阿托伐他汀对合并颈动脉不稳定斑块骨折患者围术期缺血性脑卒中的效果

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Abstract Objective To investigate the clinical effect of Atorvastatin in the treatment of fracture patients with unstable carotid plaque occurred ischemic stroke in perioperative. Methods From January 2015 to January 2017, 86 fracture patients combined with carotid artery plaques occurred ischemic stroke in perioperative in Jiangjin District Central Hospital were selected. They were divided into study group (43 cases) and observation group (43 cases) according to the therapeutic schedule. They were treated by the routine treatment, such as anticoagulation, improved microcirculation and neuroprotective function, and the patients in the study group were treated with Atorvastatin based on those treatments. All the patients were treated for 6 months. Before and after treatment, the levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), carotid intima-media thickness (IMT) and carotid artery plaque were detected. The nerve function damage of patients was evaluated by neurological deficit score (NIHSS). Then the transient ischemic attack (TIA), recurrent stroke and adverse reactions of the two groups were compared. Results After treatment, the levels of TC, TG, LDL-C, IMT, maximum diameter, plaque area, and NIHSS scores in the study group were lower than those in the control group, while the level of HDL-C was higher than that in control group, with statistically significant difference (P < 0.05). The incidence of TIA and ischemic stroke recurrence rate in the study group were lower than those in the control group (P < 0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion The effect of Atorvastatin in fracture patients combined with carotid artery plaques occurred ischemic stroke in perioperative is significant. Atorvastatin can obviously improve the patient's blood lipid levels and carotid artery plaque instability state, promote nerve functional recovery, reduce the incidence of cerebral ischemic events, and has a certain safety, so it is worthy of clinical application.

Key words： Atorvastatin Fracture Carotid plaques Perioperative period Ischemic stroke

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	CHEN Xiaolin ZHANG Zuowen▲

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CHEN Xiaolin ZHANG Zuowen▲. Effect of Atorvastatin on perioperative ischemic stroke in fracture patients with unstable carotid artery plaque[J]. 中国医药导报, 2018, 15(5): 164-167.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I5/164

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