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| Research progress on PLOD family in tumor |
| WANG Anqi1,2 LIU Yunpeng1,2 LU Wenqing1,2 ZHENG Chunlei1,2 CHE Xiaofang1,2 |
1.Department of Medical Oncology, the First Hospital of China Medical University, Liaoning Province, Shenyang 110001, China;
2.Key Laboratory of Anticancer Drugs and Biotherapy, Liaoning Province, Shenyang 110001, China |
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Abstract The procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) family includes three members, PLOD1, PLOD2 and PLOD3, and encodes lysine hydroxylase 1 (LH1), LH2 and LH3, respectively. The main role of PLOD is to promote collagen maturation and secretion by catalyzing the hydroxylation on lysine residues of procollagen. The expression of PLODs is mainly regulated by HIF-1, TGFβ-1 and so on. PLODs not only can promote collagen maturation and extracellular matrix remodeling, but also can induce epithelial mesenchymal transformation and can play vital role in tumorigenesis and development. This paper reviews the structural features, regulatory factors, functions of PLOD and its role in tumor progression.
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