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| Research progress on the effect of Toll-like receptor 4 on brain injury and its treatment after hemorrhagic stroke |
| FENG Yuxuan YAO Shengtao KUANG Shuman YU Guoqing XIANG Chengming |
| Department of Cerebrovascular Disease, Affiliated Hospital of Zunyi Medical University, Guizhou Province, Zunyi 563000, China |
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Abstract Hemorrhagic stroke is a common acute and severe illness. The main cause of the disease usually refers to the rupture of vessels in the cerebral parenchyma or circle of willis. Recently, domestic and foreign experts and scholars divide it into many types according to the area of hemorrhage, and they find that the occurence of secondary brain damage will influence the patients prognosis through research and analysis. However, recent studies have found that Toll-like receptor 4 (TLR4) signal transduction pathways are widespread in post-cerebral hemorrhage inflammation, neuronal apoptosis, cerebral vasospasm and hydrocephalus, and we can reduce the incidence of brain injury by inhibiting TLR4 signaling pathways. Therefore, this article reviews the research progress on the effect of TLR4 on brain injury and its treatment after hemorrhagic stroke.
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