多囊卵巢综合征患者外周血RAS与胰岛素抵抗及脂代谢的关系

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Abstract Objective To investigate the relationship between the renin angiotensin system (RAS) in peripheral blood and insulin resistance and lipid metabolism in patients with polycystic ovary syndrome. Methods A total of 116 cases of patients with polycystic ovary syndrome from January 2015 to December 2017 treated in Xiamen Children′s Hospital ("our hospital" for short) were selected, which were divided into the insulin resistance group (HOMA-IR≥2.69, n = 47) and the non insulin resistance group (HOMA-IR<2.69, n = 69) according to insulin resistance index (HOMA-IR), and 60 cases of healthy women in our hospital were selected as the control group. Plasma renin activity (PRA), angiotensin Ⅱ (AngⅡ), fasting insulin (FINS), sex hormone, blood lipid and ultrasonic features were compared between the groups, and the correlation between each index and PRA, AngⅡ were analyzed. Results The insulin resistance group of peripheral blood PRA, AngⅡ, FINS, HOMA-IR, luteinizing hormone (LH), luteinizing hormone / follicle stimulating hormone (LH / FSH), testosterone (T) level were significantly higher than that in the non insulin resistance group and the control group, the peripheral blood PRA, AngⅡ, LH, LH/FSH, T level in the non insulin resistance group were significantly higher than the control group (all P ＜ 0.05). The levels of peripheral blood triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in the insulin resistance group were significantly higher than that of the non insulin resistance group and the control group (all P ＜ 0.05), peripheral blood TG, TC, LDL-C, high density lipoprotein cholesterol (HDL-C) and BMI in the non insulin resistance group were not significantly different from those in the control group (all P ＞ 0.05). The number of follicles and the resistant index of uterus artery (RI) in the insulin resistance group were significantly higher than those in the non insulin resistance group and the control group, RI of ovarian stromal artery was significantly lower than that in the non insulin resistance group and the control group (all P ＜ 0.05), ovarian volume, follicle number and RI of uterine artery in the insulin resistance group were significantly higher than the control group, RI of ovarian stromal artery was significantly lower than the control group (all P ＜ 0.05). PRA and AngⅡ in peripheral blood of patients with polycystic ovary syndrome were positively correlated with FINS, HOMA-IR, LH, LH/FSH, T, LDL-C, TG, TC, ovarian follicle number and RI of uterine artery (all P ＜ 0.05), and negatively correlated with RI of ovarian interstitial artery (all P ＜ 0.05). Conclusion Patients with polycystic ovary syndrome have hyperactivity of RAS in peripheral blood. The levels of PRA and AngⅡ can affect insulin resistance, lipid metabolism and follicle formation.

Key words： Polycystic ovary syndrome Renin angiotensin system Insulin resistance Lipid metabolism

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	FAN Kejun1 WANG Jian2

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FAN Kejun1 WANG Jian2. The relationship between RAS in peripheral blood and insulin resistance and lipid metabolism in patients with polycystic ovary syndrome[J]. 中国医药导报, 2019, 16(3): 84-88.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I3/84

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