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2019 Vol. 16, No. 24 Published: 2019-08-25

	7	Pathological study of Baicalin combined with Berberine on two animal models of non-alcoholic steatohepatitis
		XU Chang1 MA Zhijie2 HUANG Feng3 ZHONG Xiaosong1
		Objective To investigate the effect of Baicalin combined with Berberine on non-alcoholic steatohepatitis (NASH) in two animal models from the pathological point of view. Methods 40 SD rats and 40 C57BL/6 mice aged 6 weeks were divided into four groups according to random number table method: normal control group, NASH model group, Berberine group, Baicalin + Berberine group, 10 rats (or mice) in each group. In addition to normal control group, the other three groups prepared SD rats NASH model induced by high fat diet and C57BL/6 mice NASH model induced by methionine-choline deficiency diet. Berberine group was given Berberine by gavage, Baicalin + Berberine group was given Baicalin and Berberine by gavage. The rats were taken after 8 weeks, and the mice were taken after 2 weeks. Paraffin sections of liver tissue were stained with HE, frozen sections were stained with oil red O. After light microscopy, non-alcoholic fatty liver disease activity scale (NAS) was used to evaluate NASH in each group. Results The scores of hepatic steatosis, intralobular inflammation, hepatocyte balloon-like degeneration and total NAS in NASH model group were significantly higher than those in normal control group of two animal models (P < 0.01). The scores of hepatic steatosis, intralobular inflammation, hepatocyte balloon-like degeneration and NAS in Berberine group and Baicalin + Berberine group were significantly lower than those in NASH model group of two animal models (P < 0.05 or P < 0.01). Conclusion Baicalin and Berberine can significantly inhibit the occurrence and development of pathological changes in NASH. They have certain intervention effect on NASH.
		2019 Vol. 16 (24): 7-10,14 [Abstract] ( 152 ) HTML (1 KB) PDF (1064 KB) ( 139 )

	11	Expression and clinical pathological significance of SOX11 in glioblastoma
		WU Jing LI Xiaojie HE Jie
		Objective To investigate the expression and clinical pathological significance of SOX11 in glioblastoma. Methods A total of 264 cases of paraffin-embedded glioblastoma were collected from the Department of Pathology, Anhui Provincial Hospital from September 2010 to January 2017. Each sample was selected from the tumor area and the normal brain tissue of the tumor to make tissue chips. The expression of SOX11 was detected by immunohistochemistry and the relationship between SOX11 expression and clinicopathological features was analyzed. Results The total positive rate and strongly positive rate of SOX11 expression in glioblastoma was significantly higher than that in matched normal tissues of the tumor (P < 0.01). The expression of SOX11 was correlated with tumor diameter and Ki67 proliferation index (P < 0.01), but it was not related to the patient′s age, gender, single/multiple lesions (P > 0.05). Conclusion SOX11 is specifically expressed in glioblastoma and can be used as a marker for the pathological diagnosis of glioblastoma. The expression level of SOX11 may be related to tumor progression.
		2019 Vol. 16 (24): 11-14 [Abstract] ( 195 ) HTML (1 KB) PDF (755 KB) ( 131 )

	15	Protective effect and mechanism of Chinese eaglewood extract on gastric ulcer induced by ethanol in rats
		MA Lin1 ZHANG Xin2 CHEN Huanxin2 ZHOU Hailing1 LI Jiaqi2 WANG Lingli2
		Objective To study the protective effect of Chinese eaglewood extract on gastric ulcer tissue and its mechanism. Methods Sixty SPF Sprague-Dawley (SD) male rats were divided into normal group (not to deal with), model group (equal volume of normal saline), positive control group (Lansoprazol 0.003 g/mL), Chinese eaglewood extract low (0.4 g/mL), medium (0.8 g/mL) and high (1.6 g/mL) dose groups by random number table method, the dosage of each group was 1 mL/100 g, with 10 rats in each group. The acute gastric mucosal injury model was established by intragastric administration of anhydrous ethanol 1 mL. The positive control group and Chinese eaglewood extract groups were given intragastric administration once a day for 7 days. The contents of Bcl-2 and Bax were examined by immunohistochemical method. The kit was used to detect the content of oxidative factor malondialdehyde (MDA) and the activity of antioxidant factor superoxide dismutase (SOD) and trace reduced glutathione (GSH) in rat serum. Results Compared with the normal group, the expression of Bcl-2 protein in the gastric tissue of the model group decreased, and the expression of Bax protein increased (P ＜ 0.05). Compared with the model group, the expression of Bcl-2 in the gastric tissue of Chinese eaglewood extract groups increased, and the expression of Bax protein decreased (P ＜ 0.05). Compared with the model group, the activity of SOD and GSH of Chinese eaglewood extract groups increased and the content of MDA decreased (P ＜ 0.05). Conclusion Chinese eaglewood extract can improve the gastric ulcer induced by absolute ethanol through increasing the expression of Bcl-2 protein in gastric tissue, reducing the expression of Bax protein, improving the activity of serum SOD and GSH and decreasing the content of MDA.
		2019 Vol. 16 (24): 15-18 [Abstract] ( 164 ) HTML (1 KB) PDF (572 KB) ( 38 )

	19	Mining diabetes cardiomyopathy expression profile chip based on bioinformatics
		SHI Lei1 LI Wanpeng2 AN Junyu1 LIU Yi1 WU Peng1 WU Wenyu3 CAO Yunshan2 HUANG Yan2
		Objective To explore differentially expressed genes and their function related to diabetic cardiomyopathy (DC) based on bioinformatics technology. Methods The gene expression profile data set GSE4547 was analyzed using bioinformatics methods. Results The original chip data was mined and 79 differentially expressed genes were screened. Based on gene ontology functional annotation and related pathway analysis, as well as the construction of differentially coexpressed genes protein-protein interaction and module analysis, 10 key genes of Hk2, Col1a2, Col1a1, Col3a1, Slc2a1, Cpt1a, Slc2a4, Cd36, Ucp3 and Pdk4 were finally obtained as the key genes of Streptozozin induced DC. Conclusion The 10 key genes eventually obtained may become potential therapeutic targets for the treatment of DC in the future, and provide a new perspective and guidance for the exploration of functional changes of DC related genes and signaling pathways in the future.
		2019 Vol. 16 (24): 19-23 [Abstract] ( 218 ) HTML (1 KB) PDF (1187 KB) ( 75 )

	24	Research progress of traditional Chinese medicine based on metabolomics technology
		YANG Bo YANG Qiang ZHANG Aihua WANG Xijun
		Metabolomics could explore the correlation between metabolites and physiological and pathological changes through high-throughput analysis of metabolites in the body, and clarify the interaction of complex systems and response to the outside body. Metabolomics emphasizes that the biochemical phenotype of the functional state of the organism as a whole that is highly similar to the holistic view of traditional Chinese medicine (TCM) theory. Metabolomics has its unique overall and dynamic expression characteristics coincides with the overall view of Chinese medicine and dialectical treatment diagnosis. The metabolomics technology is used to clarify the scientific effects related to the effectiveness mechanism, material basis and compatibility of TCM, to realize the organic integration of TCM theory and modern life science and technology, and fully understand the theoretical value of TCM theory and the practical value of TCM clinical experience. This paper explores the application of the holistic and dynamic characteristics of metabolomics to the specific practice of TCM, and solves key problems, such as the effect evaluation of Chinese herbal medicine, the interpretation of prescription compatibility, the relationship research of prescription and syndrome, and the discovery of syndrome biomarkers. It will provide the technical support for the evaluation of the effectiveness of TCM, the basis of prescription substances and the understanding essence of TCM syndromes.
		2019 Vol. 16 (24): 24-28 [Abstract] ( 175 ) HTML (1 KB) PDF (657 KB) ( 81 )

	29	Research progress on PLOD family in tumor
		WANG Anqi1,2 LIU Yunpeng1,2 LU Wenqing1,2 ZHENG Chunlei1,2 CHE Xiaofang1,2
		The procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) family includes three members, PLOD1, PLOD2 and PLOD3, and encodes lysine hydroxylase 1 (LH1), LH2 and LH3, respectively. The main role of PLOD is to promote collagen maturation and secretion by catalyzing the hydroxylation on lysine residues of procollagen. The expression of PLODs is mainly regulated by HIF-1, TGFβ-1 and so on. PLODs not only can promote collagen maturation and extracellular matrix remodeling, but also can induce epithelial mesenchymal transformation and can play vital role in tumorigenesis and development. This paper reviews the structural features, regulatory factors, functions of PLOD and its role in tumor progression.
		2019 Vol. 16 (24): 29-31,39 [Abstract] ( 152 ) HTML (1 KB) PDF (667 KB) ( 154 )

	32	Research progress on mechanism of thrombosis for myeloproliferative neoplasms
		LIU Yanci SUN Penghui LU Chaoyang HUI Wuhan▲
		Classic negative Ph chromosome of myeloproliferative neoplasms (MPN) is a clonal disease of hematopoietic stem cells. Thrombus is the most important complication that affects the survival of MPN patients. The mechanism of thrombosis of MPN may be related to a variety of mechanisms including increased blood cell counts and activation, abnormal endothelial cells, activation of the blood coagulation system, increased microparticles and inflammatory cytokines, and JAK2V617F gene mutation. This paper reviews the research progress of MPN complicated thrombosis mechanism, elucidates that these mechanisms are helpful for clinical search new biological markers to predict thrombosis, so as to provide reference for thrombus prevention and treatment in MPN patients.
		2019 Vol. 16 (24): 32-35 [Abstract] ( 155 ) HTML (1 KB) PDF (651 KB) ( 57 )

	36	Application progress of metabonomics in the treatment of type 2 diabetes mellitus
		JIA Keqing GAO Yan CHENG Xiao XIA Wenhua WEN Ying
		Type 2 diabetes mellitus (T2DM) is a metabolic disease with increasing prevalence and mortality year by year. Its occurrence and development have brought enormous challenges to global public health. Metabonomics can detect metabolic changes in vivo before and after T2DM treatment and identify effective metabolites, so as to evaluate or predict the therapeutic effect, infer the therapeutic mechanism and provide new ideas for the treatment of T2DM. Therefore, this article reviews the metabonomics and its application in the treatment of T2DM with drug, bioactive food component, bariatric surgery and exercise, in order to provide reference for further research on the treatment of T2DM.
		2019 Vol. 16 (24): 36-39 [Abstract] ( 167 ) HTML (1 KB) PDF (651 KB) ( 48 )

	40	Recent advances in drug therapy for diabetic cataract
		CHEN Wenjing LIU Ping
		Diabetic cataract (DC) is a common eye complication of diabetes, and surgical treatment is the main treatment method. However, surgical risk is high and there are many complications. Some effective drugs may be able to control the occurrence and development of DC, so as to delay or treat DC. This paper summarizes the recent research progress and clinical application of DC-related drugs in prevention and treatment.
		2019 Vol. 16 (24): 40-42,58 [Abstract] ( 141 ) HTML (1 KB) PDF (664 KB) ( 151 )

	43	Research progress of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in endometriosis
		ZHANG Qiong LIU Songping▲
		The etiology of endometriosis has not beeh known clearly so far. CXCL12-CXCR4/CXCR7 biological axis can regulate the proliferation, migration and invasion of endometrial stem cells, which may become a new target for diagnosis and treatment of endometriosis. This article reviews the role of CXCL12-CXCR4/CXCR7 biological axis in the occurrence and development of endometriosis at home and abroad in recent years.
		2019 Vol. 16 (24): 43-46 [Abstract] ( 177 ) HTML (1 KB) PDF (653 KB) ( 116 )

	47	Research progress on the influence of intramural hysteromyoma without uterine cavity compression on pregnancy
		CHU Chunfang1 WU Yumei2▲
		Uterine fibroids can affect fertility. Intermural uterine fibroids, even without uterine pressure, can negatively affect pregnancy by causing abnormal peristalsis and contraction of uterus and affecting the morphology and function of endometrium. At present, there is no consistent recommendation for the treatment of asymptomatic and non-uterine intramural myoma with fertility requirements at home and abroad. Individualized treatment should be adopted according to the patient′s age, size and location of the myoma. Surgical removal of the intramural myoma with diameter greater than 4 cm may help to improve the pregnancy rate.
		2019 Vol. 16 (24): 47-50 [Abstract] ( 172 ) HTML (1 KB) PDF (653 KB) ( 146 )

	51	Discussion on the historical evolution, influencing factors and main diseases of floating pulse
		AN Erxia1 LIU Jia2 ZHOU Lingyun2 WANG Nanyue2
		As one of the guiding veins of pulse-diagnosis, the floating pulse is a common physiological and pathological pulse in clinic, which is of great significance for clinical diagnosis and treatment. From Qin-Han dynasties to the present, the development and improvement of the theory of floating pulse have experienced a history of thousands of years. In the ancient medical books on pulse-diagnosis, the record of floating pulse is in the first place among many pulse signs, which has been paid attention by doctors of all dynasties. With the progress of modern science and technology, the study of floating pulse is advancing with the times. According to the influencing factors, the floating pulse can be divided into physiological floating pulse affected by body type, season, lungs and emotion and pathological floating pulse related to the conflict between positive and evil factors, and human body′s Qi-Blood-Yin-Yang. To the pathologic floating pulse that appears in clinic, this paper also discusses from two aspects: each of the bar and cubit, three parts at wrist where the pulse is usually taken, appears as a floating figure, and all three have floating. The main clinical features of floating pulse as single factor, the main diseases of parallel pulse composed of floating pulse, and the clinical significance of floating are described in brief. The clinical identification of floating pulse is affected by many factors, which need to be judged by comprehensive analysis and objective diagnostic, so as to better serve the clinic.
		2019 Vol. 16 (24): 51-54 [Abstract] ( 675 ) HTML (1 KB) PDF (651 KB) ( 276 )

	55	New research progress of acupuncture in the treatment of malignant tumor
		ZOU Xiangni YAN Jun
		As one of the three major non-natural death diseases, malignant tumor has a high fatality rate, and its pain and adverse reactions after chemotherapy seriously affect the quality of life of patients. According to traditional Chinese medicine, malignant tumor is mainly caused by cancer toxicity, phlegm and blood stasis toxicity, heat-toxicity, qi stagnation, blood stasis, phlegm blocking, vital qi exhaustion, and so on. Therefore, heat-clearing and detoxification, qi-activating and blood-activating methods are often used in the treatment of malignant tumors. Acupuncture, as a traditional Chinese treatment method, can regulate nutrient qi and defensive qi, dispel cold and regulate menstruation, dispel pathogenic wind and dredge collaterals, promote blood circulation for removing blood stasis, balance qi, blood, yin and yang by stimulating the surface acupoint and dermal parts of the twelve apoheurotic system. It has unique advantages in improving the size of lesions, alleviating cancer pain, relieving adverse reactions after treatment, and so on. It can also regulate immune function and significantly improve the quality of life of patients with malignant tumor. Therefore, the treatment of malignant tumor by acupuncture or combined with acupuncture will provide new ideas for clinical treatment of malignant tumor.
		2019 Vol. 16 (24): 55-58 [Abstract] ( 151 ) HTML (1 KB) PDF (677 KB) ( 53 )

	59	Study on comparison of medical expenses between hemodialysis and peritoneal dialysis in patients with end-stage renal disease
		NIE Chen1 GAO Shuangqing2 CHEN Jinyu1 ZHANG Fang1
		Objective To investigate the direct medical expenses of hemodialysis and peritoneal dialysis in patients with end-stage renal disease in the real world and their influencing factors, so as to provide evidence support for policy formulation. Methods The data of dialysis patients in the urban insured patients database of China Health Insurance Research Association in 2015 was retrospectively analyzed. According to the inclusion and exclusion criteria, 2655 hemodialysis patients and 360 peritoneal dialysis patients were included. The 1∶1 propensity score matching method was used to balance the variables with imbalanced basic data between the groups and obtain matched patients, and multiple linear regression method was used to analyze the influencing factors of direct medical expenses. Results After propensity score matching, 584 dialysis patients were acquired, and the annual per capita direct medical expenses of hemodialysis were significantly higher than that of peritoneal dialysis (P ＜ 0.05). Multiple linear regression analysis showed that anemia, hypertension, dialysis mode, diabetes, regional and dyslipidemia were important factors affecting the direct medical expenses(P ＜ 0.05). Conclusion The direct medical expenses of peritoneal dialysis in patients with end-stage renal disease is lower than hemodialysis, the main influencing factors are complications and regions, in order to reduce the social and economic burden, payment mode should be adjusted to eliminate peritoneal dialysis fluid from drug proportion, promoting the promotion of peritoneal dialysis technology.
		2019 Vol. 16 (24): 59-61,66 [Abstract] ( 181 ) HTML (1 KB) PDF (561 KB) ( 240 )

	62	Screening of mild cognitive impairment among the elderly in urban and rural areas of Shanghai and analysis on its related factors
		LIU Jialu1 YU Dehua1,2 LU Yuan1,2 WANG Hao1,3
		Objective To investigate the prevalence rate and influencing factors of mild cognitive impairment (MCI) among the elderly in urban and rural areas of Shanghai. Methods According to the age stratification, the elderly in the same community was selected randomly. From September to November 2018, the cognitive function of residents in the Outpatient Department of Community Health Service Center and the Activity Center of Neighborhood Committee was investigated, as well as the general information, including gender, educational year, age, family structure, smoking history, drinking history, drink, religious belief, coronary heart disease history, hypertension history, diabetes history. The prevalence rate and risk factors were analyzed by the generalized MCI method. Results A total of 554 people were investigated effectively, and 73 cases were screened for MCI (MCI group), with a prevalence rate of 13.2%. The prevalence of MCI was 8.2% for those aged 60-64 years old, 9.5% for those aged >64-69 years old, 14.7% for those aged >69-74 years old, 23.5% for those aged >74-79 years old, 25.7% for those aged >79-84 years old, and 27.3% for those aged >84 years old, respectively, the remaining 481 cases were in the normal group. Univariate analysis showed that there were no significant differences in gender, smoking, alcoholism, drink and religious beliefs between the MCI group and the normal group (P ＞ 0.05); there were highly statistically significant differences in educational year, age and coronary heart disease between the two groups (P ＜ 0.01); there were statistically significant differences in family structure, hypertension and diabetes between the two groups (P ＜ 0.05). Multiple Logistic regression analysis showed that, advanced age (OR = 1.08, 95%CI: 1.03-1.13, P ＜ 0.01), smoking (OR = 2.83, 95%CI: 1.11-7.16, P ＜ 0.05), coronary heart disease (OR = 2.11, 95%CI: 1.19-3.73, P ＜ 0.05), hypertension (OR = 2.21, 95%CI: 1.17-4.18, P ＜ 0.05), diabetes (OR = 1.78, 95%CI: 1.02-3.11, P ＜ 0.05) were all risk factors for MCI disease. High educational level (OR = 0.82, 95%CI: 0.75-0.91, P ＜ 0.01) was the protective factor of MCI disease. Conclusion It is helpful to reduce the prevalence rate of MCI by strengthening the prevention and control of the elderly, smokers, people with low education level, and people with coronary heart disease, hypertension and diabetes.
		2019 Vol. 16 (24): 62-66 [Abstract] ( 226 ) HTML (1 KB) PDF (441 KB) ( 107 )

	67	Analysis of HbA1c level and its related factors of patients with abnormal glucose metabolism
		HUANG Dan1 BAI Xueqin2 JIA Zhongping3 LI Yuhuan4 XU Junfeng5▲
		Objective To investigate the relationship between glycosylated hemoglobin (HbA1c) and WHR, glucose, grease in patients with abnormal glucose metabolism. Methods From January to December 2014, 169 patients with abnormal glucose metabolism whose fasting blood glucose (FPG) ≥5.6 mmol/L or blood glucose≥7.8 mmol/L within 2 h after meal in the physical examination population in Physical Examination Department of Beijing Xiaotangshan Hospital were selected, they were divided into normal group (HbA1c≤6.5%, 104 cases) and abnormal group (HbA1c>6.5%, 65 cases) according to the level of HbA1c. Pearson was used to analyze the correlation of HbA1c with age, BMI, WHR, LDL-C, HDL-C, TG, TC, SBP, DBP and FPG. Multivariate Logistic regression was applied for data analysis. Results Multivariate Logistic regression analysis revealed that WHR (OR = 1.150, 95%CI: 0.783-1.964, P < 0.05), FPG (OR = 1.742, 95%CI: 0.798-2.914, P < 0.05), LDL-C (OR = 1.935, 95%CI: 1.635-3.389, P < 0.05), HDL-C (OR = 0.715, 95%CI: 0.527-1.741, P < 0.05), and TC (OR = 1.552, 95%CI: 0.174-1.592, P < 0.05) were all the influence factors of abnormal HbA1c in patients with abnormal glucose metabolism. Pearson correlation analysis showed that, level of HbA1c was positively correlated with waist-hip ratio and FPG (r = 0.220, P < 0.05), while negatively correlated with LDL-C, HDL-C and TC (r = -0.175, -0.156, -0.184, all P < 0.05), but the correlation was not significant. Level of HbA1c was positively correlated with FPG (r = 0.809, P < 0.01). Conclusion The WHR, FPG, LDL-C, HDL-C, and TC can affect the level of HbA1c, early and effectively control of these factors is the key to the prevention and treatment of diabetes.
		2019 Vol. 16 (24): 67-69 [Abstract] ( 681 ) HTML (1 KB) PDF (314 KB) ( 50 )

	70	Clinical effect of Bushen Tongguan Decoction combined with moxibustion in the treatment of diabetic neurogenic bladder
		LUAN Zhongqiu1 JIN Lixia1 ZHAO Dapeng1 WANG Jing1 FAN Zhenliang2
		Objective To explore the effect of Bushen Tongguan Decoction combined with mild moxibustion on urinary dysfunction in diabetic neurogenic bladder patients. Methods A total of 43 diabetic neurogenic bladder patients admitted to Department of Nephrology of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from March to August 2018 and depended on catheterization in varying degrees were divided into routine treatment group (20 cases) and combined treatment group (23 cases) by using random number table method. Routine treatment group received 4 weeks bladder voiding rehabilitation training (Crede oppression method) on the basis of strict control of blood sugar, and combined treatment group received oral Bushen Tongguan Decoction and Zhongji, Guanyuan and Qihai points mild moxibustion for 4 weeks on the basis of voiding rehabilitation training. The bladder residual urine volume, urodynamic parameters, AUA-SI score before and after treatment, and the situation of getting rid of catheter and clinical effect after treatment of 4 weeks were compared between two groups. Results After treatment, the residual urine volume of bladder in both groups was significantly less than that before treatment (P < 0.05), and the reduction of residual urine volume of bladder in combined treatment group was greater than that in routine treatment group (P < 0.05). The maximum urinary flow rate and average urinary flow rate after treatment in both groups were significantly higher than those before treatment (P < 0.05), and the increase of maximum urinary flow rate and average urinary flow rate in combined treatment group was greater than that in routine treatment group (P < 0.05). After treatment, AUA-SI scores in both groups were significantly lower than those before treatment (P < 0.05), and the reduction of AUA-SI scores in combined treatment group was greater than that in routine treatment group (P < 0.05). After treatment of 4 weeks, there was a significant difference between two groups in getting rid of the catheter (P < 0.05). After treatment of 4 weeks, the curative effect of combined treatment group was significantly better than that of routine treatment group (P < 0.05). Conclusion Rehabilitation training of bladder voiding alone or combined with Bushen Tongguan Decoction and mild moxibustion can significantly improve the voiding function of diabetic neurogenic bladder patients, and the combined treatment is better than the simple voiding rehabilitation training.
		2019 Vol. 16 (24): 70-73 [Abstract] ( 182 ) HTML (1 KB) PDF (494 KB) ( 97 )

	74	Feasibility of retrograde ureteroscopic surgery for ipsilateral symptomatic ureteral calculi and asymptomatic kidney stones
		ZHAO Guobin1 LIU Xin1 TANG Yuhong2 SU Hongwei1 TANG Lidong3 FENG Chao1 LI Chaoyang1 LI Xiangdong1
		Objective To investigate the feasibility of retrograde ureteral calculi and asymptomatic renal calculi treated by intrarenal operation with ureteroscope. Methods Clinical data of 122 patients with symptomatic ureteral calculi combined with ipisional asymptomatic kidney stones admitted to the First Affiliated Hospital of Hebei North University from December 2016 to January 2018 was retrospectively analyzed. According to the treatment method, the patients were divided into two groups, group A (62 cases) dealt with symptomatic ureteral stones and asymptomatic kidney stones, and group B (60 cases) dealt with ureteral stones alone. The perioperative and postoperative clinical features of the two groups were compared. Results The mean stone load, mean length of stay and incidence of complications of the two groups were compared, and the differences were not statistically significant (P ＞ 0.05). The mean operation time and decrease data of hemoglobin in group A were significantly longer or higher than those in group B (P < 0.01). The auxiliary treatment rate and reoperation rate of group B (mean follow-up period > 12 months) were significantly higher than those of group A, with high statistically significant differences (P ＜ 0.01). Conclusion It is safe and effective to treat ipsilateral symptomatic ureteral calculi and asymptomatic renal calculi with retrograde ureteroscopy, without increasing surgical complications.
		2019 Vol. 16 (24): 74-76,80 [Abstract] ( 211 ) HTML (1 KB) PDF (539 KB) ( 42 )

	77	Clinical effect of herbal fumigation and washing therapy of Zhuang medicine on chronic abacterial prostatitis
		ZHU Min1 LU Zhihua2 DAI Fang1 HUANG Cunchao1 JIANG Jianling2 MAI Pengyu2 LIU Ying1
		Objective To observe the clinical effect of herbal fumigation and washing therapy of Zhuang medicine on chronic abacterial prostatitis (CAP). Methods 160 CAP patients from January 2015 to August 2016 in Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine were randomly divided into treatment group and control group with 80 cases in each group by using random number table method. Treatment group was fumigated and washed with Qianlieshu external lotion, while control group was intervened with Qianlie′an Suppository. Both groups were treated with 28 days as a course of treatment. After one course of treatment, clinical total effective rate was compared between two groups. NIH-CPSI score, TCM syndrome score and levels of interleukin (IL)-2, IL-8 and IL-10 in prostatic fluid were compared between two groups before and after treatment. Results After treatment, total effective rate of treatment group was higher than that of control group (P < 0.05). After treatment, the scores of NIH-CPSI and TCM syndromes in two groups were lower than those before treatment (P < 0.05), and the scores in treatment group were lower than those in control group (P < 0.05). After treatment, the level of IL-8 in prostatic fluid of two groups was lower than that before treatment (P < 0.05), and the level of IL-8 in treatment group was lower than that in control group (P < 0.05). After treatment, the levels of IL-2 and IL-10 in prostatic fluid of both groups were higher than before treatment (P < 0.05), and treatment group was higher than control group (P < 0.05). Conclusion The fumigation and washing therapy of Zhuang medicine has better effect on CAP. This method can reduce the level of IL-8 in prostatic fluid and increase the levels of IL-2 and IL-10 in prostatic fluid. This may be one of the mechanisms of herbal fumigation and washing therapy for CAP in Zhuang medicine.
		2019 Vol. 16 (24): 77-80 [Abstract] ( 146 ) HTML (1 KB) PDF (497 KB) ( 118 )

	81	Effect of open reduction internal fixation with bone plate assisted by subtalar joint retractor in comminuted intra-articular fractures of the calcaneus
		HUANG Lei1 DENG Zhongliang1 LUO Wenzhong2 LI Bo2 MA Xihong2
		Objective To evaluate the effect of subtalar joint distractor assisted open reduction and internal fixation in comminuted intra-articular fractures of the calcaneus. Methods The clinical data of 76 patients with comminuted intra-articular fractures of the calcaneus admitted to Chongqing Sixth People′s Hospital from January 2014 to August 2017 was analyzed retrospectively. According to different treating methods, the patients were divided into control group (36 cases) and the research group (40 cases). The control group was treated with Steinmann pin traction and percutaneous reduction by leverage, while the research group was treated with open reduction internal fixation with bone plate assisted by subtalar joint retractor. The curative effect, surgical indexes, injured feet function, complications and the pain scores of the two groups were observed and compared. Results The total effective rate of the research group was significantly higher than that of the control group (P ＜ 0.05). The hospital stay and fracture healing time in the research group were significantly shorter than those in the control group, and the score of American Orthopaedic Foot and Ankle Society ankle-hindfoot scale was significantly higher than that of the control group, the differences were statistically significant (P ＜ 0.05). The incidence of complications in the research group was significantly lower than that of the control group (P ＜ 0.05). 3, 6, 12 months after operation, the pain scores in the research group were significantly lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The open reduction internal fixation with bone plate assisted by subtalar joint retractor in the treatment of comminuted intra-articular fractures of the calcaneus has ideal effects, the possibility of complications is low, and it is worthy of further popularization and application in clinic.
		2019 Vol. 16 (24): 81-85 [Abstract] ( 164 ) HTML (1 KB) PDF (678 KB) ( 34 )

	86	Systematic evaluation of the efficacy and safety of hemagglutinase sequential low molecular weight heparin for perioperative hemostasis in orthopedic surgery
		WU Yue1 TIAN Liu2 CHEN Ying1 ZHOU Benhong1
		Objective To systematically the effect of hemocoagulase sequential low molecular weight heparin treatment on hemorrhage and postoperative coagulation function of patients during perioperative period of orthopedic surgery. Methods Randomized controlled trials (RCTs) on the using of hemocoagulase during orthopedic surgery and low-molecular-weight heparin before surgery were searched from the building database to November 11, 2017 in CNKI, Wanfang Data, PubMed, and the references of all RCTs were further traced. After RCTs screening, data extraction, and quality evaluation carried out by two researchers according to the standards, RevMan 5.3.0 was used for Meta analysis. Results Six hundred and ninety-nine patients of 6 RCTs were included in 22 preliminary screening articles. The Meta analysis showed that, compared with control group, the intraoperative blood loss (SMD = -3.02, 95%CI [-4.44, -1.59], P ＜ 0.0001) and 24 h postoperative blood loss (SMD = -1.44, 95%CI [-2.50, -0.38], P = 0.008) of study group decreased significantly. There was no statistically significant difference in 24 h prothrombin time, partial thromboplastin time, fibrinogen (P > 0.05). Conclusion The therapeutic schedule of hemocoagulase sequential low molecular weight heparin during perioperative period of orthopedic surgery can reduce the peroperative bleeding and drainage 2 h after the operation, without increasing the incidence of adverse events, it has better security.
		2019 Vol. 16 (24): 86-90 [Abstract] ( 146 ) HTML (1 KB) PDF (1158 KB) ( 42 )

	91	The relationship between hand pain sensitivity and the function, pain and health status before and after operation in patients with lumbar intervertebral disc herniation
		LIN Sixin ZENG Qiao CHEN Bingquan
		Objective To investigate the relationship between hand pain sensitivity and function, pain and health status before and after operation in patients with lumbar intervertebral disc herniation. Methods Eight-seven patients with lumbar intervertebral disc herniation who were admitted to Panyu Hospital of Chinese Medicine in Guangzhou from February 2016 to October 2018 were prospectively selected for the study. Quantitative sensory test (QST) was used to detect the hand pain sensitivity, including heat pain threshold (HPT), cold pain threshold (CPT) and pressure pain threshold (PPT). Oswestry dysfunction index (ODI), visual analogue scale (VAS), hospital anxiety and depression scale (HADS), European five-dimensional health scale (EQ-5D) (including EQ-5D, EQ-VAS), self-efficacy scale (SES) was used to evaluate patients' function, pain and health status before and 3 months after operation. Results The ODI, waist pain intensity VAS, leg pain intensity VAS, HADS anxiety scale and HADS depression scale of patients with lumbar intervertebral disc herniation after operation were lower than those before operation (P ＜ 0.05), while EQ-5D, EQ-VAS and SES were higher than those before operation (P ＜ 0.05). There was no significant correlation between hand HPT and function, pain, health status before and after operation in patients with lumbar intervertebral disc herniation (P ＞ 0.05). CPT in hand of patients with lumbar intervertebral disc herniation was positively correlated with pre-and post-operative function and pain, and negatively correlated with SES (P ＜ 0.05), however, there was no correlation with preoperative pain, health status, postoperative HADS, EQ-5D and EQ-VAS (P ＞ 0.05). PPT in hands of patients with lumbar intervertebral disc herniation was negatively correlated with preoperative ODI, HADS anxiety scale, HADS depression scale and post-operative ODI (P ＜ 0.05), but positively correlated with pre-and post-operative SES (P ＜ 0.05). Conclusion CPT and PPT in hand pain sensitivity are correlated with higher postoperative pain degree and lower self-efficacy and function.
		2019 Vol. 16 (24): 91-94 [Abstract] ( 137 ) HTML (1 KB) PDF (518 KB) ( 108 )

	95	Correlation study of expression of ADAM8, IRF1 in peripheral blood and pulmonary function in children with bronchial asthma
		WANG Kaimei1 HU Xiangying1 ZHENG Guangqiang1 QIU Wenhai2 LIN Zhixiong1
		Objective To study the correlation of the expression of deintegrin metalloproteinase 8 (ADAM8), interferon regulatory factor 1 (IRF1) in peripheral blood and pulmonary function in children with bronchial asthma (BA). Methods Eighty-four children with BA who were treated in Haikou Women ＆ Children Hospital ("our hospital" for short) from January to August 2018 were selected as observation group, and they were divided into mild group (30 cases), moderate group (44 cases) and severe group (10 cases) according to the severity of the disease. Eighty healthy children who underwent physical examination in our hospital at the same time were selected as control group. The pulmonary function indices, the expression levels of ADAM8, IRF1 mRNA and protein in peripheral blood of each group were detected and compared. The correlation between the expression of ADAM8, IRF1 protein in peripheral blood and pulmonary function indices was analyzed. Results The expression levels of ADAM8, IRF1 mRNA and protein in peripheral blood of observation group and mild, moderate, severe group were significantly higher than those of the control group, the differences were highly statistically significant (P < 0.01); the expression levels of ADAM8, IRF1 mRNA and protein in peripheral blood of the severe group and moderate group were significantly higher than the mild group, and those of the severe group were significantly higher than the moderate group, the differences were statistically significant (P < 0.05). The forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity (FEV1/FVC), peak expiratory flow (PEF) in the observation group and mild, moderate, severe group were significantly lower than the control group, the differences were statistically significant (P < 0.05). The levels of FEV1, FEV1/FVC and PEF in the severe group and moderate group were significantly lower than the mild group, while the severe group was significantly lower than the moderate group, the differences were statistically significant (P < 0.05). Pearson correlation analysis showed that, the expression of ADAM8, IRF1 protein was negatively correlated with FEV1, FEV1/FVC and PEF (rADAM8=-0.780, -0.773, -0.682, P < 0.01; rIRF1=-0.684, -0.710, -0.768, P < 0.01). Conclusion The expression of levels ADAM8 and IRF1 in peripheral blood of children with BA are significantly increased, and it is closely related to pulmonary function. It can be considered as the monitoring target of children with BA, in order to assist the diagnosis and treatment process.
		2019 Vol. 16 (24): 95-98,106 [Abstract] ( 187 ) HTML (1 KB) PDF (598 KB) ( 53 )

	99	Meta analysis of the association between MTHFR gene polymorphisms and cervical cancer
		ZHOU Qing LIU Shuaimei ZHANG Ruijin SHI Hui LIN Ning WU Yulin XU Haoqin
		Objective To analyze the relationship between 5,10-Methyleneterahydrofolate reductase gene polymorphisms (MTHFR A1298C) and cervical cancer in order to provide reliable data for better prevention and treatment of cervical cancer. Methods Database of Wanfang, CNKI and PubMed were searched from the time of building database to November 12, 2018, and a total of 7 articles about the relationship between MTHFR gene (A1298C) polymorphisms and cervical cancer were included in this Meta-analysis, including 823 cases and 1607 controls. The odds ratio (OR) and 95% confidence interval (CI) were calculated and to assess the associations, meanwhile, the sensitivity and publication bias were analyzed. Results There were significance associations in the comparison C vs. A (OR = 1.11, 95%CI: 1.02-1.22, P = 0.015), AC vs. AA (OR = 1.24, 95%CI: 1.02-1.52, P = 0.030) and (CC+AC) vs. AA (OR = 1.15, 95%CI: 1.03-1.29, P = 0.013). Conclusion MTHFR (A1298C) gene polymorphisms may increase the risk for cervical cancer.
		2019 Vol. 16 (24): 99-102 [Abstract] ( 297 ) HTML (1 KB) PDF (619 KB) ( 50 )

	103	Clinical effect of Guizhi Fuling Capsules combined with Didrogesterone in the treatment of abnormal uterine bleeding with endometrial uneven echo
		SUN Jiaqi ZHU Fuli HUANG Yuxiao▲
		Objective To study the clinical effect of Guizhi Fuling Capsules combined with desdrogesterone in the treatment of endometrial uneven echo detected by transvaginal ultrasound. Methods From January to October 2018, 60 cases of abnormal uterine bleeding with endometrial uneven echo by ultrasound within 10 days of menstruation were collected in the Department of Gynecology of Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine. According to their actual medication method, they were divided into observation group and control group, 30 cases in each group. The control group was treated with Dydrogesterone only in the second half of menstruation (from 15th to 25th day), while the observation group was treated with Dydrogesterone in the second half cycle (the same as the control group) and Guizhi Fuling Capsules on the 20th day of menstruation for 11 days. The clinical effects and adverse reactions of the two groups were recorded. Results After 3 months of treatment, the thickness of endometrium, rate of slightly higher echo in uterine cavity and the uneven rate of endometrial echo in both groups decreased significantly compared with before treatment, the differences were statistically significant (P < 0.05 or P < 0.01); the thickness of endometrium in observation group was lower than that of the control group, the difference was statistically significant (P < 0.05); There were no statistically significant differences in the rate of slightly higher echo in uterine cavity and the uneven rate of endometrial echo between the two groups (P > 0.05). There was no obvious adverse reactions occurred in the two groups. Conclusion Guizhi Fuling Capsules combined with Dydrogesterone in the treatment of endometrial uneven echo by ultrasound can improve the clinical efficacy and abnormal uterine bleeding, without increasing the incidence of adverse reactions, which is safe and reliable.
		2019 Vol. 16 (24): 103-106 [Abstract] ( 194 ) HTML (1 KB) PDF (586 KB) ( 27 )

	107	Clinical value of early interventional therapy with fiberoptic bronchoscopy in children with Mycoplasma pneumoniae pneumonia complicated with airway mucus embolism
		TAO Pei XIA Wanmin
		Objective To investigate the clinical value of early interventional therapy with fiberoptic bronchoscopy in children with Mycoplasma pneumoniae pneumonia (MPP) complicated with airway mucus embolism. Methods Clinical data of 92 MPP children complicated with airway mucus embolism in Department of Children′s Respiratory of Chengdu Women's and Children′s Central Hospital from February 2015 to February 2017 A retrospective, they were grouped according to the course of disease that from admission to fiberoptic bronchoscopy interventional therapy, children with the course of disease more than 10 days were defined as the control group (45 cases) and whose the course of disease less than or equal to 10 days were defined as the observation group (47 cases). The therapeutic effects of the two groups were compared and analyzed. Results The duration of fever, hospitalization, recovery time of white blood cell count and C-reactive protein in the observation group were significantly shorter than those in the control group, the differences were highly statistically significant (P < 0.01). There was statistically significant difference in the proportion of children with 60%-90% pulmonary consolidation absorption area 1, 3 months after treatment (P < 0.05); the pulmonary consolidation absorption areas of children in the observation group 1, 2, 3 months after treatment were better than those in the control group, the differences were statistically significant (P < 0.05). The incidence of atelectasis in the observation group was significantly lower than that in the control group 1, 2, 3 months after treatment, the differences were statistically significant (P < 0.05). Conclusion Early intervention of fiberoptic bronchoscopy in the treatment of MPP patients with airway obstruction with intraairway mucus embolism has a good safety and high clinical value, which is worthy of clinical promotion.
		2019 Vol. 16 (24): 107-110 [Abstract] ( 160 ) HTML (1 KB) PDF (560 KB) ( 138 )

	111	Effect of different mixing methods on the compressive strength of glass ionomer cements
		QIU Tao1,2 CHEN Xinlei1,2 HUANG Juan1,2 YE Dan1,2 MAO Bochun1,2 XIAO Jingyi1,2 XU Qinghong1,2
		Objective To investigate the effect of different mixing methods on the compressive strength of glass ionomer cement fillings, and to provide guidance for clinical operators in the correct use of glass ionomer cement in the filling treatment of tooth defects. Methods In order to control irrelevant variables, except mixing method, all other variables in each group were controlled the same. According to the technical requirements of the mixing methods of glass ionomer cement commonly used in clinic, four kinds of commonly used mixing methods were used to mix glass ionomer cement materials, namely, unidirectional clockwise rotation method (groupⅠ), unidirectional anticlockwise rotation method (groupⅡ), two-way alternating rotation method (group Ⅲ) and the pulling and pushing with folding method (group Ⅳ), with five copies of each method, and filled into a special mold for compressive strength testing. After it was completely solidified, its compressive strength was tested and statistical analysis was performed. Results Compressive strength of glass ionomer cement fillings prepared by pulling and pushing with folding method was compared with the other three methods, the differences were statistically significant (P < 0.05). The compressive strength of glass ionomer cement in group Ⅳ was significantly lower (pulling and pushing with folding method) than that in groups Ⅰ, Ⅱ and Ⅲ, the differences were statistically significant (P < 0.05). Conclusion Unidirectional clockwise rotation method, unidirectional anticlockwise rotation method and the alternate two-way rotation method should be recommended in clinical practice. At the same time, it is necessary to further strict mixing requirements to improve the qualification rate of material mixing.
		2019 Vol. 16 (24): 111-114 [Abstract] ( 143 ) HTML (1 KB) PDF (453 KB) ( 96 )

	115	Effect of modified crown extension and orthodontic traction plus crown extension on upper anterior gingival defect
		MO Zhiyuan GAO Yongbo
		Objective To investigate the effect of modified crown extension and orthodontic traction plus crown extension in the treatment of upper anterior gingival defect. Methods A total of 150 patients with anterior gingival defect diagnosed by the Department of Stomatology, Hangzhou Red Cross Hospital of Zhejiang Province from June 2015 to October 2018 were selected and divided into control group and observation group according to random number table method, with 75 patients in each group. The control group was treated with modified crown extension, while the observation group was given orthodontic traction plus crown extension. The results of restoration and periodontal health, including tooth mobility (TM), probing pocket depth (PPD), gingival index (GI), gingival sulcus bleeding index (SBI), plaque index (PLI), were compared between the two groups. Results There was no significant difference in the rate of excellent and good repair between the two groups at 1 month after operation (P > 0.05). PPD, SBI, PLI, GI and TM of the two groups at 1 month after operation were lower than those before operation (P < 0.01), but there were no significant differences in PPD, SBI, PLI, GI and TM between the two groups at 1 month after operation (P > 0.05). The crown height at 6 and 12 weeks after operation were higher than that at 2 weeks after operation (P < 0.01); there was no significant difference in the incidence of follow-up complications between the two groups (P > 0.05). Conclusion Modified crown extension, orthodontic traction and crown extension can effectively repair the upper anterior gingival defect, improve the periodontal health status, promote crown height recovery, and have fewer postoperative complications. The treatment method can be selected according to the actual situation and needs of the individual.
		2019 Vol. 16 (24): 115-118 [Abstract] ( 137 ) HTML (1 KB) PDF (456 KB) ( 58 )

	119	Relationship between serum trough concentration of Vancomycin and renal injury and clinical efficacy in children with severe infection
		ZHU Desheng1 ZENG Fangling2 YAO Zhenya1 ZHOU Wu1
		Objective To investigate the relationship between serum trough concentration of Vancomycin and renal injury and clinical efficacy in children with severe infection. Methods A total of 158 children with severe infection admitted to the Hu′nan Children′s Hospital from May 2017 to May 2018 were enrolled. They were divided into group A (n = 52, <5 mg/L), group B (n = 53, 5-10 mg/L) and group C (n = 53, >10 mg/L) according to the serum concentration of Vancomycin. The clinical efficacy, bacteriological efficacy, and renal function related indexes of the three groups were compared. The incidence of adverse reactions during the treatment of the three groups was recorded. Results There was significant difference in the total clinical effective rate among the three groups (P < 0.05). The total clinical effective rate of group B and group C was significantly higher than that of group A, and group B was higher than that of group C, the differences were statistically significant (P < 0.05). The total effective rate of bacteriology in group B and group C was significantly higher than that in group A, and group B was higher than that in group C, the differences were statistically significant (P < 0.05). Urea nitrogen (BUN), serum creatinine (Scr) and cystatin-C (Cys-C) increased after treatment in three groups, and BUN, Scr and Cys-C in group C were higher than those in group A and group B, the differences were statistically significant (P < 0.05), but there was no significant difference in BUN, Scr and Cys-C between two groups after treatment (P > 0.05). There was no significant difference in mortality among the three groups (P > 0.05). Conclusion The different serum concentrations of Vancomycin have different clinical total effective rate and total bacteriological efficiency. Among them, the serum concentration of 5-10 mg/L Vancomycin is better, and the effect on kidney injury is lighter. It will not increase the mortality rate of children and has certain clinical application value.
		2019 Vol. 16 (24): 119-122,149 [Abstract] ( 151 ) HTML (1 KB) PDF (997 KB) ( 193 )

	123	Effect of Tripterygium Glycosides Tablets combined with Compound α-ketoacid Tablets on patients with chronic renal failure
		LIN Jianmei
		Objective To investigate the effects of Tripterygium Glycosides Tablets combined with Compound α-ketoacid Tablets on patients with chronic renal failure. Methods The clinical data of 300 patients with chronic renal failure admitted to the Department of Nephrology, the First People′s Hospital of Ziyang, Sichuan Province from February 2013 to February 2018 were divided into control group and observation group according to different treatment methods, with 150 cases in each group. The levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), transforming growth factor-beta 1 (TGF-β1) and urinary collagen type Ⅳ (Ⅳ-C) were observed before and after treatment in the two groups. Results There were no significant differences in the levels of CRP, TNF-α, MDA, SOD, GSH-Px, TGF-β1 and Ⅳ-C between the two groups before treatment (P > 0.05). Compared with before treatment, the levels of CRP, TNF-α, MDA, TGF-β1, Ⅳ-C in the two groups after treatment decreased, while the levels of SOD and GSH-Px increased. The levels of CRP, TNF-α, MDA, TGF-β1, Ⅳ-C in the observation group were lower than those in the control group after treatment, the levels of SOD and GSH-Px were higher than those in the control group, and the differences were statistically significant (P < 0.05). The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion The clinical effects of Tripterygium Glycosides Tablets combined with Compound α-ketoic Tablets in the treatment of patients with chronic renal failure are obvious, which is worthy of clinical promotion and application.
		2019 Vol. 16 (24): 123-126 [Abstract] ( 149 ) HTML (1 KB) PDF (473 KB) ( 86 )

	127	Application and compatibility rules of traditional Chinese medicine in the treatment of cervical radiculopathy
		ZHU Liguo1* TANG Bin1,2* WEI Xu3 GAO Yun4 XIE Qi5 ZHANG Xingping1 YIN He1 WANG Hao1
		Objective To analyze the application rules of traditional Chinese medicine in treating cervical radiculopathy (CR) in clinical practice. Methods The information sharing system of traditional Chinese medical treatment and clinical scientific research was used to collect CR patient information of inpatient and outpatient treatment in Wangjing Hospital, China Academy of Chinese Medical Sciences from December 2012 to July 2014. A total of 274 cases of CR patients taking traditional Chinese medicine were studied. The PLSQL and excel were used for standardized classification and statistical analysis, and Liquorice software was used to calculate the correlation frequency and mutual information value of compatibility rules of traditional Chinese medicine, and to draw a complex network diagram. Results A total of 430 prescriptions were collected. According to the frequency analysis of drug use, Rhizoma Ligustici Chuanxiong, Radix Glycyrrhizae, Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Corydalis, Ramulus Cinnamomi, Radix Clematidis, Radix Astragali seu Hedysari and other traditional Chinese medicine were most used. According to the analysis of aspects of drug nature, drug taste and channel tropism, warm drugs were most commonly used (48.65%), bitter taste drugs(49.24%) and sweet taste drugs (46.63%) were more relatively used, and liver channel drugs were most commonly used (51.80%). The compatibility analysis of traditional Chinese medicine showed that Rhizoma Ligustici Chuanxiong had a relatively high correlation with Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Angelicae Sinensis and Rhizoma Corydalis, with mutual information values of 22.31, 16.52, 18.55 and 21.88 respectively. The results of complex network diagram showed that the classical prescription Huangqi Guizhi Wuwu Decoction or Guizhi plus Gegen Decoction might be the basic prescription for treating CR. Conclusion According to the analysis of clinical practice, for the CR, the use of traditional Chinese medicine takes promoting blood circulation for removing blood stasis as the principle of treatment, combined with traditional Chinese medicine, which has the effects of benefiting vital energy and nourishing blood, dispelling wind, eliminating dampness, dispelling cold, and so on. The treatment can be modified according to syndrome based on Huangqi Guizhi Wuwu Decoction or Guizhi plus Gegen Decoction.
		2019 Vol. 16 (24): 127-131,153 [Abstract] ( 177 ) HTML (1 KB) PDF (910 KB) ( 101 )

	131	Treatment of metrorrhagia and metrostaxis from “three types of disease causes” theory by Professor Feng Xiaoling
		LI Qiang1 LI Jiawei1 CHEN Lu2 FENG Xiaoling2
		Metrorrhagia and metrostaxis is a disease, in which, the menstrual cycle, menstrual period, and menstrual flow are severely disordered, the menstrual blood is not stop during non-menstrual period or the blood is dripping and leaching. It is a common and frequently-occurring disease in gynecology, and it is also a difficult and serious disease. Feng Xiaoling Professor takes the overall concept as the leading idea and treat syndrome differentiation as a treatment feature. She believes that although the disease is in the kidney and spleen, the effect of social and natural environment on human emotions is taken into account when the prescription is used. By comparing the advantages and disadvantages of Chinese and Western medicine treatment, the remedy of metrorrhagia and metrostaxis is discussed from the ″three types of disease causes″ theroy. This article expounds Professor Feng′s diagnosis and treatment of metrorrhagia and metrostaxis, the rules of medication and typical cases, so that TCM artificial menstrual cycle treatmert combined with Dydrogesterone for the treatment of metrorrhagia and metrostaxis is clearer, and the clinical effect is excellent.
		2019 Vol. 16 (24): 131-134 [Abstract] ( 156 ) HTML (1 KB) PDF (768 KB) ( 122 )

	135	Effect of Ginseng combined with Taohong Siwu Decoction on cardiac function and blood lipid in patients with coronary heart disease and angina pectoris
		CHEN Jianhao WANG Jinliang ZENG Mingzhu
		Objective To investigate the effect of Ginseng combined with Taohong Siwu Decoction on cardiac function and blood lipid in patients with coronary heart disease and angina pectoris. Methods One hundred and one patients with coronary heart disease and angina pectoris admitted to Baiyun Branch of Guangdong Second Hospital of Traditional Chinese Medicine from September 2015 to June 2018 were selected. The patients were divided into control group (50 cases) and study group (51 cases) according to the random number table method. The control group was treated with routine comprehensive treatment, while the study group was treated with Ginseng combined with Taohong Siwu Decoction on the basiss of the control group. The changes of clinical efficacy, cardiac function index and blood lipid index were compared between the two groups, and the adverse reactions during treatment were observed. Results The total effective rate of the study group was 94.12% after treatment, which was significantly higher than that in the control group (74.00%), and the difference was statistically significant (P ＜ 0.05). After treatment, the left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) of the study group were significantly lower than that of the control group, and the left ventricular ejection fraction (LVEF) was significantly higher than that of the control group, and the differences were statistically significant (P ＜ 0.05). Compared with before treatment, LVESD and LVEDD were significantly decreased and LVEF was significantly increased in the two groups after treatment, and the differences were statistically significant (P ＜ 0.05). After treatment, the triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in the study group were lower than those in the control group, and high density lipoprotein cholesterol (HDL-C) was significantly higher than that in the control group, the differences were statistically significant (P ＜ 0.05). Compared with before treatment, TG, TC and LDL-C were significantly decreased in both groups, and HDL-C was significantly increased, the differences were statistically significant (P ＜ 0.05). There was no significant difference in adverse reactions between the two groups during treatment (P ＞ 0.05). Conclusion Ginseng combined with Taohong Siwu Decoction in the treatment of patients with coronary heart disease and angina pectoris has a definite curative effect, which can effectively improve the cardiac function and blood lipid status of patients without increasing the incidence of adverse reactions. It has certain clinical application value.
		2019 Vol. 16 (24): 135-138 [Abstract] ( 181 ) HTML (1 KB) PDF (769 KB) ( 132 )

	139	Xu Rongqian′s experience in the differentiation and treatment of multiple tic disorder in children
		LIU Yan SONG Yuehan CHEN Guangyao GE Xiaobo XU Rongqian
		Multiple tic disorder in children is one of the common mental illnesses in pediatrics. Professor Xu Rongqian has rich experience in treating this disease and has achieved good results. The author consults Professor Xu and summarizes the academic concept of treating this disease. Multiple tic disorder children′s congenital genetic constitution is insufficiency of gallbladder, induced by environmental stimuli, external invasion of the body′s pathogenic factors, gradually involving the organs of the body. Liver wind stirring up internal manifests as frequent tics. Lung, spleen and kidney dysfunction leads to turbidity endogenous, then slang frequently. The syndrome of liver wind stirring up internal appears to be frequent twitching. Lung spleen and kidney dysfunction lead to turbidity endogenous, then slang frequently. The condition is repeated and unstable, and it is transformed into fire due to long illness, accompanied by emotional abnormalities, and even sees agitated behaviors such as beating people.
		2019 Vol. 16 (24): 139-142 [Abstract] ( 154 ) HTML (1 KB) PDF (804 KB) ( 193 )

	143	Effect of Jianpi Yifei method in the treatment of stable period in chronic obstructive pulmonary disease
		KE Jia1 TIAN Fa′nian2 ZHENG Lan1 LI Yong1
		Objective To study the effect of Jianpi Yifei method in the treatment of stable period in chronic obstructive pulmonary disease (COPD). Methods 116 patients with stable period in COPD admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from October 2017 to September 2018 were divided into control group and treatment group by using random lottery method, 58 cases in each group. After admission, all patients were given basic treatment of western medicine. The treatment group was treated with Jianpi Yifei method on the basis of western medicine. The clinical efficacy, pulmonary function and quality of life before and after treatment were compared between two groups. Results Clinical effect of treatment group was better than that of control group (P < 0.05). After treatment, the FEV1,percentage of FEV1 and FEV1/FVC in two groups were higher than those before treatment (P < 0.05), and treatment group was higher than that control group, the difference was statistically significant (P < 0.05). After treatment, SGRQ scores of two groups were lower than those before treatment (P < 0.05), and treatment group was lower than that control group, the difference was statistically significant (P < 0.05). During the treatment period, no special adverse reactions occurred in both groups. Conclusion Jianpi Yifei method combined with western medicine can improve clinical efficacy of patients with stable period in COPD. It can better improve the quality of life of patients. It is worth popularizing and applying.
		2019 Vol. 16 (24): 143-145,161 [Abstract] ( 156 ) HTML (1 KB) PDF (779 KB) ( 105 )

	146	Application of "lung and large intestine are exterior and interior" theory in the treatment of obesity asthma in children
		CONG Deyu ZHANG Guiju
		In recent years, with the increasing number of patients, childhood obesity and asthma have gradually become a global social problem endangering children′s health. Studies have shown that there is a close relationship between obesity and asthma. Obesity as one of the key risk factors can induce or aggravate asthma. With the continuous increase of obese children with asthma, traditional clinical therapy is facing severe challenges to find out specific treatment pertinently. At present, traditional Chinese medicine have played an important role in the dialectical treatment of childhood asthma. Based on the theory of "lung and large intestine are exterior and interior", the methods of purging fu-organs to eliminate heat, clearing heat and promoting dampness are used in this paper to restore lung and intestinal functions, regulate intestinal, which can effectively improve asthma symptoms and provide reference for obese asthma clinical treatment.
		2019 Vol. 16 (24): 146-149 [Abstract] ( 150 ) HTML (1 KB) PDF (764 KB) ( 255 )

	150	Effect of warm acupuncture combined with massage and point-pressing therapy at rectus femoris nerve entry point on lower limb motor dysfunction in patients with incomplete lumbar enlargement injury
		PAN Junying1 WANG Haoyang1 YAN Ni1 WANG Jun1 DING Yuxin1 SONG Zhongtao1 GAO Xiao2
		Objective To explore the effect of warm acupuncture combined with massage and point-pressing therapy at rectus femoris nerve entry point on lower limb motor dysfunction in patients with incomplete lumbar enlargement injury. Methods From March 2016 to December 2018, 48 patients with incomplete lumbar enlargement injury were selected from Massage, Rehabilitation and Acupuncture Clinics and Wards in the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine and the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine. They were divided into observation group (24 cases) and control group (24 cases) according to random number table method. Observation group was treated by warm acupuncture combined with massage and point-pressing therapy at rectus femoris nerve entry point, while control group was treated by acupuncture. The lower extremity motor function, average electromyogram (AEMG) of rectus femoris muscle and daily living ability of two groups were compared before and after treatment. Results After treatment, ASIA motor function score and Fugl-Meyer motor function score in both groups were significantly higher than those before treatment (P < 0.01), and observation group was significantly higher than that control group (P < 0.01). After treatment, AEMG and modified Barthel index scores of rectus femoris in both groups were significantly higher than those before treatment (P < 0.01), and observation group was significantly higher than that control group (P < 0.01). Conclusion Warm acupuncture combined with massage and point-pressing therapy at rectus femoris nerve entry point can improve the motor function of rectus femoris in patients with incomplete lumbar enlargement injury to improve the motor function and daily living ability of lower limbs.
		2019 Vol. 16 (24): 150-153 [Abstract] ( 130 ) HTML (1 KB) PDF (795 KB) ( 94 )

	154	Effect comparison of nape quick needling and retaining needling in the treatment of peripheral facial paralysis
		PAN Weijuan1 QU Yuming2 ZHANG Tiansheng3 HAO Chongyao4
		Objective To compare the effect of nape quick needling and retaining needling in the treatment of peripheral facial paralysis. Methods Thirty patients with peripheral facial paralysis treated in the Third Hospital of Traditional Chinese Medicine of Shanxi College of Traditional Chinese Medicine from December 2017 to September 2018 were selected as study subjects. They were divided into control group (retained needling) and treatment group (quick needling) according to random number table method, with 15 cases in each group. Control group and treatment group were treated with nape cluster retained needling and quick needling respectively. They were treated with 5 days as a course of treatment, with a total of 4 courses of treatment. After each course of treatment, they took a rest of 2 days. The efficacy and scores of the front disability index (FDI) scale before and after treatment of two groups were compared. Results After treatment, the scores of FDI scale in both groups were higher than those before treatment (P < 0.05), but there was no significant difference in the scores of FDI scale between two groups after treatment (P > 0.05). After treatment, there was no significant difference between two groups (P > 0.05). Conclusion Nape cluster quick needling and retained needling have the same effect in the treatment of peripheral facial paralysis.
		2019 Vol. 16 (24): 154-156 [Abstract] ( 182 ) HTML (1 KB) PDF (791 KB) ( 51 )

	157	Improvement effect of acpuncture at Chong and Conception Channels on sex hormones in patients with diminished ovarian reserve
		YANG Likun ZHANG Jiajia ZHANG Zhenzhu XU Shoujing
		Objective To observe the improvement effect of acpuncture at Chong and Conception Channels on sex hormones in patients with diminished ovarian reserve (DOR). Methods A total of 66 patients with DOR in the Outpatient Department of Acupuncture, Dongzhimen Hospital of Beijing University of Chinese Medicine (Branch of Tongzhou District, Dongcheng District) from May 2015 to May 2018 were selected. The patients were divided into acupuncture group (33 cases) and control group (33 cases, acupoint catgut embedding) by 1∶1 random number table method. The improvement effect of serum follicle stimulating hormone (FSH), serum FSH/luteinizing hormone (FSH/LH) and Chinese medicine symptom scores before and after treatment and during follow-up period were observed. Results There were no significant differences in the scores of FSH, FSH/LH and Chinese medicine symptom scores between the two groups before treatment (P ＞ 0.05). Compared with before treatment, the levels of FSH, FSH/LH and Chinese medicine symptom scores were significantly decreased after treatment and during follow-up period, the differences were statistically significant (P ＜ 0.05). The levels of FSH, FSH/LH and Chinese medicine symptom scores in the acupuncture group were significantly lower than those in the control group after treatment and during follow-up period, the differences were statistically significant (P ＜ 0.05). Conclusion Acupuncture and acupoint catgut embedding in coordinating Chong and Conception Channels have a therapeutic effect on DOR patients. Acupuncture at Chong and Conception Channels has a good effect on the improvement of sex hormone levels in DOR patients.
		2019 Vol. 16 (24): 157-161 [Abstract] ( 167 ) HTML (1 KB) PDF (808 KB) ( 155 )

	162	Surgical treatment of epulis guided by plaque control：a case report and literature review
		LU Jingyi1 REN Baijie1 QU Xingyuan1 WANG Lei1▲ QIAO Chunyan2
		Based on a retrospective analysis of the case data and literature of a patient with gingivoma, this paper expounds that the standardized periodontal basic treatment combined with surgical resection of gingivoma is an effective method for the treatment of gingivoma and prevention of recurrence. After treatment, chronic periodontitis is basically controlled. There is no obvious loosening of the affected teeth, good masticatory function and bone defect in the operative area. There was no sign of recurrence and the gingiva was in good shape. To clarify that in the treatment of gingival tumors, the removal of local stimulating factors such as calculus and plaque is closely related to the treatment effect of gingival tumors. The key to prevent the recurrence of gingival tumors is plaque control and periodontal maintenance.
		2019 Vol. 16 (24): 162-165,177 [Abstract] ( 168 ) HTML (1 KB) PDF (1231 KB) ( 77 )

	166	Severe hypokalemia complicated with rhabdomyolysis due to chronic diarrhea in an elderly patient
		HE Ke LIU Ling BIAN Rongrong LU Xiwan ZHU Lihua
		The etiology of hypokalaemia is a common clinical electrolyte disorder, which is complex and the clinical manifestations are diverse. The complication of rhabdomyolysis is prone to delayed diagnosis or missed diagnosis, thus affecting the prognosis. This paper reported a case of severe hypokalemia combined with rhabdomyolysis caused by chronic diarrhea in an elderly patient in Wuxi Hospital of Traditional Chinese Medicine, whose minimum potassium at 1.45 mmol/L, and rised levels of serum creatine kinase (CK), creatine kinase MB (CK-MB). After complementing potassium, hydration, diuresis, antioxidation and stabilizing cell membrane, a total of 72 g potassium chloride was supplied, then potassium returned to normal, and levels of CK, CK-MB gradually returned to stable. The purpose of this paper is to summarize the experiences of this kind of disease and give a guidance for diagnose and treatment in hypokalemia combined with rhabdomyolysis.
		2019 Vol. 16 (24): 166-168 [Abstract] ( 149 ) HTML (1 KB) PDF (399 KB) ( 90 )

	169	Discussion on strengthening the training of chief resident in pediatric surgery
		WU Zhouguang WANG Bin▲ CHEN Zimin FENG Qi ZHENG Jiachen
		The rational allocation of medical resources and the cultivation of talents needed by hospitals are two important components of the current medical system reform. In terms of talent cultivation in hospitals, the training of chief resident physicians is an important stage that cannot be leap-forward from senior resident physicians to attending physicians, and it is also the key to the gradient cultivation of specialized physicians. Pediatric surgery is different from adult surgery, and pediatric surgery diseases have their own particularity, there are some characteristics and difficulties in the training of chief resident of pediatric surgery. It is mainly manifested in the high training requirements, long period and large overall investment of the chief resident of pediatric surgery. In practical work, we should pay attention to the training of clinical thinking, strengthening operation skills, psychological quality, teaching and communication ability, scientific research ability and management of chief resident of pediatric surgery, so as to improve the professional level of chief resident of pediatric surgery. At present, our country′s pediatric surgery personnel training system is not perfect, lack of children′s surgery general resident stage of professional basic knowledge and pediatric clinical skills training, resulting in the relative shortage of children′s surgery specialist doctors, which is one of the reasons for the overcrowding of children′s specialized hospitals. Therefore, the training of chief resident of pediatric surgery should be further improved and strengthened, and more investment should be made to promote the overall development of pediatric surgery.
		2019 Vol. 16 (24): 169-172 [Abstract] ( 134 ) HTML (1 KB) PDF (583 KB) ( 93 )

	173	Research on the design of community diabetes traditional Chinese medicine management system based on mobile terminal
		YAN Yan LIU Guang WANG Tianyu SUN Yanqiu
		With the rapid development of internet technology, mobile internet technology is rapidly changing the daily work of the medical and health industry, and playing an important role in the management of chronic diseases. This study will discuss how to effectively utilize advanced information technology, improve the utilization of existing medical resources, form a diabetes community health management system integrating the characteristics of traditional Chinese medicine, and explore the basic framework of designing a diabetes community health management system based on mobile terminal. The basic functions include login and registration, data acquisition, online service, information query, data analysis, intelligent reminder, and patient statistical analysis. Discusses the significance of designing a community diabetes management platform for diabetic patients and high-risk groups, grass-roots medical workers and the prevention and control mode of chronic diseases in traditional Chinese medicine community under the new technology. With the help of the extensive mass base of traditional Chinese medicine, the advantages of traditional Chinese medicine in the field of disease prevention and control are brought into play, and new management research directions are provided for the community diabetes prevention and control management in the new era.
		2019 Vol. 16 (24): 173-177 [Abstract] ( 165 ) HTML (1 KB) PDF (799 KB) ( 137 )

	178	Value of intervention in square dance in the rehabilitation of depression among middle-aged and old women
		ZHANG Liangzhi YANG Jianquan
		Objective To explore the value of intervention in square dance in the rehabilitation of depression among middle-aged and elderly women. Methods Eighty middle-aged and elderly female depression patients in Affiliated Hospital of Xi′an Medical College received from January to December 2017 were selected as observation objects. According to the method of random number table, they were divided into control group and observation group, with 40 cases in each group. The control group was treated with drugs, the observation group only performed motortherapy of square dancing. The scores of symptom checklist (SCL-90), self-rating anxiety scale (SAS), self-rating depression scale (SDS) and side effects scale (TESS) were compared between the two groups at before treatment, the end of 1 month and 3 months of treatment. Results Before treatment, the end of the 1 month and the end of the 3 months of treatment, the scores of SCL-90, SAS and SDS of patients decreased gradually with the extension of treatment time, the differences were statistically significant (P < 0.05). The scores of SCL-90, SAS and SDS of patients in the observation group were significantly lower than those in the control group before treatment, the end of the first month and the end of the 3 months of treatment, the differences were highly statistically significant (P < 0.01). There were no side effects in the observation group. The TESS scores of the control group were (5.43±2.01) and (4.78±2.03) scores at the end of 1 month and 3 months of treatment, respectively, and decreased with the extension of treatment time (P < 0.05). Conclusion It is safe and effective for middle-aged and elderly female depression patients to participate in square dance exercise, which can promote anxiety, improve the symptoms of depression, improve the degree of mental health, and has a high clinical application value.
		2019 Vol. 16 (24): 178-180,189 [Abstract] ( 223 ) HTML (1 KB) PDF (664 KB) ( 49 )

	181	The role of five-level electronic medical record application system in medical administration management
		TIAN Weijuan
		With the continuous development of modern science and technology, the traditional medical record setting cannot meet the development needs of hospital information system. In order to create a good atmosphere of medical activity management, hospitals should pay attention to the application of electronic medical records, which can transform the medical record management mode and promote the reform of hospital medical quality management and medical operation management. This paper discusses the strategic environment of hospitals, the key benefits of hospital informatization construction, the scope and goal of implementing health information work, the construction work of five-level electronic medical record in hospitals, and the activities of implementing reform, aiming to elaborate the specific application and practice of five-level electronic medical record application system in modern medical administration management.
		2019 Vol. 16 (24): 181-184 [Abstract] ( 175 ) HTML (1 KB) PDF (641 KB) ( 79 )

	185	Clinical characteristics and rehabilitation effect of neuromyelitis spectrum diseases
		LIU Ping HE Jingjie LIU Lixu HU Xueyan▲
		Objective To investigate the clinical features and rehabilitation prognosis of neuromyelitis spectrum diseases. Methods The clinical data of 7 patients with diagnosed optic neuromyelitis spectrum disease admitted to China Rehabilitation Research Center, Beijing Boai Hospital from January 2016 to October 2018 were retrospectively analyzed, their clinical characteristics and obstacle points were analyzed, and changes in activity of daily living (ADL) ability were observed, and the rehabilitation prognosis was compared. Results The 7 patients showed different degrees of limb motor dysfunction, sensory dysfunction, urinary bowel disorder, abnormal vision and emotional disorder, all of which required ADL. After systematic and standardized rehabilitation treatment, patients′ functional dysfunction and ADL ability were significantly improved（P ＜ 0.01）. Conclusion Early and active rehabilitation therapy can reduce the dysfunction of patients and improve the ADL ability.
		2019 Vol. 16 (24): 185-189 [Abstract] ( 148 ) HTML (1 KB) PDF (840 KB) ( 49 )

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