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| The effect of traditional Chinese medicine on mitochondrial fusion and fission in related diseases based on the theory of “yin and yang balance” |
| SHI Youyang1，2 YANG Rui1，2 HAN Xianghui2 SUN Chenping1 LIU Sheng1，2 |
1.Breast Department of Integrated Chinese and Western Medicine, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;
2.Institute of Traditional Chinese Medicine Surgery, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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Abstract The theory of yin and yang is the cornerstone of traditional Chinese medicine theory. Traditional Chinese medicine hold the view that the physiological function of the human body lies in the dynamic balance between yin and yang. The occurrence of diseases is the result of imbalance between yin and yang. Mitochondrion is the center of energy metabolism in the cell, and controlled by a balance between fusion and fission. There is a relationship of opposition, restriction, mutual use and balance between the negative and the positive, which complements the theory of yin and yang. The fusion and fission not only play an important role in maintaining the structure and function of mitochondria, but also closely related to cardiovascular, central nervous, digestive system and cancer diseases. This paper attempts to discuss the effect and mechanism of traditional Chinese medicine on mitochondrial fusion and division in the related diseases from the perspective of adjusting the “yin and yang balance”.
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[1] 黄帝内经素问[M].北京：新世界出版社，2013：191．
[2] Atkins K，Dasgupta A，Chen KH，et al. The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission：implications for human disease [J]. Clin Sci，2016， 130（21）：1861-1874.
[3] Cao YL，Meng S，Chen Y，et al. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion [J]. Nature，2017，542（7641）：372-376.
[4] Liu R，Chan DC. OPA1 and cardiolipin team up for mitochondrial fusion [J]. Nat Cell Biol，2017，19（7）：760-762.
[5] Zhao J，Liu T，Jin S，et al. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission [J]. EMBO J，2011，30（14）：2762-2778.
[6] Cereghetti GM，Stangherlin A，De Brito OM，et al. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria [J]. Proceed Nat Acad Sci，2008，105（41）：15803-15808.
[7] Ramírez S，Gómez-Valadés AG，Schneeberger M，et al. Mitochondrial dynamics mediated by mitofusin 1 is required for POMC neuron glucose-sensing and insulin release control [J]. Cell Metabolism，2017，25（6）：1390-1399.
[8] Martinez JH，Alaimo A，Gorojod RM，et al. Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein [J]. Mol Cell Neurosci，2018，88：107-117.
[9] Mishra P，Chan DC. Mitochondrial dynamics and inheritance during cell division，development and disease [J]. Nat Rev Mol Cell Biol，2014，15（10）：634-646.
[10] 张业昊，姚明江，丛伟红，等.西红花提取物对局灶型脑缺血/再灌注大鼠线粒体分裂融合的影响[J].中国药理学通报，2018，34（6）：770-775.
[11] 张业昊，丛伟红，徐立，等.塞络通胶囊对局灶型脑缺血/再灌注大鼠线粒体动力学的影响[J].中国中药杂志，2015，40（10）：1984-1988.
[12] Exner N，Lutz AK，Haass C，et al. Mitochondrial dysfunction in Parkinson′s disease：molecular mechanisms and pathophysiological consequences [J]. EMBO J，2012，31（14）：3038-3062.
[13] 马浩洁.基于PINK1基因探讨大补阴丸合牵正散对帕金森细胞模型线粒体的保护机制[D].北京：北京中医药大学，2018.
[14] 郭喆，李丹，张文斌，等.染料木素对铅诱导的PC12细胞毒性的抑制效应研究[J].现代生物医学进展，2011， 11（12）：2207-2210.
[15] 姜美驰，梁静，张玉杰，等.针刺“四关”穴对阿尔茨海默病大鼠学习记忆及海马区β淀粉样蛋白42、白介素-1β和白介素-2的影响[J].针刺研究，2016，41（2）：113-118.
[16] 刘云霞.中药单体对肝细胞的保护作用及其线粒体机制研究[D].上海：复旦大学，2012：31.
[17] 罗莉川.“脂肝方”对NASH大鼠肝细胞线粒体选择性自噬及其碎片降解机制的影响[D].南宁：广西中医药大学，2017.
[18] Liu KC，Yen CY，Wu SC，et al. The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells [J]. Envir Toxicol，2014，29（4）：428-439.
[19] Huang YF，Lu L，Zhu DJ，et al. Effects of Astragalus Polysaccharides on dysfunction of mitochondrial dynamics induced by oxidative stress [J]. Oxidat Med Cell Longev，2016，2016：1-13.
[20] Huang ST，Huang CC，Sheen JM，et al. Phyllanthus urinaria′s inhibition of human osteosarcoma xenografts growth in mice is associated with modulation of mitochondrial fission/fusion machinery [J]. Am J Chin Med，2016，44（7）：1507-1523.
[21] Huang ST，Huang CC，Huang WL，et al. Tanshinone ⅡA induces intrinsic apoptosis in osteosarcoma cells both in vivo and in vitro associated with mitochondrial dysfunction [J]. Scientific Rep，2017，7：40382. |
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