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| Study on syndromes and treatment of atopic dermatitis treated by TCM based on association rule algorithm and entropy clustering of complex system |
| PEI Yue1 MO Xiumei2 ZENG Jianbo1 XUE Suqin2 YAN Fenggen2 CHEN Dacan2 LIU Junfeng2 LI Hongyi2 |
1.The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510095, China;
2.Department of Dermatological, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Province, Guangzhou 510120, China |
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Abstract Objective To analyze and discuss the experience of symptom differentiation of atopic dermatitis (AD) and its treatment with modern Chinese medicine. Methods Based on the association rule algorithm and entropy clustering of complex system, Chinese medicine literature database on the treatment of atopic dermatitis in CNKI, Wanfang, VIP, China biomedical literature database from January 1st 2017 to March 1st 2018 was retrieved. And a database containing syndrome differentiation, Chinese medicine for internal and external use was established. TCMISS V2.5 was used to analyze the data. Results The distribution of four Qi of traditional Chinese medicine was mainly warm, cold, flat, cool, five flavor distribution was mainly sweet, bitter, Xin, light, the medicine mainly concentrated in the spleen and lung meridian. The most frequent oral traditional Chinese medicine were 15 herbs, such as Poria cocos, radix glycyrrhizae, dried radix rehmanniae, dictamni cortex, Angelica sinensis and so on. The most frequent Chinese medicine for external use were 10 herbs, including cortex phellodendri, radix sophorae flavescentis, dictamni cortex, purslane, fructus kochiae and so on. Conclusion AD dialectical typing is mainly spleen deficiency type, complicated with dampness and blood dryness. Chinese oral decoctions centre the treatment as invigorating spleen and Qi, clearing damp, dispelling wind, nourishing blood and moistening dryness. External formula conforms to the principle as clearing heat, drying wet, detoxifying and relieving itching. The formula is mostly treating from spleen, which can provide reference for TCM clinical dialectical medicine.
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