动态增强MRI与SPECT肾动态显像测定GFR评估肾移植术肾功能的临床价值比较

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Abstract Objective To compare the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and single photon emission computed tomography (SPECT) renal dynamic imaging of glomerular filtration rate (GFR) measurement in the evaluation of renal function in renal transplantation. Methods A total of 70 recipients who underwent renal transplantation in Baogang Hospital in Inner Mongolia from April 2015 to April 2018 were selected research as objeets. The transplanted renal GFR was measured by DCE-MRI and SPECT (GFR-MRI, GFR-SPECT respectively), and was compared with endogenous creatinine clearance rate (Ccr). The safety of contrast agents was evaluated in DCE-MRI detection. Results The GFR-MRI and Ccr values were more biased than GFR-SPECT, and the accuracy of 30% and 50% were higher than GFR-SPECT, and the difference was statistically significant (P < 0.05). Pearson correlation analysis showed that GFR-MRI and GFR-SPECT values were positively correlated with Ccr (P < 0.05), and GFR-MRI and Ccr correlation coefficients were higher than GFR-MRI and Ccr correlation coefficients, and the difference was statistically significant (P < 0.05). By Bland-A1tman analysis, the 95% confidential interval of GFR-SPECT was 95.49 mL/(min·1.73m2), and the 95% confidential interval of GFR-MRI was 62.35 mL/(min·1.73m2), and the confidential interval of GFR-MRI was narrower. Only 2 cases developed mild rash among 70 patients, and improved on their own without any treatment. Conclusion Compared with SPECT, the bias of GFR measured by DCE-MRI and Ccr is larger, but it has higher accuracy, correlation and consistency with Ccr, and has narrower confidential interval. DCE-MRI can more accurately evaluate renal function in renal transplantation through measuring GFR, and it has high safety.

Key words： Renal transplantation Dynamic contrast-enhanced MRI Single photon emission computed tomography Renal dynamic imaging

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	GU Hong LIU Dan LI Yunhe

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GU Hong LIU Dan LI Yunhe. Comparison of clinical value of dynamic contrast-enhanced MRI and SPECT renal dynamic imaging of GFR measurement in the evaluation of renal function in renal transplantation[J]. 中国医药导报, 2019, 16(3): 167-170.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I3/167

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