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| Analysis on the literatures of adverse reactions of Polygonum multiflorum and its preparations |
| GAO Guiyuan1 LUO Yuanlin1▲ HUANG Jie1 YU Jian1 ZHANG Guoli1 ZHANG Fang1 SHAO Yingxin2 |
1.Department of Pharmacy, Huanggang Hospital of Traditional Chinese Medicine, Hubei Province, Huanggang 438000, China;
2.Department of Endocrinology, Huanggang Hospital of Traditional Chinese Medicine, Hubei Province, Huanggang 438000, China |
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Abstract Objective To explore the characteristics and general rules of adverse drug reactions (ADRs) and the mechanism of liver damage of Polygonum multiflorum and its preparations, and provide reference for clinical rational drug use. Methods The literatures of ADRs induced by Polygonum multiflorum and its preparations, retrieved from Wanfang data knowledge service platform, VIP info, CNKI, PubMed and food and drug administration website at home and abroad from January 2000 to September 2017, were statistically analyzed. Results A total of 84 reports in China (429 cases)and 9 reports abroad (39 cases), involving 468 cases induced by Polygonum multiflorum and its preparations, were collected. Main clinical manifestations were the liver damage. Polygonum multiflorum-induced ADRs had a high occurrence rate in the people over 40-＜50 years old [26 cases (34.21%) in China, 13 cases (40.63%) abroad], most ADRs occurred in 16-30 days after the medication [87 cases (48.07%) in China, 10 cases (33.33%) abroad]. The proportion of male was less than that of female in China (46.60% vs. 53.40%), the proportion of male was more than that of female abroad (56.41% vs. 43.59%). The ADRs could be caused by the different degrees of processing, normal dosage and overdose. Good prognosis could be obtained by most cases, while there were 3 death cases. Liver damage could be induced by means of metabolic abnormality, immune stress response and liver cell apoptosis, and so on. Conclusion Polygonum multiflorum and its preparations can induce serious ADRs and the occurrence of ADRs is associated with a variety of factors. It is necessary to pay more attention to the ADR of liver damage, clinical pharmacist should take initiative to monitor ADR and give close observation to the reactions of medication, so as to ensure the safety of medication.
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