (P < 0.05). After treatment, the levels of forced expiratory volume in 1 s (FEV1) and γ-interferon (INF-γ) in both groups were increased, and the levels of FEV1, PEF and INF-γ in the study group were higher than those in the control group, the differences were highly statistically significant (P < 0.05). The levels of IL-4, Gal-3 and SAA in the study group were significantly decreased, the differences were highly statistically significant (P < 0.05). There were no serious adverse reactions during the course of treatment in both groups. Conclusion The implementation of Broncho-Vaxom combined with inhalation of Beclomethasone Propionate Aerosol can effectively improve the pulmonary function of children with bronchial asthma, reduce the levels of Gal-3 and SAA, release the inflammation injury and improve airway remodeling.
		2020 Vol. 17 (3): 102-105 [Abstract] ( 258 ) HTML (1 KB) PDF (579 KB) ( 134 )

	106	Clinical effect of subepithelial connective tissue in the treatment of gingival recession
		WANG Bin1 WANG Hu2▲ KONG Min1
		Objective To observe the clinical effect of subepithelial connective tissue on gingival recession and the changes of periodontal depth (PD), periodontal attachment loss (AL), gingival recession height and gingival thickness. Methods In this study, 39 cases (56 teeth) of patients with gingival recession admitted to Chengdu First People′s Hospital from January 2017 to January 2018 were used as prospective subjects. All patients were treated with subepithelial connective tissue flap. The clinical efficacy, PD, AL, gingival recession height and gingival thickness of the patients before and 6 months after surgery were recorded, and the data were processed by statistical software. Results Thirty-nine patients had 56 affected teeth, and the the total response rate was 96.43%, and the PD and AL values of the patients 6 months after surgery were lower than those before treatment, the gingival recession height was lower than that before treatment, and the gingival thickness was higher than that before treatment, showed statistically significant differences (P ＜ 0.05). Conclusion Subepithelial connective tissue has a good clinical effect in the treatment of gingival recession. It is worthy of promotion and application to improve PD, AL value, gingival recession height and gingival thickness.
		2020 Vol. 17 (3): 106-109 [Abstract] ( 155 ) HTML (1 KB) PDF (387 KB) ( 37 )

	110	Quantification of chemical compositions in Fritillaria thunbergii from different geographical origin by HPLC-ELSD
		ZHANG Xiaoqin LYU Hongyan LAN Yan CHEN Liping
		Objective To investigate the contents of the functional components in Fritillaria thunbergii from different geographical locations. Methods Kromasil ODS C18 column (200 mm × 4.6 mm, 5 μm) column was used as the column, acetonitrile-0.03% diethylamine was used as the mobile phase, the flow rate of 1.0 mL/min. The colomn temperature maintained at 40℃. Multivariate statistical analysis was carried out by SPSS 20.0. Results The total contents of verticine and verticinone were the highest in Longbu village, Yunhe county, Lishui city (LS-YH-LB). The content of verticine was higher than that of verticinone in 14 producing areas, and the verticinone was higher than that of verticine in 5 producing areas. In the cluster analysis, eight high-content producing areas, such as LS-YH-LB and Leqing city, Wenzhou city, were grouped into one category, while other producing areas were grouped into one category. Conclusion There are obvious geographical variations in the functional components of Fritillaria thunbergii, which indicats that there are some quality differences in different producing areas of Fritillaria thunbergii. This study provides reference for the standardized planting and further development and utilization of Fritillaria thunbergii.
		2020 Vol. 17 (3): 110-114 [Abstract] ( 170 ) HTML (1 KB) PDF (814 KB) ( 118 )

	115	Effect and safety analysis of Xiangjia Pills in the treatment of advanced gastric cancer
		MA Jiheng WANG Guofang
		Objective To study the clinical efficacy and safety of Xiangjia Pills in the treatment of advanced gastric cancer. Methods Seventy-two patients with advanced gastric cancer who had failed second-line treatment in the Department of Oncology, Danyang Hospital of Traditional Chinese Medicine from June 2014 to May 2018 were included, and they were divided into the experimental group and the control group by random number table. There were 51 cases in the experimental group and 21 cases in the control group. The experimental group was treated with Xiangjia Pills combined with the best supportive treatment, which lasted for 15 consecutive days for one course of treatment, and at least two courses of treatment, until the disease progressed significantly or the drug could not be tolerated. The control group was treated with the best supportive treatment. The fatigue, poor appetite, Numerical rating scale (NRS) score, Karnofsky functional status (KPS) score, tumor markers, toxicity and side effects, and overall survival (OS) of patients in both groups were observed. Results In the experimental group, 51 patients entered the study, of which 2 cases fell out and 49 cases completed the study. All 21 patients in the control group completed the study. The effective rates of fatigue and poor appetite after treatment in the experimental group were significantly higher than those in the control group, with highly statistically significant differences (P < 0.01). There was no significant difference in NRS score between the experiment group and the control group after treatment (P ＞ 0.05). After treatment, the KPS score of the experimental group was higher than that of the control group, with statistically significant difference (P < 0.05). No significant blood and liver and kidney toxicity were observed in the experimental group, and 42.86% of the patients had decreased tumor markers. The average OS in the experimental group was longer than that in the control group, with statistically significant difference (P ＜ 0.05). Conclusion Xiangjia Pills can effectively treat advanced gastric cancer, increase the quality of life of patients, improve the symptoms of fatigue and poor appetite for gastric cancer. To some extent, the survival period is prolonged, and there is no obvious toxic side effect. It is worthy to promotion.
		2020 Vol. 17 (3): 115-119 [Abstract] ( 154 ) HTML (1 KB) PDF (539 KB) ( 127 )

	119	Effect of Huayu Qutan Decoction in the treatment of intractable insomnia by professor Li Yan and its influence on serum cytokines
		WANG Qi1 LI Yan2 LI Yong3 WU Xian4▲
		Objective To explore the clinical effect of Huayu Qutan Decoction in the treatment of intractable insomnia by professor Li Yan and its influence on serum cytokines. Methods From October 2018 to October 2019, 60 patients with intractable insomnia treated in Outpatient Department of LI Yan Famous Doctor Studio were selected and randomly divided into control group and treatment group, with 30 cases in each group. The control group was treated with Estazolam Tablets, while the treatment group was treated with Huayu Qutan Decoction on the basis of the control group. The two groups were treated for 3 courses (10 days as one course). The scores of TCM syndromes and Pittsburgh sleep quality index (PSQI) before and after treatment were compared between the two groups. The clinical efficacy and changes of serum cytokine levels in the two groups were observed before and after treatment. The occurrence of adverse reactions was recorded. Results The total scores of TCM syndromes and PSQI in the two groups after treatment were significantly lower than those before treatment (P ＜ 0.05), and the total scores of TCM syndromes and PSQI in the treatment group were significantly lower than those in the control group after treatment (P ＜ 0.05). The clinical efficacy of treatment group was better than that of control group, the dfference was statistically significant (P ＜ 0.05). After treatment, the serum levels of interleukin (IL)-1β, tumor necrosis factor α (TNF-α) and IL-6 in the two groups were significantly lower than those before treatment (P ＜ 0.05), and the serum levels of IL-1β, TNF-α and IL-6 in the treatment group were significantly lower than those in the control group after treatment (P ＜ 0.05). There was no significant difference in the incidence of total adverse reactions between the two groups (P ＞ 0.05). Conclusion Huayu Qutan Decoction can significantly improve the clinical symptoms and sleep quality of patients, enhance the therapeutic effect, reduce the levels of serum IL-1β, TNF-α and IL-6, and it is safe and has the value of promotion and application.
		2020 Vol. 17 (3): 119-122 [Abstract] ( 217 ) HTML (1 KB) PDF (542 KB) ( 76 )

	123	Clinical effect of Ulinastatin combined with Imipenem and Cilastatin Sodium for Injection in the treatment of severe pneumonia with respiratory failure
		FENG Xianrong1 WU Nan1 NIU Weiwei2
		Objective To explore clinical effect and safety of Ulinastatin combined with Imipenem and Cilastatin Sodium for Injection in the treatment of severe pneumonia with respiratory failure. Methods Eighty cases of severe pneumonia patients with respiratory failure admitted to Jinzhou Central Hospital from January 2014 to May 2019 were selected and divided into the control group (40 cases) and the observasion group (40 cases) according to random number table method. The control group was treated with Imipenem and Cilastatin Sodium for Injection, and the observation group was treated with Ulinastatin combined with Imipenem and Cilastatin Sodium for Injection. The two groups were treated for 10 days. Clinical effect was evaluated after treatment. The forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF), arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), oxygenation index (OI), serum procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6) of the two groups were compared. The adverse reactions of the two groups during the treatment were recorded and compared. Results The total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). After treatment, the FEV1, FVC, PEF, PaO2, OI of the two groups were significantly higher than those before treatment (P ＜ 0.05), and PaCO2 was significantly lower than those before treatment (P ＜ 0.05), while FEV1, FVC, PEF, PaO2 and OI in the observation group were significantly higher than those in the control group (P ＜ 0.05), and PaCO2 was significantly lower than that in the control group (P ＜ 0.05). The levels of serum PCT, CRP and IL-6 in the two groups after treatment were significantly lower than those before treatment (P ＜ 0.05), and the levels of serum PCT, CRP and IL-6 in the observation group after treatment were significantly lower than those in the control group (P ＜ 0.05). During treatment, there was no adverse reaction in the two groups. Conclusion Ulinastatin combined with Imipenem and Cilastatin Sodium for Injection in the treatment of severe pneumonia with respiratory failure has a significant effect, which can improve the lung function and blood gas indexes, reduce the serum levels of inflammatory factors, and has good safety.
		2020 Vol. 17 (3): 123-126 [Abstract] ( 256 ) HTML (1 KB) PDF (497 KB) ( 36 )

	127	Study on the influencing factors of phlegm-dampness diathesis and qi deficiency in diathesis obese/overweight people
		ZHAO Yan1，2 WANG Xiaoqin2，3
		Objective To explore the influencing factors of phlegm-dampness and qi deficiency in obese/overweight people. Methods From January 2015 to January 2017, a total of 1435 obese/overweight people in Hubei Provincial Hospital of Chinese Medicine with a quality of physique, phlegm-dampness and qi deficiency were collected for age, sex, socioeconomic status, marriage, etc. Statistical analysis was carried out on sociodemographic factors and behavioral factors such as diet, entertainment and exercise patterns. Multivariate logistic analysis was used for continuous variables. Results The results of single factor analysis showed that the diathesis of different ages, occupation, education, incomes, weight loss, frequency of carbonated drinks, frequency of tea drinks, frequency of fruit juice drinks, and sleep quality had statistically significant differences (P ＜ 0.05). Multivariate analysis results showed that the influencing factors of phlegm-dampness were age (30-＜40 years old) (OR = 1.913, 95%CI: 1.251-2.925, P ＜ 0.05), weight loss (OR = 1.383, 95%CI: 1.075-1.780, P ＜ 0.05); the influencing factors of qi-deficiency included age (50-＜60 years old) (OR = 0.359, 95%CI: 0.192-0.672, P ＜ 0.05), education level (junior high to high school) (OR = 6.012, 95%CI: 1.821-19.848, P ＜ 0.05), education level (junior college and above) (OR = 6.204, 95%CI: 1.788-21.530, P ＜ 0.05), and poor sleep quality (OR = 1.971, 95%CI: 1.235-3.146, P ＜ 0.05). Conclusion The older the obese/overweight person, the more likely it is to be phlegm-dampness. The older the obese/overweight person, the less likely it is to be qi-deficiency. The higher the education level, the more likely it is to be qi-deficiency. The person taking weight-loss measures is more likely to be phlegm-dampness. People with poor sleep quality are more likely to be qi-deficiency than those with good sleep quality.
		2020 Vol. 17 (3): 127-131,154 [Abstract] ( 232 ) HTML (1 KB) PDF (792 KB) ( 139 )

	132	The effect of traditional Chinese medicine on mitochondrial fusion and fission in related diseases based on the theory of “yin and yang balance”
		SHI Youyang1，2 YANG Rui1，2 HAN Xianghui2 SUN Chenping1 LIU Sheng1，2
		The theory of yin and yang is the cornerstone of traditional Chinese medicine theory. Traditional Chinese medicine hold the view that the physiological function of the human body lies in the dynamic balance between yin and yang. The occurrence of diseases is the result of imbalance between yin and yang. Mitochondrion is the center of energy metabolism in the cell, and controlled by a balance between fusion and fission. There is a relationship of opposition, restriction, mutual use and balance between the negative and the positive, which complements the theory of yin and yang. The fusion and fission not only play an important role in maintaining the structure and function of mitochondria, but also closely related to cardiovascular, central nervous, digestive system and cancer diseases. This paper attempts to discuss the effect and mechanism of traditional Chinese medicine on mitochondrial fusion and division in the related diseases from the perspective of adjusting the “yin and yang balance”.
		2020 Vol. 17 (3): 132-134,158 [Abstract] ( 151 ) HTML (1 KB) PDF (775 KB) ( 66 )

	135	Analysis of times of Chinese medicine culture education
		FU Wendi
		Doing a good job in Chinese medicine culture education is the basis and foundation for inheriting and promoting traditional Chinese medicine. The development of traditional Chinese medicine culture education should be based on the principle of “inheriting the development and abandoning the innovation” and insisting that inheritance is the foundation, discarding is guarantee, and development is the fundamental guiding ideology. Inheritance should be forward-looking and should be based on the current scientific progress, medical development and the characteristics of students. Development must be viewed backwards, taking the cultural background, developmental origin and historical evolution of traditional Chinese medicine into account. We must clarify the urgency of Chinese medicine culture education and identify the entry point for Chinese medicine culture education in the new area of the development of traditional Chinese medicine. Finding out the focus and basic content of Chinese medicine culture education and grasping the core ideas from the Chinese cultural maternal body then strengthening the scientific research of Chinese medicine culture education and highlighting the historical mission for Chinese medicine culture educators. Constructing a modern Chinese medicine concept with Chinese medicine thinking and international view. To establish traditional Chinese medicine thought for students and then make them can promote the inheritors of Chinese medicine, and prosper traditional Chinese medicine.
		2020 Vol. 17 (3): 135-138 [Abstract] ( 271 ) HTML (1 KB) PDF (717 KB) ( 41 )

	139	Effect of “Conception Channel moxibustion for strengthening the meridians with age” in the treatment of neurogenic bladder after suprasacral spinal cord injury
		LENG Jun1 WEI Fangyue2 MA Sai3 TIAN Meng4 LIU Huimin2 GUO Wen2 ZHANG Chen2
		Objective To observe the effects of “Conception Channel moxibustion for strengthening the meridians with age” in the treatment of neurogenic bladder after suprasacral spinal cord injury. Methods Sixty cases of neurogenic bladder after suprasacral spinal cord injury patients from May 2017 to February 2019 in the Rehabilitation Medicine Department of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine were selected and divided into observation group and control group according to the method of random number table, with 30 cases in each group. Both groups were treated with Conception Channel moxibustion for about 1.5 hours, and observation group was treated with “Ren pulse moxibustion for strengthening the meridians with age”. Once a week for 4 weeks. Before and 4 weeks after treatment, 24-h urination diary indexes (24-h urination times, 24-h leakage times, single urine volume), bladder safety capacity and residual urine volume of two groups were recorded and compared. Results After treatment, the number of micturition and leakage of urine in two groups were less than those before treatment, and the amount of urine in a single time in two groups was more than that before treatment, and observation group improved significantly compared with control group, the difference was statistically significant (P < 0.05). The bladder safety volume of two groups after treatment was more than that before treatment, and the residual urine volume of two groups after treatment was less than that before treatment, and observation group improved significantly compared with control group, the difference was statistically significant (P < 0.05). Conclusion “Conception Channel moxibustion for strengthening the meridians with age” is better than traditional moxibustion in increasing bladder safety capacity, promoting urination, improving urination frequency and leakage, especially in promoting urination. It is easy to calculate, master the best moxibustion quantity and standardize the operation.
		2020 Vol. 17 (3): 139-142 [Abstract] ( 171 ) HTML (1 KB) PDF (770 KB) ( 131 )

	143	Clinical effect of Kuncao Qilian Decoction in the treatment of consumptive thirst complicated with urine microprotein
		WU Suqin SHI Nan LI Ting
		Objective To study clinical effect of Kuncao Qilian Decoction in the treatment of consumptive thirst complicated with urine microprotein. Methods Eighty-eight cases of consumptive thirst complicated with urine microprotein who were treated in Heze Traditional Chinese Medicine Hospital from June 2017 to December 2018 were selected. They were divided into control group 1 (28 cases), control group 2 (30 cases) and study group (30 cases) according to the random number table method. Control group 1 was treated with Enalapril Maleate Tablets, control group 2 was treated with Liuwei Dihuang Decoction on the basis of control group 1, and study group was treated with Kuncao Qilian Decoction on the basis of control group 1. Clinical efficacy and main symptoms score of traditional Chinese medicine, serum creatinine (Scr), cystatin C (CysC), endogenous creatinine clearance rate (Ccr), 24-hour urinary protein quantification, 24-hour urinary microprotein excretion and adverse reactions were compared among three groups. Results Total effective rate of study group was higher than that of control group 1 and control group 2, and that of control group 2 was higher than that of control group 1 (P < 0.05). After treatment, the scores of main symptoms score of traditional Chinese medicine in study group were lower than those in control group 1 and control group 2, while those in control group 2 were lower than those in control group 1 (P < 0.05). After treatment, Scr, CysC, 24-hour urinary protein quantification and 24-hour urinary microprotein excretion in study group were lower than those in control group 1 and control group 2, and those in control group 2 were lower than those in control group 1 (P < 0.05). Ccr of study group was higher than that of control group 1 and control group 2, and that of control group 2 was higher than that of control group 1 (P < 0.05). There was no significant difference in the incidence of adverse reactions among three groups (P > 0.05). Conclusion Kuncao Qilian Decoction is effective in treating consumptive thirst patients complicated with urinary microprotein. It has higher safety, which can provide reference for clinical treatment of the disease.
		2020 Vol. 17 (3): 143-146 [Abstract] ( 162 ) HTML (1 KB) PDF (731 KB) ( 50 )

	147	Clinical effect of traditional Chinese medicine combined with acupuncture in the treatment of postoperative gastroparesis syndrome
		YANG Liangliang PANG Rui
		Objective To study clinical effect of traditional Chinese medicine combined with acupuncture in the treatment of postoperative gastroparesis syndrome. Methods Eighty patients with clinically diagnosed gastroparesis syndrome after abdominal surgery from January 2015 to December 2017 in Xinjiang Medical University Affiliated Tumor Hospital were selected. The patients were divided into control group and treatment group according to the random number table, with 40 cases in each group. Both groups were treated with fasting, effective continuous gastrointestinal decompression, water, electrolyte and acid-base balance, and enteral nutrition treatment through enteral nutrition tube. Control group was given gastrointestinal motility drugs. According to the patient′s specific syndrome type, treatment group was given the corresponding Chinese medicine decoction and stomach tube injection combined with acupuncture treatment. Results The flow of gastric juice in treatment group was more than that in control group, and the recovery time of self feeding, the first defecation time and the treatment time in treatment group were shorter than those in control group (P < 0.05). The effective rate of treatment group was significantly higher than that in control group (P < 0.05). Conclusion Traditional Chinese medicine combined with acupuncture is an effective method for the treatment of postoperative gastroparesis syndrome, which can significantly improve the clinical symptoms and shorten the course of treatment.
		2020 Vol. 17 (3): 147-150 [Abstract] ( 184 ) HTML (1 KB) PDF (724 KB) ( 19 )

	151	Study on the change of pulse power of young college students in one university in four seasons
		YU Lintong1 LIU Jia2 ZHOU Lingyun2 QU Wenbai1 WANG Yiguo2 WANG Nanyue2▲
		Objective To study the features in pulse-diagnosis signals of undergraduates in one university. Methods Three probe intelligent pulse information acquisition device was used to collect pulse information of the same group of undergraduates from Beijing University of Traditional Chinese Medicine from November 2017 to September 2018 in spring, summer, autumn and winter. After preprocessing the pulse information, the continuous pulse waves of multiple periods were selected as the research object. The least square regression of 12 harmonics was carried out for each period and the mathematical model was established. After obtaining the characteristic parameters, SAS was used for statistical analysis. Results The mean value of h1 in autumn was lower than that in other three seasons (P < 0.05). There was no significant difference in the mean value of h1 between spring, summer and winter (P > 0.05). There was significant difference in the mean value of h1 between different parts of pulse in summer and winter (P < 0.05). There was no significant difference in the mean value of h1 between different parts of pulse in spring and autumn (P > 0.05). There was significant difference in h1 in different seasons (P < 0.05). There was no significant difference in h1 between left and right ruler in different seasons (P > 0.05). Conclusion The four seasons pulse force and its changing law are basically consistent with the physiological state of normal people and the pulse condition of traditional Chinese medicine. The comparison of six pulses partly reflects the theory of “five viscera responding to time”.
		2020 Vol. 17 (3): 151-154 [Abstract] ( 139 ) HTML (1 KB) PDF (794 KB) ( 234 )

	155	An investigation of the price management history of ancient Chinese medicine
		WANG Jing1 ZHOU Wenli2 ZHOU Yan′an3
		The price of Chinese medicines under state control began in Wester Zhou Dynasty, and the price of Chinese medicines is stabilized by means of Pingtiao, Pingdi and drug reserve. Before 221 B.C.(before Qin Dynasty), the price of traditional Chinese medicines is the natural price foemed by the natural economy. In Han Dynasty, 14 kinds of traditional Chinese medicines, such as Rhizoma Coptidis, Radix Cyathulae, Radix Saposhnikoviae and Radix Dipsaci, average 8 Wen per Liang, 160 times as such grain, and the price is dominated by the seller. Tang Dynasty adopt the Changping policy, Hezhi and Pingzhu methods and the strict three-lever price system. The average price of 43 kinds of medicines, such as Coptic chinensis and Scutellaria baicalensis is 15.03 times that of grain, 23.1 times that of grain. Song Dynasty follows the price management system of the Tang Dynasty, and the price of medicines is 45.6 times that of grain, the price of monopolized drugs is less than one third of the market price. In Ming and Qing Dynasty, the policy of Changping is still applied, and the price of medicines is 82.16 and 12.6 times higher than that of grain respectively. In a word, the price formation mechanism of traditional Chinese medicines from Han Dynasty to Qing Dynasty is composed of stste intervention and production competition. The ancient drug monopoly system has certain practical significance.
		2020 Vol. 17 (3): 155-158 [Abstract] ( 151 ) HTML (1 KB) PDF (726 KB) ( 679 )

	159	Retroperitoneal schwannoma: a case report
		JIANG Xu CAO Haiming WU Guanwei DONG Zhuang MA Xueping YANG Xuezhen
		The clinical data of one case of retroperitoneal schwannoma in the Second Affiliated Hospital of Bengbu Ｍedical College in 2017 was retrospectively analyzed to explore the diagnosis and treatment of retroperitoneal schwannoma. In this case report, the patient was admitted due to biochemical recurrence of prostate cancer and found para-inferior vena cava space occupying during CT review, but the patient had no specific clinical manifestations and the nature of the mass could not be determined before surgery. After complete preoperative preparation, laparoscopic surgical resection was performed for the patient, and postoperative pathology confirmed that the patient was a schwannoma. The patient had a good prognosis, and there was no recurrence of schwannoma during 1-year follow-up. Through the study of relevant literature, we believe that retroperitoneal schwannoma is a rare tumor, and such patients lack specific clinical manifestations and imaging features, so a definite diagnosis cannot be made before surgery. The diagnosis of this tumor depends on postoperative pathological examination. The best treatment is complete surgical resection, and the prognosis of patients after surgery is good. At present, the recurrence of retroperitoneal schwannoma is rarely reported.
		2020 Vol. 17 (3): 159-163,180 [Abstract] ( 225 ) HTML (1 KB) PDF (1533 KB) ( 134 )

	164	A case of autoimmune polyendocrine syndromes and literature review
		ZHANG Liting1 WU Hao1 ZHU Lingling1 CAI Quanfang1 CHEN Pin2▲
		One case of autoimmune polyendocrine syndromes (APS) was reported and the literatures were reviewed in this paper for improve the diagnosis and treatment of the disease by clinicians. The patient was diagnosed with “type 1 diabetes” in June 2017 in the 910th Hospital of the Chinese People′s Liberation Army, the adult female represented with symptomatic “Hashimoto′s thyroiditis” in March 2018. She showed “primary hypogonadism” through examination in June 2019, and diagnosed with “APS-Ⅱ”. According to the etiology and clinical characteristics, APS was divided into two types: APS-Ⅰ and APS-Ⅱ. APS Ⅱ includes at least two of them among type 1 diabetes, Addison′s disease and autoimmune thyroid disease. Treatment is mainly involved in the exogenic hormone replacement for the function of corresponding endocrine glands and symptomatic treatment.
		2020 Vol. 17 (3): 164-167 [Abstract] ( 216 ) HTML (1 KB) PDF (429 KB) ( 125 )

	168	Analysis on the influencing factors of pharmaceutical market size based on supply and demand model and fishbone diagram
		CHEN Juan ZHANG Ting LU Yan OUYANG Zhaolian▲
		This paper displays the calculation method of market size based on supply and demand model, analyzes the characteristics of the supply and demand curve of the pharmaceutical market, and explores the impact of the shift of the supply and demand curve on the pharmaceutical market size. Then, based on the results of above analysis, the literature research method and the fishbone diagram are adopted to determine the factors affecting the market size of pharmaceutical industry. We find that the market size of pharmaceutical industry is mainly influenced by the following four factors: the patient population, the payment capacity, the policies and the selection range of products. These four factors are further affected by seven secondary factors: population structure, disease spectrum, economic level/income, medical insurance, medical system, industry policy, medical science and technology progress.
		2020 Vol. 17 (3): 168-171 [Abstract] ( 130 ) HTML (1 KB) PDF (871 KB) ( 112 )

	172	A case of atypical Cushing syndrome with hyperglycemia and elevated CA199 as the first symptom： a report and literature review
		LI Jia
		The systemic manifestations of atypical Cushing′s syndrome were studied by detailed inquiry, comprehensive physical examination, biochemical and imaging examination of a newly diagnosed diabetic patient with elevated glycogen antigen 199. The patient had a history of osteoporosis, multiple fractures, hypertension which can be controlled by multi-anti-hypertention drug combination. After the examination, mixed density mass in the lower edge of the lateral branch of the left adrenal gland. Combined with medical history, physical examination, hormone level and imaging results, the citation of the left adrenal adenoma was considered. After laparoscopic excision, the corticosteroid level decreased, blood pressure returned to normal and blood sugar decreased significantly. There are various clinical manifestations of Cushing syndrome, especially for patients′s with subclinical Cushing syndrome, through a comprehensive review of the history, physical examination, hormone evaluation and imaging examination, it is clear that the adrenal occupied space, and through surgical treatment, the patients′ blood glucose, blood pressure and osteoporosis are improved.
		2020 Vol. 17 (3): 172-175 [Abstract] ( 208 ) HTML (1 KB) PDF (692 KB) ( 133 )

	176	Application and development analysis of the bank-hospital one-card pass system in general hospital
		BAI Jing1 HU Tingting2 LI Yufen1 YU Shuxin3 PAN Limin4▲
		Modern hospitals need to fully integrate the current development trend of the internet industry, introduce a large number of new service models and management concepts, improve patients′ treatment experience, and promote better clinical medical services. With the establishment of the one-card system, the automatic processing of financial business among hospitals, consumers and banks has been realized, which saves unnecessary time waste for patients, and makes more time available for consultation, so as to make full use of medical resources. Based on the development trend of the silver medical card, this paper analyzes the significance of the new service mode, optimizes the process of patients′ medical treatment to a great extent, analyzes the thinking of its function and design ideas, looks forward to the future development prospects of the silver medical card, and encourage modern medical institutions to provide more comprehensive and high-quality medical and financial services for patients.
		2020 Vol. 17 (3): 176-180 [Abstract] ( 184 ) HTML (1 KB) PDF (763 KB) ( 44 )

	181	Thinking and application of scientific research development strategy of specialized hospital based on SWOT in scientific research performance management design
		ZHANG Di* JIANG Xiaoying* ZHENG Xiaojing JIANG Hui LIU Fangchao ZHANG Zongde MI Fengling
		Scientific research ability is an important potential factor for hospital development, and it also directly influences the hospital′s scientific and technological innovation, the level of clinical diagnosis and treatment, and even the sustainable development of the discipline. Based on the experience of Beijing Chest Hospital, Capital Medical University, this paper uses SWOT analysis to analyze the internal and external factors of scientific research development. And based on the results, a scientific research development strategy was built up to guide the design and optimization of scientific research performance management plan in hospital. Through targeted optimization, the hospital made significant progress in research project funding, output and technology impact. In the future, we should guide the construction of scientific research performance management system in specialized hospitals, so that scientific research performance management will be more scientific and reasonable. Furthermore, by objectively evaluating the research status and deficiencies of specialized hospitals, leading the development direction of scientific research, and encouraging the enthusiasm and creativity of researchers, the overall goal of the specialist hospital will be achieved.
		2020 Vol. 17 (3): 181-184 [Abstract] ( 168 ) HTML (1 KB) PDF (950 KB) ( 107 )

	185	Discussion on the teaching reform of medical genetics for clinical medicine students in higher vocational college
		ZHONG Yan1 PENG Fenglan2
		Facing the difficulties and problems of medical genetics teaching in higher vocational college, focusing on the aim of improving students′ learning interest and teaching effectiveness, and based on the characteristics of clinical medicine students, the current situation of school and the talent training objectives, this paper analyzes the curriculum orientation, curriculum objectives and curriculum content setting of medical genetics for clinical medicine students in higher vocational colleges, discusses the patterns and methods to optimize abstracted, high theoretical and important course contents with examples, proposes the methods for reformation and innovation of classroom teaching, assessment and evaluation means, to improve students′ learning initiative, and probes the strategies to improve teaching quality of medical genetics course in higher vocational college.
		2020 Vol. 17 (3): 185-188,192 [Abstract] ( 158 ) HTML (1 KB) PDF (814 KB) ( 222 )

	189	Practice and exploration on innovation and entrepreneurship education into the cultivation of pharmaceutical marketing professionals
		WANG Qiuying LI Baoqin
		Under the background of the rapid development of the pharmaceutical industry and the aging society, the pharmaceutical industry has gradually become the focus of social attention. The demand for pharmaceutical marketing talents has been increasing and higher requirements have been put forward for pharmaceutical marketing talents. Medical schools have the responsibility of cultivating applied talents. Taking Heilongjiang University of Chinese Medicine as an example, this paper analyzes the present situation and the existing problems of innovation entrepreneurship education into professional talent cultivation, moreover, explores the path of the innovation entrepreneurship education into the pharmaceutical marketing professional talent cultivation from two aspects: the innovation education and entrepreneurship education, proposes that the innovative entrepreneurship education should be integrated into the professional education, the ideological and political education, and the exploration of the second classroom activities.
		2020 Vol. 17 (3): 189-192 [Abstract] ( 143 ) HTML (1 KB) PDF (779 KB) ( 112 )

	193	Foodborne diseases in children and management of surveillance
		HE Xin ZHANG Baoyuan
		Foodborne diseases are important public health problems all over the world. The main causes are bacteria, toxins and viral infections. Children are the main victim of foodborne diseases. Because of their age, diet structure, feeding style, feeding environment and immune function, the incidence, epidemiology and monitoring management of foodborne diseases in children are different from those of adults. In this paper, based on the pathogenic characteristics of children′s foodborne diseases, the content of active surveillance, epidemiological characteristics, etc., the author puts forward monitoring problems, combined with the author′s supervision and management of foodborne diseases in children′s hospitals, and put forward suggestions for active monitoring.
		2020 Vol. 17 (3): 193-196 [Abstract] ( 195 ) HTML (1 KB) PDF (687 KB) ( 87 )

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