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2019 Vol. 16, No. 3
Published: 2019-01-25
 
 
4 Protective effect of coptisine on vascular endothelial cells injured by hydrogen peroxide
WEI Sheng LIU Jinchun GE Weihong
Objective To investigate the protective effect and mechanism of coptisine on vascular endothelial cells induced by hydrogen peroxide (H2O2). Methods Human umbilical vein endothelial cells (EA.hy926) cultured in vitro were divided into control group, model group and drug administration group. The control group was added with fresh medium, and the model group was stimulated by H2O2 for 4 h. The drug-treated group was pretreated with different concentrations of coptisine (2.5, 5, 10, 20, 40 μmol/L) for 4 h, and then stimulated with H2O2 for 4 h. Cell viability was detected by MTS assay, intracellular reactive oxygen species (ROS) was detected by ROS fluorescent probe - dihydroethidine (DHE) staining, apoptosis was detected by Annexin V-FITC/PI double staining, and Western blot was used to detect the changes of apoptosis-related proteins caspase-3, Bcl-2 and Bax. Results Compared with the control group, the cell viability and Bcl-2 protein levels of the model group were markedly decreased, whereas the ROS levels, apoptotic rate, caspase-3 and Bax protein levels were significantly increased (P < 0.01). However, compared with the model group, the cell viability and Bcl-2 protein levels of dosing group were increased gradually with the increasing concentration of coptisine, while the ROS levels, apoptotic rate, caspase-3 and Bax protein levels were decreased gradually with the increasing concentration of coptisine (P < 0.01). Conclusion Coptisine exerts its protective effect on vascular endothelial cells injured by H2O2 in a dose-dependent manner by inhibiting the decrease of survival rate, the increase of ROS, the increase of apoptotic rate, the up-regulation of caspase-3 and Bax protein expression and the down-regulation of Bcl-2 protein expression in EA.hy926 cells induced by H2O2.
2019 Vol. 16 (3): 4-7,21 [Abstract] ( 269 ) HTML (1 KB)  PDF (948 KB)  ( 93 )
8 The role of IL-6, CAT and MPO in hepatic ischemia-reperfusion injury in rats
ZHANG Xiaobing1 ZHAI Shuping2 YUAN Wei2 YAN Yong2 ZHANG Beiping1 WANG Bailin2▲
Objective To investigate the relationship between interleukin-6 (IL-6), catalase (CAT), myeloperoxidase (MPO) and hepatic ischemia-reperfusion injury (HIRI) in rats and its mechanism. Methods A total of 150 SD rats aged 6 weeks were selected and the HIRI model was established by blocking hepatic portal blood flow. Rats were divided into HIRI group (n = 75) and liver ischemia-reperfusion (Control) group (n = 75). Each group was divided into three subgroups: 1 h group, 3 h group and 6 h group after ischemia-reperfusion, with 25 rats in each subgroup. The inferior vena cava blood of the two groups were extracted at 1, 3 and 6 h after ischemia-reperfusion to detect the level of IL-6 in serum. The appropriate amount of liver tissue was cut, the activities of CAT and MPO in liver tissue were measured, and the situations of HIRI were evaluated at each time point in the two groups. Results Compared with the Control group, IL-6 and MPO activities in the HIRI group were higher than those in the Control group at 1, 3, and 6 h after hepatic ischemia-reperfusion, but the CAT activity was lower than that in the Control group (all P < 0.05). Conclusion The HIRI in rats is associated with the increase of IL-6 and MPO as well as with oxygen free radical scavenging disturbance caused by inhibition of CAT release.
2019 Vol. 16 (3): 8-10 [Abstract] ( 313 ) HTML (1 KB)  PDF (526 KB)  ( 95 )
11 Effects of subchronic Olanzapine treatment on metabolism of glycogen and expression of glucose transporter in rats
DONG Wenfeng DU Xiangdong
Objective To study the effects of subchronic Olanzapine treatment on the metabolism of glycogen and expression of glucose transporter in rats and to investigate the possible mechanism of Olanzapine′s effects on glycometabolism. Methods Twelve healthy male SPF grade Sprague-Dawley (SD) rats were divided into control group (n = 6) and drug group (n = 6) according to random number table method. Rats in drug group were given 2.1 mg/kg Olanzapine suspension per day according to body weight by gavage and rats in control group were given the same volume of distilled water by gavage for 63 days. The food intake, change of body weight, levels of fasting blood glucose (FBG) and fasting insulin (FINS) were detected periodically. The insulin sensitivity index (ISI) and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. After 63 days, the liver, muscle and adipose tissues were collected and the content of glycogen and activity of glycogensynthase (GS) in liver and muscle tissues were detected. Western blot was used to assay the protein expression of GS in liver and muscle tissues and glucose transporter (GLUT) in liver, muscle and adipose tissues. PCR was used to assay the mRNA expression of GLUT in liver, muscle and adipose tissues. Results Compared to rats of control group, the subchronic Olanzapine treatment led to an increase of food intake, body weight, FBG and FINS in drug group, while the content of glycogen was reduced, the activity of GS was increased but the protein expression of GS was unchanged; the protein and mRNA expression of GLUT in liver, muscle and adipose tissues were decreased with highly statistically significant differences (P ＜ 0.01). Conclusion Subchronic Olanzapine treatment can increase glycogenolysis, decrease the capacity of glucose transport and result in generating insulin resistance, which may be one of the mechanisms lead to abnormal glucose metabolism after subchronic administration of Olanzapine.
2019 Vol. 16 (3): 11-15 [Abstract] ( 217 ) HTML (1 KB)  PDF (872 KB)  ( 150 )
16 The predictive value of high-sensitive troponin I in acute myocardial infarction of patients with emergency chest pain
HAN Min SHEN Qing SHAO Zhoujun SUN Yanni GUO Ruimin▲
Objective To provide an effective predictive tool in patients with acute myocardial infarction (AMI) via exploring the dynamic changes of the high-sensitive troponin I (hs-cTnI) at different time points, and to identify the range of changes at different diagnostic cut-off point. Methods A total of 142 chest paining patients in Putuo Hospital Affiliated to Shanghai Traditional Chinese Medicine University were collected from November 2016 to December 2017. Seventy-five AMI patients and 37 unstable angina (UA) patients were finally diagnosed. Thirty healthy subjects who underwent physical examination in the same period were selected as the healthy control group. Serum levels of hs-cTnI were measured at admission to hospital (T0) and 3 hours later (T3) by direct chemiluminescence immunoassay. The absolute change value of hs-cTnI and slop coefficient of hs-cTnI (△hs-cTnI) were calculated based on the two time points. The receiver operating characteristic curve (ROC) and Youden index were determined to provide the best diagnostic cut-off point and the optimal ranges. Results ① If chest pain symptoms were improved significantly, (T0) hs-cTnI≥0.04 ng/mL, (T3) hs-cTnI≥0.48 ng/mL [AUC: 0.994, the cutoff: 0.48 ng/mL] or T3-T0 hs-cTnI absolute changes≥0.45 ng/mL [AUC: 0.952, the cutoff: 0.45 ng/mL] were valuable to diagnosis of AMI. ② If chest pain symptoms were persisted, the absolute changes T3-T0 hs-cTnI≥1.001 ng/mL [AUC: 0.945, the cutoff: 1.001 ng/mL] were valuable to diagnosis of AMI. ③ If chest pain transiently occurred, (T0) hs-cTnI≥0.05 ng/mL [AUC: 0.483, the cutoff: 0.05 ng/mL], and the absolute changes hs-cTnI falling≥0.015 ng/mL [AUC: 0.686, the cutoff: -0.015 ng/mL] were valuable to diagnosis of UA. ④△hs-cTnI in the AMI group increased significantly compared with the UA group (P < 0.01). Conclusion AMI can not be effectively diagnosed by hs-cTnI of T0 or T3. The △hs-cTnI single point diagnostic values (T0 or T3) combined with the absolute changes of hs-cTnI are valuable for AMI diagnosis.
2019 Vol. 16 (3): 16-21 [Abstract] ( 200 ) HTML (1 KB)  PDF (645 KB)  ( 146 )
22 Research progress on the effect of Toll-like receptor 4 on brain injury and its treatment after hemorrhagic stroke
FENG Yuxuan YAO Shengtao KUANG Shuman YU Guoqing XIANG Chengming
Hemorrhagic stroke is a common acute and severe illness. The main cause of the disease usually refers to the rupture of vessels in the cerebral parenchyma or circle of willis. Recently, domestic and foreign experts and scholars divide it into many types according to the area of hemorrhage, and they find that the occurence of secondary brain damage will influence the patients prognosis through research and analysis. However, recent studies have found that Toll-like receptor 4 (TLR4) signal transduction pathways are widespread in post-cerebral hemorrhage inflammation, neuronal apoptosis, cerebral vasospasm and hydrocephalus, and we can reduce the incidence of brain injury by inhibiting TLR4 signaling pathways. Therefore, this article reviews the research progress on the effect of TLR4 on brain injury and its treatment after hemorrhagic stroke.
2019 Vol. 16 (3): 22-27 [Abstract] ( 221 ) HTML (1 KB)  PDF (567 KB)  ( 114 )
28 Research progress on epidemiology, treatment and prevention of malignant melanoma of skin
LIN Qianli ZHANG Wenjun WANG Hui JIANG Hua▲
Melanoma is one of the deadliest types of skin cancer. Over the past two decades, the prevalence rate of melanoma of skin was on the rise. Melanoma of the skin as a clinical problem has become a serious public health issue and has drawn much attention. This review discusses the epidemiology of melanoma of the skin, as well as the treatment and prevention of the condition. The purpose of this review is to present an introduction to the subject, and to be assisted in better understanding for clinicians.
2019 Vol. 16 (3): 28-32 [Abstract] ( 232 ) HTML (1 KB)  PDF (551 KB)  ( 258 )
33 Research progress on the mechanism of intestinal mucosal barrier injury in acute pancreatitis
LIU Chengsi1,2 WANG Weixing1,2▲
Acute pancreatitis (AP) is a common clinical disease. Multiple organ dysfunction syndrome and systemic inflammatory response synthesis are its secondary diseases, which are also common causes of high AP mortality. AP can lead to intestinal mucosal barrier damage, resulting in bacterial translocation, which can lead to endotoxemia and secondary infection of pancreatic tissue. Microcirculation disturbance, excessive release of inflammatory mediators, ischemia-reperfusion injury and intestinal epithelial cell apoptosis secondary to AP also play an important role in intestinal mucosal barrier injury. Clinical study of AP intestinal mucosal barrier damage is of great significance.
2019 Vol. 16 (3): 33-36 [Abstract] ( 182 ) HTML (1 KB)  PDF (546 KB)  ( 54 )
37 Research progress on mechanism of tension-type headache
SUN Yongxin1,2 YAO Gang1 YU Tingmin1 MAN Yuhong1
Tension-type headache (TTH) is the most common type of primary headache, which is still lacking enough attention. Factors such as peripheral sensitization, craniocerebral muscle tenderness and abnormal muscle activity, abnormal regulation mechanism of central nervous system pain, cytokines and metabolic disorders of inflammatory mediators may participate in the pathogenesis of TTH from different aspects. Electrophysiological techniques, neuroimaging techniques and testing techniques provide an effective means for the study of the pathogenesis of TTH. This article briefly summarizes the possible pathogenesis of TTH and the corresponding research progress, in order to deepen the understanding of this disease, and provide reference for basic research and clinical diagnosis and treatment.
2019 Vol. 16 (3): 37-39,48 [Abstract] ( 177 ) HTML (1 KB)  PDF (759 KB)  ( 45 )
40 Research progress on mechanism of traditional Chinese medicine against drug-resistant Pseudomonas aeruginosa
LIU Chuanling WANG Jiahe▲
Pseudomonas aeruginosa has become one of the most common pathogens of nosocomial infection in clinic, and its drug resistance has made it more difficult to treat the infection of Pseudomonas aeruginosa. The drug resistance mechanism of multidrug resistant Pseudomonas aeruginosa (MDR-PA) is complex and changeable, and it often produces multiple drug resistance by simultaneous effects of multiple drug resistance mechanisms. Application of traditional Chinese medicine against drug-resistant Pseudomonas aeruginosa is expected to postpone, to inhibit or even reverse the drug resistance of Pseudomonas aeruginosa. Traditional Chinese medicine can intervene in multiple links in the production of drug resistance of MDR-PA. This article reviews the research progress on mechanism of traditional Chinese medicine against drug-resistant Pseudomonas aeruginosa. These studies provide new research methods and ideas for further study of traditional Chinese medicine against drug-resistant Pseudomonas aeruginosa.
2019 Vol. 16 (3): 40-43 [Abstract] ( 273 ) HTML (1 KB)  PDF (548 KB)  ( 101 )
44 The changes of outpatient expenses in Alzheimer disease patients before and after the medical reform in a third-grade class-A Chinese medicine hospital
XIE Qixin1 CHENG Wei2 NI Jingnian3 ZHAO Xuan1 SHI Jing3 TIAN Jingzhou3
Objective To investigate the cost burden of outpatient Alzheimer disease in a third-grade class-A Chinese medicine hospital in Beijing City and assess the changes before and after the medical reform. Methods Retrospective methods were used to collect the outpatients mainly diagnosed as Alzheimer disease in the third-grade class-A Chinese medicine hospital in Beijing city from January 2016 to August 2017. The direct medical expenses related to diseases such as Western medicine, proprietary Chinese medicine, Chinese herbal medicine, and examination fees for a single visit were recorded, and the costs before and after the medical reform were analysed. Statistical methods such as quantitative description and One-way ANOVA were used to analyze the data. Results The average cost for a single visit was 1644.30 yuan, of which, Western medicine was 681.52 yuan, Chinese medicine was 851.49 yuan, and the proportion of total medicine was 93.81%. There was no statistically significant difference in the average cost of patients before and after medical reform (1666.39 yuan before medical reform, 1584.74 yuan after medical reform, P ＞ 0.05). There were only statistically significant differences in the costs of Western medicine, Chinese herbal medicine, Granules, self-paying drugs, and medical treatment fees before and after medical reform (P ＜ 0.05). There were no statistical differences in other fees(P ＞ 0.05). It was estimated that patients would receive annual direct medical expenses for 25 181 yuan. Conclusion Before and after the medical reform of the annual outpatient clinic for Alzheimer disease in a third-grade class-A Chinese medicine hospital in Beijing city, there is no significant difference in the total average cost. Medical reform has reduced the cost of Western medicine for Beijing medical insurance patients, and has little effect on self-paying medical patients.
2019 Vol. 16 (3): 44-48 [Abstract] ( 230 ) HTML (1 KB)  PDF (355 KB)  ( 55 )
49 Progress and enlightenment of naming medical devices in the United States
YANG Wanjuan LI Jingli▲
Medical devices are directly related to human health. Normative naming is very important for accurate identification and correct use of medical devices, and it is also an important basic work of medical device supervision. The United States Food and Drug Administration (FDA) identifies all levels of names in the classified database by category, allows enterprises to use commodity names to release personalized needs, encourages enterprises to adopt third-party terminology system to deal with international trade, and gradually forms an official and commercial complementary naming system. This paper summarized the status quo of medical device naming in the United States, combed the application of the level, type and name of medical device naming in the United States, briefly described the progress of medical device naming in China, compared the similarities and differences of medical device naming between China and American, and analysed the potential reasons, so as to provide reference for the construction of medical device naming system in China.
2019 Vol. 16 (3): 49-52 [Abstract] ( 224 ) HTML (1 KB)  PDF (543 KB)  ( 96 )
53 The influence of different management modes on blood glucose control compliance rate in patients with type 2 diabetes
ZHANG Xiaolin1,2 LIU Min1 LI Gang2 GU Hongqing2 DAI Jie2 LIU Huifang1 YI Ping3 CHEN Fengling1
Objective To explore comprehensive diabetes management mode that combines mobile medical treatment (mobile phone application APP) as the media, community general practice and endocrinology specialty in tertiary hospitals by comparing the effects of four different management modes on the blood glucose control compliance rate of type 2 diabetes patients. Methods From January to December 2017, a total of 861 patients with type 2 diabetes in Baoshan District of Shanghai Youyi Street Community Health Service Center were selscted, according to the different management mode, they were divided into four groups (outpatient follow-up, telephone follow-up, on-site follow-up and comprehensive management), and managed for six months, respectively. Before and after the management glycated hemoglobin (HbA1c) and fasting plasma glucose (FBG) level and success rate were compared between two groups. Results After the comprehensive management mode, the compliance rate of HbA1c was the highest, followed by the on-site follow-up mode. After the on-site follow-up mode management, the FBG compliance rate was the highest, followed by the comprehensive management mode. HbA1c, FBG and the compliance rate of dual indicators compliance rate of patients in the comprehensive management mode showed the most significant increase. The HbA1c and FBG levels after the comprehensive management mode and the on-site follow-up mode were significantly lower than those before the management (P ＜ 0.05), and the decrease of HbA1c and FBG levels were the most significant after the comprehensive management mode (P ＜ 0.05). Conclusion Among the four management modes, the HbA1c and FBG levels of the comprehensive management mode are significantly reduced, and the compliance rate of HbA1c and FBG are increased. Moreover, the implementation of the comprehensive management mode is relatively convenient and easy for patients to accept, which is worth further discussion and promotion.
2019 Vol. 16 (3): 53-56,70 [Abstract] ( 197 ) HTML (1 KB)  PDF (663 KB)  ( 112 )
57 Meta-analysis of efficacy and safety of percutaneous nephrolithotomy surgery and retrograde intrarenal surgery for treatment of solitary kidney calculi
NI Dawei XI Junhua WU Wei YANG Zhenxing ZHANG Yanbin▲
Objective To systematically evaluate the efficacy and safety of percutaneous nephrolithotomy surgery (PCNL) and retrograde intrarenal surgery (RIRS) in the patients with solitary kidney calculi. Methods Wanfang, VIP and CNKI databases were retrieved by computer and hand to obtain relevant Chinese documents, and PubMed and Web of Knowledge databases were retrieved to obtain relevant English documents. The search date is June 2010 to June 2017. The Chinese search terms include "flexible ureteroscope, percutaneous nephroscopy, isolated kidney" and so on. Subsequently, literature screening, data extraction and quality evaluation were carried out, the data in the relevant document obtained were divided into PCNL group and RIRS group. Results The stone clearance rate in PCNL group was higher than that in RIRS group (P < 0.00001, OR = 2.54, 95%CI: 1.80-3.58), the operation time was shorter than that in RIRS group (P < 0.0001, MD = -21.69, 95%CI: -31.85--11.53), the bleeding volume in RIRS group was less than that in PCNL group (P = 0.03, MD = 76.28, 95%CI: 5.99-146.56), the hospitalization time was shorter than that in PCNL group (P = 0.0003, MD = 2.41, 95%CI: 1.09-3.74), and the risk of transfusion was also lower than that of the PCNL group (P = 0.02，OR = 6.37, 95%CI: 1.42-28.52); there was no significant difference in the overall complications between the two groups. Conclusion The choice of treatment method for solitary kidney calculi can be judged by balancing the advantages and disadvantages of surgery and combining the actual situation of patients.
2019 Vol. 16 (3): 57-61 [Abstract] ( 247 ) HTML (1 KB)  PDF (1151 KB)  ( 71 )
62 The effect of decompression and non-fusion dynamic stabilization on the treatment of spinal stenosis with degenerative lumbar scoliosis
FU Haiping WANG Fei
Objective To investigate the effect of decompression and non-fusion dynamic stabilization in the treatment of spinal stenosis with degenerative lumbar scoliosis (DLS), and provides a new reference for clinical practice. Methods From January 2014 to June 2016, 189 patients with lumbar spinal stenosis admitted to the Department of Spine Surgery of the People′s Hospital of Inner Mongolia Autonomous Region were selected, 66 DLS patients were randomly divided into the non-fusion dynamic stability group (n = 34) and the fusion group (n = 32) by simple random sampling. Patients in the non-fusion dynamic stability group received decompression surgery and Dynesys system non-fusion stability surgery, while patients in the fusion group received fusion surgery. Preoperative general data, fixed segment, intraoperative mean operation time, intraoperative blood loss, and average hospital stay were statistically analyzed. Postoperative efficacy (sacrum Angle, thoracic kyphoid Angle, and mobility, etc.) and related complications were statistically evaluated. Results Patients in the non-fusion dynamic stability group underwent decompression and non-fusion stability surgery in 64 segments, while patients in the fusion group underwent fusion fixation in 67 segments. The mean operation time, intraoperative blood loss, average length of hospital stay and time of underground activities of the patients in the two groups were compared, the fusion group were greater than those of the dynamic non-fusion group, and the differences were statistically significant (P ＜ 0.05). The mean values of sacral Angle, thoracic kyphosis Angle and L3/4  intervertebral activity in the final follow-up of the dynamic non-fusion group were all higher than those in the final follow-up of the fusion group (P ＜ 0.05). Visual analogue score (VAS), leg pain VAS and Oswestry disability index questionnaire (ODI) score of the dynamic non-fusion group at the last follow-up visit were all lower than those of the preoperative fusion group (P ＜ 0.05). Conclusion Stenosis associated with mild to moderate scoliosis (angle of < 30 °) in middle-aged and elderly patients, the clinical curative effect of implementation of the fusion decompression technology is better than fixed.
2019 Vol. 16 (3): 62-66 [Abstract] ( 189 ) HTML (1 KB)  PDF (729 KB)  ( 56 )
67 Effect of anterior ankle arc incision combined with MIPO therapy on ankle joint morphology and ankle function after Pilon fracture surgery
MA Jia1 MENG Qingfeng1 ZHENG Lianxiang1 XU Yinghui2
Objective To investigate the effect of anterior ankle arc incision combined with MIPO on the morphology of ankle point and ankle joint function in patients with Pilon fracture after operation. Methods From July 2014 to July 2017, 60 cases of Pilon fracture patients treated in Fushun Central Hospital were selected as the research objects. The patients were divided into the control group and the observation group using the random number table method, 30 cases in each group. Patients in the observation group were treated with anterior ankle arcuate incision combined with MIPO therapy, while patients in the control group were treated with open internal fixation. The differences of postoperative fracture healing, ankle function recovery, ankle point recovery and complications between the two groups were compared and observed. Results Anatomical reduction rate and excellent and good ankle function rate of the observation group were significantly higher than those of the control group (P ＜ 0.05). Patients in the observation group had poor ankle joint width, poor coronal angle and lower sagittal angle than those in the control group (P ＜ 0.05). The amount of intraoperative blood loss, operation time and postoperative complications in the observation group were less than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Arcuate incision combined with MIPO technique is effective for the treatment of pilon fracture patients, which can significantly improve the excellent and good operation rate of patients, restore the ankle joint function and ankle point morphology of patients, reduce the peripheral injury, and reduce postoperative complications. Therefore, it is worth popularizing in clinical work.
2019 Vol. 16 (3): 67-70 [Abstract] ( 245 ) HTML (1 KB)  PDF (514 KB)  ( 106 )
71 The effect of percutaneous balloon expansion comparison with open reduction and internal fixation for schatzkerⅢ type of fracture of tibial plateau
QIU Yu WEI Li WEI Xiangke ZHONG Tao
Objective To compare the effect of percutaneous balloon expansion comparison with open reduction and internal fixation for schatzkerⅢ type of fracture of tibial plateau. Methods Retrospective analysis in July 2010 to July 2016 in the First People′s Hospital of Yibin City of Sichuan Province 62 cases of bone subject SchatzkerⅢ cases of patients with fracture of tibial plateau. According to different treatment methods, they were divided into balloon dilation group (23 cases) and internal fixation group (39 cases). In the balloon dilation group, with the assistance of arthroscopy, the bone cement was filled after the balloon dilation and reduction. The internal fixation group underwent open reduction, allograft and locking plate fixation under arthroscopic surveillance. The operative time, intraoperative blood loss, length of hospitalization, total cost, complications, knee mobility and knee hospital speeial surgry knee score (HSS) score at 12 months after surgery were compared between the two groups. Results The operation time, intraoperative blood loss and hospitalization daily average of the balloon dilation group were lower than those of the internal fixation group, and the differences were statistically significant (P ＜ 0.05). The average hospitalization cost in the balloon group was higher than that in the internal fixation group, and the difference was statistically significant (P ＜ 0.05). The incidence of complications in the balloon group was lower than that in the internal fixation group, and the difference was statistically significant (P ＜ 0.05). Twelve months after surgery, the knee mobility and HSS function scores of the balloon group were higher than those of the internal fixation group, and the differences were statistically significant (P ＜ 0.05). Conclusion The balloon expansion of the arthroscopic assisted treatment Schatzker Ⅲ type tibial plateau fracture operation time and shorter hospitalization time, less bleeding, fewer postoperative complications, and the risk of knee can obtain better activity and function of using to be promoted. Arthroscopically assisted balloon dilatation has advantages including shorter duration of operation, shorter length of hospital stay, less intraoperative blood loss, less complications and better mobility and functions of knee joint in the treatment of Schatzker Ⅲ type tibial plateau fracture, so it is worthy of widely use.
2019 Vol. 16 (3): 71-74 [Abstract] ( 256 ) HTML (1 KB)  PDF (514 KB)  ( 68 )
75 Clinical analysis of 151 cases of trial of labor after cesarean section
YANG Yuxia1 WANG Xiaoxin2 ZHANG Chengyan2 ZOU Liying2▲
Objective To explore the factors influencing the success rate of vaginal delivery after cesarean section. Methods One hundred and fifty-one pregnant women after cesarean section and voluntary vaginal delivery, who did their prenatal care in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from January 2016 to June 2017, were involved. They were divided into the success group and the failure group according to the outcome of trial of labor after cesarean (TOLAC). The general situation and prognosis of two groups were compared and analyzed. Results In 151 cases of TOLAC, 125 cases were successfully delivered (success group) and 26 cases were transferred to cesarean section after failure (failure group). The success rate was 82.78%. There was 1 uterine rupture and the uterine rupture rate was 0.66%. There was no significant difference in the pre-pregnancy body mass index (BMI), ante partum BMI, the gravidity, the parity, thickness of the lower uterine segment and the interval time of the previous cesarean section between two groups (P ＞ 0.05). The age of success group was highly significantly higher than that of failure group (P ＜ 0.01). After removing preterm birth cases, there was no statistically significant difference in the age between two groups (P ＞ 0.05). The induction rate of success group was lower than that of failure group (P ＜ 0.01). There was no significant difference in postpartum 2 h blood loss and neonatal body weight between the two groups (P ＞ 0.05). The 1 min Apgar score of the success group was significantly higher than that of the failure group (P ＜ 0.05). Conclusion Age, the gravidity, the parity, pre-pregnancy BMI, ante partum BMI, thickness of lower uterine segment before delivery and the interval time of previous cesarean section do not affect the outcome of TOLAC. The inability to spontaneous labor and the intervention of induced labor may be related to the decrease of the success rate of vaginal delivery.
2019 Vol. 16 (3): 75-79 [Abstract] ( 495 ) HTML (1 KB)  PDF (566 KB)  ( 72 )
80 Effect of prenatal low-frequency pulse combined with manual acupoint massage on primipara childbirth and postpartum lactation
ZHONG Na LIANG Xuxia SU Yong WANG Xiangyang FANG Yu LAI Xiaoli
Objective To explore the clinical application of low-frequency pulse combined with manual acupoint massage in promoting the delivery and postpartum lactation of primipara. Methods One hundred and twenty primparae in the People's Hospital of Guangxi Zhuang Autonomous Region were selected and divided into observation group and control group according to the order of hospitalization, with 60 cases in each group. The control group received routine nursing care according to the term of labor, the observation group was treated with prenatal low-frequency pulse combined with manual acupoint massage on the basis of the control group. The cervical Bishop score, vaginal delivery rate, time of the first period of labor, lactation start time, the volume of postpartum lactation, degree of breast milk deposition and breast comfort level between two groups were compared. Results The cervical Bishop score of the two groups of pregnant women showed a trend of increasing with time, and the increase range in the observation group was higher than that in the control group (P ＜ 0.01). The vaginal delivery rate of observation group was higher than that of the control group; time of the first period of labor and lactation start of observation group was shorter than those of the control group; the volume of postpartum lactation at day 3 and 7, degree of breast milk deposition and breast comfort level at day 3 of observation group were better than those of the control group, the differences were statistically significant (P ＜ 0.05 or P < 0.01). Conclusion Prenatal manual acupoint massage combined with low-frequency pulse has obvious effect on promoting cervical maturation, which can effectively shorten the first delivery period and increase the rate of vaginal delivery. And it can promote early postpartum lactation, which increases the volume of lactation, alleviates the degree of milk siltation of the primipara and thus increases the comfort of the breast.
2019 Vol. 16 (3): 80-83,88 [Abstract] ( 143 ) HTML (1 KB)  PDF (611 KB)  ( 68 )
84 The relationship between RAS in peripheral blood and insulin resistance and lipid metabolism in patients with polycystic ovary syndrome
FAN Kejun1 WANG Jian2
Objective To investigate the relationship between the renin angiotensin system (RAS) in peripheral blood and insulin resistance and lipid metabolism in patients with polycystic ovary syndrome. Methods A total of 116 cases of patients with polycystic ovary syndrome from January 2015 to December 2017 treated in Xiamen Children′s Hospital ("our hospital" for short) were selected, which were divided into the insulin resistance group (HOMA-IR≥2.69, n = 47) and the non insulin resistance group (HOMA-IR<2.69, n = 69) according to insulin resistance index (HOMA-IR), and 60 cases of healthy women in our hospital were selected as the control group. Plasma renin activity (PRA), angiotensin Ⅱ (AngⅡ), fasting insulin (FINS), sex hormone, blood lipid and ultrasonic features were compared between the groups, and the correlation between each index and PRA, AngⅡ were analyzed. Results The insulin resistance group of peripheral blood PRA, AngⅡ, FINS, HOMA-IR, luteinizing hormone (LH), luteinizing hormone / follicle stimulating hormone (LH / FSH), testosterone (T) level were significantly higher than that in the non insulin resistance group and the control group, the peripheral blood PRA, AngⅡ, LH, LH/FSH, T level in the non insulin resistance group were significantly higher than the control group (all P ＜ 0.05). The levels of peripheral blood triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in the insulin resistance group were significantly higher than that of the non insulin resistance group and the control group (all P ＜ 0.05), peripheral blood TG, TC, LDL-C, high density lipoprotein cholesterol (HDL-C) and BMI in the non insulin resistance group were not significantly different from those in the control group (all P ＞ 0.05). The number of follicles and the resistant index of uterus artery (RI) in the insulin resistance group were significantly higher than those in the non insulin resistance group and the control group, RI of ovarian stromal artery was significantly lower than that in the non insulin resistance group and the control group (all P ＜ 0.05), ovarian volume, follicle number and RI of uterine artery in the insulin resistance group were significantly higher than the control group, RI of ovarian stromal artery was significantly lower than the control group (all P ＜ 0.05). PRA and AngⅡ in peripheral blood of patients with polycystic ovary syndrome were positively correlated with FINS, HOMA-IR, LH, LH/FSH, T, LDL-C, TG, TC, ovarian follicle number and RI of uterine artery (all P ＜ 0.05), and negatively correlated with RI of ovarian interstitial artery (all P ＜ 0.05). Conclusion Patients with polycystic ovary syndrome have hyperactivity of RAS in peripheral blood. The levels of PRA and AngⅡ can affect insulin resistance, lipid metabolism and follicle formation.
2019 Vol. 16 (3): 84-88 [Abstract] ( 222 ) HTML (1 KB)  PDF (602 KB)  ( 111 )
89 Analysis of the influencing factors of prognosis of children with Legionella pneumophila pneumonia combined with Mycoplasma pneumoniae infection
ZHANG Dongyan WANG Jianzhong LI Xuechao GU Yuxiu
Objective To explore the risk factors of poor prognosis of children with Legionella pneumophila pneumonia combined with Mycoplasma pneumoniae infection. Methods The clinical data of 151 children with Legionella pneumoniae pneumonia complicated with Mycoplasma pneumoniae infection admitted to Maternal & Child Care Centre of Qinhuangdao from January 2014 to January 2017 were retrospectively analyzed. According to the prognosis, the children were divided into good prognosis group (n = 112) and poor prognosis group (n = 39). The risk factors of poor prognosis were identified by univariate analysis and multivariate logistic regression analysis. Results After routine comprehensive treatment of 151 children with Legionella pneumoniae pneumonia complicated with Mycoplasma pneumoniae infection, 112 cases had good prognosis, 39 cases had poor prognosis, and the incidence of adverse prognosis was 25.83%. There was no significant difference in genders between the poor prognosis group and the good prognosis group (P ＞ 0.05). The constituent ratios of the age＜5 years old, the course of disease≥7d, the history of using immunosuppressive agents, the peripheral blood CD4+/CD8+＜1.4, IgA＜0.69 g/L, with history of asthma and helicobacter pylori antibody positive of the poor prognosis group were significantly higher than those of the good prognosis group (P ＜ 0.05), all of which were the independent risk factors of poor prognosis of children with Legionella pneumophila pneumonia combined with Mycoplasma pneumoniae infection (OR = 3.362, 3.036, 3.753, 4.235, 3.897, 2.968, 3.562, P ＜ 0.05). Conclusion The poor prognosis of children with Legionella pneumophila pneumonia combined with Mycoplasma pneumoniae infection is related to age, course of disease, using of immunosuppressive agents, CD4+/CD8+ reduction, IgA reduction, asthma history and helicobacter pylori antibody positive, which has important guiding value for clinical treatment.
2019 Vol. 16 (3): 89-92 [Abstract] ( 222 ) HTML (1 KB)  PDF (613 KB)  ( 123 )
93 Effect of different energy coefficients on blood sugar in patients with gestational diabetes mellitus and neonatal weight
HAN Yuyu ZHAO Xiuling▲ MA Wei TIAN Dan PANG Yaru
Objective To investigate of the effects of daily energy supply on blood sugar management of patients with gestational diabetes mellitus and neonatal weight using different energy coefficients. Methods From October 2016 to June 2017, 85 patients with gestational diabetes mellitus enrolled in the One-day Outpatient for Diabetes of Beijing Luohe Hospital affiliated to Capital Medical University ("our hospital" for short) were selected as the study group, and the patients who calculated the energy supply with the lower limit of the energy coefficient as the study group A (n = 43), the patient who calculated the energy supply with the upper limit of the energy coefficient as the study group B (n = 42); the patients with gestational diabetes mellitus who took the pregnancy test at the same time and did not participate in the One-day Outpatient for Diabetes in our hospital as the control group (n = 50). The glycosylated hemoglobin, the positive rate of urinary ketone body and neonatal weight in the study group and the control group were monitored and followed up. The blood sugar before and 2 hours after meals in One-day Outpatient for Diabetes, urinary ketone body and neonatal weight in group A and group B were monitored. Results The glycated hemoglobin of the study group was significantly lower than that of the control group (P < 0.05). The neonatal weight in the study group was significantly lower than that of the control group (P < 0.05). The blood sugar compliance rate of study group A was higher than that of study group B, and the difference was statistically significant (P < 0.05). The postprandial blood sugar of study group A was lower than that of study group B, the difference was not statistically significant (P > 0.05). The neonatal weight of study group A was significantly lower than that of the study group B, and the difference was statistically significant (P < 0.05). Conclusion One-day Outpatient for Diabetes is beneficial to patients with gestational diabetes to better control blood sugar and reduce the incidence of macrosomia. Taking the lower limit of the energy coefficient to calculate the total calories can ensure the energy needs of pregnant women, and does not increase the incidence of hypoglycemia and the positive rate of ketone body, which is conducive to blood sugar compliance.
2019 Vol. 16 (3): 93-96 [Abstract] ( 218 ) HTML (1 KB)  PDF (589 KB)  ( 79 )
97 Analysis of influence factors of phacoemulsification combined with IOL implantation on the incidence of exudation in anterior chamber in cataract patients
WANG Ying CHEN Xialin
Objective To investigate the related influence factors of phacoemulsification (PE) combined with intraocular lens implantation (IOL) on the incidence of exudation in anterior chamber (AC). Methods The clinical data of 389 cataract patients (405 eyes) treated with PE combined with IOL implantation in Liuzhou Liutie Central Hospital from March 2015 to October 2017 were analyzed retrospectively. There were 23 cases (24 eyes) occuring exudation in AC as study group, and 366 cases (381 eyes) without exudation in AC as control group. Statistical analysis of the incidence of AC exudation after surgery were performed. Multivariate Logistic regression analysis was carried out. Results High myopia, glaucoma, preoperative intraocular pressure(IOP)＞21 mmHg(1 mmHg=0.133 kPa), preoperative vision＜1, posterior capsular rupture (PCR), in ultrasonic accumulated energy complex parameter (AECP)＞7.25(%×min), intraoperative pupil diameter＜3 mm, uveitis, lenticular nucleus classification≥Ⅳ levels, all the 9 indices had significant difference between the two groups (P ＜ 0.05), and they were risk factors of exudation in AC. Among the 9 factors, 7 factors, glaucoma, uveitis, high myopia, PCR, ultrasonic in AECP＞7.25(%×min), preoperative IOP＞21 mmHg, lenticular nucleus classification≥Ⅳ levels were independent risk factors (P ＜ 0.05). Conclusion The preoperative IOP＞21 mmHg and patients' nucleus classification of lens≥Ⅳ degree, patients with high myopia, uveitis, glaucoma, and ultrasound AECP＞7.25 (%×min) are main risk factors for AC exudation after PE combined with IOL implantation in cataract patients. Early prevention and treatment should be taken in clinical practice.
2019 Vol. 16 (3): 97-100 [Abstract] ( 185 ) HTML (1 KB)  PDF (382 KB)  ( 73 )
101 Study on the consistency of Aspirin enteric-coated tablets process and quality in vitro
HOU Fei LUO Sihai FANG Xiaqin ZHANG Yujia ZHENG Wensheng
Objective To optimize the preparation process of Aspirin enteric-coated tablets and evaluate its quality consistency in vitro. Methods Three factors including L100-55, TEC and talc powder were investigated by orthogonal experiment with in vitro dissolution as the index to screen the optimal prescription dosage. Using acetonitrile-tetrahydrofuran-glacial acetic acid-water (20∶5∶5∶70) as mobile phase, C18 column with detection wavelength of 276 nm and flow rate of 1.0 mL/min as chromatographic conditions, the similarity of dissolution behavior of self-made tablets and reference preparations in vitro was determined by direct comparison method and f2 similarity factor. Results Orthogonal test showed that the best combination of factors was A2B3C1D3. The contents of aspirin in three batches of self-made tablets were 98.9%, 100.3% and 99.9% of the labeled amount respectively, which were in accordance with the provisions of the Pharmacopoeia of the People′s Republic of China. In the solution of hydrochloric acid at pH 1.2, no release was found in the self-made tablets, and the f2 values of self-made tablets and the reference were 50%, 65%, 80% in the solution of pH 6.0, pH 6.2, pH 6.8, respectively. Conclusion The formulation of the preparation is simple, the process is feasible and the repeatability is high. It can be used to guide industrial production. The analytical method established in this study can be used for the quality control of Aspirin enteric-coated tablets.
2019 Vol. 16 (3): 101-104 [Abstract] ( 305 ) HTML (1 KB)  PDF (526 KB)  ( 150 )
105 Verification of the industry standard for parathyroid hormone detection kits
QU Shoufang YU Ting SUN Nan HUANG Jie
Objective To establish the industry standard of parathyroid hormone assay kit, and to validate the standard by chemiluminescence detection kit, and to evaluate the applicability of the standard. Methods The detection limits, linearity, accuracy, precision and specificity of five kinds of kits from different manufacturers were verified by magnetic particle chemiluminescence and chemiluminescent particle immunoassay according to the requirements and test methods of formulating industry standards. Results The detection limit of the kit was not higher than 13.7 pg/mL, and other items such as accuracy, linearity, precision and specificity could meet the requirements of drafting the industry standard of parathyroid hormone detection kit. Conclusion The formulation of industry standard for parathyroid hormone detection kit can standardize the technical requirements of parathyroid hormone detection kit, and provide the basis for the detection of parathyroid hormone and the supervision and management after the listing.
2019 Vol. 16 (3): 105-108 [Abstract] ( 181 ) HTML (1 KB)  PDF (478 KB)  ( 154 )
109 Systematic review and Meta-analysis of preventive treatment for low-dose Aspirin-associated gastrointestinal injury in patients with history of peptic ulcer
WAN Ning1 ZHANG Tiantian2 DONG Yanmin3 JI Bo1
Objective To demonstrate the efficacy of proton pump inhibitors (PPIs) and control drugs in the prevention of low dose Aspirin (LDA) related gastrointestinal (GI) injuries in patients with peptic ulcer history, thus reducing the abuse of PPIs. Methods By searching PubMed, Cochrane Library and Embase database upto May 2018, the randomized controlled trials on the efficacy of preventive therapy [PPIs, H2 receptor antagonist (H2RA), Vonoprazan, and gastric mucosal protective agents] in reducing the risks of GI events in patients taking long term LDA were collected. Results A total of 9 studies were included with a total of 3067 patients. PPIs were superior to placebo and gastric mucosal protective agents in preventing ulcer recurrence and upper gastrointestinal bleeding (UGIB). Vonoprazan (OR = 2.61, 95%CI: 0.81-8.41) and H2RA (OR = 0.36, 95%CI: 0.04-3.54) showed similar efficacy to PPIs in preventing peptic ulcer recurrence. As for prevention of UGIB, Vonoprazan was superior to PPIs, while H2RA was inferior to that of PPIs. In patients with a history of Hp-induced upper GI hemorrhage, Hp eradication treatment had a similar prophylactic effect as PPIs. Conclusion The results suggest that Vonoprazan and H2RA are as effective as PPIs for the prevention of recurrent peptic ulcer, and Vonoprazan exhibits better efficacy for the prevention of UGIB with PPIs. In patients with a history of Hp infection, the eradication treatment has a similar effect as PPIs. Hence, PPIs may not be the best choice for the prevention of LDA associated GI injures.
2019 Vol. 16 (3): 109-114,135 [Abstract] ( 196 ) HTML (1 KB)  PDF (1458 KB)  ( 97 )
115 Professor LI Xiangyun′s experience in treating recurrent volvovaginal candidiasis from Chong Ren meridians and the commonly used herbal pairs
JIA Lina1 LI Xiangyun2
This article aims to introduce feature experience in the treatment of recurrent volvovaginal candidiasis(RVVC) of Professor LI Xiangyun, who is a national expert in Chinese traditional medicine. Professor Li thinks that the essence of RVVC treatment is similar to the method of regulating menstruation. The main pathogenesis of RVVC is the deficiency of Chong and Ren meridians. Experienced prescription Gu Chong Tang from the Book Records of Traditional Chinese and Western Medicine in Combination, was used as the basic prescription. The theory of “blood and water with the same treatment” was applied in astringing Chong and Ren meridians′ gliding. The occurrence of this disease cannot be separated from the key pathogenesis, containing wet, heat and blood stasis. So in the decoctions, clearing away heat and activating blood, dispelling Chong and Ren′s pathogens, and regulating the Chong and Ren channels were commonly used in clinic. This article summarizes the commonly used herbal pairs by Professor LI for mutual encouragement.
2019 Vol. 16 (3): 115-119 [Abstract] ( 196 ) HTML (1 KB)  PDF (827 KB)  ( 109 )
120 Analysis of medication regularity of Professor LIN Yi in treatment of granulomatous mastitis based on data mining
XIE Wanjun1 LIN Yi2 ZHONG Shaowen2 SITU Honglin2 LIU Xiaoyan2 ZHU Huayu2
Objective To analyze medication rule of Professor LIN Yi in the treatment of granulomatous mastitis (GM) with the traditional Chinese medicine inheritance support system. Methods Effective cases with GM treated by Professor LIN Yi in Outpatient of Guangdong Provincial Hospital of Chinese Medicine from January 2014 to January 2018 were collected and input onto traditional Chinese medicine inheritance support system. The methods were used such as association rule, improved mutual information method, complex system entropy clustering were used to summarize the frequent used drugs by Professor LIN Yi in treatment for GM, and prescription-formulating principle was analyzed. Results A total of 68 patients and 349 prescriptions were involved. The top 10 most frequently used drugs were Platycodon Grandiflorum, Atractylodes Macrocephala, Pericarpium Citri Reticulatae Viride, Vaccaria Segetalis, Radix Curcumae, Taraxacum Mongolicum, Spina Gleditsiae, Squama Manitis, Rhaponticum Uniflorum, Concha Ostreae orderly. The most frequently existing properties were warm and placid, and bitter and sweet for most frequent existing tastes. The top three meridians were stomach, spleen and liver meridian. Association rules among the herbs were conformed, 6 core combinations and 3 new prescriptions were mined from the database. Conclusion The conclusion shows that Professor LIN’s experience in treating GM can be summarized as: cautiously grasping the pathogenesis of disease, supporting healthy energy to eliminate pathogens, combination the attack of pathogens and strengthening body resistance, treating both symptoms and radical. The disease is related to the all viscera and the treatment needs to start from many aspects, among which the liver and spleen are the most important organs, and finally achieve the goal of balancing the viscera. The treatment should be in accordance with seasonal-local conditions and patient′s individuality, plusing or subtracting drugs according to syndrome differentiation, combinating drugs appropriately, and using drugs gently.
2019 Vol. 16 (3): 120-123 [Abstract] ( 242 ) HTML (1 KB)  PDF (852 KB)  ( 100 )
124 Study on syndromes and treatment of atopic dermatitis treated by TCM based on association rule algorithm and entropy clustering of complex system
PEI Yue1 MO Xiumei2 ZENG Jianbo1 XUE Suqin2 YAN Fenggen2 CHEN Dacan2 LIU Junfeng2 LI Hongyi2
Objective To analyze and discuss the experience of symptom differentiation of atopic dermatitis (AD) and its treatment with modern Chinese medicine. Methods Based on the association rule algorithm and entropy clustering of complex system, Chinese medicine literature database on the treatment of atopic dermatitis in CNKI, Wanfang, VIP, China biomedical literature database from January 1st 2017 to March 1st 2018 was retrieved. And a database containing syndrome differentiation, Chinese medicine for internal and external use was established. TCMISS V2.5 was used to analyze the data. Results The distribution of four Qi of traditional Chinese medicine was mainly warm, cold, flat, cool, five flavor distribution was mainly sweet, bitter, Xin, light, the medicine mainly concentrated in the spleen and lung meridian. The most frequent oral traditional Chinese medicine were 15 herbs, such as Poria cocos, radix glycyrrhizae, dried radix rehmanniae, dictamni cortex, Angelica sinensis and so on. The most frequent Chinese medicine for external use were 10 herbs, including cortex phellodendri, radix sophorae flavescentis, dictamni cortex, purslane, fructus kochiae and so on. Conclusion AD dialectical typing is mainly spleen deficiency type, complicated with dampness and blood dryness. Chinese oral decoctions centre the treatment as invigorating spleen and Qi, clearing damp, dispelling wind, nourishing blood and moistening dryness. External formula conforms to the principle as clearing heat, drying wet, detoxifying and relieving itching. The formula is mostly treating from spleen, which can provide reference for TCM clinical dialectical medicine.
2019 Vol. 16 (3): 124-127 [Abstract] ( 221 ) HTML (1 KB)  PDF (833 KB)  ( 92 )
128 Exploration of four-season theory of traditional Chinese medicine in traditional health physical education teaching in traditional Chinese medicine colleges and universities
LIU Xijuan1 ZHANG Jun2 SHI Zhenwen1
Based on the characteristics of traditional health physical education, this paper explores the application of the four-season health theory of traditional Chinese medicine in traditional health physical education, and puts forward the importance of the four-season theory of traditional Chinese medicine to traditional health physical education, proposing new ideas and methods for teaching, giving play to the teaching characteristics of traditional Chinese medicine colleges and universities, cultivating students′ traditional Chinese medicine thinking, improving the application ability of TCM theory, and leading traditional health physical courses in traditional Chinese medicine colleges and universities.
2019 Vol. 16 (3): 128-131 [Abstract] ( 220 ) HTML (1 KB)  PDF (746 KB)  ( 96 )
132 Analysis of the inheritance and protection of traditional Chinese medicine from the kampo medicine improvement
YU Huanghe1,2 ZENG Rong2 LI Xin1 WANG Wei2 CAI Xiong1
Kampo medicine is a medicine applied under the guidance of the localization of traditional Chinese medicine (TCM) to Japan. In the process of its development, it has formed a unique medical system. In recent years, national emphasis on TCM and TCM strength have made it more and more internationalized, and have got great contributions to the protection of human health. Therefore, the responsibility for the inheritance and protection of TCM is increasing. This article analyzes the cause of rapid development, supervision and research, patent protection and other factors from the background of kampo medicine. In order to inherit, protect and develop this important cultural resource, we put forward some measures to strictly supervise the quality of Chinese medicine, and attach importance to research and development and strengthen patent protection.
2019 Vol. 16 (3): 132-135 [Abstract] ( 259 ) HTML (1 KB)  PDF (747 KB)  ( 107 )
136 Thirst symptom differentiation and treatment from Li Dongyuan
GAO Ya AN Hong XU Shijie
Thirst is a common clinical symptom, this article summarizes Li Dongyuan′s understanding of thirst symptom and drug use, and puts forward that thirst is based on the disorder of Qi and fire as fundamental, primary location is spleen and stomach, and then spreads in turn of the other five internal organs: heart, lung, liver, kidney. The thought is presented that Li Dongyuan cured this symptom focusing on spleen and stomach and according to deficiency and excess change among the five internal organs. Discussion on the differentiation and treatment of thirst symptom by Li Dongyuan will help later generations to grasp the theory of spleen and stomach better, and find out the convenient way to distinguish and treat thirst and related diseases.
2019 Vol. 16 (3): 136-138,143 [Abstract] ( 183 ) HTML (1 KB)  PDF (765 KB)  ( 69 )
139 The influence of large area of warming moxibustion with moxa on the numbness of lower limb in lumbar disc herniation patients with syndrome of blockade of cold-dampness
SHI Xiaoli1 XIE Xiaolong2 WANG Peirong3 FANG Wei4 LI Hui4
Objective To investigate the influence of large area of warming moxibustion with moxa on the numbness of lower limb in lumbar disc herniation patients with syndrome of blockade of cold-dampness. Methods The clinical data of numbness of lower limb in 100 cases of lumbar disc herniation patients with syndrome of blockade of cold-dampness admitted to TCM Hospital of Meishan City in Sichuan Province from July 2017 to March 2018 was analyzed. The patients were divided into control group (conventional acupuncture) and observation group (large area of warming moxibustion with moxa) according to different treatment methods, with 50 cases in each group. The visual analogue scale (VAS), Japanese Orthopaedic Association (JOA) scores, lumbar motility of the two groups were observed before and after treatment. The clinical effect, satisfaction degree and recurrence rate within 3 months of two groups were compared. Results Before treatment, there were no statistically significant differences of the VAS score, JOA score, lumbar motility between the two groups (P ＞ 0.05). After treatment, the VAS scores of the two groups were lower than those before treatment, the JOA scores, lumbar motility were higher than those before treatment, and the VAS scores of observation group after treatment were lower than those of control group, the JOA scores and lumbar motility were higher than those of control group, the differences were statistically significant (P ＜ 0.05). The clinical total effective rate, satisfaction degree of observation group were higher than those of control group, the recurrence rate within 3 months was lower than that of control group, the differences were statistically significant (P ＜ 0.05). Conclusion The application of large area of warming moxibustion with moxa on the numbness of lower limb in lumbar disc herniation patients with syndrome of blockade of cold-dampness can relieve pain of patients, improve the prognosis recovery and curative effect, decrease recurrence rate, which is worthy of clinical promotion and application.
2019 Vol. 16 (3): 139-143 [Abstract] ( 232 ) HTML (1 KB)  PDF (827 KB)  ( 143 )
144 Clinical efficacy of warming needling therapy combined with Zusanli acupoint injection in the treatment of postpartum urinary retention
CHEN Pengdian1 ZHOU Chan2 NING Yan1 LIU Fang1 BEI Jianhong1 WANG Bo1 QIU Tingting1 QIU Xiaoling1
Objective To explore the clinical therapeutic effects of warming needling combined with Zusanli (ST36) acupoint injection in the treatment of postpartum urinary retention. Methods Total 94 patients with postpartum urinary retention admitted to Obstetrics Ward of Shenzhen Maternity & Child Healthcare Hospital Affiliated to Southern Medical University from August 2016 to June 2017 were divided into treatment group and control group by random number table method, with 47 cases in each group. The control group was given routine Zusanli acupoint injection with Neostigmine Methylsulfate solution, on basis of which, the treatment group was added with warming needling therapy, with the acupoints selection of Guanyuan (CV4), Qihai (CV6), Zhongji (CV3), bilateral Shuidao (ST28), bilateral Yinlingquan (SP9) and bilateral Sanyinjiao (SP6). The treatment lasted for 30 minutes each time, once per day for successive 2 days. The clinical therapeutic effects, the first time for automatic micturition and the bladder residual urine volumes between the two groups were compared. Results After treatment, the total effective rate was 91.4% in the treatment group and 66.0% in the control group, with highly statistically significant difference between the two groups (P ＜ 0.01). After treatment, the first time for automatic micturition and the bladder residual urine volumes in the treatment group were lower than those in the control group respectively, with highly statistically significant difference between the two groups (P ＜ 0.01). Conclusion Warming needling combined with Zusanli acupoint injection has definite therapeutic effects in the treatment of postpartum urinary retention, which can effectively accelerate the urination and reduce the bladder residual urine volumes and it is superior to the simple acupoint injection therapy.
2019 Vol. 16 (3): 144-146,154 [Abstract] ( 192 ) HTML (1 KB)  PDF (1096 KB)  ( 96 )
147 Clinical effects of needle knife combined with core muscle strength training in the treatment of lumbar intervertebral disc herniation
LIU Peng FENG Xiaoying
Objective To observe the clinic effects of needle knife combined with core muscle strength training in the treatment of lumbar intervertebral disc herniation (LDH). Methods Sixty cases of patients diagnosed as LDH and subordinated to the inclusion criteria in Outpatient and Inpatient Department of Rehabilitation in Shiyan Hospital of Integrated Chinese and Western Medicine of Hubei Province from July to November 2017 were divided into 2 groups by random number table method, with 30 cases in each group respectively. The treatment group was given needle knife combined with core muscle strength training, whereas, the control group was only given needle knife. Needle knife treatment was conducted once a week, with twice as a course of treatment; the course of core muscle strength training was 8 weeks. Results After treatment for 8 weeks and 3 months, the visual analogue scale (VAS) and Oswestry disability index (ODI) of the two groups were significantly lower than those before treatment, the differences were statistically significant (P ＜ 0.05), and the VAS scores and ODI values of treatment group were significantly lower than those of control group, the differences were statistically significant (P ＜ 0.05). Conclusion Compared with single needle knife treatment, needle knife combined with core muscle strength training has better effects on relieving patients′ pain, improving patients' dysfunction and enhancing quality of life, which is worthy of clinical promotion.
2019 Vol. 16 (3): 147-150 [Abstract] ( 265 ) HTML (1 KB)  PDF (467 KB)  ( 108 )
151 The mechanism of overall acupotome lysis in the treatment of anterior scalenus syndrome
ZENG Lin1 TANG Hongtu1,2 ZHANG Tianmin1,3
This paper explains the concept of former scalene syndrome, epidemiology, and needle knife applied anatomy knowledge of the disease, leading to the new cognition of acupotomology for the pathogenesis and pathological structure from the two aspects of human bowstring mechanics anatomical system in basic theories of acupotomology and pathological structure -- mesh theory respectively, and points out that the root cause of this disease is the force balance disorders of head - ridge - shoulder bowstring mechanics anatomical subsystem, head - ridge - chest bowstring mechanics anatomical subsystem and neck section bowstring mechanics anatomical subsystems, its essence is pathologic adhesion, scar and contracture, and its pathological framework is a three-dimensional network pathological framework with points, lines and facial bodies. At last, it is concluded that the overall acupotome lysis is used to treat the disease in accordance with specific conditions and in different parts according to the courses of treatment, so as to provide a new idea for clinical treatment of this disease.
2019 Vol. 16 (3): 151-154 [Abstract] ( 245 ) HTML (1 KB)  PDF (514 KB)  ( 62 )
155 Investigation and analysis of causes for nearly valid drugs in our hospital and discussion on solutions
SANG Wentao YU Fangrong LI Bo LUO Xuehu DUAN Jie WU Yao
Through collecting the data of the nearly valid drugs registered in the Outpatient and Hospitalized Pharmacy Department of Pidu District People′s Hospital of Chengdu City from January to December 2017 to analyze, it is determined that the key improvement is the injection and oral preparation, and the key management of the injection in the nearly valid is to manage the emergency injection preparation. This paper analyzes the causes leading to so many nearly valid drugs on pharmacy personnel, methods, equipment, materials and physicians five aspects, and the cause analysis questionnaire is carried out. The five main causes leading to so many nearly valid drugs: the drugs applied in individual clinical department are not used in time or the use rate is low; the dismantling drugs are not easy to manage; a few drugs for replacing packages or manufacturers leading to have a small amount of residual drugs not to be dispensed out; the nearly valid drugs are not timely inspected; the low use rate and poor management of emergency medicine; a long period of renewing of individual drug. According to the analysis of the present situation and causes, this paper discusses the measures in three aspects on improving the management regulations, strengthening the specific management and strengthening the education and training of relevant personnel, aiming at reducing the production of the nearly valid drugs, ensuring the quality of the drugs, ensuring the safety of the clinical medication and avoiding the waste of the drug resources.
2019 Vol. 16 (3): 155-158,178 [Abstract] ( 188 ) HTML (1 KB)  PDF (992 KB)  ( 143 )
159 A study on turnover intention of elderly nursing staff based on structural equation model
MIN Gui ZHAO Guoqin WANG Aiqin
Objective To explore the relationship among job embeddedness, emotional intelligence and turnover intention of the elderly nursing staff, and to verify the mediating effect on emotional intelligence. Methods A total of 202 elderly nursing staff in Jiangxi Province from January to March 2017 were selected. Convenient sampling method was used, and job embeddedness scale, emotional intelligence scale, turnover intention scale, in combination with occupation career cycle theory, a structural equation model was constructed with SPSS 24.0 and AMOS 24.0 software. Results Career cycle, gender, marital status, monthly income and education level were effective factors on job embeddedness, emotional intelligence and turnover intention (P ＜ 0.05). Job embeddedness was negatively related to turnover intention (r = -0.701, P = 0.000), while emotional intelligence was positively correlated with job embeddedness (r = 0.144, P = 0.041), negatively correlated with turnover intention (r = -0.638, P = 0.000). Emotional intelligence appears partially mediate impact of job embeddedness on turnover intention (ratio of mediating effects = 11.16%). Conclusion Elderly nursing staff with fine emotional intelligence are helpful for interpersonal relationship, harmony group life and peaceful working environment, and also can increase job embeddedness and organizing capability, which can reduce turnover intention and turnover rate.
2019 Vol. 16 (3): 159-162,封三 [Abstract] ( 195 ) HTML (1 KB)  PDF (903 KB)  ( 93 )
163 Effect of clinical pathway management in the standardization of wound therapists
FU Xiaoyu1 CHEN Xiaofen1▲ LIN Bailang2
Objective To explore the clinical routine of wound therapists and the standardization of their paths and treatment. Methods From November 2015 to October 2017, 260 patients with pressure ulcers, acute contusion and abrasion, and chronic wound admitted to the wound stomatology center of Haikou Hospital Affiliated to Xiangya Medical College of Central South University were selected as the research objects. According to the random number table method, they were divided into control group and research group, with 130 cases in each group. The patients in the control group were treated with conventional treatment methods, and the patients in the study group were treated with clinical pathway management. The clinical treatment effect, the occurrence of adverse reactions after treatment, the satisfaction rate of the patients and the complaint rate of the patients, as well as the changes of the skin quality of life of the two groups were compared. Results The total effective rate of the study group was significantly higher than that of the control group (P ＜ 0.05). The total incidence of adverse reactions in the study group was significantly lower than that in the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the satisfaction rate of patients in the study group was significantly higher than that in the control group (P ＜ 0.05), and the complaint rate was significantly lower than that in the control group (P ＜ 0.05). There was no statistically significant difference in skin quality of life between the pre-treatment study group and the control group (P ＞ 0.05). After treatment, the skin quality of life was improved in both groups, the study group was significantly superior to the control group in scores of psychology, physiology, interpersonal communication, social activities and family, with statistically significant differences (P ＜ 0.05). Conclusion The application of clinical routine and its pathological treatment for patients with pressure ulcers, acute contusions and chronic wounds has a high efficiency, which can effectively reduce the incidence of adverse reaction symptoms, reduce the patient′s complaint, alleviate doctor-patient relationships,and improve the quality of life of the patient's skin, it is worth promoting.
2019 Vol. 16 (3): 163-166 [Abstract] ( 209 ) HTML (1 KB)  PDF (619 KB)  ( 38 )
167 Comparison of clinical value of dynamic contrast-enhanced MRI and SPECT renal dynamic imaging of GFR measurement in the evaluation of renal function in renal transplantation
GU Hong LIU Dan LI Yunhe
Objective To compare the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and single photon emission computed tomography (SPECT) renal dynamic imaging of glomerular filtration rate (GFR) measurement in the evaluation of renal function in renal transplantation. Methods A total of 70 recipients who underwent renal transplantation in Baogang Hospital in Inner Mongolia from April 2015 to April 2018 were selected research as objeets. The transplanted renal GFR was measured by DCE-MRI and SPECT (GFR-MRI, GFR-SPECT respectively), and was compared with endogenous creatinine clearance rate (Ccr). The safety of contrast agents was evaluated in DCE-MRI detection. Results The GFR-MRI and Ccr values were more biased than GFR-SPECT, and the accuracy of 30% and 50% were higher than GFR-SPECT, and the difference was statistically significant (P < 0.05). Pearson correlation analysis showed that GFR-MRI and GFR-SPECT values were positively correlated with Ccr (P < 0.05), and GFR-MRI and Ccr correlation coefficients were higher than GFR-MRI and Ccr correlation coefficients, and the difference was statistically significant (P < 0.05). By Bland-A1tman analysis, the 95% confidential interval of GFR-SPECT was 95.49 mL/(min·1.73m2), and the 95% confidential interval of GFR-MRI was 62.35 mL/(min·1.73m2), and the confidential interval of GFR-MRI was narrower. Only 2 cases developed mild rash among 70 patients, and improved on their own without any treatment. Conclusion Compared with SPECT, the bias of GFR measured by DCE-MRI and Ccr is larger, but it has higher accuracy, correlation and consistency with Ccr, and has narrower confidential interval. DCE-MRI can more accurately evaluate renal function in renal transplantation through measuring GFR, and it has high safety.
2019 Vol. 16 (3): 167-170 [Abstract] ( 180 ) HTML (1 KB)  PDF (624 KB)  ( 69 )
171 Curative effect of potato chips on subcutaneous lipohypertrophy caused by insulin injection
SONG Yin1 ZHANG Xiaoyi2▲
Objective To observe the effect of potato chips on subcutaneous lipohypertrophy in patients with insulin injection. Methods From December 2015 to November 2016, 80 dzabetes mellitus patients who met the inclusion and exclusion criteria in the Affiliated Hospital of Nantong University were selected, and the patients were divided into the external application group and the control group by random number table. The external application group was treated with general nursing, health courses and external application of potato slices. The control group was given general nursing and health courses. The blood glucose and glycated hemoglobin were companed ketween the two groups be ore and after the intervention, and the effect of external application of potato chips on subcutaneous fat was observed. Results A total of 78 patients completed the study, including 38 patients in the external application group and 40 patients in the control group. After intervention, the efficacy of subcutaneous fat hyperplasia between the two groups was observed and compared, and the difference was statistically significant (P ＜ 0.05). There were significant differences in pain and leakage between the two groups (P ＜ 0.05). The difference in fasting blood glucose and HbA1c between the two groups before and after intervention were statistically significant (P ＜ 0.05). Conclusion Standard healthy education is an important guarantee to reduce the occurrence of local adverse reactions. Potato chips sticking can effectively treat the subcutaneous fat hyperplasia caused by insulin injection.
2019 Vol. 16 (3): 171-174 [Abstract] ( 199 ) HTML (1 KB)  PDF (662 KB)  ( 74 )
175 Comparative study on the classification of ICD-10 and ICD-11 in nervous system diseases
BAI Xue1 CUI Shengnan1 FENG Ming2 REN Huiling3 ZHANG Zhan4 LIU Zhenyu5 WANG Yi1
Objective To compare the distribution of nervous system diseases in ICD-11 and ICD-10. Methods They were compared from three dimensions in number and proportion on ICD-10 category, subhead category and ICD-11 4 bit code, 5 bit code and 6 bit code. Results There were 318 kinds of neurological diseases in ICD-11, while only 157 in ICD-10. Conclusion ICD-11 has a wide coverage and more detailed classification than ICD-10. Researchers can code in ICD-10 according to the distribution of ICD-11, who will code more accurate and the range of disease will be more comprehensive.
2019 Vol. 16 (3): 175-178 [Abstract] ( 320 ) HTML (1 KB)  PDF (621 KB)  ( 136 )
179 Diagnostic value of reticulated platelets, C-reactive protein and procalcitonin in secondary infection of acute leukemia
LI Ni
Objective To investigate the value of reticulated platelets, C-reactive protein (CRP) and procalcitonin (PCT) in patients with acute leukemia secondary infection. Methods Sixty patients with acute leukemia who were hospitalized in the Department of Hematology in Shuangshan Hospital in Anshan City from May 2017 to July 2018 were collecteded as leukemia secondary infection group, which were diagnosed as secondary infection according to etiology and imaging findings. At the same time, 60 healthy subjects were selected as the control group. The peripheral blood percentage of reticulated platelets (RP%)， CRP and PCT of the two groups were detected and recorded. Results The value of RP%, CRP and PCT of the leukemia secondary infection group were higher than those of the control group, the differences were highly statistically significant (P ＜ 0.01). The receiver operating characteristics curve (ROC) area of RP%, CRP and PCT in the diagnosis of leukemia secondary infection were 0.89, 0.66, 0.81; the ROC area of RP% in the diagnosis of leukemia secondary infection was the largest. Conclusion The value of reticulated platelets in diagnosis of leukemia secondary infection is higher than that of CRP and PCT.
2019 Vol. 16 (3): 179-封三 [Abstract] ( 169 ) HTML (1 KB)  PDF (742 KB)  ( 116 )
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