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2018 Vol. 15, No. 5
Published: 2018-02-15
 
 
4 Effect of low-level vagus nerve stimulation on atrialfibrillation induced by obstructive sleep apnea in dogs
MENG Qingjun ZHANG Ling Jiasuoer·Xiaokereti WANG Xuesheng ZHOU Xianhui TANG Baopeng▲
Objective To investigate the mechanism of low-level vagus nerve stimulation (LL-VNS) in the treatment of atrial fibrillation (AF) induced by obstructive sleep apnea (OSA) in dogs. Methods Eighteen adult male healthy beagle dogs were randomly divided into three groups:control group (n = 6),OSA group (n = 6) and OSA + LL-VNS group (n = 6). All animals were intubated under general anesthesia. Both the OSA group and the LL-VNS group performed the same OSA process,which was suffocated for 2 min, ventilated for 8 min, and 10 min was a cycle lasting 6 h. The OSA + LL-VNS group was given LL-VNS from the third hour to the end of the experiment and the control group was not suffocated. The changes of blood gas indexes at 0, 1, 3 h, and 6 h, and inflammatory markers including tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2) and interleukin-6 (IL-6) at 0, 3 h and 6 h after modeling were detected. The canine arterial blood pressure was recorded throughout the whole experiment. At the end of the experiment, the atrial muscle tissue was taken for hematoxylin-eosin (HE) staining. Results OSA model was successfully established (P < 0.05). The systolic blood pressure of OSA group and OSA + LL-VNS group had significantly changed before and after OSA (P < 0.05), but there was no significant difference between the two groups (P > 0.05). Inflammation indicators-TNF-α, IL-2 at 6 hours in OSA group were significantly higher than the control group, but in OSA + LL-VNS group, it was significantly lower than the control group, the differences were statistically significant (P < 0.05). IL-6 showed no significant change in each time period (P > 0.05). In OSA group the atrial relative refractory period (ERP) was gradually shortened, and AF duration was gradually prolonged (P < 0.05). In OSA + LL-VNS group, from 0 h to 3 h the atrial ERP was gradually shortened and the duration of AF was gradually prolonged (P < 0.05); from 3 h to 6 h after given LL-VNS, the atrial ERP was gradually extended and AF duration reduced compared with 0 h to 3 h (P < 0.05). Compared with the control group, the HE slices of the atrial muscle in the OSA group showed that the atrial myocytes were disordered and the cell gap widened and After LL-VNS intervention, the above changes were reversed to some extent. Conclusion Inflammatory factors are positively correlated with the genesis and development of AF, and LL-VNS can reduce the incidence of AF. Therefore, reducing the body's inflammatory response may be one of the mechanisms by which LL-VNS reduces AF inducibility.
 
2018 Vol. 15 (5): 4-8 [Abstract] ( 228 ) HTML (1 KB)  PDF (1007 KB)  ( 95 )
9 Hyperbaric oxygen on the expression of ADAM10 of rat oligodendrocyte precursors in vitro after acute carbon monoxide poisoning
GUO Dazhi FENG Yuan HU Huijun LI Na PAN Shuyi
 Objective To investigate the effect of hyperbaric oxygen （HBO) treatment on the xpression of Oligodendrocyte Precursors （OPCs) ADAM10 mRNA in the acute carbon monoxide poisoning（ACOP) rats. Methods OPCs cells of neonatal rat were cultured in vitro and divided into three groups: control, ACOP and HBO groups. Control group: no treatment, ACOP group: the OPC cells were placed in a sealed container and injected with 1% carbon monoxide according to the volume ratio, HBO group: OPCs cells after ACOP were placed in animal experiments of hyperbaric oxygen chamber, with 98% O2, 2%CO2 washing 10 min, then 15 min 0.35 MPa pressure staying 2 h, at last 20 min reducing to normal pressure. The chamber temperature was controlled at 37℃. The end time of HBO treatment was set as 0 h, the three groups were collected at 6 , 24 h and 48 h for subsequent experiments. The expression of ADAM10 mRNA at 6, 24 h, and 48 h were detected by RT-PCR. Results 6, 24 h, and 48 h, the expression of ADAM10 mRNA was no change in control group, but gradually decreased in ACOP group, and increased in HBO group, there was statistically significant among the three groups (F = 8.491, P < 0.01). Compared with control group, the expression of ADAM10 mRNA at 6, 24, 48 h was significantly reduced in ACOP group, while was significantly increased in HBO group （F = 88.692, P < 0.01). Conclusion ADAM10 of OPCs may play an important role in the injury of central nervous system after ACOP and HBO.
2018 Vol. 15 (5): 9-12 [Abstract] ( 241 ) HTML (1 KB)  PDF (556 KB)  ( 176 )
13 Effects of Chaihuan Ningshen Granules on the behavior and hypothalamic-pituitary-adrenal axis of rats with insomnia with syndrome of stagnation of liver qi
DU Jianeng1 NIE Chunxia1 XU Wenwen2 LIU Cong2 KANG Yong2 NI Yan2 HAO Xuliang2
Objective To investigate the effects of Chaihuan Ningshen Granules on the behavior and hypothalamic-pituitary-adrenal (HPA) axis of rats with insomnia with syndrome of stagnation of liver qi induced by multifactor combination therapy. Methods Seventy SD rats (half male and half female) were randomly divided into 7 groups: blank group, model group, high, medium and low dose of Chaihuan Ningshen Granules groups (2.25, 1.125, 0.5625 g/kg), Jieyu Anshen Granules group (1.25 g/kg), Estazolam group (0.5 mg/kg). Except for the blank group, rats in each group were established for the model with syndrome of stagnation of liver qi by multifactorial stimulation including tie, pinch-tail and PCPA. Each administration group was treated daily with an oral infusion of corresponding drug, whereas, the blank group and the model group were given equal volume of saline once a day for 14 days. All rats were tested on the 0, 7th, 14th, 21st d for body weight, sugar consumption, sleep status, water maze navigation and spatial search ability to evaluate the behavior of rats, The levels of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and serum cortisol (CORT) in the hypothalamus of rats were detected by enzyme linked immunosorbent assay (ELISA). Results Compared with blank group, the body weight, sugar consumption, sleep duration and spatial search ability of the model group were significantly decreased, while the hypothalamic CRH, plasma ACTH, serum CORT and water maze positioning sailing time were markedly increased (P ＜ 0.05). Compared with the model group, all medicine groups could significantly increase body weight, sleep duration, consumption of sugar water and the number of crossing platform (P ＜ 0.05), meanwhile decrease the levels of the hypothalamic CRH, plasma ACTH and serum CORT, as well as water maze positioning sailing time, the differences were statistically significant (P ＜ 0.05). Conclusion Chaihuan Ningshen Granules can remarkably improve the behavior of rats with insomnia with syndrome of stagnation of liver qi, and prolong their sleep time, the mechanism underlying this event is mainly dependent on the improvement effect of Chaihuan Ningshen Granules on the function of HPA axis.
2018 Vol. 15 (5): 13-17 [Abstract] ( 216 ) HTML (1 KB)  PDF (788 KB)  ( 169 )
18 Effect of histone deacetylase inhibitor combined with HPV16E7-DNA vaccine in the treatment of cervical cancer and study on its mechanism
HUANG Zhuomin LI Qing YAO Xiuhua JIN Ping
Objective To investigate the effect of combination of histone deacetylase inhibitor (HDACI) Suberoylanilide Hydroxamic Acid (SAHA) combined with human papilloma virus 16 E7-DNA (HPV16E7-DNA) vaccine in the treatment of cervical cancer and its immunological mechanism. Methods The model of mice with TC-1 cervical cancer was made, then on the 5th day after tumor bearing, the mice were randomly divided into HPV16E7-DNA group, SAHA group, SAHA and HPV16E7-DNA group, control group by random number table method. The therapeutic regimen was as followed: HPV16E7-DNA group was given vaccine 5 μg/kg, SAHA group was given SAHA 20 mg/kg, SAHA and HPV16E7-DNA group was given vaccine 5 μg/kg+SAHA 20 mg/kg, the control group was given 100 μL phosphate solutions (PBS). Once every 3 days, total for 4 times. The tumor growth curve was drawn; the amount of CD8+T cells in peripheral blood of mice in each group was detected by flow cytometry; the effects of different doses of SAHA (25.0, 12.5 nmol/L) for the expression of H-2Kb of MHC class Ⅰ in TC-1 cells were detected by experiment in vitro. Results Compared with the other three groups, the tumor growth rate in SAHA and HPV16E7-DNA group was significantly slowed down, the amount of HPVE7 specific CD8+T cells in peripheral blood of mice was significantly increased (P ＜ 0.05). In-vitro experiment showed that compared with control group, the expression of H-2Kb of MHC class Ⅰ in SAHA group was increased significantly (P ＜ 0.05), while there was no significant difference between low dose of SAHA group and high dose of SAHA group (P ＞ 0.05). Conclusion HDACI combined with HPV16E7-DNA vaccine comes into significant anti-tumor effects may be through up-regulating expression of MHC class Ⅰ of the tumor cells and activating the immune response of CD8+T cells, which is expected to be used in the immunotherapy of cervical cancer.
2018 Vol. 15 (5): 18-21 [Abstract] ( 249 ) HTML (1 KB)  PDF (804 KB)  ( 122 )
22 Research progress of pathogenic mechanism of periodontitis and active oxygen
FANG Hui LIU QI
Recent studies suggest that the direct and indirect participation of oxidative stress is also a key factor in the destruction of periodontal tissue. Reactive oxygen species (ROS) is a product of oxidative stress in the body. It has become a hot research topic in the pathogenesis of periodontitis in recent years. Physiological levels of ROS can participate in physiological activities such as homeostasis, signal transduction and apoptosis in cells as second messengers. Excessive ROS play a cytotoxic role, causing oxidative damage to proteins , lipids and DNA, interfering with cell growth and cell cycle progression , and induce gingival fibroblast apoptosis. These effects of ROS together cause irreversible and direct damage to the periodontal tissue. In addition, ROS can also indirectly cause serious damage to periodontal tissues by activating inflammatory factors, nuclear factor κB (NF-κB), c-Jun N-terminal kinases and autophagy. This article summarizes the relationship between the excessive production of ROS and its activated signal transduction pathway and periodontitis, so as to provide evidence for further exploration of the correlation between ROS and periodontitis.
2018 Vol. 15 (5): 22-26 [Abstract] ( 243 ) HTML (1 KB)  PDF (527 KB)  ( 366 )
27 Research advance of animal models of colorectal precancerous lesion
ZHANG Huayue LI Qi FU Xiaoling
Colorectal cancer is one of the most common malignancies in the world, and aberrant crypt foci and adenomatous polyps are considered to be the most important precancerous lesions of colorectal cancer. This paper mainly describes the rectum related animal model method of precancerous lesions from two aspects: chemical induction and genetic engineering. The chemical induction method will introduce the method of establishing different models of categories, including colorectal inflammatory bowel disease related cancer model, classic aberrant crypt foci precancerous lesions, β-catenin-accumulated crypt precancerous model and sporadic colorectal adenomas polyps, while genetic engineering technology mainly argues from the gene mutation, gene knock out and related technology, and describes characteristics and applications of each building method in details, aiming at providing evidences for the research of animal models of colorectal cancer lesion.
2018 Vol. 15 (5): 27-31,36 [Abstract] ( 303 ) HTML (1 KB)  PDF (547 KB)  ( 188 )
32 Roles of peroxisome proliferator activated receptor β in cardiometabolic diseases
LIU Sen1.2 WANG Dan1.2 CAI Guocai1.2 WANG Peijian1.2
The prevalence and mortality rate of cardiometabolic diseases continue to rise, which seriously threaten human’s health. Peroxisome proliferator activated receptor β (PPARβ) and its ligands has the role of anti-inflammatory, anti-oxidative stress and improving the metabolism of glucose and lipid, that is to show the role of protecting cardiovascular and adjusting metabolism. In this paper, PPARβ and its ligands were reviewed in the aspects of lowering blood pressure, anti-atherosclerosis, improving endothelial function, reversing cardiomyocyte hypertrophy, improving insulin sensitivity and preventing obesity, to provide a reference for colleagues to further dig the prevention and treatment value of PPARβ on cardiovascular disease.
2018 Vol. 15 (5): 32-36 [Abstract] ( 301 ) HTML (1 KB)  PDF (524 KB)  ( 140 )
37 Progress in diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy
LI Qi1 ZHAO Dongjie1 WANG Yuhua1 DONG Sha1 CHANG Lei1 ZHANG Peng1 NI Yao2，3
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated peripheral neuropathy characterized by weakness and sensory disturbances that may be associated with other neurological disorders. In addition to the classic CIDP, there are many variants which easily lead to misdiagnosis, so that improving the diagnosis of variant CIDP is very important. Diagnosis usually incorporates clinical manifestations, electrophysiological examinations, and other supporting evidence, such as nerve biopsy, somatosensory evoked potential, cerebral spinal fluid examination, MRI and ultrasound support evidence, CIDP first-line treatment including corticosteroid (CS), intravenous immunoglobulin (IVIg), plasma exchange (PE) and immunosuppressive treatment. The purpose of this study is to review the clinical manifestations, diagnosis and treatment of CIDP.
2018 Vol. 15 (5): 37-40 [Abstract] ( 196 ) HTML (1 KB)  PDF (513 KB)  ( 140 )
41 Study on the status of knowledge and influencing factors towards Alzheimer's disease among school medical students in Suzhou
LYU Shujiao1,2 LI Huiling2 LIN Lu1,2
Objective To explore the degree of knowledge of Alzheimer′s disease (AD) and its influencing factors of the school medical students with different demographic characteristic in Suzhou. Methods From February to August in 2017, 603 school medical students were selected by convenience sampling method. They were surveyed by self-designed questionnaire, including their degree of knowledge of AD were assessed by the Alzheimer′s Disease Knowledge Scale (ADKS). Results The results of single factor analysis showed that female students′ scores in overall AD knowledge and such dimensions as course of disease, treatment and management were higher (P < 0.05). In general, graduate students′ scores were higher than undergraduates in overall AD knowledge and dimensions other than risk factors, impact on life and other areas of care (P < 0.05). Whether or not family members with AD, or had the experience of taking care of AD patients were related to ADKS total score and multiple dimension scores (P < 0.05). Multiple linear regression analysis indicated that the total score of ADKS was closely correlated with gender and academic degree (P < 0.05), female students′ scores were higher on the course of disease, treatment and management, and overall AD knowledge (P < 0.05), and the scored of students with experience of care were higher on symptoms and treatment and management (P < 0.05). Conclusion The school medical students of Suzhou have a poor acquisition of AD knowlege in an overall level. And it is necessary to make an education revolution, set up AD related thoery curriculumn and clinical practice, in order to facilitate the school medical students master professional knowledge and skill, which can provide more proficient medical service for AD patients and imporve their living quality.
2018 Vol. 15 (5): 41-45 [Abstract] ( 802 ) HTML (1 KB)  PDF (524 KB)  ( 122 )
46 Study on mental state of coal miners with functional dyspepsia
ZHANG Xiujing MA Lizhuan ZHANG Xuejun LI Zhiting ZHANG Guoshun
Objective To investigate the status of anxiety, depression and sleep quality in coal miners with functional dyspepsia (FD). Methods A total of 246 coal miners examined by gastroscopy in North China University of Science and Technology Affiliated Hospital were interviewed from April to August in 2016. Among them, 50 cases were completely healthy people (control group), 196 cases were FD patients (FD group). They were carried out psychological assessments by self-rating anxiety scale (SAS) and self-rating depression scale (SDS), and evaluated sleep quality was by Pittsburgh sleep quality index questionnaire (PSQI). Results The SAS score, depression index, and rates of anxiety and depression in the FD group were higher than those in the control group, with statistically significant difference (P < 0.05). The PSQI total score, subjective sleep quality, sleep latency, sleep time, sleep efficiency and daytime function scores, and sleep disorder rate in the FD group were higher in the control group, with statistically significant difference (P < 0.05). Conclusion Coal miners with FD are with high prevalence of anxiety, depression and sleep disorders. Management department and the health administrative departments should strengthen their psychological health education and the rational allocation of mental health resources.
2018 Vol. 15 (5): 46-48 [Abstract] ( 248 ) HTML (1 KB)  PDF (466 KB)  ( 81 )
49 Analysis of the utilization of antibiotics for special use in hospital patients in traditional Chinese medicine hospital
XIE Jing TAN Xiying▲ YAO Yi ZHANG Xiaoping ZHOU Zhuxiu
Objective To provide reference for clinical rational use and scientific management through analyzing the utilization of antibiotics for special use of inpatients in Jiangsu Province Hospital of TCM (“our hospital” for short). Methods The data and drug information of 4234 patients treated with antibiotics for special use in our hospital from January to December in 2016 were analyzed retrospectively. Results Such drugs were most applied in Department of Pneumology and Hematology. The rate of microbiological examination was 58.03%, which did not reach the national standard. The number of men was more than women. Most patients were the elder whose mean age was 68 years old. The mean time of usage was 7 days. Most patients were respiratory infections. The frequency of drug use in the first three was Cefepime, Imipenem / Cilastatin and Cefoselis respectively. Conclusion The application of antibiotics for special use for inpatients in our hospital is basically reasonable, but also needs to be further strengthened.
2018 Vol. 15 (5): 49-53 [Abstract] ( 279 ) HTML (1 KB)  PDF (477 KB)  ( 71 )
54 Effects of Metoprolol combined with Ivabradine in controlling the heart rate for the short-term prognosis of patients with emergency PCI
YI Rixia LI Peng LI Rui ZOU Yongguang HU Wei XU Jianhui WANG Dandan
Objective To investigate the effects of Metoprolol combined with Ivabradine for the heart rate control and short-term prognosis of patients with acute ST segment elevation myocardial infarction (STEMI) receiving emergency percutaneous coronary intervention (PCI) therapy. Methods The clinical data of 152 cases of patients with STEMI receiving emergency PCI admitted to Department of Cardiology, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology from July 2015 to July 2017 was analyzed retrospectively, and the patients were divided into combined treatment group (75 cases) and control group (77 cases). The combined treatment group received Metoprolol Succinate Sustained-release Tablets and Ivabradine to control heart rate strictly (resting heart rate≤65 times/min), control group only received Metoprolol Succinate Sustained-release Tablets to control heart rate (resting heart rate≤75 times/min). All patients were followed up for one month, the heart rate, left ventricular ejection fraction (LVEF), N-terminal probrain natriuretic peptide (NT-proBNP) and the occurrence of cardiovascular events of each patient were observed and recorded. Results One month after operation, the heart rate of the two groups was significantly lower than the second day after surgery, the levels of LVEF and NT-proBNP were higher than the second day after surgery, the differences were statistically significant (P ＜ 0.05). One month after operation, the heart rate of patients in the combined treatment group was significantly lower than that in the control group, the levels of LVEF and NT-proBNP were significantly higher than the control group, the differences were statistically significant (P ＜ 0.05). The rates of recurrence of angina pectoris (4.00% vs. 19.48%, P ＜ 0.05), repeat revascularization (2.67% vs. 14.29%, P ＜ 0.05) and malignant arrhythmia (1.33% vs. 10.39%, P ＜ 0.05) of combined treatment group were significantly lower than those of control group during the follow-up period of 1 month. Conclusion Metoprolol Succinate Sustained-release Tablets combined with Ivabradine can further control the heart rate of patients with emergency PCI, improve cardiac function and the prognosis of these patients, which is worthy of clinical promotion.
2018 Vol. 15 (5): 54-57 [Abstract] ( 290 ) HTML (1 KB)  PDF (455 KB)  ( 320 )
58 The value of resting heart rate in predicting early diabetic nephropathy in patients with type 2 diabetes mellitus
SU Dongyun
Objective To investigate the value of the resting heart rate (RHR) in predicting early diabetic nephropathy (EDN) in patients with type 2 diabetes mellitus. Methods One hundred and twenty patients with type 2 diabetes mellitus treated in department of internal medicine of Huai'an Maternity and Child Healthcare Hospital affiliated to Yangzhou university from January 2013 to December 2016 were selected as research objects. The enrolled patients were devided into RHR1 group (RHR≤70 times/min), RHR2 group (70 times/min＜RHR≤80 times/min) and RHR3 group (RHR≥80 times/min) according to the RHR. The changes of glycosylated hemoglobin, serum creatinine, blood urea nitrogen, estimated glomerular filtration rate and urinary microalbumin were observed. The receiver operating characteristic (ROC) curve in predicting EDN by the RHR was drawn. Results The urinary microalbumin and estimated glomerular filtration rate in RHR3 group were higher than those in RHR1 group and RHR2 group respectively, and the differences were statistically significant (P ＜ 0.05). The RHR were respectively positively correlated with systolic blood pressure, diastolic blood pressure, serum creatinine and urinary microalbumin (r < 0, P < 0.05) and negatively correlated with the estimated glomerular filtration rate and the heart rate difference between standing position and supine position ((r > 0, P ＜ 0.05). The area under the ROC curve of early renal injury predicted by RHR was 0.881 (0.806-0.956), the difference was statistically significant (P ＜ 0.05). The cutoff point of diagnosis was 78 times/min, sensitivity was 76.7%, specificity was 91.1%, positive predictive value was 71.8% and negative predictive value was 92.1%. Conclusion In patients with type 2 diabetes mellitus, the RHR is correlated with early injury parameters of renal function, and the RHR might be used as a warning indexes of the early diabetic nephropathy.
2018 Vol. 15 (5): 58-61 [Abstract] ( 236 ) HTML (1 KB)  PDF (529 KB)  ( 132 )
62 The influence of Trimetazidine on the cardiac function and levels of serum NT-proBNP and cTn-I in patients with coronary heart disease and acute heart failure
ZHU Hailong WANG Jun LIANG Yi ZHANG Yi WU Juan
Objective To investigate the influence of Trimetazidine on the cardiac function and levels of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTn-I) in patients with coronary heart disease and acute heart failure. Methods The clinical data of 96 cases of patients with coronary heart disease and acute heart failure admitted to ICU of the Second People's Hospital of Deyang City from February 2014 to March 2017 was analyzed retrospectively, and they were divided into control group and observation group by different treatment methods. 46 cases of control group were given diuretic Furosemide and vasodilator Nitroglycerin, and 50 cases of observation group were given diuretic Furosemide and vasodilator Nitroglycerin and Trimetazidine. Both groups were treated continuously for 7 d. Before and after treatment, the cardiac functional grading, the levels of NT-proBNP and cTn-I, and the clinical effects of two groups were observed. Results There were no statistically significant differences of cardiac functional grading, the levels of NT-proBNP and cTn-I between the two groups before treatment (P ＞ 0.05). After treatment, the cardiac functional grading of the two groups was better than that before treatment, and the levels of NT-proBNP and cTn-I in the two groups were lower than those before treatment, and the cardiac functional grading of observation group was better than that of control group, the levels of NT-proBNP and cTn-I in the observation group were lower than those of control group, the differences were statistically significant (P ＜ 0.05). The total effective rate of observation group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Trimetazidine in the treatment of patients with coronary heart disease and acute heart failure can significantly improve cardiac function, decrease the levels of serum NT-proBNP and cTn-I, with good curative effect, which is worthy of clinical promotion and application.
2018 Vol. 15 (5): 62-65 [Abstract] ( 225 ) HTML (1 KB)  PDF (491 KB)  ( 162 )
66 Relationship of cognitive function and depression in elderly patients with amnestic mild cognitive impairment
LIU Yan HUANG Xiaobo CHEN Wenqiang WANG Ningqun CHEN Yujing
Objective To investigate the relationship between cognitive function and depression in elderly amnestic mild cognitive impairment (aMCI) patients. Methods From January 2016 to February 2017, 105 elderly patients with mild cognitive impairment in Xuanwu Hospital Capital Medical University were selected, except 36 patients were not meet the inclusion criteria, finally, 69 cases of aMCI patients were studied. According to the scores of hamilton depression scale (HAMD), The elderly aMCI patients who met the study criteria were divided into aMCI non depression group (n=39) and aMCI depression group (n=30). In the same period, 38 normal elderly were selected as control group (NC group). The cognitive functions of the three groups were evaluated by the montreal cognitive assessment (MoCA) and the auditory verbal learning test (AVLT), and the correlation between the HAMD scores and the cognitive function with MoCA and AVLT was analyzed. Results The visual space and executive ability, naming, attention, delayed recall and total score of MoCA in aMCI non depression group and aMCI depression group were lower than those of NC group (P < 0.05, P < 0.01). The visual space and executive ability, attention, delayed recall and total score of MoCA in aMCI depression group were lower than those of aMCI non depression group (P < 0.05), among them, the score of delayed recall was the most significant (P < 0.01). The immediate recall, short delayed recall, long delayed recall, long delayed recognition and total score of AVLT in aMCI non depression group and aMCI depression group were lower than those of NC group (P < 0.01). The immediate recall, short delayed recall, long delayed recall and total score of AVLT in aMCI depression group were lower than those of aMCI non depression group (P < 0.05). The attention and delayed recall were significantly negatively correlated with each dimension score of HAMD (P < 0.05, P < 0.01), the visual space and executive ability, and the total score of MoCA were negatively correlated with each dimension scores (except weight) of HAMD (P < 0.05, P < 0.01). The anxiety/somatization, block and sleep disturbance were negatively correlated with each dimension score of MoCA and total score (P < 0.05, P < 0.01). The immediate recall, short delayed recall, long delayed recall and total score of AVLT were negatively correlated with each dimension scores of HAMD (P < 0.05, P < 0.01). The anxiety/somatization, block and sleep disturbance were negatively correlated with each dimension score of AVLT and total score (P < 0.05, P < 0.01). Conclusion The visual space and executive ability, attention, immediate recall and delayed recall of cognitive function in elderly aMCI patients with depressive disorder are lower than aMCI non depressive patients. Attention and delayed recall are significantly negatively correlated with anxiety, somatization, block and sleep disturbance in cognitive function of elderly aMCI patients.
2018 Vol. 15 (5): 66-70 [Abstract] ( 646 ) HTML (1 KB)  PDF (497 KB)  ( 218 )
71 Effects of motor imagery therapy combined with western medicine and rehabilitation training on balance function and surface electromyography in stroke patients with hemiplegia
JIANG Yuyan1 GUO Liangtang2
Objective To explore the effects of exercise imagery therapy combined with western medicine and rehabilitation training on balance function and surface electromyography (sEMG) in stroke patients with hemiplegia. Methods From May to December 2016, 70 cases of stroke patients with hemiplegia treated in Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Chinese Medicine were selected, and randomly divided into treatment group and the control group, with 35 cases in each group. The control group was treated by western medicine and routine rehabilitation training, and the control group was treated by the motor imagery therapy on the basis of the control group, and they were treated for 3 months. The simplified Fugl-Meyer assessment (FMA) (lower limb) and Berg balance scale (BBS) were used to evaluate the motor function and balance function of lower limbs, and the sEMG was used to measure the integrated electromyograph (iEMG) score and the root mean square amplitude (RMS) of quadriceps femoris, tibialis anterior muscle and gastrocnemius muscle of the two groups before and after treatment, and the time and phase parameters of three-dimensional gait [leg speed, stride frequency, stride length ratio (affected limb/healthy limbs)] was recorded, and the adverse events was observed at the same time. Results The scores of FMA and BBS after treatment in the two groups were all higher than before treatment (P < 0.05), and after treatment, the scores of FMA and BBS in the treatment group were higher than those of the control group (P < 0.05). The iEMG levels of quadriceps femoris, tibialis anterior muscle and gastrocnemius muscle after treatment in the two groups were all increased more than before treatment, while the RMS level was lower than before treatment (P < 0.05), and after treatment, the iEMG levels of quadriceps femoris, tibialis anterior muscle and gastrocnemius muscle in the treatment group were higher than those in the control group, while the RMS level was lower than that in the control group (P < 0.05). The leg speed, stride frequency, stride length ratio (affected limb/healthy limbs) after treatment in the two groups were all higher than before treatment (P < 0.05), and after treatment, the leg speed, stride frequency, stride length ratio (affected limb/healthy limbs) in the treatment group were higher than those of in the control group (P < 0.05). The incidence rate of adverse events in the treatment group was lower than that in the control group (P < 0.05). Conclusion Motor imagery therapy combined with western medicine and rehabilitation training can improve the motor function and balance function, and promote the recovery of quadriceps femoris and tibialis anterior and gastrocnemius muscle function with low adverse events, therefore it is worthy of clinical promotion and application.
2018 Vol. 15 (5): 71-75 [Abstract] ( 243 ) HTML (1 KB)  PDF (516 KB)  ( 217 )
76 The observations of clinical efficacy of press-needle combining thread embedding on treating patients with hand dysfunction after ischemic stroke
TAN Hui
Objective To observe the clinical efficacy of press-needle combine thread embedding on treating patients with hand dysfunction after ischemic stroke. Methods From January 2015 to December 2016, 60 patients with hand dysfunction after ischemic stroke in Department of Rehabilitation Medicine and Neurology of Guangzhou Twelfth people's Hospital were selected as research objects, and divided into treatment group and control group by random number table, with 30 cases in each group. The treatment group was treated by press-needle combined thread embedding on the basis of routine treatment, and the control group was treated by press-needle combined functional acupuncture on the basis of routine treatment. The curative effect was evaluated and compared before and after treatment by the Fugl-Meyer Assessment (FMA) and the Barthel Index (BI). Results After treatment, the FMA score and BI score in both group were all higher than before treatment (P < 0.05), and the treatment group was better than control group, the difference was statistically significant (P < 0.05). Conclusion Based on routine treatment, the treatment of press-needle combined thread embedding is better than press-needle combined functional acupuncture on treating patients with hand dysfunction after ischemic stroke.
2018 Vol. 15 (5): 76-79,88 [Abstract] ( 240 ) HTML (1 KB)  PDF (893 KB)  ( 134 )
80 Application of hysteroscopy in diagnosis and management of gestational trophoblastic disease
YANG Shuli WU Yumei LI WEI TIAN Ming MIAO Jinwei▲
Objective To study the value of diagnosis and treatment with hysteroscopy for gestational trophoblastic disease. Methods From January 2013 to January 2017, clinical data of 69 patients with GTD were admitted to Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, and underwent hysteroscopy was retrospectively analyzed. The and outcome of these patients were reviewed. Results Among these 69 patients, 42 cases were confirmed Hydatidiform moles, 5 cases underwent the first hysteroscopy and curettage, 37 cases underwent hysteroscopy and curettage again. None was residue after curettage. 27 cases were confirmed with GTN including invasive mole in 24 cases, choriocarcinoma in 2 cases, PSTT in 1 case. All the GTN except 1 patient with PSTT achieved complete remission by standard chemotherapy. 1 patient with PSTT was cured by lesion excision. No recurrence was fund in all the GTN patients. Conclusion Selective curettage of residual trohpoblastic tissue directed by hysteroscopy is safe and effective. Hysteroscopy is an effective alternative of diagnosis for GTN, and no effects on the prognosis.
2018 Vol. 15 (5): 80-83 [Abstract] ( 225 ) HTML (1 KB)  PDF (557 KB)  ( 174 )
84 Effect of radical hysterectomy with preservation of pelvic autonomic nerve on postoperative quality of life in patients with middle aged cervical cancer
LENG Shaohua1 WANG Yanzhou2 ZHAO Xiaolan3▲
Objective To analyze the effect of laparoscopic nerve sparing radical hysterectomy (LNSRH) with pelvic autonomic nerve preservation on postoperative quality of life in middle-aged patients with cervical cancer and to explore its clinical value. Methods One hundred and seventy-three cases of middle age cervical cancer treated in the Southwest Hospital of Army Military Medical University from July 2014 to July 2016 were analyzed retrospectively. According to the surgical procedure for the treatment of patients, 89 cases received LNSRH were included into the LNSRH group, while 84 patients treated with the conventional laparoscopic radical hysterectomy (LRH) were enrolled into LRH group. The situation of operation, recovery and complications of patients were compared between the two groups, and the cervical cancer function evaluation system (FACT-Cx) was used to evaluate the changes of life quality before and 6 months after surgery. Results The operative time in LNSRH group was longer than that in LRH group, and the difference was statistically significant (P < 0.05). There was no significant difference in the amount of bleeding and lymph node dissection between the two groups (P > 0.05). The indwelling time, residual urine volume, exhaust time and defecation time of LNSRH group were all lower than that in LRH group, and the differences were statistically significant (P < 0.05). The incidence of urinary retention in LNSRH group was lower than that in LRH group, and the difference was statistically significant (P < 0.05). In LNSRH group, there was no significant change in quality of life 6 months after operation (P > 0.05). The scores of additional attention items and FACT-Cx total score 6 months after operation in LRH group were significantly lower than those in preoperative group (P < 0.05). Conclusion The LNSRH surgery can effectively avoid pelvic nerve injury, shorten the postoperative function recovery of bowel and bladder, reduce postoperative complication risk and mitigate the adverse effects of surgery on the quality of life, is a safe and effective operation, worthy of promotion.
2018 Vol. 15 (5): 84-88 [Abstract] ( 229 ) HTML (1 KB)  PDF (566 KB)  ( 158 )
89 Etiological analysis of pediatric acute respiratory infection in Tongzhou District of Beijing
WU Hongbo1 LIU Wei1 YANG Hongxiu1 ZHANG Shuqin2 LI Lihua1
Objective To detect the common pathogens of acute respiratory tract infection (ARI) of children in Tongzhou District of Beijing, so as to provide clinical evidences for the prevention and treatment of children′s ARI. Methods Children with ARI were enrolled who hospitalized in the Children′s Center of Beijing Luhe Hospital, affiliated to Capital Medical University from September 1st, 2015 to Augest 31st, 2017. 2 mL of venous blood was collected, and 8 kinds of common respiratory pathogens IgM antibody were detected by indirect immunofluorescence, including RSV, ADV, INFA, INFB and PIVs. Then etiology tendency was analyzed. Results A total of 1319 children were enrolled and 962 positive samples were detected, accounting for 72.93%. Among them, MP positive detection was the most, accounting for 61.85%, followed by INFB, CPn, RSV, INFA, PIVs and ADV in turn. Among the positive samples, single pathogenic infection accounted for 58.63%, two pathogenic infection (double infection) accounted for 38.36% and three or more pathogenic infection (multiple infection) accounted for 3.01%. The most common pathogens combination of double infection was MP and INFB. Pathogens infection showed obvious seasonal changes. MP infection mainly concentrated in September to November. INFB infection increased from September, reached a peak in November and December, then decreased gradually, and reached a peak again in the following March (P < 0.05). The susceptible ages of different pathogens were significantly different (P < 0.05). The peak age of single pathogen infection (MP or INFB) was 3 years old, while the age of the highest positive rate of double infection (MP and INFB) was 11 months-3 years old. Positive detection rate of pathogens was similar in female and male (P > 0.05). Pneumonia was the main cause of hospitalization. Among them, double infection (MP and INFB) was the main cause, accounting for 25.83%, followed by MP infection and INFB infection, respectively accounted for 25.39% and 13.84%. Myocardial damage was the most common complication, accounting for 21.45%. Conclusion The main pathogens of respiratory tract infection in this region are MP and INFB. The main types of infection are single infection and double infection (MP+INFB). The number of cases increase from the fall, peak in winter and reach a small peak in the following spring again. The single infection mostly occurs in 3-6 years old and double infection mainly occurs in 11 months-3 years old.
2018 Vol. 15 (5): 89-93 [Abstract] ( 181 ) HTML (1 KB)  PDF (839 KB)  ( 264 )
94 Application of enteral nutrition tolerance management program in early enteral nutrition for children with severe sepsis
ZHANG Xianmin ZHANG Gang▲
Objective To explore the effect of enteral nutrition (EN) tolerance management on early EN tolerance in children with severe sepsis. Methods Ninety-six children with severe sepsis in pediatric intensive care unit (PICU) of the First People′s Hospital in Yibin from March 2015 to September 2017 were selected as the subjects. According to the order of admission time, the children were divided into the observation group and the control group, 48 cases in each group. Children of the two groups were given EN within 24-48 h after admission to PICU. The control group was given routine observation and treatment, and the observation group was evaluated by self-designed EN tolerance evaluation and management program. The tolerability during EN, nutrition index at PICU and 1 weeks after admission [serum total protein (TP), albumin (ALB), prealbumin (PA), fibronectin (FN), transferrin (TF), hemoglobin (Hb) and body mass index (BMI)], stay PICU time, hospitalization expenses and 28 d fatality rate were compared between two groups. Results The number of intolerance cases in the observation group during EN was lower than that in the control group (P < 0.05); the tolerance rate of EN in the observation group was higher than that in the control group (P < 0.05); the serum levels of TP, ALB, PA, TF and Hb in the observation group 1 week after EN were higher than those in the control group (P < 0.05); the PICU stay time, hospitalization expenses and 28 d fatality rate of the observation group were lower than those of the control group (P < 0.05). Conclusion Assessment and management of severe sepsis in children receiving EN support therapy using EN tolerance assessment management program can effectively improve EN tolerance, improve nutritional indicators and prognosis of children with severe sepsis.
2018 Vol. 15 (5): 94-97,112 [Abstract] ( 199 ) HTML (1 KB)  PDF (894 KB)  ( 62 )
98 Study of vaginal predominant bacteria and Lactobacilli in three kinds of vaginoplasty
LU lili LIU Jianhua▲
Objective To investigate the vaginal predominant bacteria distribution and the existence of Lactobacilli after sigmoid vaginopalsty, skin graft vaginoplasty and COOK soft tissue graft vaginoplasty. Methods Twelve women with sigmoid vaginopalsty, 12 women with skin graft vaginopalsty and 12 women with COOK soft tissue graft vaginopalsty from January 2014 to January 2016 in Shanghai Ninth People's Hospital Affiliated to School of Medicine of Shanghai JiaoTong University. These patients underwent vaginopalsty were selected. The vaginal discharge in the cases were collected respectively at 1 month, 6 months and 1 year after vaginopalsty. Various kinds of bacteria culture media were used to identify the predominant bacteria and to detect vaginal Lactobacilli in the cases. Results The predominant bacteria distributions in the three kinds of artificial vagina were different. The species of vaginal predominant bacteria varied at 1 month, 6 months and 1 year after vaginopalsty in some cases. Vaginal Lactobacilli had been found in 4 women with sigmoid vaginopalsty and 3 women with COOK soft tissue graft vaginopalsty. Conclusion The vaginal predominant bacteria distributions after the three kinds of vaginoplasty present their respective characteristics. Several patients with sigmoid vaginopalsty and with COOK soft tissue graft vaginopalsty have Lactobacilli in their artificial vagina. These patients′ vaginal microecological environment may be closer to that of healthy women.
2018 Vol. 15 (5): 98-102 [Abstract] ( 220 ) HTML (1 KB)  PDF (569 KB)  ( 178 )
103 Drug therapy and prognostic factors of postmenopausal women with breast cancer
FANG Jian1 WEN Shimin2 ZHAO Junjian1 TANG Zhili1 ZHANG Xinping2 CHEN Silin2
Objective To analyze the efficacy, safety and the related factors of S-1 and Capecitabine in treatment of advanced breast cancer in postmenopausal women's. Methods From January 2013 to June 2015, 61 cases of menopausal women with advanced breast cancer admitted to Department of Oncology in Nanchong Central Hospital were selected as subjects, and all subjects were randomly divided into S-1 treatment group (31 cases) and Capecitabine treatment group (30 cases) by random number table. The clinical efficacy and prognosis of the two groups were compared and prognostic factors of all patients were analyzed. Results There was no significant difference in rate of ORR (32.26% vs. 30%, χ2=0.036, P=0.849), DCR (67.74% vs. 63.33%, χ2=0.131, P=0.717) in S-1 group and Capecitabine group, and there was no significant difference in median PFS time between the two groups (5.7 months vs. 5.1 months, χ2=0.107, P=0.744). The incidence of hyperbilirubinemia of the S-1 group was higher than that of the Capecitabine group (χ2=10.227, P=0.001), and the incidence of hand foot syndrome of the Capecitabine group was higher than that of the S-1 group (χ2=10.377, P=0.001). Disease free survival and the number of metastases was independent factors of PFS. Conclusion The clinical efficacy of S-1 and Capecitabine in treatment of advanced breast cancer in postmenopausal women is equivalent, and all can obtain good curative effect, the adverse reaction is slightly different, but all can be tolerated.
2018 Vol. 15 (5): 103-106 [Abstract] ( 220 ) HTML (1 KB)  PDF (458 KB)  ( 119 )
107 Survival analysis of chemotherapy and Targeted therapy for patients with advanced non-small-cell lung cancer and EGFR mutated-unknown
ZHANG Chongguo1 WANG Jirong1 LI Juan1 WANG Keming1 WANG Zhaoxia1 LI Yadong2
Objective To compare and analyze the overall survival (OS) of patients with advanced non-small-cell lung cancer and EGFR mutated-unknown after the treatment of EGFR-TKI and intercalated combination of chemotherapy and EGFR-TKI. Methods Clinical data of 58 patients with advanced histopathology confirmed non-small-cell lung cancer and EGFR mutated-unknown treated in the Second Affiliated Hospital of Nanjing Medical University from January 2010 to December 2014 was analyzed retrospectively. 36 patients were treated with intercalated combination of chemotherapy and EGFR-TKIs (rotational therapy group) and 22 patients were treated with chemotherapy alone (chemotherapy group). The survival rate was calculated by Kaplan-Meier method and compared by Log-rank test. Cox single and multivariate prognosis analysis was performed. Results 22 patients received chemotherapy, the median age was 28 years, the mean age was 30.444 (*) ± 5.122.36 patients received intercalated combination of chemotherapy and EGFR-TKI, the median age was 36 years, the mean age was 42.740 (*) ± 3.668. There was significant difference in OS between the intercalated combination of chemotherapy and EGFR-TKIs and chemotherapy groups (P=0.0413). Drug treatment modalities was the only predictor of OS (P=0.047, 0.008), while cigarette smoking, age, pathology, and sex were not (P > 0.05). Conclusion Intercalated combination of chemotherapy and EGFR-TKIs treatment is better than chemotherapyin the advanced non-small-cell lung cancer with EGFR mutated-unknown.
2018 Vol. 15 (5): 107-112 [Abstract] ( 213 ) HTML (1 KB)  PDF (693 KB)  ( 137 )
113 Significant of serum albumin, prealbumin, retinol binding protein and transferrin in postoperative parenteral nutrition support of gastric cancer
LIU Huilin1 ZHANG Dan2 DENG Xiangzhu3 LUN Limin2
Objective To study the nutritional monitoring value of serum albumin (ALB), prealbumin (PA), retinol binding protein (RBP), and transferrin (TRF) in parenteral nutrition support for patients after gastric cancer surgery. Methods From June 2016 to June 2017, 80 patients with gastric cancer surgery stayed in the Gastrointestinal Surgery, the Affiliated Hospital of Qingdao University were selected, and they were started with total parenteral nutrition (TPN) (≥5 d) on the first day after gastric cancer surgery. The serum specimen of blood routine examinations on the day of hospital admission (before surgery), on the first day and the sixth day after surgery were collected respectively, and changes of ALB, PA, RBP and TRF level in serum were measured respectively as well. Results ①Concentration changes of ALB, PA, RBP and TRF before surgery, on the first day after surgery and the sixth day after surgery were comparerd, the differences were statistically significant (P < 0.01). ②On the first day after surgery, ALB, PA, RBP and TRF dropped compared with before surgery, the differences were statistically significant (P < 0.01). ③On the sixth day after surgery, ALB, PA, RBP and TRF climbed up compared with the first day after surgery, the differences were statistically significant (P < 0.01). ④On the sixth day after surgery, PA and RBP were compared with before surgery, the differences were not statistically significant (P > 0.05), and ALB and TRF were compared with before surgery, the differences were statistically significant (P < 0.05). Conclusion Serum ALB, PA, RBP and TRF can reflect patients′ nutritional status and they play a guiding role in parenteral nutrition support for patients after gastric cancer surgery.
2018 Vol. 15 (5): 113-116 [Abstract] ( 243 ) HTML (1 KB)  PDF (546 KB)  ( 131 )
117 Influence factors of treatment delay in patients with acute myocardial infarction and countermeasures
RAO Hanwei ZHONG Ze▲ ZHOU Yan
Objective To discuss the influenc factors of treatment delay in patients with acute ST-segment elevation myocardial infarction (STEMI) and countermeasures. Methods From March 2014 to June 2017, in the First Peoples′ Hospital of Jiande, 304 STEMI patients were selected, the patients′ sex, age, combined disease, personal history, educational level, symptoms, physical examination, laboratory tests, electrocardiogram and other information, record patients to emergency time, electrocardiogram time, call consultation time, preoperative talk time, preoperative preparation time, catheterization room staff in place, operating room preparation time, patients′ DTB time, the correlation between factors and DTB time correlation was observed. Results Among the 304 patients, 238 patients had DTB≤90 min, accounting for 78.29%, and 66 patients had DTB > 90 min, accounting for 21.71%. Electrocardiogram-consultation time, consultation-completion time of conversation in patients with DTB > 90 min were significantly lower than those in patients with DTB≤90 min, the differences were statistically significant (P < 0.05), but emergency-ECG time, preoperative preparation time, catheterization staff in-service time and operating room preparation time were comapared, the differences were not statistically significant (P > 0.05). Univariate analysis showed that ethnicity, age, household location, number of family members, smoking, drinking, hypertension, hyperlipidemia, diabetes and infarction were not the influence factors of DTB time (P > 0.05). Gender, first onset, family monthly income, patients with STEMI, family knowledge of stemi, cost of payment, educational level, history of prior PCI, typical STEMI symptoms, STEMI symptoms, secondary reciprocation, symptoms-non-work-time visits were influence factors of DTB time (P <0.05). Multivariate Logistic analysis showed that first onset and non-working hours were independent risk factors of DTB (P <0.05). Typical clinical symptoms, typical STEMI electrocardiogram, troponin positive, education above junior college were protective factors of DTB (P < 0.05). Conclusion ECG-consultation time, consultation-completed the talk is the main reason for delays caused by DTB, clinic can be given optimize the green channel, optimize the intervention process, optimize conversation skills, and so on, in order to shorten the DTB.
2018 Vol. 15 (5): 117-121,126 [Abstract] ( 246 ) HTML (1 KB)  PDF (552 KB)  ( 146 )
122 Clincal effect of PFNA and external fixation in elderly patients with highrisk of intertrochanteric fracture
TIAN Yafeng YAO Xingbao YANG Gang YU Jian ZHU Yanfeng WEN Zhigang HAN Kun
Objective To investigate and compare the clinical curative effect between the external fixation and the proximal femoral nail antirotation (PFNA) in high-risk elderly patients with intertrochanteric fracture. Methods Sixty elderly patients with high-risk of intertrochanteric fracture in Department of Orthopaedics and Traumatology, Hebei Provincial Hospital of Traditional Chinese Medicine from January 2015 to January 2017 were selected. Patients were divided in two groups regarding to treatment. In group A (n=30), all patients were treated with external fixator under local anesthesia, while in group B (n=30) were treated with PFNA under subarachnoid anesthesia or general anesthesia. The changes of Hb and ALB before and after operation were recorded, meanwhile the operation time, the amount of intraoperative bleeding, the number of intraoperative fluoroscopy, the bed time after operation, and the Harris hip joint score at 6 months after operation were recorded. Results All patients received satisfactory reduction during operation, the fixator was well accepted and no patient had significant difficulties while sitting or lying. The decrease of Hb and ALB after operation were lower in group A than that in group B, and the difference between the two groups was statistically significant (P < 0.05). The operation time, the amount of intraoperative bleeding, the number of intraoperative fluoroscopy and the days of hospitalization were lesser in group A than those in the group B, and the difference between the two groups was statistically significant (P < 0.01). The hip joint score after operation has no statistically significant difference between the two groups (P > 0.05). 3 patients in group B had pin-track infection of grade Ⅱ, and all patients were treated by oral antibiotics and dressing. All patients had no complications such as the loss of fracture position, the withdrawal of screw or the fixed needle, wound infection postoperative and bedsore. Conclusion External fixation is an safe and effective treatment for intertrochanteric fractures in elderly high risk patients. It has advantages include quick and simple application, low risk of anesthesia, short operative time, less bleeding during operation, less radiation exposure, adequate fixation, early discharge from hospital, obvious pain relief and low treatment cost.
2018 Vol. 15 (5): 122-126 [Abstract] ( 286 ) HTML (1 KB)  PDF (572 KB)  ( 156 )
127 Effect of comprehensive intervention on rehabilitation of patients with severe mental disorders
CHU Qingwen SUN Qiufang LU Yi ZHANG Zhanxing SONG Feng
Objective To discuss the clinical effect of comprehensive intervention on the rehabilitation of patients with severe mental disorders. Methods From July 2014 to June 2015, 83 patients with severe mental disorders and registered in Mental Health Center of Shanghai Baoshan District were selected, all patients received comprehensive intervention included health education, psychological intervention, diet intervention, exercise intervention. The patient′s condition, the doctor′s advice, labor ability and quality of life before and after the intervention were compared. Results The stability degree of patients before and after intervention was compared, the difference was statistically significant (P < 0.05). After the intervention, the proportion of convalescent patients was significantly higher than before the intervention, and the proportion of patients with recurrence after intervention was significantly lower than before intervention, the differences were statistically significant (P < 0.05). The labor ability of the patients before and after intervention were compared, the difference was statistically significant (P < 0.05). After the intervention, the proportion of no working ability was significantly lower than that before the intervention, the difference was statistically significant (P < 0.05). The prescribed medication compliance of patients before and after the intervention were compared, the differences were statistically significant (P < 0.05). After the intervention, the proportion of full compliance was higher than before the intervention, the noncompliance ratio was lower than before the intervention, the differences were statistically significant (P < 0.05). The physical function, psychological function, social function, material life and the total scores of GQOLI-74 after intervention were significantly higher than those before intervention, the differences were statistically significant (P < 0.05). Conclusion Comprehensive intervention can significantly improve the community patients with severe mental disorders disease, increase the treatment compliance, and improve the ability to work and quality of life of patients, promote the rehabilitation of diseases, which has important application value, worthy of promotion.
2018 Vol. 15 (5): 127-130 [Abstract] ( 323 ) HTML (1 KB)  PDF (539 KB)  ( 174 )
131 Analysis on the literatures of adverse reactions of Polygonum multiflorum and its preparations
GAO Guiyuan1 LUO Yuanlin1▲ HUANG Jie1 YU Jian1 ZHANG Guoli1 ZHANG Fang1 SHAO Yingxin2
Objective To explore the characteristics and general rules of adverse drug reactions (ADRs) and the mechanism of liver damage of Polygonum multiflorum and its preparations, and provide reference for clinical rational drug use. Methods The literatures of ADRs induced by Polygonum multiflorum and its preparations, retrieved from Wanfang data knowledge service platform, VIP info, CNKI, PubMed and food and drug administration website at home and abroad from January 2000 to September 2017, were statistically analyzed. Results A total of 84 reports in China (429 cases)and 9 reports abroad (39 cases), involving 468 cases induced by Polygonum multiflorum and its preparations, were collected. Main clinical manifestations were the liver damage. Polygonum multiflorum-induced ADRs had a high occurrence rate in the people over 40-＜50 years old [26 cases (34.21%) in China, 13 cases (40.63%) abroad], most ADRs occurred in 16-30 days after the medication [87 cases (48.07%) in China, 10 cases (33.33%) abroad]. The proportion of male was less than that of female in China (46.60% vs. 53.40%), the proportion of male was more than that of female abroad (56.41% vs. 43.59%). The ADRs could be caused by the different degrees of processing, normal dosage and overdose. Good prognosis could be obtained by most cases, while there were 3 death cases. Liver damage could be induced by means of metabolic abnormality, immune stress response and liver cell apoptosis, and so on. Conclusion Polygonum multiflorum and its preparations can induce serious ADRs and the occurrence of ADRs is associated with a variety of factors. It is necessary to pay more attention to the ADR of liver damage, clinical pharmacist should take initiative to monitor ADR and give close observation to the reactions of medication, so as to ensure the safety of medication.
2018 Vol. 15 (5): 131-135 [Abstract] ( 278 ) HTML (1 KB)  PDF (490 KB)  ( 127 )
136 Analysis on the application situations of antibacterial agents in patients with community-acquired pneumonia
SHENG Chunqin1 ZHU Jingjie1 FENG Tingting2
Objective To explore the application situations of antibacterial agents in patients with community-acquired pneumonia (CAP) in Zhujiajiao People′s Hospital of Qingpu District in Shanghai City (“our hospital” for short), so as to improve the rationality of clinical application of antibacterial agents. Methods The medical history of patients diagnosed as CAP in all medical records of our hospital from January 2016 to June 2017 was summarized retrospectively. The type of antibacterial agents, frequency, drug combination, course of treatment, therapeutic effect and so on were analyzed statistically, the drug utilization index (DUI) was used as judging indicator of drug use. Results Among the antibacterial agents of CAP treatment in our hospital, the top three of use frequency was cephalosporins, fluoroquinolones and penicillins, the most widely-used was Cefotiam, all was in double combinations, the most common was combination of cephalosporins and fluoroquinolones [14 cases (33.33%)], the course was (5.28±3.83) d. Among 153 cases of patients, 50 cases (32.68%) were cured, 98 cases (64.05%) were improved, 2 cases (1.31%) were not healed, 3 cases (1.96%) were discharged or transferred. There were 4 kinds (26.67%) of antibacterial agents with DUI ranged from 0.9 to 1.1, 3 kinds (20.00%) of antibacterial agents with DUI＜0.9, 8 kinds (53.33%) of antibacterial agents with DUI＞1.1. Conclusion The total application situations of antibacterial agents in patients with CAP in our hospital are basically reasonable, but there are still some disadvantages and the drug use still needs further standardized.
2018 Vol. 15 (5): 136-139 [Abstract] ( 288 ) HTML (1 KB)  PDF (436 KB)  ( 75 )
140 Influencing factors of sleep disorders and nursing strategies for patients with chronic sinusitis
CHEN Jing LEI Weiwei HUA Qingquan▲
Sleep disorder is one of the common complications for patients with chronic sinusitis, which has high morbidity and affects the treatment and rehabilitation process of the patients. The mainly risk factors for the onset of sleep disorders in patients with chronic sinusitis include inflammatory factors, disease symptoms, psychological problems and external environment. This paper reviewed the influence factors and summarized the nursing intervention of sleep disorders, so as to provide theoretical supports and practical references for the nursing of patients with chronic rhinosinusitis.
2018 Vol. 15 (5): 140-143,147 [Abstract] ( 224 ) HTML (1 KB)  PDF (614 KB)  ( 147 )
144 Effect of comprehensive nursing intervention on neurological function recovery in patients with ischemic stroke
SAN Jianchao1 LYV Zheng2▲
Objective To investigate the effect of comprehensive nursing intervention on neurological function recovery in patients with ischemic stroke. Methods From July 2014 to February 2016, 106 patients with ischemic stroke treated in the First Affiliated Hospital of Harbin Medical University were selected as the research subjects and divided into the control group and the study group according to the random number table, with 53 cases in each group. The control group was given routine nursing intervention, while the study group was given comprehensive nursing intervention on the basis of the control group. The recovery of neurological function, the recovery of daily activiy and the incidence of nursing satisfaction were compared before and after the intervention of 1, 2, 4 weeks. Results After the intervention of 1, 2, 4 weeks, the scores of clinical neurological deficits were lower and the scores of daily activity ability were higher than those of before intervention, and the study group improved much more remarkably, with statistically significant differences (P ＜ 0.05). The total incidence of nursing satisfaction of the patient in the study group was higher than that of control group, with statistically significant difference (P ＜ 0.05). Conclusion Comprehensive nursing intervention can effectively promote the recovery of neurological function and motor function in patients with ischemic stroke, improve the nursing satisfaction and the prognosis of patients. It is worthy of clinical promotion and application.
2018 Vol. 15 (5): 144-147 [Abstract] ( 245 ) HTML (1 KB)  PDF (627 KB)  ( 113 )
148 Clinical effect of rhubarb powder sticking at Shenque point in the treatment of patients with slow transit constipation after acupotomology
JI Liandi1 JI Hui1 ZHOU Jianbin2
Objective To investigate the effect of rhubarb powder at Shenque point in the treatment of patients with slow transit constipation after acupotomology. Methods From June 2015 to December 2016, 100 clinical data of patients treated in Nanjing Integrated Traditional Chinese and Western Medicine Hospital were analyzed retrospectively and divided into the control group (48 cases) and the treatment group (52 cases) by different treatment. The control group was given routine treatment, while the treatment group was given rhubarb powder sticking at Shenque point after acupotomology, with 24 h per time, 3 days for a course. The total effective rate, first time defecation, symptom scores and nursing satisfaction were compared between the two groups. Results The total effective rate in the treatment group was (90.38%) higher than that of control group (85.42%), but with no statistically significant difference (P ＞ 0.05). The first time defecation in the treatment group [(14.5±6.4) h] was shorter than that of control group [(18.7±1.2) h], with statistically significant difference (P ＞ 0.05). The symptom scores after treatment in the two groups were all lower than those of before treatment, with statistically significant differences (P ＞ 0.05); but after treatment, there was no statistically significant difference between the two groups (P ＞ 0.05). The nursing satisfaction in the treatment group was higher than that of control group, with statistically significant difference (P ＞ 0.05). Conclusion The efficacy of rhubarb powder at Shenque point in the treatment of patients with slow transit constipation after acupotomology is good. It is worthy of clinical promotion and application.
2018 Vol. 15 (5): 148-150,176 [Abstract] ( 246 ) HTML (1 KB)  PDF (999 KB)  ( 130 )
151 The correlation between quality of life and symptom distress in patients with thoracoscopic and laparoscopic esophagectomy
YAN Xuemei1 HAN Yan2 MA Lijuan1 SU Jianping3
Objective To investigate the relationship between symptom distress and quality of life in patients with thoracic and laparoscopic radical resection of esophageal carcinoma. Methods From December 2016 to April 2017, 94 patients with esophageal cancer treated by thoracic laparoscopy combined with radical resection of esophageal carcinoma were investigated by convenient sampling method, and the status of symptom distress and the quality of life score were analyzed. Pearson correlation analysis was used to analyze the correlation between symptom distress and quality of life after radical resection of esophageal carcinoma. Results The most plagued for patients with thoracic laparoscopy combined with radical esophagectomy was the concern for the prospects, the rest in turn were the appearance changes, fatigue, pain, insomnia, loss of appetite and so on. The score of cognitive functional dimension was the highest and the somatic functional status were the lowest in all functional areas of postoperative quality of life. There were no significant differences in the scores of cognitive function, emotional function, diarrhea when compared with Norwegian norm in symptom domains and single item (P ＞ 0.05);the scores of physical function, role function, social function, general health status, constipation and pain were lower than the norm, with statistically significant differences (P ＜ 0.05); Shortness of breath, loss of appetite, fatigue, nausea and vomiting, insomnia, economic difficulties were higher than the norm (P ＜ 0.05). Pearson correlation analysis showed that the scores of symptom distress were negatively correlated with the overall health status, physical function, emotional function, social function, cognitive function and role function of quality of life (P ＜ 0.001). Conclusion After radical resection of esophageal cancer, the symptoms of the patients are common and suffer from multiple symptoms, the quality of life is at a low level. Nursing staff should pay attention to the evaluation and management of patients' symptoms, pay attention to the outcome of nursing care, so as to improve the quality of life in patients with esophageal cancer after operation.
2018 Vol. 15 (5): 151-155 [Abstract] ( 212 ) HTML (1 KB)  PDF (636 KB)  ( 155 )
156 The body temperature protective effect of inflatable warming blanket during transurethral prostatectomy and its influence on the coagulation function of the patients
XIA Ying1 LIU Yi1 HAN Wenjun2
Objective To investigate the body temperature protective effect of inflatable warming blanket during transurethral prostatectomy (TURP) and its influence on the coagulation function of the patients. Methods From February 2016 to July 2017, 126 patients with benign prostatic hyperplasia in Changhai Hospital were selected and divided into the control group and the observation group, with 63 cases in each group. The control group was given conventional body temperature intervention, while the observation group was given inflatable warming blanket on the bases of control group. The perioperation body temperature, coagulation function before and after surgery and the incidence of complications were compared between the two groups. Results The one-way analysis of variance showed that there were statistically significant differences in the two groups before and after different time points of anesthesia (F=46.24, 92.86, P ＜ 0.05). There were no statistically significant differences before and after anesthesia of 15 min between the two groups (P ＞ 0.05). After anesthesia of 30, 45, 60 min and at the end of operation, the temperature in the observation group were higher than those of control group, with statistically significant differences (P ＜ 0.05). There were no statistically significant differences of prothrombin time, activated partial thrombin time and fibrinogen in the observation group (P ＞ 0.05), but the indicators above in the control group after the operation were higher than those of before operation, with statistically significant differences (P ＜ 0.05). The incidences of hypothermia, shiver and cystospasm in the observation group were lower than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion The application of inflatable warming blanket during TURP has a good body temperature protection effect, which can avoid the coagulation dysfunction caused by hypothermia.
2018 Vol. 15 (5): 156-159 [Abstract] ( 214 ) HTML (1 KB)  PDF (594 KB)  ( 87 )
160 Effects of targeted nursing intervention in the treatment of oxygen-driven aerosol inhalation in children with moderate and severe asthma
YANG Liqun DU Meina▲
Objective To explore the effects of targeted nursing intervention in the treatment of oxygen-driven aerosol inhalation in children with moderate and severe asthma. Methods From April 2016 to May 2017, 96 patients with moderate and severe asthma in the treatment of oxygen-driven aerosol inhalation in the Department of Pediatrics, the Affiliated Hospital of Inner Mongolia Medical University were selected as the reaserch subjects and divided into the control group and the observation group by random number table, with 48 cases in each group. The control group was given routine nursing case and the observation group was given targeted nursing intervention on the basis of control group. The nursing compliance and the adverse events were compared between the two groups. Results The nursing compliance in the observation group was higher than that of control group, the total incidence of adverse events in the observation group was lower than that of control group, with statistically significantly differences (P ＜ 0.05). Conclusion Targeted nursing intervention can improve the compliance of children with moderate and severe asthma in the treatment of oxygen-driven aerosol inhalation and it is safe. It is worthy of promotion and application.
2018 Vol. 15 (5): 160-163 [Abstract] ( 212 ) HTML (1 KB)  PDF (591 KB)  ( 147 )
164 Effect of Atorvastatin on perioperative ischemic stroke in fracture patients with unstable carotid artery plaque
CHEN Xiaolin ZHANG Zuowen▲
Objective To investigate the clinical effect of Atorvastatin in the treatment of fracture patients with unstable carotid plaque occurred ischemic stroke in perioperative. Methods From January 2015 to January 2017, 86 fracture patients combined with carotid artery plaques occurred ischemic stroke in perioperative in Jiangjin District Central Hospital were selected. They were divided into study group (43 cases) and observation group (43 cases) according to the therapeutic schedule. They were treated by the routine treatment, such as anticoagulation, improved microcirculation and neuroprotective function, and the patients in the study group were treated with Atorvastatin based on those treatments. All the patients were treated for 6 months. Before and after treatment, the levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), carotid intima-media thickness (IMT) and carotid artery plaque were detected. The nerve function damage of patients was evaluated by neurological deficit score (NIHSS). Then the transient ischemic attack (TIA), recurrent stroke and adverse reactions of the two groups were compared. Results After treatment, the levels of TC, TG, LDL-C, IMT, maximum diameter, plaque area, and NIHSS scores in the study group were lower than those in the control group, while the level of HDL-C was higher than that in control group, with statistically significant difference (P < 0.05). The incidence of TIA and ischemic stroke recurrence rate in the study group were lower than those in the control group (P < 0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion The effect of Atorvastatin in fracture patients combined with carotid artery plaques occurred ischemic stroke in perioperative is significant. Atorvastatin can obviously improve the patient's blood lipid levels and carotid artery plaque instability state, promote nerve functional recovery, reduce the incidence of cerebral ischemic events, and has a certain safety, so it is worthy of clinical application.
2018 Vol. 15 (5): 164-167 [Abstract] ( 233 ) HTML (1 KB)  PDF (567 KB)  ( 112 )
168 Effect of square dance on the fat content in different parts of the obese middle-aged and elderly women with type 2 diabetes mellitus
YU Genxiu1 LIU Jianyu2 ZHOU Li′na2
Objective To evaluate the effect of square dance on the fat content in different parts of the obese middle-aged and elderly women with type 2 diabetes mellitus (T2DM). Methods From January 2014 to December 2015, 52 cases of the obese middle-aged and elderly women with T2DM were selected as the study subjects, which were staff of Chongqing institutions with medical examinations in the Fifth People′s Hospital of Wanzhou. They were divided into exercise group and control group, with 26 cases in each group. The exercise group was treated with square dance for 16 weeks, and the control group was not treated with special sports. Besides, they were required to control both fats and total calories. Before and after treatment, their body fat rate (FAT%), skinfold thickness (SFT), visceral fat area (VFT), fasting blood-glucose (FPG), fasting insulin concentration (FIns) and insulin resistance index (HOMA-IR) were compared. Results After treatment, the levels of FAT%, SFT, VFA, FPG, FIns and HOMA-IR in the exercise group were decreased, which were lower than those in the control group, with statistically significant difference (P < 0.05). Conclusion Square dance can reduce the body fat of the obese middle-aged and elderly women with T2DM. While it has different effects on the fat in different parts, and the effect of reducing visceral fat content is more significant than that of reducing subcutaneous fat. Square dance can be used as a means of exercise therapy for the obese middle-aged and elderly patients with T2DM.
2018 Vol. 15 (5): 168-171 [Abstract] ( 242 ) HTML (1 KB)  PDF (569 KB)  ( 108 )
172 Recognition and evaluation of the innovation and scientific nature of Chinese medical science and technology papers
CUI Jingyan1 DENG Yuan1 LI Chunmei1 PANG Xiaokun2 ZHAO Yuhao2▲
Scientific and technological papers are the best way to report and disseminate scientific research results, including Chinese medical science and technology papers, of which the innovation and scientific nature is the key basis for publication. The innovation of Chinese medical science and technology papers has a wide range, covering the innovation in research subject, method, content, ideas and design innovation, etc. Based on science of the characteristics such as objective law, advanced or frontier, fluidity and division, to investigate the liquidity, advancement or frontier of innovation knowledge is the key factor to recognize and evaluate the scientific nature of Chinese medical science and technology papers. Meanwhile, the papers are required to be correct, reasonable, integrable and can produce sensational effect.
2018 Vol. 15 (5): 172-176 [Abstract] ( 269 ) HTML (1 KB)  PDF (617 KB)  ( 192 )
177 Research on the status and policy of health industry in medical care
SUN Shihui
On the medical health industry development direction, to explore a new model of the development of the pension industry. This article discusses the related research on health care industry and the trend of industrial development, mainly from 4 aspects: mode, significance, implementation difficulties and development strategies. Through research, it finds that many factors restrict the development of Chinese health care industry, such as idea, system, policy, talent and profit, in terms of the aging situation, family changes and the actual needs of the elderly. The medical education multi industry integration model is in the original hospital and pension combined mode, full integration of medical colleges and universities, professional teaching and scientific research, human capital source advantage, realizeing the seamless link between medical personnel, pension and continuous output, ensuring sustainable development of "medical support and education integration mode". And it can get the breakthrough from the aspects of the main body, the top design, the service extension, the team building and the industrial development. The future research should pay more attention to model integration, the introduction of far perspective and the extension of the research content.
2018 Vol. 15 (5): 177-180 [Abstract] ( 210 ) HTML (1 KB)  PDF (613 KB)  ( 234 )
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