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| Analysis on medication rule of Chinese medicine in treating precocious puberty based on data mining technology |
| LIU Zhiwei1 LIU Lujia1 JING Weichao2 QU Wanying3 WANG Youpeng2 |
1.The Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Department of Pediatrics, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150001, China; 3.Department of Pediatrics, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract Objective To dig out the characteristics and rules of Chinese medicine in treating precocious puberty, and extract new prescriptions. Methods Through retrieving CNKI, Wanfang Data Knowledge Service Platform, and VIP database on therapeutic precocious puberty of Chinese medicine from January 1, 1979 to October 1, 2018. And TCM inheritance support system was used to carry on the statistics analysis. Results Total 104 articles and 124 prescriptions were included in the reseach. It was concluded that the most frequently used drugs were Anemarrhena asphodeloides, Phellodendron amurense, Peony bark, Poria cocos, Rehmannia glutinosa and Paeonia lactiflora. Based on the association rules, the potential prescriptions have got. And then 22 core combinations of 3 flavors, 10 core combinations and 5 new prescriptions were explored from the database. Conclusion This study analyzes the prescription rule of Chinese medicine for treating precocious puberty, and obtains new prescriptions with the main principles of enrich liver and kidney, nourish yin and clear heat, boost qi and promote fluid and move qi and dissipate binds, which provides the basis for the clinical treatment of this disease by Chinese medicine, and also provides a reference for the development of new drugs for this disease.
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[1] 林甦，杨文庆，俞建.中医儿科临床诊疗指南·性早熟（修订）[J].中医儿科杂志，2016，12（3）：1-5.
[2] 尹蔚萍，李小丝，张亚男，等.疏肝泻火方对雌性性早熟大鼠性腺、雌激素和下丘脑GnRH、垂体GnRH-R表达的影响[J].中药药理与临床，2018，34（3）：150-153.
[3] 艾丽丽，贾守梅，张玉侠，等.性早熟儿童自我概念与抑郁的相关性[J].中国学校卫生，2018，39（8）：1189-1191.
[4] 桂永浩，罗小平.儿科内分泌遗传代谢性疾病诊疗规范[M].北京：人民卫生出版社，2017：77.
[5] 冯凡，曹卫平，白玲，等.镇江市城区4~10岁儿童性早熟发育的现状调查及其危险因素分析[J].中国儿童保健杂志，2018，26（6）：651-653.
[6] Mrug S，Elliott MN，Davies S，et al. Early puberty，negative peer influence，and problem behaviors in adolescent girls [J]. Pediatrics，2014，133（1）：7-14.
[7] Schoelwer MJ，Donahue KL，Bryk K，et al. Psychological assessment of mothers and their daughters at the time of diagnosis of precocious puberty [J]. Int J Pediatr Endocrinol，2015，2015（1）：5.
[8] Menk TAS，Inácio M，Macedo DB，et al. Assessment of stress levels in girls with central precocious puberty before and during long-acting gonadotropin-releasing hormone agonist treatment：a pilot study [J]. J Pediatr Endocrinol Metab，2017，30（6）：657-662.
[9] Lin YC，Chang TT，Chen HJ，et al. Characteristics of traditional Chinese medicine usage in children with precocious puberty：A nationwide population-based study [J]. J Ethnopharmacol，2017，205：231-239.
[10] 国家药典委员会.中华人民共和国药典[M].北京：中国医药科技出版社，2015.
[11] 杨素兰，杨璐绫，冯轲昕，等.国内近10年儿童性早熟文献分析[J].济宁医学院学报，2018，41（2）：102-105.
[12] 龚勤，李智平，俞建.中医药治疗儿童性早熟的研究进展[J].中国医药指南，2012，10（18）：31-32，36.
[13] 欧光顺.女童特发性中枢性性早熟中医药治疗的系统评价[D].兰州：兰州大学，2015.
[14] 欧光顺，王舒雅，陈虹，等.中药治疗女童性早熟有效性及安全性的系统评价[J].儿科药学杂志，2015，21（9）：8-13.
[15] 陈安静，庞韩星，廖品东.中医药治疗儿童性早熟的研究进展[J].湖北中医杂志，2016，38（6）：78-79.
[16] 艾智慧.特发性中枢性性早熟小儿抑郁情绪及心理指导分析[J].心理月刊，2018（4）：30-31.
[17] 包弘扬.性早熟女童身心发育特点及其脑功能变化的研究[D].合肥：安徽医科大学，2018：8-12.
[18] Joinson C，Heron J，Araya R，et al. Early menarche and depressive symptoms from adolescence to young adulthood in a UK cohort [J]. J Am Acad Child Adolesc Psychiatry，2013，52（6）：591-598.
[19] 黄河.中药辨证治疗特发性性早熟验案2则[J].时珍国医国药，2001，12（12）：1108.
[20] 赵鋆，虞坚尔，朱敏华，等.抗早2号方治疗女童真性性早熟150例临床观察[J].上海中医药大学学报，2005， 19（1）：15-17.
[21] 黄梦雪，刘建忠，张雪荣，等.刘建忠教授治疗女童性早熟经验[J].中医药导报，2017，23（24）：99-100. |
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