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| Analysis of medication regularity of Professor LIN Yi in treatment of granulomatous mastitis based on data mining |
| XIE Wanjun1 LIN Yi2 ZHONG Shaowen2 SITU Honglin2 LIU Xiaoyan2 ZHU Huayu2 |
1.The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2.Department of Breast Disease, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Province, Guangzhou 510120, China |
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Abstract Objective To analyze medication rule of Professor LIN Yi in the treatment of granulomatous mastitis (GM) with the traditional Chinese medicine inheritance support system. Methods Effective cases with GM treated by Professor LIN Yi in Outpatient of Guangdong Provincial Hospital of Chinese Medicine from January 2014 to January 2018 were collected and input onto traditional Chinese medicine inheritance support system. The methods were used such as association rule, improved mutual information method, complex system entropy clustering were used to summarize the frequent used drugs by Professor LIN Yi in treatment for GM, and prescription-formulating principle was analyzed. Results A total of 68 patients and 349 prescriptions were involved. The top 10 most frequently used drugs were Platycodon Grandiflorum, Atractylodes Macrocephala, Pericarpium Citri Reticulatae Viride, Vaccaria Segetalis, Radix Curcumae, Taraxacum Mongolicum, Spina Gleditsiae, Squama Manitis, Rhaponticum Uniflorum, Concha Ostreae orderly. The most frequently existing properties were warm and placid, and bitter and sweet for most frequent existing tastes. The top three meridians were stomach, spleen and liver meridian. Association rules among the herbs were conformed, 6 core combinations and 3 new prescriptions were mined from the database. Conclusion The conclusion shows that Professor LIN’s experience in treating GM can be summarized as: cautiously grasping the pathogenesis of disease, supporting healthy energy to eliminate pathogens, combination the attack of pathogens and strengthening body resistance, treating both symptoms and radical. The disease is related to the all viscera and the treatment needs to start from many aspects, among which the liver and spleen are the most important organs, and finally achieve the goal of balancing the viscera. The treatment should be in accordance with seasonal-local conditions and patient′s individuality, plusing or subtracting drugs according to syndrome differentiation, combinating drugs appropriately, and using drugs gently.
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