雷公藤多苷片联合复方 ■-酮酸片对慢性肾衰竭患者的影响

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Abstract Objective To investigate the effects of Tripterygium Glycosides Tablets combined with Compound α-ketoacid Tablets on patients with chronic renal failure. Methods The clinical data of 300 patients with chronic renal failure admitted to the Department of Nephrology, the First People′s Hospital of Ziyang, Sichuan Province from February 2013 to February 2018 were divided into control group and observation group according to different treatment methods, with 150 cases in each group. The levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), transforming growth factor-beta 1 (TGF-β1) and urinary collagen type Ⅳ (Ⅳ-C) were observed before and after treatment in the two groups. Results There were no significant differences in the levels of CRP, TNF-α, MDA, SOD, GSH-Px, TGF-β1 and Ⅳ-C between the two groups before treatment (P > 0.05). Compared with before treatment, the levels of CRP, TNF-α, MDA, TGF-β1, Ⅳ-C in the two groups after treatment decreased, while the levels of SOD and GSH-Px increased. The levels of CRP, TNF-α, MDA, TGF-β1, Ⅳ-C in the observation group were lower than those in the control group after treatment, the levels of SOD and GSH-Px were higher than those in the control group, and the differences were statistically significant (P < 0.05). The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion The clinical effects of Tripterygium Glycosides Tablets combined with Compound α-ketoic Tablets in the treatment of patients with chronic renal failure are obvious, which is worthy of clinical promotion and application.

Key words： Tripterysium Glycosides Tablets Compound α-ketoacid Tablets Chronic renal failure Superoxide dismutase Glutathione peroxidase Urinary transforming growth factor β1 Urinary type Ⅳ collagen

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LIN Jianmei. Effect of Tripterygium Glycosides Tablets combined with Compound α-ketoacid Tablets on patients with chronic renal failure[J]. 中国医药导报, 2019, 16(24): 123-126.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I24/123

[1] 郑剑琴，王晓光.百令胶囊联合复方α-酮酸片治疗慢性肾衰竭临床分析[J].实用中医药杂志，2018，34（10）：1230-1231.
[2] 卢发菊，陈永建，杨磊.尿毒清颗粒保留灌肠联合复方α-酮酸片治疗慢性肾衰竭脾肾阳虚证疗效观察[J].现代中西医结合杂志，2016，25（26）：2932-2934.
[3] 黄琳，庞捷，李锦山，等.百令胶囊联合尿毒康合剂对腹膜透析患者残余肾功能及微炎症状态的影响[J].陕西中医，2016，37（11）：1477-1479.
[4] 易继飞.健脾益肾泄浊方治疗慢性肾衰竭临床研究[J].实用中医药杂志，2016，32（10）：969-970.
[5] Abedini A，Roomizadeh P. The association between apoli-poprotein E polymorphism and diabetic nephropathy in Iranian patients [J]. Saudi J Kidney Dis Transpl，2018，29（2）：478-479.
[6] 林莉，李真真，黄静.前列地尔联合百令胶囊辅助腹膜透析对慢性肾衰竭患者残余肾功能及营养状况的影响[J].现代中西医结合杂志，2018，27（1）：58-61.
[7] 吴炜飞，程志群，施向东，等.雷公藤多苷联合缬沙坦治疗慢性肾小球肾炎合并高血压患者的临床疗效及对炎症因子的影响[J].中国生化药物杂志，2016，36（8）：101-104.
[8] 潘妍，刘金祥.益气化瘀排浊汤保留灌肠联合复方α-酮酸片治疗慢性肾衰竭临床研究[J].新中医，2016，48（3）：61-63.
[9] 王芳，谢敏妍，张东升，等.小剂量初次腹膜透析治疗慢性肾衰竭患者的疗效及安全性[J].中国医药科学，2017，7（23）：211-214.
[10] 胡新民，黄建明，曾艺鹏，等.十味芪黄益肾方配合复方α-酮酸片对脾肾亏虚型慢性肾衰竭患者β2-MG、CTGF、BMP-7水平及血清炎性因子的影响[J].四川中医，2018，36（3）：124-128.
[11] 陆再英，钟南山.内科学[M].7版.北京：人民卫生出版社，2002.
[12] 于亚萍，马腾.健脾汤治疗慢性肾衰竭脾肾气虚证临床研究[J].河北中医，2017，39（2）：230-233.
[13] 董萍，茆瑞全，朱辟疆，等.加味六君子汤对慢性肾衰竭合并营养不良患者Leptin、CＲP、IL-6、TNF-α的影响[J].中国中西医结合肾病杂志，2016，17（8）：689-691.
[14] 谢圣芳，盛梅笑，柳震伦，等.益肾清利方对低剂量雷公藤多苷片治疗慢性肾炎的增效作用[J].中药材，2016， 39（9）：2136-2139.
[15] 张媛媛，远方.远方愈肾方联合雷公藤多苷片治疗肾性蛋白尿经验[J].江西中医药，2017，48（416）：33-34，44.
[16] Neto JR，Figueiredo ECL，Santos DOF，et al. Comparison between two physiotherapy protocols for patients with chronic kidney disease on dialysis [J]. J Phys Ther Sci，2016，28（5）：1644-1650.
[17] 叶甫丽.雷公藤多苷联合缬沙坦对早期糖尿病肾病患者细胞炎性因子的影响[J].现代中西医结合杂志，2016， 25（8）：842-844.
[18] Kontomanolis EN，Panagoutsos S，Pasadakis P，et al. Chronic renal failure，diabetes mellitus type-Ⅱ，and gestation：an overwhelming combination [J]. Clin Exp Obstet Gynecol，2016，43（2）：276-278.
[19] 陈东，孟元.雷公藤多苷片联合替米沙坦治疗老年慢性肾小球肾炎合并高血压的临床研究[J].中西医结合心脑血管病杂志，2017，15（19）：2410-2413.
[20] 马亚丽，陈宝平.百令胶囊联合α-酮酸片对非透析慢性肾衰竭患者微炎症状态及营养状况的影响[J].新乡医学院学报，2016，33（6）：527-529.
[21] 彭勇，周霞.益肾化瘀排浊汤联合复方α-酮酸片治疗慢性肾衰竭临床观察[J].中国当代医药，2017，24（29）：124-126.
[22] 卢发菊，陈永建，杨磊.尿毒清颗粒保留灌肠联合复方α-酮酸片治疗慢性肾衰竭脾肾阳虚证疗效观察[J].现代中西医结合杂志，2016，25（26）：2932-2934.
[23] 陈远珍.复方α-酮酸片辅助治疗慢性肾衰竭脾肾阳虚证的效果评价[J].中国医药科学，2018，8（24）：59-61， 114.
[24] Schnitzler EG，Seifert NA，Ghosh S，et al. Hydration of the simplest alphaketo acid：a rotational spectroscopic and ab initio study of the pyruvic acidwater complex [J]. PCCP，2017，19（6）：4440-4446.
[25] Fischer EK，Drago A. A molecular pathway analysis stresses the role of inflammation and oxidative stress towards cognition in schizophrenia [J]. J Neural Transm （Vienna），2017，124（7）：765-774.