北京市通州地区小儿急性呼吸道感染病原学分析

Abstract
Figure/Table
References (26)
Related Citation (6)

Download: PDF (839 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To detect the common pathogens of acute respiratory tract infection (ARI) of children in Tongzhou District of Beijing, so as to provide clinical evidences for the prevention and treatment of children′s ARI. Methods Children with ARI were enrolled who hospitalized in the Children′s Center of Beijing Luhe Hospital, affiliated to Capital Medical University from September 1st, 2015 to Augest 31st, 2017. 2 mL of venous blood was collected, and 8 kinds of common respiratory pathogens IgM antibody were detected by indirect immunofluorescence, including RSV, ADV, INFA, INFB and PIVs. Then etiology tendency was analyzed. Results A total of 1319 children were enrolled and 962 positive samples were detected, accounting for 72.93%. Among them, MP positive detection was the most, accounting for 61.85%, followed by INFB, CPn, RSV, INFA, PIVs and ADV in turn. Among the positive samples, single pathogenic infection accounted for 58.63%, two pathogenic infection (double infection) accounted for 38.36% and three or more pathogenic infection (multiple infection) accounted for 3.01%. The most common pathogens combination of double infection was MP and INFB. Pathogens infection showed obvious seasonal changes. MP infection mainly concentrated in September to November. INFB infection increased from September, reached a peak in November and December, then decreased gradually, and reached a peak again in the following March (P < 0.05). The susceptible ages of different pathogens were significantly different (P < 0.05). The peak age of single pathogen infection (MP or INFB) was 3 years old, while the age of the highest positive rate of double infection (MP and INFB) was 11 months-3 years old. Positive detection rate of pathogens was similar in female and male (P > 0.05). Pneumonia was the main cause of hospitalization. Among them, double infection (MP and INFB) was the main cause, accounting for 25.83%, followed by MP infection and INFB infection, respectively accounted for 25.39% and 13.84%. Myocardial damage was the most common complication, accounting for 21.45%. Conclusion The main pathogens of respiratory tract infection in this region are MP and INFB. The main types of infection are single infection and double infection (MP+INFB). The number of cases increase from the fall, peak in winter and reach a small peak in the following spring again. The single infection mostly occurs in 3-6 years old and double infection mainly occurs in 11 months-3 years old.

Key words： Etiology Acute respiratory infection Children Beijing

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WU Hongbo1 LIU Wei1 YANG Hongxiu1 ZHANG Shuqin2 LI Lihua1

Cite this article:

WU Hongbo1 LIU Wei1 YANG Hongxiu1 ZHANG Shuqin2 LI Lihua1. Etiological analysis of pediatric acute respiratory infection in Tongzhou District of Beijing[J]. 中国医药导报, 2018, 15(5): 89-93.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I5/89

[1] 李璐，史伟峰，董文，等.儿童急性呼吸道感染9种病原体检测和流行病学调查[J].国际检验医学杂志，2013，34（6）：684-685.
[2] Hon KL，Leung AS，Cheung KL，et al. Typical or atypical pneu monia and severe acute repiratory symptoms in PICU [J]. Clin Respir J，2015，9（3）：366-371.
[3] Huong Pie T，Hien PT，Lan NT，et al. First report on prevalence and risk factors of severe atypical pneumonia in Vietnamese children aged 1-15 years [J]. BMC Public Health，2014，14（1）：1-8.
[4] Piedra PA，Mansbach JM，Jewell AM，et al. Bordetella pertussis is an uncommon pathogen in children hospitalized with bronchiolitis during the winter season [J]. Pediatr Infect Dis J，2015，34（6）：566-570.
[5] 江载芳，申昆玲，沈颖.诸福棠实用儿科学[M].第8版.北京：人民卫生出版社，2015.
[6] 何秀娟，李全亭，王红，等.2730例呼吸道病原体谱抗体IgM检测结果分析[J].中国卫生检验杂志，2016，26（3）：2246-2248.
[7] 夏丽君，巫雯嘉，杨瑾，等.9种呼吸道病原体IgM抗体联合检测的临床意义[J].中国实验诊断，2016，20（9）：1477-1479.
[8] 廖冰洁，周迎春，李翠，等.呼吸道病原体IgM抗体联合检测在呼吸道感染诊断中的应用[J]国际检验医学杂，2014，35（10）：1339-1340.
[9] 冉健，裴元元，汤菊妹，等.深圳地区9种常见呼吸道病原体IgM抗体结果[J].热带医学杂志，2016，16（9）：1112-1114.
[10] 李爱国，龚春华.2000-2009年江苏海安地区儿童肺炎支原体感染的流行病学分析[J].南通大学学报：医学版，2011，31（3）：176-178.
[11] 许爽，祝洪珍，李静，等.长春地区冬季儿童上呼吸道感染病毒病原学检测结果分析[J].中国卫生工程学，2011， 10（3）：227-229.
[12] 陈恒，江立千，李亚东，等.儿童急性呼吸道感染九种病原体的IgM抗体检测结果分析[J].检验医学与临床，2016， 13（12）：1665-1666.
[13] 郑辉，彭亮，卓广超，等.儿童呼吸道感染病原体IgM抗体检测结果分析[J].中华医院感染学杂志，2015，25（1）：235-237.
[14] 牛小斌，李永伟.小儿9项呼吸道感染病原体IgM抗体检测结果分析[J].中华卫生检验杂志，2015，25（4）：520-521.
[15] 罗丹，张晓阳，高向阳，等.普洱市儿童呼吸道感染病原体IgM抗体九联检临床应用分析[J].国际检验医学杂志，2016，37（9）：1205-1029.
[16] Cila G，Onate E，Perez-Yarza EG，et al. Virusesin community-acquired pneumonia in children aged less than 3 years old：high rate of viral coinfection [J]. Med V，2008， 80（10）：1843-1849.
[17] 周俊新.儿童支原体肺炎早期诊断分析[J].亚太传统医药，2013，9（3）：126-127.
[18] Richard N，Komurian-Pradel F，Javouhey E，et al. The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis [J]. Pediatr Infect Dis J，2008，27（3）：213-217.
[19] 严华杰，盛军，董蔚，等.2007-2013年上海南翔地区呼吸道感染儿童鼻咽部病毒病原学哨点监测及分析[J].临床儿科杂志，2014，32（11）：1052-1056.
[20] Dumke R，Christian L，Jacobset E，et al. Low rate of macrolide resistance in Mycoplasma pneumoniae strains in Germany betwen 2009 and 2012 [J]. Antimicrob Agents Chemother，2013，57（7）：3460.
[21] Chen ZR，Yan YD，Wang YQ，et al. Epidemiology of community acquired Mycoplasma Pneumoniae respiratory tract infections among hospitalized Chinese children，including relationships with meteorological factors [J]. Hippokratia，2013，17（1）：20-26.
[22] 勾朝阳，白峰岩.南阳市呼吸道感染住院患儿非细菌病原体IgM抗体检测分析[J].中国实用医刊，2015，42（2）：68-69.
[23] 李宁霞，王明磊，曹东辉，等.9项病原体IgM抗体在患儿呼吸道感染检测的应用研究[J].国际检验医学杂志，2015，36（14）：2059-2060，2062.
[24] 薛白，刘洁，胡志刚，等.呼吸道感染患者病原学调查分析[J].中华医院感染学杂志，2014，24（2）：309-311.
[25] 陈海霞，黄燕，崔振泽，等.280例儿童社区获得性肺炎住院患儿病毒病原学研究[J].医学研究杂志，2009，38（8）：73-75.
[26] Aberle JH，Aberle SW，Pracher E，et al. Single versus dual respiratory virus infections in hospitalized infants impact on clinical course of disease and interferon-gamma response [J]. Pediatr Infect Dis J，2005，24（7）：605-610.