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| Application effect of Dexmedetomidinein postoperative intravenous controlled analgesia in elderly patients undergoing surgery |
| SU Yanping TANG Fang XIANG Tao LIAO Caiping PENG Qingxiong |
| Department of Anesthesiology, Changsha First Hospital, Hu′nan Province, Changsha 410005, China |
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Abstract Objective To explore the effect of Dexmedetomidinein (DEX) in postoperative intravenous controlled analgesia (PCIA) in elderly patients. Methods From January to December 2017, 140 elderly patients who underwent surgical treatment in the Changsha First Hospital were randomly divided into the experimental group and the control group, with 70 patients in each group. PCIA analgesia was used in both groups after surgery. The Dexmedetomidine in the experimental group was treated with sufentanil for PCIA, the control group only used PCIA with Sufentanil. The Montreal cognitive function scale (MoCA), simple mental state scale (MMSE), test of delirium (CAM-CR) scores and agitation scores at different time points before and after surgery were compared between the two groups. Results There was no significant difference in MoCA score between the two groups before surgery (P ＞ 0.05). The MoCA scores of the experimental group were significantly higher than those of the control group at 12, 24 and 48 h after operation (P ＜ 0.05). There was no significant difference in MMSE score between the two groups before surgery (P ＞ 0.05). The MMSE scores of the experimental group were significantly higher than those of the control group at 12, 24 and 48 h after operation (P ＜ 0.05). The CAM-CR scores of the experimental group were lower than those of the control group at 12 h and 24 h after operation (P ＜ 0.05). At 12 h after operation, the Ramsay score of the experimental group was higher than that of the control group (P ＜ 0.05). Conclusion Postoperative PCIA analgesia in elderly patients with Dexmedetomidine is consistent with Sufentanil in reducing postoperative cognitive dysfunction, agitation, and spasm.
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