保元汤合血府逐瘀汤对慢性心力衰竭患者心功能及炎性因子的影响

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Abstract Objective To investigate the effects of Baoyuan Decoction and Xuefu Zhuyu Decoction on cardiac function and inflammatory factors in patients with chronic heart failure. Methods Seventy patients with chronic heart failure who were admitted to Department of Cardiology, Traditional Chinese Medicine Hospital of Dianjiang County in Chongqing City from December 2016 to June 2018 were selected as research subjects, they were divided into the control group and the treatment group by random number table method, with 35 cases in each group. The control group was given standardized drug therapy for chronic heart failure, the treatment group was additionally treated with Baoyuan Decoction and Xuefu Zhuyu Decoction on the basis of the control group. Both groups took 2 weeks as a course of treatment. The clinical effect, TCM syndrome effect, plasma NT-proBNP levels and inflammatory factor indices [high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] were compared between the two groups before and after treatment. Results After one course of treatment, the results of comparison of clinical efficacy and TCM symptom efficacy between the two groups showed that the total effect rates of treatment group were all higher than those of control group, with statistically significant differences (P ＜ 0.05). After treatment, the levels of NT-proBNP, hs-CRP, IL-6, TNF-α in the two groups were all lower than those before treatment (P ＜ 0.01), and the levels of NT-proBNP, hs-CRP, IL-6, TNF-α in the tretment group were all lower than those in the control group (P ＜ 0.05). Conclusion Baoyuan Decoction and Xuefu Zhuyu Decoction has reliable curative effects for patients with chronic heart failure, which can improve clinical symptoms and TCM syndromes significantly, and decrease the levels of NT-proBNP and inflammatory factors.

Key words： Baoyuan Decoction Xuefu Zhuyu Decoction Chronic heart failure Cardiac function Inflammatory factors

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	ZHOU Aiming YANG Deqian ZHAO Fenglin

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ZHOU Aiming YANG Deqian ZHAO Fenglin. Effects of Baoyuan Decoction and Xuefu Zhuyu Decoction on cardiac function and inflammatory factors in patients with chronic heart failure[J]. 中国医药导报, 2019, 16(10): 128-131.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I10/128

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