骨髓增殖性肿瘤血栓形成机制研究进展

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Abstract Classic negative Ph chromosome of myeloproliferative neoplasms (MPN) is a clonal disease of hematopoietic stem cells. Thrombus is the most important complication that affects the survival of MPN patients. The mechanism of thrombosis of MPN may be related to a variety of mechanisms including increased blood cell counts and activation, abnormal endothelial cells, activation of the blood coagulation system, increased microparticles and inflammatory cytokines, and JAK2V617F gene mutation. This paper reviews the research progress of MPN complicated thrombosis mechanism, elucidates that these mechanisms are helpful for clinical search new biological markers to predict thrombosis, so as to provide reference for thrombus prevention and treatment in MPN patients.

Key words： Thrombosis Myeloproliferative neoplasms Activation of cells Gene mutation

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	LIU Yanci SUN Penghui LU Chaoyang HUI Wuhan▲

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LIU Yanci SUN Penghui LU Chaoyang HUI Wuhan▲. Research progress on mechanism of thrombosis for myeloproliferative neoplasms[J]. 中国医药导报, 2019, 16(24): 32-35.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I24/32

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