小儿嗜肺军团菌肺炎合并肺炎支原体感染预后的影响因素分析

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Abstract Objective To explore the risk factors of poor prognosis of children with Legionella pneumophila pneumonia combined with Mycoplasma pneumoniae infection. Methods The clinical data of 151 children with Legionella pneumoniae pneumonia complicated with Mycoplasma pneumoniae infection admitted to Maternal & Child Care Centre of Qinhuangdao from January 2014 to January 2017 were retrospectively analyzed. According to the prognosis, the children were divided into good prognosis group (n = 112) and poor prognosis group (n = 39). The risk factors of poor prognosis were identified by univariate analysis and multivariate logistic regression analysis. Results After routine comprehensive treatment of 151 children with Legionella pneumoniae pneumonia complicated with Mycoplasma pneumoniae infection, 112 cases had good prognosis, 39 cases had poor prognosis, and the incidence of adverse prognosis was 25.83%. There was no significant difference in genders between the poor prognosis group and the good prognosis group (P ＞ 0.05). The constituent ratios of the age＜5 years old, the course of disease≥7d, the history of using immunosuppressive agents, the peripheral blood CD4+/CD8+＜1.4, IgA＜0.69 g/L, with history of asthma and helicobacter pylori antibody positive of the poor prognosis group were significantly higher than those of the good prognosis group (P ＜ 0.05), all of which were the independent risk factors of poor prognosis of children with Legionella pneumophila pneumonia combined with Mycoplasma pneumoniae infection (OR = 3.362, 3.036, 3.753, 4.235, 3.897, 2.968, 3.562, P ＜ 0.05). Conclusion The poor prognosis of children with Legionella pneumophila pneumonia combined with Mycoplasma pneumoniae infection is related to age, course of disease, using of immunosuppressive agents, CD4+/CD8+ reduction, IgA reduction, asthma history and helicobacter pylori antibody positive, which has important guiding value for clinical treatment.

Key words： Children Legionella pneumophila Mycoplasma pneumoniae Risk factors

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	ZHANG Dongyan WANG Jianzhong LI Xuechao GU Yuxiu

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ZHANG Dongyan WANG Jianzhong LI Xuechao GU Yuxiu. Analysis of the influencing factors of prognosis of children with Legionella pneumophila pneumonia combined with Mycoplasma pneumoniae infection[J]. 中国医药导报, 2019, 16(3): 89-92.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I3/89

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