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| The clinical effect of Virus-Clearing Oral Liquid combined with Oseltamivir in the treatment of influenza children with syndrome of heat toxicity attacking lung |
| HUANG Jie ZHANG Xiaoli WANG Xuecui TANG Yanqiu FENG Chunhui |
| Department of Pediatrics, Nanning Traditional Chinese Medicine Hospital, Guangxi Zhuang Autonomous Region, Nanning 530000, China |
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Abstract Objective To analyze the clinical effect of Virus-Clearing Oral Liquid combined with Oseltamivir in the treatment of influenza children with syndrome of heat toxicity attacking lung. Methods A retrospective analysis was made on the clinical data of 100 cases of influenza children with syndrome of heat toxicity attacking lung admitted to Nanning Hospital of Traditional Chinese Medicine from January to August 2018. According to different treatment methods, they were divided into control group and observation group, with 50 cases in each group. The control group was treated with Oseltamivir, the observation group was treated with Oseltamivir combined with Virus-Clearing Oral Liquid. The clinical effects of the two groups after treatment were analyzed. Results The total effective rate of the observation group was higher than that of the control group (P ＜ 0.05). The fever time, the improvement time of cough and nasal obstruction, the improvement time of throat swelling and pain and the hospitalization time of the observation group were shorter than those of the control group (P ＜ 0.05). Before treatment, there were no significant differences in the levels of interleukin-8 (IL-8), interferon-γ (IFN-γ) and C-reactive protein (CRP) between the two groups (P ＞ 0.05). After treatment, the levels of IL-8 in the two groups were higher than those before treatment, the levels of IFN-γ and CRP were lower than those before treatment, and the level of IL-8 in the observation group was higher than that in the control group, while the levels of IFN-γ and CRP were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Before treatment, there was no significant difference in the level of immunoglobulin between the two groups (P ＞ 0.05). After treatment, the levels of CD4+, IgA and IgM in the two groups were higher than those before treatment, and the levels of CD8+ in the two groups were lower than those before treatment, and the levels of CD4+, IgA and IgM in the observation group were higher than those in the control group, the level of CD8+ in the observation group was lower than that in the control group, the differences were statistically significant (P ＜ 0.05). The incidence of adverse reactions had no statistically significant difference between the two groups (P ＞ 0.05). Conclusion Oseltamivir combined with Virus-Clearing Oral Liquid is effective in the treatment of influenza in children, which can significantly improve clinical symptoms and immunity, the complications are less, and it is worthy of clinical further promotion and application.
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