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2019 Vol. 16, No. 10
Published: 2019-04-05
 
 
4 Identification of a small peptide targeting epithelial adhesion molecule EpCAM
ZHU Yichao1 MA Xiaowen2,3 HE Lei2 ZHOU Jiming2,4 PANG Zhijun2 ZHANG Xinlei2 MAO Zhuang1 LI Meng2
Objective To find the molecular target of an esophagus adenocarcinoma specific binding peptide (SNF*). Methods Pull Down and Mass Spectrum were used to identify the potential target; molecular docking, Western blot, laser scanning confocal microscopy, flow cytomertry, RNA interference and gene transfection were used to verify the target of SNF*. Results Epithelial adhesion molecule (EpCAM) was the potential target of SNF*. SNF* specifically bound with EpCAM which overexpressed in colon cancer cells and tissues. Conclusion Except esophagus adenocarcinoma, SNF* can be used in the early diagnosis and targeted therapy in colorectal cancer with high EpCAM expression.
2019 Vol. 16 (10): 4-6,29 [Abstract] ( 224 ) HTML (1 KB)  PDF (946 KB)  ( 72 )
7 Effect of substance P and ERK1/CREB signaling pathway activation in spinal dorsal horn on the mechanism of discogenic visceral pain development in rats
TANG Yuanzhang SUN Chenli GUO Yu′na YANG Liqiang WU Baishan WEI Ya NI Jiaxiang▲
Objective To investigate the molecular mechanisms of discogenic visceral pain resulted from autologous degenerative nucleus pulposus (NP) injection. Methods A total of 24 male SD rats were divided into na?觙ve group (n = 8), sham group (n = 8) and NP-treated group (n = 8) according to random number table method, with 8 rats in each group. Under fluoroscopic, autologous degenerative NP suspension was injected into right sympathetic trunk of rats in NP-treated group and the same dose of saline was administrated to right sympathetic trunk of animals in sham group, while the rats in the na?觙ve group did not receive any treatment. After 14 days postoperatively, the expression of substance P (SP), extracellular regulated protein kinases 1/2 (ERK1/2), p-ERK1/2, cyclic AMP response element binding protein (CREB) and p-CREB in the L1-L3 spinal cord of each group was analyzed by Western blot. Results The SP, p-ERK1, p-CREB expression in NP-treated group was significantly increased compared with those in na?觙ve group and control group (P ＜ 0.05), while there was no significant difference in p-ERK2 expression among the three groups (P ＞ 0.05). Conclusion The development of discogenic visceral pain induced by autologous degenerative NP injection is concerned with SP release and p-ERK1/CREB signaling pathway activation.
2019 Vol. 16 (10): 7-10 [Abstract] ( 205 ) HTML (1 KB)  PDF (649 KB)  ( 104 )
11 Protective effect of Xiaochuangning Granules on Th1/Th2 balance and STAT1 phosphorylation in asthma rats
SHAN Minmin1 LI Changan2 CUI Hongsheng3
Objective To observe the effect of Xiaochuangning Granules on Th1/Th2 balance and STAT1 pathway in asthma, and to explore its anti-Xiaochuangning mechanism. Methods Fourty SPF male SD rats in total, using the digital random method randomly divided into 5 groups, the normal group, asthma group, IL-27 prevention, Xiaochuangning Granules group and the asthma rather pellet + Fludarabine (STAT1 inhibitors) group, each group of eight rats, were established by intraperitoneal injection of ovalbumin joint aluminum hydroxide sensitization and intranasal ovalbumin excitation method were established. Each group was treated with IL-27 nasal drops (IL-27 prevention group) in the pre-sensitization stage, or by gavage of Xiaochuangning Granules (Xiaochuangning Granules group) in the excitation stage, or combined with intraperitoneal injection of the STAT1 inhibitor Fludarabine to observe the effect. Rats in each group were sacrificed after the last stimulation, serum and BALF were collected, the expression levels of IL-4 and IFN-γ were detected by ELISA, and the expression levels of pSTAT1 (STAT1 phosphorylated protein), signal transduction and transcriptional activator 1 (STAT1) in lung tissues were detected by Western blot. Results Compared with the model rats in asthma group, the IL-4 contents in serum and BALF were significantly decreased and the IFN-γ contents were significantly increased in Xiaochuangning Granules group and IL-27 prevention group (P ＜ 0.05). Compared with Xiaochuangning Granules group, Fludarabine inhibited the therapeutic effect of Xiaochuangning Granules (P ＜ 0.05). Compared with the asthma group model rats, the expression level of pSTAT1 protein in the lung tissues of the Xiaochuangning Granules group and the IL-27 prevention group was significantly increased (P ＜ 0.05), and Fludarabine inhibited the expression of pSTAT1 protein in the lung tissues of the Xiaochuangning Granules group (P ＜ 0.05). Conclusion Xiaochuangning Granules can effectively improve Th1/Th2 imbalance in Xiaochuangning rats, and up-regulate the level of inhibited pSTAT1 protein and increase the phosphorylation of the STAT1 pathway. The mechanism of asthma treatment may be related to the IL-27 induced phosphorylation of the STAT1 pathway.
2019 Vol. 16 (10): 11-15 [Abstract] ( 178 ) HTML (1 KB)  PDF (608 KB)  ( 131 )
16 Effect of 17-AAG combined with Caspofungin on invasive pulmonary aspergillosis in rats with neutrophil deficiency
ZHAN Xin1 WU Shiheng1 DENG Lin1 ZHANG Hongyue1 GAO Fusheng2▲
Objective To explore the effects of the combination of Hsp90 inhibitor 17-AAG (17-allyl-17-demethoxygeldanamycin) and Caspofungin (CAS) in the treatmemt of invasive aspergillosis (IPA) with neutrophil deficiency. Methods Forty male Wistar rats were divided into 4 groups, group A, group B, group C and group D, according to random number table method, with 10 rats in each group. Neutrophil deficiency models were made by intraperitoneal injection of Cyclophosphamide in four groups of rats, and then Aspergillus fumigatus spore suspension was inhaled through nose. Group A was fed normally and served as blank control. Group B and C were given CAS of 1 mg/kg and 17-AAG of 1 mg/kg respectively by intraperitoneal injection. Group D was given 17-AAG combined with CAS (the same usage and dosage) for 10 days. The survival status of rats was recorded. The serum galactomannan antigen (GM) was detected on the 3rd and 7th day after treatment, and the lung tissues were stained with GMS to observe the fungal load at the infected sites. Results Compared with group A, the survival rates of group B and group D were significantly increased (P < 0.01), and the average survival time of group D was longer than that of group B, but the difference was not statistically significant (P > 0.05). Compared with group A, there was no significant difference in GM values between the groups on the third day of treatment (P > 0.05). On the 7th day of treatment, the GM values of each treatment group were lower than those of group A (P < 0.01), while group D was lower than group B (P < 0.05). GMS staining of lung slices showed that the lesions of fungal infection decreased in all treatment groups, and the most significant reduction was found in group D. No lesions were found on the 15th day of treatment. Conclusion 17-AAG improves the efficacy of CAS in the treatment of IPA by inhibiting stress response.
2019 Vol. 16 (10): 16-19 [Abstract] ( 174 ) HTML (1 KB)  PDF (754 KB)  ( 68 )
20 Protective effects of Minocycline on 5-Fluorouracil-induced intestinal mucositis in mice
HUANG Yixin LIU Wei
Objective Forty investigate the protective effect of Minocycline on 5-Fu induced intestinal mucostitis. Methods 40 male Balb/c mice were randomly divided into four groups (n = 10), Control group, 5-Fu induced mucositis model, high dose or low dose of Minocycline treated group. After the mice were intraperitoneal administrated with 80 mg/kg 5-Fu for 3 days and simultaneously treated with 30 or 60 mg/kg orally in Balb/c mice, the body weight loss, diarrhea scores, and HE stain of the intestinal, pro-inflammatory cytokines in intestine tissue and short chain fatty acids in colon contents were also determined. Results Data from this study indicated that high dose minocycline could attenuate the 5-Fu induced body weight loss (P < 0.01), and lower the diarrhea scores (P < 0.01). Also minicycline in high dose increased the intestinal vill length (P < 0.01), decreased the IL-6 (P < 0.05) and TNF-α (P < 0.01). In the colon contents, Minocycline could significantly increase the SCFAs concentration, especially for aceticacid butyricacid (P < 0.01). Conclusion All these results demonstrated that Minocycline exert protective effects on 5-Fu induced intestinal damage in mice, and these protective effects may partially oriented from its anti-inflammatory effects and enhancing short chain fatty acid production.
2019 Vol. 16 (10): 20-24 [Abstract] ( 172 ) HTML (1 KB)  PDF (566 KB)  ( 48 )
25 MAPK pathway mediates the ability of Prx-1 to inhibite myofibroblast transformation in mice with silicosis
LIU Yan HONG Fan WANG Peng LI Qian BAI Zhaorong SUN Ying▲
Objective To investigate the role of mitogen-activated protein kinase (MAPK) pathway in the transformation of thioredoxin peroxidase-1 (Prx-1) against myofibroblasts of silicosis. Methods Forty male C57BL/6 mice were randomly divided into control group (saline), model group (SiO2), transfection control group (SiO2 + lentivirus vector) and PRX-1 transfection group (SiO2 + Prx-1 lentivirus). Normal saline, SiO2 and lentivirus were perfused through bronchus. After modeling, mice were fed for 12 weeks. Immunohistochemistry and immunofluorescence were used to detect the expression of α-smooth muscle actin (α-SMA) and 8-hydroxydeoxyguanosine (8-OHdG) respectively. Western blot was used to detect the expression of collagen type Ⅰ, collagen type Ⅲ, Prx-1, phosphorylated extracellular signal-regulated kinase (p-ERK1/2), phosphorylated-mitogen-activated protein kinase p38 (P-p38) and phosphorylated amino-terminal kinase (p-JNK). Results Silicon nodules and pulmonary interstitial fibrosis were found in model group and transfection control group, but the lesions were alleviated in Prx-1 transfection group. There was no difference in Prx-1 expression between model group and transfection control group, but compared with model group, Prx-1 expression increased in Prx-1 transfection group. Compared with control group, the expression of α-SMA, 8-OHdG, collagen type Ⅰ and collagen type Ⅲ, p-ERK1/2, p-P38 and p-JNK were increased in lung tissue of the other groups.  Compared with the model group and the transfection control group, the expression of the above indicators in the Prx-1 transfection group were decreased. Conclusion Prx-1 can inhibit SiO2-induced myofibroblast transformation and pulmonary fibrosis, which is related to the reduction of oxygen-active substances and the inhibition of activation of MAPK pathway.
2019 Vol. 16 (10): 25-29 [Abstract] ( 157 ) HTML (1 KB)  PDF (678 KB)  ( 134 )
30 Observation and comparison of biological traits of Rosa rugosa in different producing areas
LI Longhao1 LI Ming2 YANG Bingbing2 SUN Jingjing2
Objective To compare the biological traits of the original plants of Rosa rugosa from different habitats, so as to provide the basis for species classification and germplasm resources analysis. Methods The biological traits of shrubs, stems, branches, leaves, flowers and fruits of Rosa rugosa in 5 producing areas were observed and compared by means of literature survey, field survey and communication survey. Results There were differences in the original plant biological traits of Rosa rugosa from five producing areas. The biological traits of Rosa rugosa from four producing areas of "Fenghua" "Shanxian" "Kushui" "Miaofeng Mountain" were slightly different, and the biological traits of "Dahonghua" were significantly different from those of other producing areas. Conclusion There are significant differences in the biological traits of Rosa rugosa in different habitats, which can be used as the basis for classification.
2019 Vol. 16 (10): 30-32,36 [Abstract] ( 147 ) HTML (1 KB)  PDF (469 KB)  ( 131 )
33 Ultrasonic extraction and antioxidant activity of total polyphenols from Myrtle root
YIN Huihui1 LIU Wei1 ZHAO Wu1 YANG Wuning2 MENG Fei1 JIANG Yuanming1 QIN Zhenhua1 SUN Jianhua1
Objective To study the ultrasonic extraction technology and antioxidant activity of total polyphenols from the root of Myrtle. Methods The extraction process of total polyphenols from the root of Myrtle was optimized by single factor and orthogonal experiment, and the absorbance of total polyphenols from the root of Myrtle was determined by Foline reagent under ultraviolet-visible spectrophotometer, and the extraction yield was calculated. The antioxidant activity was evaluated by 1,1-Diphyeny1-2-picrylhydrazyl free radical (DPPH·) scavenging rate and total antioxidant activity test. Results The optimum extraction conditions were ethanol concentration 60%, solid-liquid ratio 1∶40 (g/mL), extraction temperature 60℃, extraction time 50 min. Under these conditions, the extraction yield was 78.03 mg/g. The total antioxidant activity and DPPH· scavenging rate of total polyphenols in the root of Myrtle were higher than that of ascorbic acid. Conclusion Ultrasound extraction is suitable for the extraction of total polyphenols from the root of Myrtle, which is a natural antioxidant and free radical scavenger.
2019 Vol. 16 (10): 33-36 [Abstract] ( 178 ) HTML (1 KB)  PDF (519 KB)  ( 117 )
37 Research progress of bioactive peptides in the field of medicine
ZHANG Zhihui SU Xiulan
Bioactive peptides are the focus of research in the 21st century. In recent years, the research of bioactive peptides in the field of medicine has been more and more in-depth. From terrestrial bioactive peptides to marine bioactive peptides, they play an important role in the field of biomedicine. With the discovery and recognition of the physiological functions of bioactive peptides, these functions have been widely used in the field of medicine, and have become a research topic with promising prospects in the field of biomedicine. Most active substances in human body exist in the form of peptides. Bioactive peptides are known as the new darling of human health. It can make the human body in a balanced state, thus maintaining the stability of human life activities.
2019 Vol. 16 (10): 37-40 [Abstract] ( 193 ) HTML (1 KB)  PDF (572 KB)  ( 212 )
41 Research progress on risk factors of implantable venous access port-related infection
YU Yonggang ZHU Huijuan LI Zhou▲
Use of implantable venous access port improves the quality of life of patients in need of long-term intravenous chemotherapy. Since the first implant of implantable venous access port performed in 1982, it has increasingly been used in the field of oncology treating. The major complications of implantable venous access port include infection, thrombosis, dysfunction and so on. Among these above, implantable venous access port related infection is the most prevalent complication. This paper reviews the risk factors of implantable venous access port related infection, aiming at providing reference for clinical staffs to take effective prevention measures.
2019 Vol. 16 (10): 41-44 [Abstract] ( 208 ) HTML (1 KB)  PDF (597 KB)  ( 82 )
45 Research progress on the mechanism of acupuncture intervention for perimenopausal depression
CHEN Pengdian1 YANG Zhuoxin2▲ NING Yan1▲ LIU Fang1 BEI Jianhong1 TANG Meng1 HU Shan1 WANG Bo1
This paper analyzes the possible mechanisms of acupuncture intervention to perimenopausal depression in rats in recent years, which proposes that the mechanisms are closely correlated to the following aspects: acupuncture could intervene the perimenopausal depression by regulating the nerve-endocrine network function, harmonizing the neural transmitters contents, mediating the correlated signaling transductions and inhibiting the neuronal cellular apoptosis.
2019 Vol. 16 (10): 45-48 [Abstract] ( 179 ) HTML (1 KB)  PDF (574 KB)  ( 106 )
49 Advances in the treatment of normal high blood pressure in traditional Chinese medicine
ZENG Meng1 WANG Lanmiao1 YANG Jie2 YANG Chuanghua2
In recent years, epidemiological studies at home and abroad show that hypertension has become an important risk factor for cardiovascular and cerebrovascular diseases. The normal high blood pressure as a transitional stage between normal blood pressure and hypertension is very necessary for its research. Traditional Chinese medicine plays an important role in its treatment with its unique advantages. This article reviews the epidemiological studies of high normal blood pressure and the related studies of high normal blood pressure from the perspective of traditional Chinese medicine.
2019 Vol. 16 (10): 49-51,55 [Abstract] ( 236 ) HTML (1 KB)  PDF (587 KB)  ( 145 )
52 Research progress of biomarkers for early identification and prognosis evaluation in sepsis
CHEN Shilin1 WANG Lan2 DENG Yaping2
Sepsis is a group of clinical syndromes with high incidence and high mortality. Early recognition and diagnosis is the key to improve its prognosis. Biomarkers can evaluate the physiopathologic mechanism objectively, contribute to diagnose disease, monitor curative effect and predict prognosis. In order to better guide clinical diagnosis and treatment, it is necessary to seek new biomarkers. In recent years, many scholars have done a lot of work on sepsis biomarkers. Most of the researches focus on the molecules expressed on the phagocytic cell membrane, cytokines and acute phase proteins. This paper is to discuss the recent researches on related biomarkers.
2019 Vol. 16 (10): 52-55 [Abstract] ( 212 ) HTML (1 KB)  PDF (576 KB)  ( 233 )
56 Progress of TSG-6 in repairing cartilage and promoting tendon-bone healing
XU Zhi1,2 LIU Yi1,2▲ ZOU Gang1,2
Locomotor system injuries includes the injuries of tendons, ligaments, cartilage and other soft tissue injuries, which is a common disease in young adults in China. Because the original tissue regeneration ability is weak, scar formation and local inflammation evolution increase the risk of later traumatic arthritis. The ability of the original tissue regeneration is weak, leading to scar formation and local inflammation evolution, which increase the risk of later traumatic arthritis. At present, the use of growth factor intervention for the treatment of locomotor system injury is more popular. TSG-6 was found to regulate the response of injury signals to reduce inflammation, prevent the formation of fibrous vascular tissue, improve the structure and adhesion strength of the healing tendon-bone interface, which promotes cartilage formation and tendon-bone healing. This paper will elaborate on the study of TSG-6 inhibition of scar formation, promotion of tendon-bone healing, and protection of cartilage.
2019 Vol. 16 (10): 56-58,74 [Abstract] ( 204 ) HTML (1 KB)  PDF (936 KB)  ( 162 )
59 Investigation and analysis of awareness of hospice care in nursing students
LI Jun LIU Jiayu LI Yiting
Objective To explore the cognition of hospice care in nursing students, and provide reference for the curriculum design of education on the death and hospice care, taking medical university S as an example. Methods Combination of questionnaire and in-depth interview. Besides in-depth interviews to recruited 12 nursing students, questionnaires were surveyed among nursing students (including 39 students in Grade 1, 28 students in Grade 2, and 50 students in Grade 3), which about the knowledge of hospice care, attitude for death and advises of the development of hospice care in May, 2017. Results There was statistically significant difference in Grade 3 and Grade 1 of nursing students′ on understanding of both hospice care and death education (P < 0.05). Through the score of the thought that death education was very necessary was (3.27±0.76) scores, only the accuracy about the concept of hospice care was 63.2%. Conclusion It should improve the course duration and the teaching models about the education of hospice care, and  teach in diverse way according to genders, religions and so on of the nursing students targeted and systematically.
2019 Vol. 16 (10): 59-62 [Abstract] ( 270 ) HTML (1 KB)  PDF (574 KB)  ( 121 )
63 Problems and rethinking of current health education activities for hematological malignancies
FENG Yimei WU Fangfang ZHANG Xi
Health education for hematological diseases can benefit patients, family members, and caregivers. At present, there are more or less problems in the health education activities for patients with hematological malignancies. For instance, the level of health education personnel is not high enough; the methods of health education are few, simple and lacking of deeper connotations; the evaluation system is not perfect. This paper summarized the experience from the health education activities, discussed the way of health education, the level of implementers, educational contents and management models, in order to provide reasonable suggestions for health education of patients with hematological malignancies.
2019 Vol. 16 (10): 63-66 [Abstract] ( 156 ) HTML (1 KB)  PDF (530 KB)  ( 159 )
67 Practice and exploration on teaching for international students of clinical medicine
ZHANG Fengyun WANG Zhirong▲
With the rapid development of clinical medical in China, education teaching in clinical medicine for international students has shown a good trend of development. Due to the differences in national background and education means，problems such as the lack of language and culture, professional teachers and teaching materials, and the confusion in education method selection still remains in the education teaching for foreign students. In view of the main problems suffered by the international students in the study of clinical medicine, we focused our attention on the concept of education, teaching management and evaluation system, teaching materials construction, teacher training, teaching mode and some other aspects, and put forward the suitable strategies for education teaching of international students, so as to ensure the steady development of education for international students.
2019 Vol. 16 (10): 67-70 [Abstract] ( 194 ) HTML (1 KB)  PDF (527 KB)  ( 58 )
71 Application of CBL teaching mode combined with simulation training in clinical anesthesiology teaching
SU Mingping1 LI Linji1▲ JING Shixia2 REN Pusheng1
Objective To study the application effect of case-based learning (CBL) combined with simulated training in clinical anesthesiology teaching. Methods From July 2017 to July 2018, in Nanchong Central Hospital, 50 undergraduate interns of anesthesia were selected, all the interns were divided into two groups according to the random number table method, 25 interns in the research group were given CBL+simulation teaching mode for teaching, 25 interns in the control group were given the traditional teaching method for teaching. After class, the theory achievement and skill operation level of students in the two groups were assessed, and the scores were compared and analyzed. Results Before training, there was no statistically significant difference in theoretical scores and skill performance scores in the two groups (P > 0.05). After the training, the theory and skill operation scores of the students in the research group were significantly higher than the control group, the differences were statistically significant (P < 0.05). The scores of noun interpretation, blank filling and question-and-answer in the study group were higher than the control group, the differences were statistically significant (P < 0.05). Conclusion CBL teaching mode combined with simulated training has a good effect in clinical anesthesiology teaching, it can significantly improve the theoretical knowledge and clinical practice ability of anesthesiology, it is worth popularizing in clinical teaching.
2019 Vol. 16 (10): 71-74 [Abstract] ( 330 ) HTML (1 KB)  PDF (573 KB)  ( 89 )
75 Effectiveness of Omalizumab for patients with refractory allergic asthma: a Meta analysis of randomized controlled studies
MOU Shan ZHANG Wei JIANG Depeng
Objective To evaluate the effectiveness of Omalizumab in patients with refractory allergic asthma. Methods The databases including PubMed, Web of Science, Embase, Cochrane Library, and ScienceDirect were searched by computer, and the retrieval time of each database was from the database establishment to November 2017. Then 2 reviewers screened studies, extracted data, and evaluated the quality of included randomized controlled trials, and Meta-analyses were conducted with RevMan 5.3. Results A total of 12 clinical randomized controlled trials were included. Compared with placebo, Omalizumab treatment was associated with an improved asthma-related quality of life at the end of the stable (RR = 1.56, 95%CI: 1.32-1.85, P ＜ 0.000 01) and steroid dose reduction phases (RR = 1.90, 95%CI: 1.45-2.49, P ＜ 0.000 01). Meanwhile, compared with placebo, Omalizumab therapy showed a significantly increased number of patients with investigator global evaluation of therapy effective rated as excellent or good at the end of both phases (RR = 1.36, 95%CI: 1.25-1.49, P ＜ 0.000 01; RR = 1.48, 95%CI: 1.36-1.61, P ＜ 0.000 01). Besides, Omalizumab reduced the number of patients with severe exacerbations during stable-steroid phase (RR = 0.51, 95%CI: 0.41-0.64, P ＜ 0.000 01). Conclusion The addition of Omalizumab to standard therapy in patients with refractory allergic asthma can improve asthma related quality of life, relieve symptoms and reduce severe asthma exacerbations.
2019 Vol. 16 (10): 75-79,99 [Abstract] ( 245 ) HTML (1 KB)  PDF (1351 KB)  ( 125 )
80 Clinical study of Atorvastatin combined with enteral nutrition in the treatment of senile non-alcoholic fatty liver with metabolic syndrome
MIAO Yanxia1 WANG Fang2 QIAO Liangmei1 LIU Yixin1 LYV Yangmei1
Objective To investigate the clinical effect of Atorvastatin combined with enteral nutrition in the treatment of senile non-alcoholic fatty liver with metabolic syndrome. Methods From January 2017 to May 2018, 83 elderly patients with non-alcoholic fatty liver disease associated with metabolic syndrome admitted to Xi′an Central Hospital Affiliated to Xi′an Jiaotong University were selected as research objects. Patients were randomly divided into the control group (n = 41) and the study group (n = 42) according to the random number table method. The control group was treated with enteral nutrition, and the study group was treated with Atorvastatin on this basis. The clinical efficacy of the two groups after treatment, the nutritional indexes before and after treatment, and the levels of inflammatory factors including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) were compared between the two groups. Results The total clinical effective rate of the study group was significantly higher than that of the control group (P ＜ 0.05). IL-6, TNF-α and hs-CRP of the two groups before treatment showed no significant difference (P ＞ 0.05), while IL-6, TNF-α and hs-CRP of the two groups after treatment were lower than before treatment, and the study group were significantly lower than the control group (P ＜ 0.05). Body mass index (BMI), triceps brachii musculocutaneous fold thickness (TSF) and waist-to-hip ratio (WHR) of the two groups before treatment showed no statistically significant difference (P ＞ 0.05). After treatment, BMI and TSF of the two groups both decreased, and BMI of the study group was lower than that of the control group (P ＜ 0.05). TSF and WHR were compared between the two groups after treatment, and the difference was not statistically significant (P ＞ 0.05). The incidence of adverse reactions in the study group was significantly lower than that in the control group (P ＜ 0.05). Conclusion Atorvastatin combined with enteral nutrition in the treatment of senile non-alcoholic fatty liver with metabolic syndrome has definite effect, can significantly improve the nutritional status of patients, reduce the inflammatory response of patients, and has certain clinical application value.
2019 Vol. 16 (10): 80-83 [Abstract] ( 216 ) HTML (1 KB)  PDF (636 KB)  ( 150 )
84 The effect of wedged hepatic venography with CO2 during TIPS in the treatment of acute upper gastro-intestinal bleeding in liver cirrhosis
LU Wei YANG Chao ZHANG Jiacheng YANG Jian MA Junpeng ZHENG Hao DU Peng JIANG Fuqiang
Objective To investigate the efficacious of wedged hepatic venography with CO2 for guiding portal vein puncture during transjugular intra-hepatic porto-systemic shunt (TIPS) in the treatment of acute upper gastro-intestinal bleeding due to liver cirrhosis. Methods Clinical data of 40 patients with acute upper gastro-intestinal hemorrhage due to rupture of esophageal or gastric varicose veins in liver cirrhosis underwent TIPS in the Sixth Medical Center, Chinese People′s Liberation Army General Hospital from June 2010 to June 2018 were analyzed retrospectively. All patients received wedged hepatic venography before TIPS. Among the patients, 20 cases were performed hepatic venography with CO2 (groups A), and the other 20 cases were performed hepatic venography with Ioversol (group B) according to the admission time. Visualization of the main portal vein and its′ branch in the two groups were evaluated. The frequency, time of portal vein puncture in the two groups were compared. The successful portal vein puncture rate of the two groups were compared. Results There were 17 cases had clear display portal vein trunk and its main branches in group A, and 5 cases had clear display portal vein trunk and its main branches in group B, imaging quality in group A was better than group B, the difference was highly statistically significant (P ＜ 0.01). The average frequency of portal vein puncture in the group A was fewer than the group B, the difference was highly statistically significant (P ＜ 0.01). Time of portal vein puncture in the group A was less than that in the group B, the difference was highly statistically significant (P ＜ 0.01). Successful portal vein puncture rate were both 100% in the two groups, and there was no statistically significant difference (P ＞ 0.05). There were no severe adverse reactions in the two groups. Conclusion Wedged hepatic venography with CO2 is effective in visualization of portal vein and its branches for guiding portal vein puncture during TIPS in the treatment of acute upper gastro-intestinal bleeding in liver cirrhosis. It can guide portal vein puncture, reduce puncture times and shorten puncture time, which is worthy of clinical promotion.
2019 Vol. 16 (10): 84-87 [Abstract] ( 261 ) HTML (1 KB)  PDF (698 KB)  ( 97 )
88 Study on the health status of medical staff based on cardiopulmonary exercise test
ZHANG Xi CAI Qian LI Jiqiang HUANG Xiaocui
Objective Based on cardiopulmonary exercise tests (CEPT), to explore and study the changes of cardiopulmonary exercise function of medical staff under current medical intensity, to provide reference for different medical staff to develop a reasonable exercise prescription. Methods From November 2017 to June 2018, 59 medical staff from University Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine were selected and they were divided into exercise group 30 cases and non-exercise group 29 cases according to different exercise time. CEPT was performed in the two groups. The electrocardiogram, blood pressure, maximum oxygen consumption (VO2max), anaerobic threshold (AT), maximum minute ventilation (VEmax), maximum heart rate (HRmax), and oxygen pulse (O2pulse) were monitored in the two groups. The symptoms of shortness of breath during exercise are graded according to the Borg subjective feeling fatigue rating scale (RPE) in the two groups. Results AT in the exercise group was lower than that in the non-exercise group, while VO2max, VEmax, HRmax, O2pulse were higher in the exercise group, and the differences were all statistically significant (P ＜ 0.05 or P ＜ 0.01). RPE grading in the two groups concentrated in difficulty (17-18 points), and the differences had no statistically significant (P ＞ 0.05). Conclusion The average cardiopulmonary function level of the medical staff in the exercise group is significantly higher than that in the non-exercise group. The results of CEPT provide a scientific basis for the exercise prescriptions for medical staff, which is conducive to the development of individualized exercise programs and improvement of health level, and provides protection for various clinical tasks such as rescue, surgery and duty.
2019 Vol. 16 (10): 88-91 [Abstract] ( 173 ) HTML (1 KB)  PDF (670 KB)  ( 138 )
92 Relationship between reflux esophagitis and related factors of metabolic syndrome
CHENG Yi′an TAN Shiyun LI Ming LU Mingjun
Objective To investigate the relationship between reflux esophagitis (RE) and related factors of metabolic syndrome. Methods From November 2016 to March 2018, 176 patients who underwent endoscopy at the endoscopy center of Renmin Hospital of Wuhan University and were diagnosed with RE were enrolled as RE group. And 331 patients with normal gastroscopy or only mild chronic superficial gastritis in the same period were selected as control group. General information and past history were collected. Abdominal ultrasonography and blood biochemical tests were performed in both groups. The differences of age, sex, body mass index (BMI), detection rate of nonalcoholic fatty liver disease (NAFLD), smoking rate, prevalence rate of hypertension, blood sugar, blood lipid and other independent risk factors between the two groups and the independent risk factors for RE were analyzed. Results The percentage of males, BMI, NAFLD detection rate, smoking rate, prevalence of hypertension, alanine transferase, fasting blood sugar and triglyceride levels in RE group were significantly higher than those in the control group (P < 0.05), and the level of high density lipoprotein was significantly lower than that in the control group (P < 0.05). Male, overweight and hypertension were independent risk factors for RE (OR = 2.274, 3.389, 2.145, P < 0.05). Conclusion Male, overweight and hypertension are the risk factors of RE, which should be paid attention to in clinical prevention and treatment.
2019 Vol. 16 (10): 92-95 [Abstract] ( 210 ) HTML (1 KB)  PDF (673 KB)  ( 262 )
96 Study on the occurrence and influencing factors of post-traumatic stress disorder in ICU patients
SANG Yanjie HUANG Qiongqiong CAO Yanhui
Objective To explore and analyze the occurrence of post-traumatic stress disorder (PTSD) in patients in intensive care unit (ICU) and its influencing factors. Methods From June 2016 to June 2018, 86 patients admitted to the First Affiliated Hospital of Harbin Medical University who had undergone comprehensive ICU and with stable condition and consciousness were selected as study subjects. The patients were evaluated by the basic situation questionnaire and the Impact of Event Scale-Revised (IES-R) and Intensive Care Experience with Mechanical Ventilation (ICE-MV) to explore the occurrence and influencing factors of PTSD in ICU patients. Results The patient′s PTSD score was 1 to 57 points, with an average of (33.45±12.73) points. In the three dimensions, the invasive dimension factor score (total score of the dimension items/the number of the dimension items) was the highest. Using the total score of PTSD as a dependent variable, mechanical ventilation or not, different types of surgery, ICU stay time, emotional state, previous severe trauma history, history of alcohol dependence, and negative life events were included in the independent variables. Logistic multivariate regression analysis showed that mechanical ventilation or not, ICU stay time, emotional state, previous severe trauma history, and negative life events were the influencing factors of PTSD (P < 0.05). Conclusion Mechanical ventilation or not, ICU stay time, emotional state, previous severe trauma history, negative life events can be used as high-risk factors affecting the occurrence of PTSD. Clinical staff need to develop different interventions to protect patients′ life and health.
2019 Vol. 16 (10): 96-99 [Abstract] ( 178 ) HTML (1 KB)  PDF (672 KB)  ( 144 )
100 Comparison of clinical application value between painless gastroenteroscopy and routine gastroenteroscopy in digestive tract diseases
SUN Lili ZHANG Jian HE Hua
Objective To compare the clinical application value of painless gastroenteroscopy and routine gastroenteroscopy in digestive tract diseases. Methods From July 2016 to March 2018, 410 patients with digestive tract diseases were divided into observation group and control group by random number table method, with 205 cases in each group. The painless gastroenteroscopy was performed in the observation group and the routine gastroenteroscopy was performed in the control group. The changes of heart rate, blood pressure and oxyhemoglobin saturation (SPO2) before at different time point in the two groups. The efficacy and complication rate of the two groups were compared. Results Heart rate, blood pressure and SpO2 in the observation group were compared at different times, and the differences were not statistically significant (P ＞ 0.05). Heart rate, blood pressure and SpO2 of patients in the control group were compared at different time points, and the differences were statistically significant (P ＜ 0.05). Heart rate, blood pressure and SpO2 in the observation group during operation were all lower than those in the control group at the same time point, and the difference was statistically significant (P ＜ 0.05). The incidence of total complications in the observation group was significantly lower than that in the control group (P ＜ 0.05). The excellent and good rate in the observation group was significantly higher than that in the control group (P ＜ 0.05). Conclusion Painless gastroenteroscopy for patients with digestive tract disease has a good examination effect, higher excellent and good rate and better tolerance.
2019 Vol. 16 (10): 100-102 [Abstract] ( 196 ) HTML (1 KB)  PDF (625 KB)  ( 139 )
103 Establishment and analysis of a nonalcoholic fatty liver disease nomogram prediction model based on serum Betatrophin level
GAO Fulai XIE Changshun ZHANG Lili
Objective To establish a nomogram predictive model by analyzing the risk factors of nonalcoholic fatty liver disease (NAFLD), and to establish a nomogram model based on serum Betatrophin level, and evaluate the accuracy of prediction. Methods From January 2017 to April 2018, 180 patients with NAFLD admitted to the First Hospital of Qinhuangdao were selected as the NAFLD group, and 72 patients with normal liver fat content (LF < 9.15%) were selected as control group. Univariate analysis of factors associated with NAFLD, statistically significant indicators were included in the multivariate Logistic regression model, and the risk factors for the NAFLD were analyzed. Based on the results of the regression analysis, a preoperative model was established. The receiver operating characteristic curve (ROC) and the Hosmer-Lemeshow test were used to evaluate the model prediction performance. Results Multivariate analysis showed that Betatrophin, triglyceride (TG) and aspartate aminotransferase (AST) were risk factors for NAFLD, and high-density lipoprotein (HDL) was a protective factor for NAFLD (P < 0.05). The nomogram prediction model for predicting the occurrence of NAFLD was successfully established by using R software. The Hosmer-Lemeshow test showed that the model had a predicted performance of 85.71% and the model fit well (P < 0.05). The area under the curve (AUC) for predicting the occurrence of NAFLD was 0.877, the specificity was 88.68%, and the sensitivity was 82.98%. Conclusion The nomogram prediction model based on the serum Betatrophin level of NAFLD has good specificity and sensitivity. The model is well fitted and has high clinical value.
2019 Vol. 16 (10): 103-106,119 [Abstract] ( 248 ) HTML (1 KB)  PDF (1107 KB)  ( 141 )
107 Application effect of Dexmedetomidinein postoperative intravenous controlled analgesia in elderly patients undergoing surgery
SU Yanping TANG Fang XIANG Tao LIAO Caiping PENG Qingxiong
Objective To explore the effect of Dexmedetomidinein (DEX) in postoperative intravenous controlled analgesia (PCIA) in elderly patients. Methods From January to December 2017, 140 elderly patients who underwent surgical treatment in the Changsha First Hospital were randomly divided into the experimental group and the control group, with 70 patients in each group. PCIA analgesia was used in both groups after surgery. The Dexmedetomidine in the experimental group was treated with sufentanil for PCIA, the control group only used PCIA with Sufentanil. The Montreal cognitive function scale (MoCA), simple mental state scale (MMSE), test of delirium (CAM-CR) scores and agitation scores at different time points before and after surgery were compared between the two groups. Results There was no significant difference in MoCA score between the two groups before surgery (P ＞ 0.05). The MoCA scores of the experimental group were significantly higher than those of the control group at 12, 24 and 48 h after operation (P ＜ 0.05). There was no significant difference in MMSE score between the two groups before surgery (P ＞ 0.05). The MMSE scores of the experimental group were significantly higher than those of the control group at 12, 24 and 48 h after operation (P ＜ 0.05). The CAM-CR scores of the experimental group were lower than those of the control group at 12 h and 24 h after operation (P ＜ 0.05). At 12 h after operation, the Ramsay score of the experimental group was higher than that of the control group (P ＜ 0.05). Conclusion Postoperative PCIA analgesia in elderly patients with Dexmedetomidine is consistent with Sufentanil in reducing postoperative cognitive dysfunction, agitation, and spasm.
2019 Vol. 16 (10): 107-110 [Abstract] ( 208 ) HTML (1 KB)  PDF (474 KB)  ( 54 )
111 Effect of Ketamine plus Dexamethasone on postoperative epidural analgesia in patients with esophageal cancer
WANG Qionghua1 FANG Yanhong1 XU Binbing2
Objective To observe the effect of single and small dose of Ketamine combined with Dexamethasone on postoperative epidural analgesia in patients with esophageal cancer with single-lung ventilation. Methods Sixty patients undergoing esophageal cancer surgery with single-lung ventilation in the Department of Thoracic Surgery of Suining Central Hospital were selected. The patients collected from December 2016 to July 2017 were randomly divided into blank control group (S group), Ketamine group (K group), Dexamethasone group (D group) and Ketamine plus Dexamethasone group (KD group) according to random number table method. Preoperative epidural puncture and catheterization. Ketamine 0.5 mg/kg (K group), Dexamethasone 10 mg (D group), Ketamine 0.5 mg/kg + Dexamethasone 10 mg (KD group), 10 mL of normal saline (S group) were administered 15 minutes before induction of general anesthesia, and the four groups were diluted to 10 mL with physiological saline. Intraoperative single-lung ventilation, operation time, postoperative analgesia scores in 48 h, self-controlled analgesic compression times, total dosage of analgesics by patient-controlled epidural analgesia (PCEA) and postoperative adverse reactions of the four groups were all recorded. Results No significant difference in ventilation time and operation time was identified among the four groups (P ＞ 0.05). Compared with K group, D group and S group, the visual analogue score (VAS) and Prince-Henry score of postoperative analgesia in KD group were lower within 24 h (P ＜ 0.05). But no significant difference in VAS score and Prince-Henry score was identified at 48 h among four groups (P ＞ 0.05). The number of compression times and the total dosage of analgesics were less, the rate of nausea and vomiting was lower in KD group compared with group D, group S and group K (P ＜ 0.05). The rate of postoperative delirium was not significantly different among four groups (P ＞ 0.05). Conclusion The prophylactic use of Ketamine plus Dexamethasone before surgery can effectively increase the analgesic effect of PCEA in 24 h after surgery and reduce the dosage of analgesic drugs and postoperative adverse reactions.
2019 Vol. 16 (10): 111-114 [Abstract] ( 186 ) HTML (1 KB)  PDF (479 KB)  ( 82 )
115 Analgesic effects of adductor canal block and femoral nerve block after total knee arthroplasty
WANG Hengyue BO Lulong
Objective To investigate the analgesic effect of adductor canal block and femoral nerve block after total knee arthroplasty. Methods To analyze the clinical data of 80 total knee replacement patients admitted to Changhai Hospital, Naval Medical University from February 2016 to October 2016, there were 40 patients in adductor duct block group and 40 patients in femoral nerve block group. The rest pain digital score scale (NRS), active pain NRS and quadriceps femoris muscle strength of the two groups of total knee arthroplasty patients at different time points after surgery were observed, and the knee range of motion of total knee arthroplasty patients of the two groups at different time points after surgery were observed. Results There was no significant difference in NRS score of resting pain and NRS score of active pain between the two groups at different time points after total knee replacement (P ＞ 0.05). The muscle strength grades of quadriceps femoris in the adductor duct block group were higher than that in the femoral nerve block group at 2, 4, 8, 12, 24 and 48 h after surgery. The NRS score of resting pain and NRS score of active pain in the two groups decreased gradually with time extension, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in quadriceps femoris muscle strength grading between the two groups 72 h after surgery (P ＞ 0.05). The quadriceps femoris muscle strength grading increased gradually with the extension of time in both groups, and the difference was statistically significant (P ＜ 0.05). The ranges of motion of the knee joint in the adductor duct group 24, 48 and 72 h after surgery were higher than those in the femoral nerve block group, and the differences were statistically significant (P ＜ 0.05). Conclusion Adductor canal block and femoral nerve block have the same analgesic effect after total knee arthroplasty, but adductor canal block patients are superior to femoral nerve block in postoperative muscle strength grade of quadriceps femoris and range of motion of knee joint.
2019 Vol. 16 (10): 115-119 [Abstract] ( 262 ) HTML (1 KB)  PDF (520 KB)  ( 246 )
120 Analysis on medication rule of Chinese medicine in treating precocious puberty based on data mining technology
LIU Zhiwei1 LIU Lujia1 JING Weichao2 QU Wanying3 WANG Youpeng2
Objective To dig out the characteristics and rules of Chinese medicine in treating precocious puberty, and extract new prescriptions. Methods Through retrieving CNKI, Wanfang Data Knowledge Service Platform, and VIP database on therapeutic precocious puberty of Chinese medicine from January 1, 1979 to October 1, 2018. And TCM inheritance support system was used to carry on the statistics analysis. Results Total 104 articles and 124 prescriptions were included in the reseach. It was concluded that the most frequently used drugs were Anemarrhena asphodeloides, Phellodendron amurense, Peony bark, Poria cocos, Rehmannia glutinosa and Paeonia lactiflora. Based on the association rules, the potential prescriptions have got. And then 22 core combinations of 3 flavors, 10 core combinations and 5 new prescriptions were explored from the database. Conclusion This study analyzes the prescription rule of Chinese medicine for treating precocious puberty, and obtains new prescriptions with the main principles of enrich liver and kidney, nourish yin and clear heat, boost qi and promote fluid and move qi and dissipate binds, which provides the basis for the clinical treatment of this disease by Chinese medicine, and also provides a reference for the development of new drugs for this disease.
2019 Vol. 16 (10): 120-123,136 [Abstract] ( 180 ) HTML (1 KB)  PDF (767 KB)  ( 157 )
124 Clinical effect of Yiwei Huoxue Decoction in treating acute gastritis with syndrome of qi stagnation and blood stasis
NIU Ran WEI Wei▲ SUN Xiaohong GUO Yu LIU Yaxin
Objective To analyze the clinical efficacy of Yiwei Huoxue Decoction in the treatment of acute gastritis patients with syndrome of qi stagnation and blood stasis. Methods One hundred and twenty acute gastritis patients with syndrome of qi stagnation and blood stasis admitted to Wangjing Hospital of China Academy of Chinese Medical Sciences from February 2016 to December 2017 were selected and divided into two groups by random number table method. 60 patients in the control group were treated with conventional Western medicine, 60 patients in the observation group were added with Yiwei Huoxue Decoction on the basis of Western medicine. After 2 weeks of continuous treatment, the clinical efficacy and TCM symptom scores, the levels of gastrin and motilin, and the safety were compared between the two groups. Results The scores of Shangwan pain, loss of appetite and vomiting or hematemesis in the observation group and the control group were all lower than those before treatment (t = 20.612, 22.796, 19.474, all P ＜ 0.05; t = 16.095, 18.724, 15.163, all P ＜ 0.05), and the scores of Shangwan pain, loss of appetite and vomiting or hematemesis in the observation group were lower than those of the control group after treatment (t = 10.067, 14.858, 13.267, all P ＜ 0.05). The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (χ2 = 5.55, P ＜ 0.05). The levels of gastrin and motilin in the observation group and the control group were alll higher than those before treatment (t = 5.353, 11.277, all P ＜ 0.05; t = 2.715, 5.571, all P ＜ 0.05), and the levels of gastrin and motilin in the observation group were alll higher than those of the control group, the differences were statistically significant (t = 11.727, 20.782, all P ＜ 0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group (χ2 = 11.36, P ＜ 0.05). Conclusion Yiwei Huoxue Decoction can effectively improve the symptoms and gastrointestinal function of acute gastritis patients with syndrome of qi stagnation and blood stasis, it is safe and reliable, and it has significant application value.
2019 Vol. 16 (10): 124-127 [Abstract] ( 173 ) HTML (1 KB)  PDF (559 KB)  ( 88 )
128 Effects of Baoyuan Decoction and Xuefu Zhuyu Decoction on cardiac function and inflammatory factors in patients with chronic heart failure
ZHOU Aiming YANG Deqian ZHAO Fenglin
Objective To investigate the effects of Baoyuan Decoction and Xuefu Zhuyu Decoction on cardiac function and inflammatory factors in patients with chronic heart failure. Methods Seventy patients with chronic heart failure who were admitted to Department of Cardiology, Traditional Chinese Medicine Hospital of Dianjiang County in Chongqing City from December 2016 to June 2018 were selected as research subjects, they were divided into the control group and the treatment group by random number table method, with 35 cases in each group. The control group was given standardized drug therapy for chronic heart failure, the treatment group was additionally treated with Baoyuan Decoction and Xuefu Zhuyu Decoction on the basis of the control group. Both groups took 2 weeks as a course of treatment. The clinical effect, TCM syndrome effect, plasma NT-proBNP levels and inflammatory factor indices [high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] were compared between the two groups before and after treatment. Results After one course of treatment, the results of comparison of clinical efficacy and TCM symptom efficacy between the two groups showed that the total effect rates of treatment group were all higher than those of control group, with statistically significant differences (P ＜ 0.05). After treatment, the levels of NT-proBNP, hs-CRP, IL-6, TNF-α in the two groups were all lower than those before treatment (P ＜ 0.01), and the levels of NT-proBNP, hs-CRP, IL-6, TNF-α in the tretment group were all lower than those in the control group (P ＜ 0.05). Conclusion Baoyuan Decoction and Xuefu Zhuyu Decoction has reliable curative effects for patients with chronic heart failure, which can improve clinical symptoms and TCM syndromes significantly, and decrease the levels of NT-proBNP and inflammatory factors.
2019 Vol. 16 (10): 128-131 [Abstract] ( 188 ) HTML (1 KB)  PDF (595 KB)  ( 104 )
132 The clinical effect of Virus-Clearing Oral Liquid combined with Oseltamivir in the treatment of influenza children with syndrome of heat toxicity attacking lung
HUANG Jie ZHANG Xiaoli WANG Xuecui TANG Yanqiu FENG Chunhui
Objective To analyze the clinical effect of Virus-Clearing Oral Liquid combined with Oseltamivir in the treatment of influenza children with syndrome of heat toxicity attacking lung. Methods A retrospective analysis was made on the clinical data of 100 cases of influenza children with syndrome of heat toxicity attacking lung admitted to Nanning Hospital of Traditional Chinese Medicine from January to August 2018. According to different treatment methods, they were divided into control group and observation group, with 50 cases in each group. The control group was treated with Oseltamivir, the observation group was treated with Oseltamivir combined with Virus-Clearing Oral Liquid. The clinical effects of the two groups after treatment were analyzed. Results The total effective rate of the observation group was higher than that of the control group (P ＜ 0.05). The fever time, the improvement time of cough and nasal obstruction, the improvement time of throat swelling and pain and the hospitalization time of the observation group were shorter than those of the control group (P ＜ 0.05). Before treatment, there were no significant differences in the levels of interleukin-8 (IL-8), interferon-γ (IFN-γ) and C-reactive protein (CRP) between the two groups (P ＞ 0.05). After treatment, the levels of IL-8 in the two groups were higher than those before treatment, the levels of IFN-γ and CRP were lower than those before treatment, and the level of IL-8 in the observation group was higher than that in the control group, while the levels of IFN-γ and CRP were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Before treatment, there was no significant difference in the level of immunoglobulin between the two groups (P ＞ 0.05). After treatment, the levels of CD4+, IgA and IgM in the two groups were higher than those before treatment, and the levels of CD8+ in the two groups were lower than those before treatment, and the levels of CD4+, IgA and IgM in the observation group were higher than those in the control group, the level of CD8+ in the observation group was lower than that in the control group, the differences were statistically significant (P ＜ 0.05). The incidence of adverse reactions had no statistically significant difference between the two groups (P ＞ 0.05). Conclusion Oseltamivir combined with Virus-Clearing Oral Liquid is effective in the treatment of influenza in children, which can significantly improve clinical symptoms and immunity, the complications are less, and it is worthy of clinical further promotion and application.
2019 Vol. 16 (10): 132-136 [Abstract] ( 148 ) HTML (1 KB)  PDF (569 KB)  ( 49 )
137 A meta-analysis of evaluation of contrast-enhanced CT for renal space-occupying lesions
YANG Xue HU Yong LUO Hechuan
Objective To systematically review the cIinical value of contrast-enhanced CT (CECT) in diagnosis of renal space-occupying lesions. Methods Literatures concerning contrast-edhanced CT diagnosis of renal space-occupying lesions published from January 2008 to April 2018 were electronically searched in the databases including PubMed, Cochrane Library, Embase, CNKI, VIP and CBM. Statistical analysis were performed via Metadisc 1.4 and Stata 15.1 software, and QUADAS scale was used to evaluate the quality of the enrolled literatures. Results Totally 17 literatures that met the standards were inrolled incIuding 1099 renal space-occupying lesions cases in total. The heterogeneity of the study group was obvious, so the random effect model was adopted. The combined sensitivity (SEN), combined specificity (SPE), diagnostic ratio (DOR), positive likelihood ratio (+LR), negative likelihood ratio (-LR), area under SROC curve (AUC) and Q index of the renal space-occupying lesions diagnosed by CECT were 0.85(95%CI: 0.82-0.87), 0.68(95%CI: 0.62-0.74), 11.30(95%CI: 6.53-19.55), 2.34(95%CI：1.84-2.97), 0.24(95%CI：0.17-0.32), 0.8489, 0.7801. Conciusion CECT is effective in the diagnosis of benign and malignant renal space-occupying lesions.
2019 Vol. 16 (10): 137-141 [Abstract] ( 210 ) HTML (1 KB)  PDF (972 KB)  ( 60 )
142 Application value of double contrast-enhanced ultrasonography in the evaluation of efficacy of neoadjuvant chemotherapy for gastric cancer with liver metastasis
WU Wei1 YANG Jianjun1 FAN Huihui1 SHI Linfeng1 MO Danfei1 HU Mingfang2
Objective To investigate the application value of double contrast-enhanced ultrasonography in the efficacy evaluation of neoadjuvant chemotherapy for gastric cancer with liver metastasis (GCLM). Methods A retrospective analysis of the clinical data of 80 cases of with GCLM who received neoadjuvant chemotherapy in Central Hospital of Huzhou City, Zhejiang Province, from August 2016 to October 2017. All the cases were divided into effective group (54 cases) and progressive group (26 cases) according to clinical efficacy. The microvascular density (MVD) and peak intensity (PI), rising time (RT), time to peak (TTP), enhancement intensity (EI) were compared between the two groups after treatment, and the correlation between double contrast parameters and MVD was analyzed. Results After treatment, PI and EI of all the patients were significantly lower than those before treatment (P ＜ 0.05), and RT and TTP were significantly higher than those before treatment (P ＜ 0.05). After treatment, the MVD in progressive groups was significantly higher than that in the effective group, the difference was statistically significant (P ＜ 0.05). Through correlation analysis, MVD was positively correlated with PI and EI (rPI = 0.275, P = 0.013; rEI = 0.436, P = 0.000), and were negatively correlated with RT and TTP MVD (rRT = -0.287, P = 0.021; rTTP = -0.320, P = 0.047). Conclusion Ultrasound double contrast-enhanced parameters of PI and EI can be used to evaluate the efficacy of neoadjuvant chemotherapy for GCLM, which have high sensitivity.
2019 Vol. 16 (10): 142-145 [Abstract] ( 172 ) HTML (1 KB)  PDF (485 KB)  ( 56 )
146 A comparative study of MRI of renal clear cell carcinoma and papillary carcinoma
WANG Qian1 REN Jinwu1 YIN Yuanyuan2 ZHAO Zuhong1 WANG Shumei1 MA Congmin1▲
Objective To investigate the MRI of renal clear cell carcinoma and papillary carcinoma. Methods The clinical data of 85 patients with renal cell carcinoma admitted to Baoding First Central Hospital and China Armed Police General Hospital from May 2013 to May 2017 were retrospectively analyzed. Among the patients, 50 patients with renal clear cell carcinoma were included in the renal clear cell carcinoma group, and 35 patients with renal papillary carcinoma were included in the renal papillary carcinoma group. MRI scanning and dynamic enhancement imaging were compared between the two groups, and the lesion appearing and the tumor-cortical enhancement index were compared between the two groups. Results In renal clear cell carcinoma group, T1WI scanning showed low signal and mixed signal. The T1WI scanning of the renal papillary carcinoma group presented mixed signal, and the difference in the rate of low signal was statistically significant between the two groups (P ＜ 0.05). The T2WI scanning of the renal clear cell carcinoma group presented high signal and mixed signal, while the T2WI scanning of the renal papillary carcinoma group presented low signal and mixed signal, the difference in the proportion of high signal and mixed signal on T2WI between the two groups was statistically significant (P ＜ 0.05).  MRI showed necrosis, neovascularization, and extrarenal invasion proportion in the renal clear cell carcinoma group, which was significantly higher than that in the papillary carcinoma group, while the rate of hemorrhage and cystic degeneration was significantly lower than that of the renal papillary carcinoma group, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). MRI in the renal clear cell carcinoma group showed progressive weakening from cortical phase to delayed phase (P ＜ 0.01). MRI in the renal papillary carcinoma group showed progressive mild enhancement from cortical phase to parenchymal phase, and decreased signal from parenchymal phase to delayed phase (P ＜ 0.01). The enhancement indices of cortical, parenchymal and delayed phases were significantly higher than those of papillary carcinoma group, the differences were highly statistically significant (P ＜ 0.01). Conclusion MRI of renal clear cell carcinoma and papillary carcinoma have certain characteristics, and the enhancement degree of each kidney cancer subtype can significantly differentiate renal clear cell carcinoma and papillary carcinoma.
2019 Vol. 16 (10): 146-149,153 [Abstract] ( 249 ) HTML (1 KB)  PDF (682 KB)  ( 184 )
150 Application value of low-dose contrast-enhanced MR angiography and perfusion imaging at 3.0T in patients with acute ischemic stroke
JIANG Hailong MAO Cunnan CHEN Qian CHEN Guozhong YIN Xindao
Objective To explore application value of low-dose contrast-enhanced MRA (CE-MRA) and dynamic susceptibility contrast perfusion imaging (DSC-PWI) at 3.0T in patients with acute ischemic stroke. Methods Thirty patients with acute ischemic stroke in Nanjing First Hospital from October 2017 to March 2018 were enrolled. All the patients underwent low-dose CE-MRA and DSC-PWI examination, and DSA examination was performed within 24 h. Half-dose contrast agent concentration (0.05 mmol/kg) was used in both CE-MRA and DSC-PWI. The accuracy of CE-MRA in the diagnosis of arterial stenosis was evaluated by comparing with DSA. Inter-observer agreement tests for diagnosis of arterial stenosis with CE-MRA and mismatched areas with DSC-PWI were tested by Kappa analysis. Results The sensitivity, specificity, positive predictive value and negative predictive value of CE-MRA in the diaognosis of low grade (＜50%) and high grade (＞50%) arterial stenosis of the intracranial and cervical arteries were 82.4%, 100%, 100%, 93.8%, 100% and 82.4%, 93.8%, 100%, respectively. The inter-observer agreements in the diagnosis of arterial stenosis with CE-MRA and mismatch area with DSC-PWI were both excellent (κ = 0.87, 0.86). Conclusion Low-dose CE-MRA and DSC-PWI combination at 3.0T MRI is a feasible MRI scanning protocal for patinets with acute ischemic stroke.
2019 Vol. 16 (10): 150-153 [Abstract] ( 182 ) HTML (1 KB)  PDF (648 KB)  ( 130 )
154 Effect of Natriuretic Peptide on cardiac function in patients with the refractory heart failure after acute myocardial infarction and clinical effects observation
XUE Mang1 HU Taohong2
Objective To observe the effect of Natriuretic Peptide on cardiac function of patients in the refractory heart failure after acute myocardial infarction and clinical effect. Methods A total of 64 patients with refractory heart failure after acute myocardial infarction from January 2015 to December 2017 hospitalized in the Department of Cardiology 307 Hospital of Chinese People′s Liberation Army were selected. The patients were divided into observation group and control group with 32 cases in each group according to the admission sequence. Two groups were treated by the standardized heart failure therapy. Observation group was treated with Natriuretic Peptide on the basis of treatment in the control group for 72 h. Changes clinical curative effect of N-terminal pro-brain natriuretic peptide(NT-proBNP), left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were observed in two groups. Results After treatment, NT-proBNP, LVEDD were lower than those before treatment in the two groups, and LVEF was higher than that before treatment in the two groups, and NT-proBNP, LVEDD were lower in the observation group, LVEF was higher in the observation group than the control group, all the differences were highly statistically significant (all P ＜ 0.01). The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Natriuretic Peptide can significantly improve cardiac function level of patients with the refractory heart failure after acute myocardial infarction, which shows significant clinical effect.
2019 Vol. 16 (10): 154-156,161 [Abstract] ( 174 ) HTML (1 KB)  PDF (633 KB)  ( 88 )
157 Role of the innate immune molecule NLRP3 inflammasome in chronic bacterial prostatitis
HE Tao1 HUANG Huawu1 ZENG Yonglong2 GUO Ziwei2 XIE Qiuyu2
Objective To investigate the role of the innate immune molecule NLRP3 inflammasome in chronic bacterial prostatitis (CBP). Methods The 120 cases of CBP patients who admitted to Department of Urology, Affiliated Hospital of Youjiang Medical College (hereinafter referred to as "our hospital") for Nationalities were selected as the research objects from February 2016 to December 2017. The 60 healthy subjects in the same period in our hospital were selected as the control group. CBP patients were treated with trimethoprim plus sulfamethoxazole for 12 weeks. The chronic prostatitis symptom score scale (NIH-CPSI) and routine prostate test were used to evaluate the therapeutic effects of CBP patients. The expression of NLRP3 and its downstream regulatory elements interleukin 1β (IL-1β) and IL-18 were measured by enzyme linked immunosorbent assay in CBP patients. Results Before treatment, the content of NLRP3 inflammatory corpuscule in CBP patients was significantly higher than that in the control group (P ＜ 0.001). Patients were divided into high NLRP3 group and low NLRP3 group (60 cases in each group) according to the median NLRP3 inflammatory body content in CBP patients as the cut-off value. After treatment, pain, urination, quality of life scores and total scores of NIH-CPSI in low NLRP3 group were significantly superior than those in high NLRP3 group (P ＜ 0.05). The clinical response rate of low NLRP3 group was higher than that of high NLRP3 group (P ＜ 0.05). Before treatment, the levels of NLRP3, IL-1β and IL-18 in both groups were significantly higher than those in healthy subjects (P ＜ 0.05). After treatment, the above indexes were significantly decreased in both groups, and the reduction in low NLRP3 group were significantly greater than high NLRP3 group (P ＜ 0.05). After treatment, there was no significant difference in leukocyte and lecithin counts between the two groups (P > 0.05), and no significant adverse reactions were observed in both groups during the treatment. Conclusion The change of NLRP3 inflammasome content is a potential factor that affects the therapeutic effect of CBP. Targeting the NLRP3 inflammasome level can improve the clinical efficacy of CBP.
2019 Vol. 16 (10): 157-161 [Abstract] ( 196 ) HTML (1 KB)  PDF (439 KB)  ( 135 )
162 The relationship between TKI targeting therapy and EGFR gene mutation in patients with advanced non-small cell lung cancer
ZHAO Zheng1 LI Haijun1 CHEN Xiaoqin1 REN Jing1 ZHAO Shicai2
Objective To investigate the relationship between tyrosine kinase inhibitor (TKI) targeting therapy and epithelial growth factor receptor (EGFR) gene mutation in patients with advanced non-small cell lung cancer (NSCLC). Methods The clinical data of 180 patients with NSCLC who received TKI targeted therapy from January 2015 to January 2017 in Guangyuan Center Hospital were retrospectively analyzed. All patients were pathologically confirmed as NSCLC, on all plasma samples from patients with EGFR mutation were detected before treatment, and then received TKI targeted therapy. The relationship between EGFR mutation and patient baseline data was analyzed, and the effect of EGFR mutation on the therapeutic effect of TKI targeted therapy and prognosis were discussed. Results  A total of the 180 NSCLC patients, 118 were wild type and 62 were mutant, and the mutation rate was 34.44%. Sex, no smoking history, histology type were related to EGFR mutation (P ＜ 0.05); the other baseline data were not related to EGFR mutation (P ＞ 0.05). The EGFR mutant was higher than that of the EGFR wild type, and the difference was statistically significant (P ＜ 0.05). The 1 year survival rate of EGFR mutant patients was higher than that of EGFR wild type, and the difference was statistically significant (P ＜ 0.05). Conclusion The EGFR gene mutation in NSCLC patients is related to gender, no smoking history and histological type. EGFR mutant patients receiving TKI targeted therapy is better, which is beneficial to improve the 1 year survival rate of patients.
2019 Vol. 16 (10): 162-165 [Abstract] ( 181 ) HTML (1 KB)  PDF (467 KB)  ( 193 )
166 Analysis and reflection on the status of scientific research project of a grade A tertiary hospital in Beijing in recent ten years
DU Jun1 GAO Wenhong1 TIAN Gu1
Objective Through the analysis of the project approval situation of a grade A tertiary hospital in Beijing from January 2009 to December 2018, the development trend and deficiencies of the hospital's scientific research work were understood dynamically, and the future scientific research management direction of the hospital was analyzed and discussed in combination with the latest policies. Methods According to the research project approval status of a grade A tertiary hospital in Beijing, the project number, project amount and other indicators from January 2009 to December 2018 were retrospectively analyzed. Results From January 2009 to December 2018, the scientific research of a grade A tertiary hospital in Beijing developed rapidly, and the number and amount of scientific research projects maintained a good growth trend, but the number and amount of provincial and ministerial-level projects still decreased. Conclusion Combined with the latest national policy analysis, the scientific research work of the hospital should pay attention to grasp the policy direction and establish the resource sharing mechanism. In addition, based on the good promotion effect of the topics in the hospital, the hospital should continue to increase the investment in the research projects at the hospital level.
2019 Vol. 16 (10): 166-168,176 [Abstract] ( 217 ) HTML (1 KB)  PDF (655 KB)  ( 105 )
169 Effect of new nursing service on limb function, complications and family recognition of children′s developmental hip dislocation
YAO Chuntao1 KANG Wei1 LIU Li1 LI Guoqing2▲
Objective To explore and analyze the effect of the new nursing service of rehabilitation management on the limb function of children with developmental hip dislocation. Methods From May 2015 to May 2017, in the First Affiliated Hospital of Xinjiang Medical University, 83 children with developmental dislocation of the hip were selecred, by random number table, they were divided into the control group (40 cases, with routine postoperative rehabilitation nursing intervention), observation group (43 cases, combined with rehabilitation management bundled new nursing care on the basis of the observation group). The functional FMA grade, tear open gesso time, forward curative effect, complication rates, families of children with rehabilitation nursing value degree and rehabilitation nursing recognition in two groups were compared. Results Compared with the control group, in the observation group, the FMA score was higher, the time of dissection was shorter and the long-term efficacy score was higher, the differences were statistically significant (P < 0.05). Compared with the control group, in the observation group, the family members had a higher degree of attention and cognition of the rehabilitation nursing knowledge, the differences were statistically significant (P < 0.05). The incidence of complications in the observation group was lower than the control group, the difference was statistically significant (P < 0.05). Conclusion On the basis of conventional nursing and rehabilitation management bundled new nursing service application without developmental dislocation of the hip surgery can promote the improvement of limb function, improve the children′s family awareness of disease recovery, reduce complications, and improve treatment efficacy and safety.
2019 Vol. 16 (10): 169-172 [Abstract] ( 174 ) HTML (1 KB)  PDF (541 KB)  ( 133 )
173 Effect of cluster intervention on mechanical ventilation patients in Intensive Care Unit
LUO Yanni1 WANG Chunya1 LI Jinna3 XIE Mei ZHAO Haining1 LI Hongling1
Objective To explore the effect of clustering intervention on patients with mechanical ventilation, in order to provide a reference for clinical treatment. Methods From January 2017 to June 2018, in the Second Affiliated Hospital of Xi'an Jiaotong University, 220 patients with severe ventilator-assisted breathing in ICU were selected, according to random number table method, they were divided into control group and observation group, with 110 cases in each group. The control group was given routine nursing, in addition, the observation group was simultaneously treated with clustering intervention. The indicators included mechanical ventilation time, ICU hospitalization time, hospitalization cost, pathogen detection, VAP incidence and satisfaction rate of patients in two groups were compared. Results The mechanical ventilation time, ICU hospitalization time, hospitalization cost, the incidence of VAP and the total number of plants detected by the pathogen of the observation group were significantly lower than those of the control group, and the satisfaction rate was higher than that in the control group, the differences were statistically significant (P < 0.05). Conclusion The results indicated that cluster intervention might reduce the mechanical ventilation time, ICU hospitalization time, the hospitalization cost and the incidence of ventilator-associated pneumonia, and improve patients′ satisfaction simultaneously.
2019 Vol. 16 (10): 173-176 [Abstract] ( 232 ) HTML (1 KB)  PDF (497 KB)  ( 92 )
177 Influence of high risk pregnancy patients by KABL model health education
CHANG Zheng PAN Huirong▲ LI Yan XU Jialu MA Yimei
Objective To approach influence of high risk pregnancy patients by KABL model health education. Methods From May 2017 to May 2018, in Shanghai First Maternity and Infant Hospital, the clinical data of 330 high risk pregnancy patients were analyzed, they were divided into control group (routine nursing measures) 170 cases and detection group (KABL model health education) 160 cases by different intervention patterns. The life quality score, social support score, anxiety score, depression score of high risk pregnancy patients in two groups before and after intervention were detected, the satisfaction degree of two groups after intervention were detected. Results The life quality score, social support score, anxiety score, depression score in two groups before intervention were compared, the difference were not statistical significance (P > 0.05); after intervention, the life quality score, social support score of two groups after intervention were higher than before intervention, anxiety score, depression score were lower than before intervention, the life quality score, social support score of detection group after intervention were higher than control group, anxiety score, depression score of detection group were lower than control group, the satisfaction degree of detection group was higher than control group, the differences were statistical significance (P < 0.05). Conclusion The application of high risk pregnancy patients by KABL model health education, which could increase life quality and social support, decrease anxiety and depression, increase satisfaction of patients, it is worth to be used.
2019 Vol. 16 (10): 177-180 [Abstract] ( 179 ) HTML (1 KB)  PDF (539 KB)  ( 54 )
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