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2017 Vol. 14, No. 34
Published: 2017-12-05
 
 
4 Comparative study of tumor markers and its significance in left and right sided colorectal adenocarcinoma
ZHANG Wenjun GE Wei WU Long
Objective To explore the value and significance of CEA, CA125, CA724 and CA199 in the diagnosis and judgment of left and right sided colorectal adenocarcinomas. Methods A total of 162 patients with colorectal adenocarcinomas were diagnosed by pathology from July 2015 to July 2016 in Renmin Hospital of Wuhan University were retrospectively analyzed, including 97 cases of left colorectal adenocarcinomas and 65 cases of right colorectal adenocarcinomas. The serum tumor markers and clinical and pathological parameters of the patients were collected and the differences between left and right colorectal adenocarcinomas were analyzed. Results The positive rate of CEA, CA125, CA724 and CA199 in the left colorectal cancer patients were 38.1%, 25.8%, 62.9% and 30.9%, and the positive rate of four serum markers was 59.8%. The positive rate of CEA, CA125, CA724 and CA199 in 53 patients with right colorectal cancer were 53.8%, 23.0%, 46.2% and 40.0%, respectively, and the positive rate of the combination of four markers was 64.6%. The positive rate of CA125 in the left half of the results of neural invasion of colorectal adenocarcinoma, CA199 in the right half of the results of neural colorectal adenocarcinoma, the difference was statistically significant, CA199 in the left and right semi-colorectal adenocarcinoma vascular invasion was different with those without neural invasion (P < 0.05). Conclusion Tumor markers CEA, CA125, CA724, CA199 in the left and right colorectal adenocarcinoma in the presence of differences, combined detection can improve the positive rate. CA125 and CA199 on the left and right colorectal adenocarcinoma nerve involvement have a guiding significance, CA199 on the left and right colorectal adenocarcinoma vascular invasion has a guiding significance.
2017 Vol. 14 (34): 4-7,12 [Abstract] ( 272 ) HTML (1 KB)  PDF (566 KB)  ( 178 )
8 Effect of early intervention of Simvastatin on chronic obstructive pulmonary disease rats model
YANG Kai1 GUO Lu2▲ LIU Yuejian2 HU Rong1 DUAN Wenjuan3
Objective To explore the effects of early stage administration of Simvastatin on chronic obstructive pulmonary disease (COPD) rat model and its mechanism. Methods 42 SPF Wistar rats were randomly divided into three groups (n=14): blank group, model group and Simvastatin group. COPD rat models were replicated with the method of inhaling cigarette smoke and intratracheal instillation of LPS. Simvastatin group rats were gave lavage treatment with Simvastatin (5 mg/kg) after 2 weeks when COPD model was established. Usual manifestations and body weights of rats from the three groups were monitored. The levels of IL-6 and TNF-α in serum and BALF were measured by double antibody sandwich enzyme-linked immuno sorbent assay (ELISA). Leukocyte in BALF was counted by haemocytometer. The expression of MMP-9 in the lung tissues was measured by immunohistochemically. Pathological examination of lung tissues from every  group was analyzed by image analysis system. Results Body weights of rats from the model group and Simvastatin group were significantly reduced compared with those of the blank group (P ＜ 0.01). Levels of IL-6 and TNF-α in serum and BLAF were higher in the model group and Simvastatin group than the blank group (P ＜ 0.05). Compared with model group, the levels in Simvastatin group were decreased (P ＜ 0.05). The expression of MMP-9 in lung tissues, model group was increased than the blank group (P ＜ 0.05), Simvastatin group was lower than the model group (P ＜ 0.05). The pathologic characteristics of COPD was observed in the lung tissues from Simvastatin group and model group. Copmared with the model group, lung tissue injury, remodeling and inflammatory infiltration in Simvastation group was attenuated. Conclusion Cigarettes inhalation combined with respiratory infections can aggravate pulmonary and systemic inflammation, and up-regulate the expression of proteases, all of which are involved in the genesis and development of COPD. Simvastatin therapy as an early intervention can alleviate the lung tissue injury and remodeling to a certain degree, attenuate pulmonary and systemic inflammation and alleviate the over-activation of proteasesystem.
2017 Vol. 14 (34): 8-12 [Abstract] ( 304 ) HTML (1 KB)  PDF (710 KB)  ( 169 )
13 Study on the antidepressant effects of tubacin for the model rats with chronic unpredictable mild stress and its mechanism
SUN Guoping1 LI Kun2 LU Haozhong1 XUE Xiaobin1
Objective To investigate the antidepressant effects of histone deacetylase 6 (HDAC6) selective inhibitor tubacin for the model rats with chronic unpredictable mild stress (CUMS) and its mechanism. Methods Fifty male adult rats were randomly divided into 5 groups (n = 10): control group (group A), CUMS model group (group B), Fluoxetine treatment group (group C), tubacin treatment group (group D) and combination of Fluoxetine and tubacin treatment group (group E). The spatial learning and memory abilities of rats were tested by orientation navigation experiment and spatial probe trial of Morris water maze. Meanwhile, the levels of serum reduced glutathione (GSH) in all groups were measured by GSH kits. Results The orientation navigation experiment of Morris water maze showed that compared with group A, the mean escape latency of rats in group B was significantly lengthened (P ＜ 0.05 or P ＜ 0.01), compared with group B, the mean escape latency of rats in group C, D, E was significantly shortened (P ＜ 0.05 or P ＜ 0.01), and the mean escape latency of rats in group E was significantly shorter than those of group C, D (P ＜ 0.05 or P ＜ 0.01). In the spatial probe trial, the length of stay in the third quadrant of group C, D, E was significantly longer than those of the left three quadrants (P ＜ 0.05 or P ＜ 0.01), the length of stay in the third quadrant of group E was significantly longer than those of group C, D (P ＜ 0.01, P ＜ 0.05). The level of serum GSH in group B was significantly lower than that of group A (P ＜ 0.05), while the level of serum GSH in group C was significantly higher than that of group B (P ＜ 0.05), the level of serum GSH in group E was significantly higher than that of group C (P ＜ 0.05), there was no statistically significant difference between group E and group A (P ＞ 0.05). Correlation analysis showed that the spatial learning and memory abilities of rats were significantly correlated with the level of GSH (P ＜ 0.05). Conclusion HDAC6 selective inhibitor tubacin can improve the spatial learning and memory abilities of rats by regulating the levels of GSH, so as to play antidepressant effects.
2017 Vol. 14 (34): 13-16,20 [Abstract] ( 301 ) HTML (1 KB)  PDF (818 KB)  ( 154 )
17 Expression of miR-182 in oral squamous cell carcinoma and its effect on cell biological behaviour
WANG FeiFei AN Jinghong SONG Mei WANG Jinhui▲
Objective To investigate the expression of miRNA-182 (miR-182) in oral squamous cell carcinoma (OSCC) and explore the effects of miR-182 deficiency on proliferation and migration in OSCC cells. Methods 10 cases of OSCC samples and paired tissues were collected from Stomatological Hospital of Harbin Medical University from July 2015 to October 2016. The expression of miR-182 in OSCC tissues was detected by quantitative reverse-transcription polymerace chain reaction (RT-qPCR). Culturing TCA8113 cells and separating the samples to four groups: Control, Vehicle, miR-182-NC and miR-182-i group. After transfection with miR-182 inhibitor, TCA8113 cell proliferation and migration were examined with MTT assay and Transwell assay. Results The level of miR-182 in OSCC samples was significantly higher than that in normal paired tissue group (P < 0.05). The proliferation capability and migration capability in miR-182-i group were decreased than those in Control group (P < 0.05). Conclusion The high expression of miR-182 may be correlated with the development of OSCC. Decreased the expression of miR-182 may inhibite OSCC cancer cell proliferation and migration. Further study should be conducted to explore the function of miR-182 in OSCC development.
2017 Vol. 14 (34): 17-20 [Abstract] ( 258 ) HTML (1 KB)  PDF (686 KB)  ( 106 )
21 Optimization of matrix prescription of traditional Chinese medicine gel ointment for infantile bronchitis
WANG Yanning1 YAN Lianjiao2 WU Shuyue1
Objective To optimize matrix prescription of traditional Chinese medicine gel ointment for infantile bronchitis. Methods With sensory evaluation, adhesion, membrane residue quantity and peel strength as indices, the matrix prescription of gel ointment was investigated by single factor test and orthogonal test. Results Extracts of concentrated liquid of Chinese medicine of 20∶1 (V/V) was optimized and selected to use as medicine, the drug loading capacity was 2.5 g. The optimal matrix dosage of excipients was as followed: 0.55 g of sodium polyacrylate NP800, 0.025 g of tartaric acid, 0.2 g of PVPK90, 3.0 g of glycerol. Conclusion The gel ointment prepared according to the optimal formulation has stable quality, reasonable technique, and it is feasible.
2017 Vol. 14 (34): 21-24,49 [Abstract] ( 248 ) HTML (1 KB)  PDF (775 KB)  ( 70 )
25 Research progress of microRNA-125b in tumor
ZHAO Xueyu QIAN Yayun▲
Malignancy is one of the important factors leading to human death. The occurrence of malignant tumors is closely related to the abnormal expression of a particular gene. MicroRNA-125b (miR-125b) is a non-coding small RNA molecule that plays a pivotal role in different biological changes. More and more studies have shown that miR-125b may be an advanced biomarker for the diagnosis of certain specific malignancies and may be a potential new target for its medical treatment. According to the latest research results of the relationship between miR-125b and tumor, it is reviewed in the aspects of cell proliferation, apoptosis, invasion and metastasis and drug resistance.
2017 Vol. 14 (34): 25-28 [Abstract] ( 334 ) HTML (1 KB)  PDF (628 KB)  ( 173 )
29 New understanding of pathogenesis of steroid induced osteonecrosis of the femoral head
DENG Shuang PENG Hao
The use of glucocorticoids is the most common non-traumatic cause of osteonecrosis of the femoral head. Studies have shown that glucocorticoids can act directly or indirectly. Direct effects include inhibition of osteoblast and osteoclast precursor formation, apoptosis of osteoblasts and osteocytes, prolongation of osteoclast lifespan and apoptosis of endothelial cells. Indirect effects include increasing the risk of clot formation, inhibiting angiogenesis, interfering with bone repair, causing local vessel contraction, promoting lipogenesis in the bone marrow and increasing intramedullary pressure. Multiple pathway activation leads to the decrease of blood supply of the femoral head, resulting in osteonecrosis. Besides, there are individual differences in steroid sensitivity and other underlying mechanisms. The disease model is a multiple hit theory. The more risk factors, the greater probability of disease. More work is needed to better discover the pathomechanisms of glucocorticoids in osteonecrosis, so as to provide better choice for clinical treatment.
2017 Vol. 14 (34): 29-32 [Abstract] ( 277 ) HTML (1 KB)  PDF (588 KB)  ( 104 )
33 Research progress on the correlation between occurrence of enuresis and ADHD in children
YUAN Bin QIAN Ling
So far the specific pathogenesis of enuresis in children has not been fully elucidated because of its complexity, it is accepted that central nervous system, circadian rhythm and dysfunction of bladder are mainly involved. Clinical observation finds ADHD is closely related to PNE. However, the specific relevance remains to be further studied and revealed. Recent studies show that disturbsance of metabolic pathway of dopamine transmitter and psychological factors are common risk factors of ADHD and enuresis. Sleep arousal disorders is an important reason for ADHD to cause PNE to happen. ADHD can affect the functions of the heart, liver, spleen, lung, kidney, leading to the imbalance of yin and yang in viscera, dystrophy of the sea of marrow and causing the deficiency of lung qi and spleen qi, the weakness of kidney qi, dampness-heat of the liver, heart-kidney imbalance, etc. Above pathological changes will ultimately lead to enuresis.
2017 Vol. 14 (34): 33-36 [Abstract] ( 274 ) HTML (1 KB)  PDF (586 KB)  ( 228 )
37 Research progress of influenza A virus M2 protein
LIU Yahui GUO Chaotan
M2 protein is a kind of membrane protein with ion channel activity in the envelop of influenza virus, which plays an important role in the life cycle of influenza virus. The N-terminal of the M2 protein is highly conserved, which is an important target for researching the universal vaccine. The transmembrane domain of M2 protein plays an important role in the progress of virus ribonucleoprotein complex entering into the nucleus, it is also the target for drug binding, but the appearance of drug-resistant mutants make the research of new drugs much more urgent. M2 protein also participates in the progress of virus budding, which is of great importance for the formation of virions. M2 protein can control the autophagy and apoptosis for the purpose of controlling the replication of virus through sophisticated mechanisms. This paper makes a review of M2 protein in the following aspects: vaccine research, proton conduction, drug research, assembly and budding, autophagy and apoptosis.
2017 Vol. 14 (34): 37-40 [Abstract] ( 422 ) HTML (1 KB)  PDF (590 KB)  ( 86 )
41 Research progress of wave in the treatment of radial styloid stenosing tenosynovitis of extracorporeal shock
WU Shunjun WANG Fan HE Guoxia SUN Xinhao LIU Jie WANG Kai
The radial styloid tenosynovitis is a chronic non-specific inflammatory, which local pain and limited wrist movement are mainly clinical features. It seriously affects patients′ live quality. The pathogenesis of this disease is complex, and there is no better treatment strategy. Recently, extracorporeal shock wave (ESW) is a new physical therapy in this disease, which is non-invasion, simple operation, safe and cheap and so on, and is being gradually applied to the radial styloid stenosing tenosynovitis. In this research, the pathogenesis of radial styloid stenosing tenosynovitis, research progress of ESW and treatment of stenosing tenosynovitis of the radial styloid wave were reviewed.
2017 Vol. 14 (34): 41-44 [Abstract] ( 284 ) HTML (1 KB)  PDF (586 KB)  ( 209 )
45 Review and Prospect of indications and materials for cranioplasty
QIN JiaJun CHEN Xianzhen
Cranioplasty is a common surgical management in the department of neurosurgery, which is usually received in patients with skull defects for decompression craniectomy. However, the surgical indications and materials used for cranioplasty are still controversial. The surgical indications and the characteristics of the materials used in surgery can affect the postoperative outcome and the prognosis of the patients. This paper reviews the characteristics of the materials used currently, the indications and complications of cranioplasty. The future trends of cranioplasty materials are also prospected.
2017 Vol. 14 (34): 45-49 [Abstract] ( 174 ) HTML (1 KB)  PDF (597 KB)  ( 201 )
50 Effect of token intervention on the lack of initiation activity of chronic schizophrenic patients in the occupational therapy stage of Morita therapy
LI Ling TAO Fengying▲ CHEN Jianhua DONG Ping BAI Zhongsheng
Objective To explore the effect of token intervention on the lack of initiation activity of chronic schizophrenia patients in the occupational therapy stage of Morita therapy. Methods There were 105 patients with chronic schizophrenia who met the standard set from the Second Rehabilitation Division of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine from July 2015 to December 2016 were chosen and randomly divided into control group (n = 51) and token intervention group (n = 54). The patients in the control group were treated with both original antipsychotic drugs and Morita therapy, while those in the token intervention group were treated with token intervention in Morita therapy based on the treatment of original antipsychotic drugs. The Butler scale and NOSIE-30 scale were used to compare the patients before and after treatment. Results The results of NOSIE-30 scale comparison showed that the token intervention group′s social skills, social interests and personal hygiene factor scores were higher after treatment than before, but irritation, withdrawal and depression factor scores were lower than before, there were statistically significant differences (P < 0.01). The token intervention group′s social skills, social interests and personal hygiene factor scores were higher than those in the control group′s, but irritation, withdrawal and depression factor scores were lower than those in the control group after treatment, there were statistically significant differences (P < 0.05). The results of Butler scale comparison showed that the Butler score in the token intervention group after treatment was lower than before treatment, there was a statistically significant difference (P < 0.01). The Butler score in the token intervention group was lower than the control group after treatment, there was a statistically significant difference (P < 0.01). There was a statistically significant difference in Butler reduced rate between the two groups after treatment (P < 0.01). Conclusion The token intervention in Morita therapy can significantly improve the lack of initiation activity of the chronic schizophrenia patients.
2017 Vol. 14 (34): 50-53,57 [Abstract] ( 313 ) HTML (1 KB)  PDF (465 KB)  ( 161 )
54 Association between serum uric acid and 24 h blood pressure variability in community hypertension patients
JIN Li′na1,2
Objective To study the relationship between serum uric acid (BUA) level and 24 hours blood pressure variability of hypertension patients in Jiaodong Community of Dongcheng District in Beijing, and find out its clinical significance. Methods The data of 126 hypertensive patients including levels of BUA, blood lipid, blood glucose in Jiaodong Community from January 2015 to December 2016 were collected and analyzed retrospectively. Patients were divided into 3 groups according to BUA levels: group A with 44 cases (BUA:250-<350 μmol/L), group B with 42 cases (BUA:350-<450 μmol/L), group C with 40 cases (BUA:450-550 μmol/L). The relationship between BUA and blood pressure variability was analyzed by Pearson analysis. Results The 24 h SCV, dSCV and nSCV were compared among the three groups, which in the group C were higher than those of group B and group A, which in the group B were higher than those of group A (all P ＜ 0.05); but there were no statistically significant differences in 24 h DCV, dDCV and nDCV among the three groups (P ＞ 0.05). Pearson correlation analysis showed that SCV, dSCV and nSCV were positively correlated with BUA (P ＜ 0.05). Conclusion In community, the hypertension patients′ BUA levels have correlated with systolic blood pressure variability, which can be taken as a reference index for prompting the target organ damage in the patients.
2017 Vol. 14 (34): 54-57 [Abstract] ( 270 ) HTML (1 KB)  PDF (447 KB)  ( 84 )
58 Local infiltration analgesia versus transversus abdominis plane block for analgesia after cesarean section
ZHAN Daxing ZOU Gaorui CHEN Chao FENG Xiaoboade▲
Objective To compare analgesia effects between local infiltration analgesia and bilateral ultrasound-guided TAP block after cesarean section. Methods A total of 60 parturients scheduled for elective cesarean section in Zhongnan Hospital of Wuhan University from August to December 2016 were selected as research subjects. They were randomly divided into two groups using a random number table: local infiltration analgesia group (group I) and transversus abdominis plane block group (group T), with 30 cases in each group. All parturients underwent cesarean delivery under combined spinal and epidural anesthesia. In the group I, 0.25% Ropivacaine 20 mL was given to the abdominal incision layer in each side for infiltration analgesia before the abdomen was closed; in the group T, parturients received 0.25% Ropivacaine 20 mL bilaterally in the TAP block under the guidance of ultrasound. A Sulfentanil patient-controlled intravenous analgesia pump was used for all patients at the end of surgery. The VAS scores, the number of pressing times of the analgesic pump, the incidence of side effects (nausea and vomiting and urinary retention) and patients′ satisfaction were recorded. Results There was no significant difference in VAS scores between the two groups (P > 0.05). Compared with group I, the number of pressing times was less and patient satisfaction was higher in group T (P ＜ 0.05). The incidence of postoperative adverse reactions in group T was lower than that in group I (P < 0.05). Conclusion Compared with the incision local infiltration analgesia, ultrasound-guided TAP block is helpful in improving the effect of analgesia after cesarean section, it reduces the dosage of intravenous analgesic and the occurrence of adverse reactions related to analgesia, increases patients′ satisfaction.
2017 Vol. 14 (34): 58-61 [Abstract] ( 292 ) HTML (1 KB)  PDF (477 KB)  ( 116 )
62 Application effects of ultrasound-guided transversus abdominis plane blocks with local anesthetics and Dexmedetomidine in patients with gynecological laparotomy
WU Jianwei PENG Juxiang HE Qiang XU Le LI Xiangyu ZHAO Weixian
Objective To explore application effects of ultrasound-guided transversus abdominis plane blocks (TAPB) with local anesthetics and Dexmedetomidine in patients with gynecological laparotomy. Methods Ninety patients underwent hysterectomy and ovarian cyst resection in Guangdong Hospital of Traditional Chinese Medicine from October 2014 to August 2016 were selected as research objects, and they were randomly divided into three groups by random number table: control group (group C), local anesthetic medicine group (T group), local anesthetics and Dexmedetomidine group (DT group), with 30 cases in each group. Patients in three groups were treated with normal endotracheal intubation and general anesthetic. After induction of anesthesia, B ultrasound-guided bilateral TAPB were performed in T group and DT group. The patients in T group and DT group were respectively injected with 30 mL of 0.4% Ropivacaine and 30 mL of 0.4% Ropivacaine combined with 0.75 μg/kg Dexmedetomidine. The recovery time of spontaneous breathing, waking time and extubation time of the three groups were compared, and postoperative visual analogue scale (VAS), Ramsay score and the incidence of adverse reactions were recorded, and the rates of temperature plane block in bilateral block sides were observed. The data was analyzed by statistical software SPSS 18.0. Results Compared with group C, the amount of Propofol in T group and DT group was reduced, the recovery time of spontaneous breathing, waking time and extubation time were shortened, and the VAS scores after operation for 8, 12, 24 h (T1-T3) were reduced (P ＜ 0.05). While compared with T group, the amount of Propofol in DT group was reduced, the recovery time of spontaneous breathing, waking time and extubation time were shortened, and the VAS scores at T1-T3 were reduced (P ＜ 0.05). There were no significant differences of Ramsay scores and the incidence of adverse reactions among the three groups (P ＞ 0.05). The rate of temperature plane block in block sides of T group and DT group after operation for 24 h was 76.7%, 86.7% respectively. Conclusion Local anesthetics combined with Dexmedetomidine for B ultrasound-guided TAPB has faster recovery of anesthesia and better postoperative analgesia, with high accuracy and safety in gynecological laparotomy.
2017 Vol. 14 (34): 62-65 [Abstract] ( 326 ) HTML (1 KB)  PDF (482 KB)  ( 171 )
66 Effects of preoperative intranasal Dexmedetomidine for the bispectral index and median effective concentration of Sevoflurane in children with abdominal surgery by inhalation anesthesia of Sevoflurane
LIU Chao XIN Zhong▲
Objective To analyze the effects of preoperative intranasal Dexmedetomidine for the bispectral index (BIS) and median effective concentration [EC (50)] of Sevoflurane in children with abdominal surgery by inhalation anesthesia of Sevoflurane. Methods One hundred and twenty children received abdominal surgery in Beijing Children′s Hospital, Capital Medical University from February 2016 to February 2017 were selected, with ASA grading Ⅰ-Ⅱ and 1-3 years old. They were divided into study group and control group by random number table method, with 60 cases in each group, they were respectively given Dexmedetomidine 2 μg/kg and equal amounts of normal saline by nasal aerosolization device at 30 min before anesthesia induction. After the children entered operating room, they were given mask oxygen-inspiration and inhalation of 6% Sevoflurane for anesthesia induction. The laryngeal mask was given after children lost consciousness, and they were given drugs according to Dixon sequential experiment, the initial concentration was 3.50%. The setting of Sevoflurane for the next child was adjusted according to the conditions of laryngeal mask insertion of last one child. The changes of blood pressure, heart rate, BIS and the conditions of emergence agitation, adverse reactions before nasal spray (T0), 20 min after nasal spray (T1), and at the end of surgery (T2), recovery from anesthesia (T3) between the two groups were compared, the EC (50) and 95% confidence interval (CI) at the time of laryngeal mask insertion of Sevoflurane were analyzed. Results There were no significant differences of blood pressure and heart rate at T0 and T1 between the two groups (P ＞ 0.05). The blood pressure and heart rate of the study group at T2, T3 were significantly higher than those of the control group (P ＜ 0.05). There was no significant difference of BIS value between the two groups at T0 (P ＞ 0.05). At T1 and T2, BIS values of the study group were significantly lower than those of the control group (P ＜ 0.05). At T3, BIS value of the study group was significantly higher than that of the control group (P ＜ 0.05). The EC (50) at laryngeal mask insertion of Sevoflurane in the study group and the control group was 1.35% (95%CI = 1.05%-1.48%) and 1.89% (95%CI = 1.77%-2.18%), the differences were statistically significant (P ＜ 0.05). The incidence of emergence agitation in the study group was 5.00%, which was significantly lower than that of control group (18.33%) (P ＜ 0.05), the incidence of nausea and vomiting was 11.67%, 6.67% respectively, which was significantly lower than those of control group (26.67%, 21.67%) (P ＜ 0.05). Conclusion Preoperative intranasal Dexmedetomidine can reduce the agitation after inhalation anesthesia of Sevoflurane in children with abdominal surgery, which has positive effects for improving the quality of inhalation anesthesia of Sevoflurane and EC (50) of Sevoflurane, and it can effectively reduce adverse reactions.
2017 Vol. 14 (34): 66-69,73 [Abstract] ( 286 ) HTML (1 KB)  PDF (1033 KB)  ( 172 )
70 The influence of electroacupuncture stimulation on learning and memory ability in rats with cerebral ischemia-reperfusion injury
ZHANG Li1 PENG Ye2
Objective To study the influence of electroacupuncture stimulation on learning and memory ability in rats with cerebral ischemia-reperfusion injury, and to provide evidence for the clinical treatment of ischemic stroke. Methods Forty-five SPF male rats were divided into 3 groups (n = 15): model group, electroacupuncture group and sham operation group according to the random number table. The model group and electroacupuncture group were used to make the model of total cerebral ischemia-reperfusion injury. The electroacupuncture group was stimulated by electroacupunture, and the operation group did not block the blood flow in the middle of the cerebral artery, and the remaining operations were in the same with model group. The learning and memory ability of rats was assessed using Morris water maze, and the escape latency and  the number of crossing the platform during different time periods were recorded; Nissl staining was used to count the number of neurons in CA1 and CA3. Results Compared with the sham operation group, the escape latency in the model group was prolonged significantly, and the frequency of crossing the platform was increased significantly (P ＜ 0.05). Compared with the model group, the escape latency in the electroacupuncture group was shortened, and the frequency of crossing the platform was decreased significantly (P ＜ 0.05). Compared with the sham operation group, the number of neurons for CA1 and CA3 in the model group was decreased (P ＜ 0.05). Compared with model group, the number of neurons in the electroacupuncture group was increased (P ＜ 0.05). Conclusion Electroacupuncture can improve learning and memory ability in cerebral ischemia rats, speculates that the mechanism may be related to its hippocampal nerve protective effect on cerebral ischemia reperfusion rats.
2017 Vol. 14 (34): 70-73 [Abstract] ( 315 ) HTML (1 KB)  PDF (733 KB)  ( 154 )
74 Clinical study of Yiqi Huayu Recipe in the treatment of Hashimoto thyroiditis with normal thyroid function
LUO Yuanlin SHAO Yingxin▲ ZHOU Tao JIANG Chao
Objective To observe the effects of Yiqi Huayu Recipe on the thyroid autoantibodies and thyroid function in Hashimoto thyroiditis (HT) patients with normal thyroid function. Methods From July 2016 to February 2017, a total of 112 patients of HT with normal thyroid function in Department of Thyroid, Hubei Huanggang Hospital of Traditional Chinese Medicine, were recruited in this study. They were randomly classified into treatment group and control group, with 56 cases in each group. The treatment group was given Chinese medicine compound preparation of Yiqi Huayu Recipe, the control group did not take any medication, they were only taken iodine deficient diet. The two groups were treated for 6 months, The thyroid autoantibodies [thyroid peroxidase antibody (TPOAb), thyroglobulin antibodies (TgAb)] and thyroid function [thyrotropic hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4)] were measured before and after treatment. Results The levels of TPOAb and TgAb in the treatment group were both lower than those before treatment, the differences were statistically significant (P ＜ 0.05), which were significantly lower than those of control group (P ＜ 0.05); the levels of TPOAb and TgAb in the control group were significantly higher than those before treatment, the differences were statistically significant (P ＜ 0.05). After treatment, the level of TSH in the control group was significantly higher than that before treatment, which was significantly higher than that of treatment group (P ＜ 0.05), there was no statistically significant difference of TSH in the treatment group before and after treatment (P ＞ 0.05). There were no statistically significant differences of FT3 and FT4 before and after treatment in the two groups (P ＞ 0.05). Conclusion Chinese medicine compound preparation of Yiqi Huayu Recipe can reduce the levels of TPOAb and TgAb in HT patients with normal thyroid function, but it has little effects on thyroid function; iodine deficient diet can not control the increase of TPOAb, TgAb and TSH in HT patients.
2017 Vol. 14 (34): 74-77 [Abstract] ( 220 ) HTML (1 KB)  PDF (729 KB)  ( 186 )
78 Study on the current situation and strategies of personnel training in Yunnan traditional Chinese medicine health industry
XU Yingjian1 CHEN Lipin1 YANG Lihong2 ZHANG Difan3 GAO Chuqun1
Being an important part of the health industry, the development of traditional Chinese medicine health industry needs the support of personnels. This paper explores the demand for personnels and the current situation of personnel training in Yunnan traditional Chinese medicine health industry, and suggests that relevant colleges and institutions should raise their levels of personnel training, optimize their professional structure, change their models of personnel training, explore the education models of school-enterprise cooperation and develop continuing education to improve the quality of personnel training, so as to meet the needs of the development of the industry.
2017 Vol. 14 (34): 78-81 [Abstract] ( 298 ) HTML (1 KB)  PDF (818 KB)  ( 151 )
82 Textual Research on Names of Chinese Traditional Medicine pseudo-ginseng
KONG Xianghua1 LUO Qiao2 XIAO Yuanjie3
To provide Chinese medicine learners with an angle for more, deepen their comprehension of Chinese medicine culture and increase their interests in it, this paper explained different names of Chinese Traditional Medicine pseudo-ginseng, via Literature research, analytical method and so on. By referring to medical ancient books like "Compendium of Materia Medica", it was mainly affected by its efficacy, habitat, color, shape, processing method, medicinal part, packing season and the like.
2017 Vol. 14 (34): 82-85 [Abstract] ( 340 ) HTML (1 KB)  PDF (727 KB)  ( 413 )
86 Clinical effect of digital acupoint pressure therapy in treating cervical vertigo
LYU Yanan1 FU Min1 GAO Xin2 LIU Chaofeng2
Objective To observe the clinical curative effect of digital acupoint pressure therapy in the treatment of cervical vertigo. Methods From July 2013 to September 2016, 72 cases of cervical vertigo  were selected, which were treated in Massage Department, the People′s Hospital of Guangxi Zhuang Autonomous Region. They were divided into treatment group and control group by random number table, with 31 cases in each group. The treatment group was treated with digital acupoint pressure therapy, while the control group was treated with general massage therapy, both groups were treated once a day and treated 10 times. The curative effects and the scores of cervical vertigo symptom and functional assessment scale in the two groups were compared. Results After treatment, the curative effect in the treatment group was higher than that in the control group (P < 0.05). Before treatment, there was no statistically significant difference in the score of cervical vertigo and functional assessment scale between the two groups (P > 0.05). After treatment, the scores in the two groups were increased, and the score in the treatment group were significantly higher than that in the control group (P < 0.05). Conclusion It is effective for the patients with cervical vertigo through the digital acupoint pressure therapy and general massage therapy, while the digital acupoint pressure is better than the massage therapy.
2017 Vol. 14 (34): 86-88,93 [Abstract] ( 293 ) HTML (1 KB)  PDF (785 KB)  ( 137 )
89 Current situation and countermeasure of the application of appropriate techniques of traditional Chinese medicine
ZHANG Shuxin1 CHEN Xiaoyun2▲ HOU Yuejie1 LI Yanbo1 HUANG Wanru1 PEI Zhigang1 FENG Li1
Objective To understand the current situation and provide a scientific basis and countermeasure for further promotion of appropriate technology. Methods Through the retrieval of Wanfang database and CNKI two databases, a comprehensive search was conducted to collect relevant literatures from January 2005 to December 2016. Results Ways of appropriate technology popularization mainly included the government-leading primarily promotion, the construction of the county-township-village three-level linkage promotion, promotion association, etc; public acceptance and the curative effect of appropriate technology was the leading cause of popularization; overall promotion effect was better. Conclusion In order to solve the problem of "the difficulties and high expense in seeing a doctor", it is necessary to increase the scope of application of appropriate technology of traditional Chinese medicine, and promote the appropriate technology to meet the needs of local people, improve promotion effect.
2017 Vol. 14 (34): 89-93 [Abstract] ( 443 ) HTML (1 KB)  PDF (772 KB)  ( 202 )
94 Clinical effect of Bushen Zhuanggu Decoction in the treatment of diabetic ostecporosis
FU Jiangtao HONG Bin ZHANG Jianlin▲ LEI Liang ZHANG Ning
Objective To observe the clinical effect of Bushen Zhuanggu Decoction in the treatment of diabetic ostecporosis. Methods Eighty-two cases of patients with diabetic ostecporosis treated in Baoji Hospital of Traditional Chinese Medicine from October 2015 to January 2017 were selected as research objects, and they were divided into observation group and control group by random number table method, with 41 cases in each group. Both groups were given conventional basic therapy, on basis of conventional basic therapy, the control group was given Calcium Supplement with Vitamin D Chewable Tablets and Elcatonin Injection. On basis of control group, the observation group was added with Bushen Zhuanggu Decoction. Both groups were taken 4 weeks as a course, after 3 courses of treatment, the clinical effects were observed, the blood glucose, glycosylated hemoglobin, bone mineral density and serum calcium, phosphorus of the two groups before and after treatment were detected, the adverse reactions were recorded. Results The total effective rate of observation group was 95.1%, which was higher than that of control group (82.9%), the difference was statistically significant (P ＜ 0.05). After treatment, the levels of fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin of the two groups were significantly lower than those before treatment, the differences were highly statistically sighificant (P ＜ 0.01), and the indices above in the observation group after treatment were all lower than those of control group (P ＜ 0.05). After treatment, the spinal bone mineral density of the two groups were all higher than those before treatment, the spinal bone mineral density of observation group was higher than that of control group, the differences were all statistically significant (P ＜ 0.05), the levels of serum calcium in the two groups were higher than those before treatment, and the levels of serum phosphorus were lower than those before treatment, but the differences were not statistically significant (P ＞ 0.05), and the differences between the two groups after treatment were also not statistically significant (P ＞ 0.05). During treatment, there were no obvious adverse reactions in the two groups. Conclusion On basis of western medicine, Bushen Zhuanggu Decoction can significantly improve the clinical symptoms of patients with diabetic ostecporosis, increase bone mineral density, control blood glucose, which is worthy of clinical promotion and application.
2017 Vol. 14 (34): 94-97 [Abstract] ( 314 ) HTML (1 KB)  PDF (770 KB)  ( 140 )
98 Clinical effect of Modified Zhenwu Decoction in treating chronic heart failure
SHU Huiwen BAI Ying LI Yuhuan
Objective To study the clinical effect of Modified Zhenwu Decoction in the treating chronic heart failure with syndrome of Yang deficiency leading to water flooding. Methods The clinic data of 62 patients with chronic heart failure were analysed retrospectively, that they were treated in Beijing Xiaotangshan Hospital from January 2015 to May 2017 and divided into treatment group and control group, with 31 cases in each group. The control group was treated with conventional anti-heart failure treatment, while the treatment group was treated with Modified Zhenwu Decoction on the basis of routine treatment of western medicine. They were treated for 4 weeks. The cardiac function, heart failure scores, heart color parameters and BNP level in the two groups were compared. Results After treatment, the total effective of cardiac function and improvement of heart failure symptoms in the treatment group were higher than those of the control group (P < 0.05). After treatment, the rate of ejection fraction and stroke volume in the two group were increased, and those in the treatment group were higher than those in the control group (P < 0.05). Besides, the levels of BNP in the two groups after treatment were decreased, and the level in the treatment group was lower than that in the control group (P < 0.05). Conclusion Modified Zhenwu Decoction is effective in the treatment of chronic heart failure with syndrome of Yang deficiency leading to water flooding, which can improve the cardiac function and deserve clinical promotion.
2017 Vol. 14 (34): 98-101 [Abstract] ( 287 ) HTML (1 KB)  PDF (768 KB)  ( 102 )
102 The correlation study of MSCT and pulmonary function in patients of chronic obstructive pulmonary disease combined with bronchiectasis
LIANG Kaiyi1 YU Yanfang2 ZHOU Hui1
Objective To explore the correlation between lung volume index of multi-slice spiral CT (MSCT) and routine pulmonary function of patients suffering from chronic obstructive pulmonary disease (COPD) combined with bronchiectasis. Methods From January 2015 to December 2016, a total of 104 hospitalized patients in Department of Respiration, Shanghai Jiading District Central Hospital were selected and divided into COPD group(56 cases) and COPD combined with bronchiectasis (48 cases) by whether combined with bronchiectasis. The lung volume indexes of MSCT and routine pulmonary function were compared between the two groups. The correlation of lung volume indexes of MSCT and routine pulmonary function in the group of COPD combined with bronchiectasis were analyzed. Results FEV1%pred, FEV1/FVC, FVC%pred, DLCO%pred in the COPD combined with bronchiectasis group were lower than those of COPD group, and RV/TLC was significantly higher than that of COPD group(P ＜ 0.01). The lung volume indexes  of inspiratory volume (Vin), expiratory volume （Vex), Vex/Vin in the COPD combined with bronchiectasis group were all higher than those of COPD group(P ＜ 0.05), and the Vin-Vex was much lower than that of COPD group(P ＜ 0.05). The lung volume indexes of Vin in the COPD combined with bronchiectasis group in MSCT was negatively correlated with the lung volume indexes of FEV1 and FEV1/FVC(r ＜ 0，P ＜ 0.05), and the Vin was positively correlated with the lung volume indexes of RV, TLC and RV/TLC (r ＞ 0，P ＜ 0.05). Vex was negatively correlated with the lung volume indexes of FEV1, FEV1/FVC, TLC and RV/TLC (r ＜ 0，P ＜ 0.05), Vex was positively correlated with RV(r ＞ 0，P ＜ 0.05); Vex/Vin was negatively correlated with FEV1, TLC and RV/TLC(r ＜ 0，P ＜ 0.05); and was positivily correlated with RV.Vin-Vex/Vin was positively correlated with FEV1, FEV1/FVC, RV, TLC and RV/TLC(r ＞ 0，P ＜ 0.05). Conclusion The pulmonary function of COPD patients combined with bronchiectasis declined more apparently and indicates the condition is more serious. The pulmonary function and changes in the bronchi structure of COPD patients combined with bronchiectasis can be clarified by MSCT and it has great significance for the diagnostic, treatment and prognostic evaluation.
2017 Vol. 14 (34): 102-105 [Abstract] ( 271 ) HTML (1 KB)  PDF (338 KB)  ( 300 )
106 Analysis of the distribution and drug resistance of pathogenic bacteria from bile specimens of elderly patients
ZHANG Wenjing1 YU Boxin1 ZHANG Yajie2 WANG Jiahe1
Objective To investigate the distribution and drug resistance of pathogenic bacteria from bile specimens of elderly patients, in order to provide guidance for clinical rational use of antibiotics. Methods Identification of bacteria and antibiotic susceptibility tests were performed on the strains isolated from elderly patients in Shengjing Hospital of China Medical University ("our hospital" for short) from January 2014 to December 2016, and the results were analyzed retrospectively. Results There were 268 strains of pathogenic bacteria from bile specimens, including 191 strains of Gram-negative bacteria and 73 strains of Gram-positive strains and 4 strains of fungi, of which the top 6 pathogens were Escherichia coli, Enterococcus faecium, Klebsiella pneumoniae, Enterococcus faecalis, Acinetobacter baumannii and Pseudomonas aeruginosa. The drug resistance rates of Escherichia coli and Klebsiella pneumoniae to Carbapenems, Aminoglycosides, Cefepime, Ceftazidime, Cefotetan, Piperacillin-tazobactam were lower than 50.00%. The drug resistance rate of Acinetobacter baumannii to Imipenem was 86.67%, while to Tigecycline and Amikacin were lower. The resistant rate of Pseudomonas aeruginosa to Cefepime and Ceftazidime was 14.29% and 38.46% respectively. The drug resistance rates of Enterococcus faecium to many antibiotic drugs were higher than Enterococcus faecalis. Both of them were sensitive to Linezolid, Tigecycline, Vancomycin. Conlusion The most common pathogens from bile specimens of elderly patients in our hospital are Gram-negative strains, Amikacin may be the first choice antibiotics. For infection of the Enterococcus spp,Vancomycin and Linezolid have higher antimicrobial activities. The antimicrobial agents should be chosen reasonably according to the results of the drug susceptibility to improve the effect of the treatment.
2017 Vol. 14 (34): 106-109,131 [Abstract] ( 231 ) HTML (1 KB)  PDF (836 KB)  ( 173 )
110 The significance of apolipoprotein E gene polymorphism in cerebral infarction
LI Meizhu ZHU Changlin CHEN Binhong LI Weixuan
Objective To investigate the correlation between the gene polymorphism of apolipoprotein E (ApoE) and the development of cerebral infarction. Methods The case group of 348 patients with cerebral infarction in Neurology Department of the First People′s Hospital of Foshan ("our hospital" for short) from January 2015 to March 2017, and control group of 352 healthy people at the same time in our hospital were selected. Both groups were used the gene chip approach for the ApoE genotype tested. ApoE genotype and phenotype between the two groups, and the serum lipid levels of patients with different ApoE gene phenotypes were compared. Results The highest genotype frequency of ApoE was ε3/3 and the highest allele frequency was ε3 in the two groups. The ε2/3 and ε3/3 genotypes in the case group were significantly lower than the control group, the differences were statistically significant (P < 0.05); and the ε3/4 was significantly higher than the control group, the difference was highly statistically significant (P < 0.01). The frequency of ε2 allele in case group was significantly lower than the control group, the difference was statistically significant (P < 0.05), while the ε4 was significantly higher than the control group, the difference was highly statistically significant (P < 0.01). Compared with the levels of blood lipids in different ApoE phenotypes patients of the case group, the levels of total cholesterol and low density lipoprotein cholesterin were the lowest in E2 genotype patients, the differences were statistically significant (P < 0.05). Conclusion The ApoE gene polymorphism plays an important role in the occurrence and development of cerebral infarction.
2017 Vol. 14 (34): 110-113 [Abstract] ( 308 ) HTML (1 KB)  PDF (429 KB)  ( 118 )
114 The application of case-led seminar teaching pattern in military operational medicine
XU Shangcheng LI Min ZHANG Lei ZHOU Zhou Zhong Min YU Zhengping
Military operational medicine is an emerging discipline that reflects the extension of military medical from traditional injuries medicine, health medicine to medical typicality. The application of case-led Seminar teaching model in the teaching practice of military operational medicine can highlight the students' subject status, greatly stimulate the learning enthusiasm and the inherent potential of the students in military medical university, which strengthen the participants′ ability to present, analyze and solve problems, and achieve benefits to both teachers and students.
2017 Vol. 14 (34): 114-116 [Abstract] ( 303 ) HTML (1 KB)  PDF (606 KB)  ( 80 )
117 Medicinal chemistry teaching innovation and practice for the cultivation of drug discovery talents
ZHANG Yongqiang LI Hao LI Jian MAO Fei DENG Weiping MA Hongmei
The fast-growing pharmaceutical industry of China calls for the cultivation of many qualified drug discovery talents urgently. The research of medicinal chemistry is the major driving force of drug discovery. Therefore, the corresponding course teaching represents main approach for the cultivation of drug discovery talents. Herein, three strategies against the problems in present college medicinal chemistry course teaching were demonstrated, including topic-based teaching extension, comprehensive teaching methods innovation and two-dimensional teaching evaluation. These strategies were initially proved efficient in motivating the students to learn more practical drug design skills and in developing the innovative thinking ability for drug discovery. Furthermore, the initial teaching practice outcome was evaluated and some constructive suggestions were thus presented accordingly.
2017 Vol. 14 (34): 117-119,136 [Abstract] ( 296 ) HTML (1 KB)  PDF (684 KB)  ( 263 )
120 Application progress and enlightenment of PBL in medical education
ZHOU Bo YUAN Haihong
Problem-based learning (PBL) is a widely concerned medical education model in the world. However, there are many problems in the application of this model in China. This paper reviews the progress of PBL implementation at home and abroad in recent years, and summarizes the three core elements of PBL from the aspects of problems, teachers and groups. It can be used as reference for the PBL teachers, the change of students′ learning concept, the allocation of teaching resources and the establishment of evaluation system in medical education in China.
2017 Vol. 14 (34): 120-123 [Abstract] ( 245 ) HTML (1 KB)  PDF (619 KB)  ( 242 )
124 Design of Flipped Classroom in Pharmaceutical Analysis Based on Microlecture
WU Hong YANG Tiehong TAN Guangguo FAN Li QIAO Youbei
Microlecture has been received widespread attention from educators for the characteristics of the content of refining and clear learning objective. Flipped classroom, i.e. flipping the teaching model of traditional classroom, is a brand novel teaching idea. The new teaching model of microlecture and flipped classroom have been already applied and get good teaching effects in colleges and universities. In this paper, the feasibility of application of flipped classroom based on microlecture in pharmaceutical analysis was discussed, in order to improve the deep integration of traditional teaching methods and modern information technology in colleges and universities.
2017 Vol. 14 (34): 124-127 [Abstract] ( 277 ) HTML (1 KB)  PDF (683 KB)  ( 102 )
128 The role of pharmaceutical experimental teaching demonstration center in innovation and entrepreneurship project of college students
KANG Wenyi NIU Yingying WANG Jinmei GUO Xiuchun SUN Huiling▲
The innovation and entrepreneurship training project of undergraduate students plays an important role in promoting the reform of talents in universities, improving students′ ability of innovation and cultivating innovative talents. The successful implementation of project depends on many aspects. This paper takes He′nan University Pharmaceutical Experimental Teaching Demonstration Center as an example, from the teachers′ team, the relevant scientific research projects and the project implementation conditions to analyze the demonstration center role in undergraduate students′ innovative entrepreneurial project. At the same time, this paper discusses the problems and tests of the demonstration center in implementing the innovation and entrepreneurship project, so as to provide reference for the successful implementation of the innovation and entrepreneurship project.
2017 Vol. 14 (34): 128-131 [Abstract] ( 212 ) HTML (1 KB)  PDF (613 KB)  ( 116 )
132 Inspiration of "craftsman spirit" on the cultivation of application-oriented undergraduate nursing talents in traditional Chinese medicine
WANG Lei ZHANG Lihong HAO Meiling JI Shunxin
At present stage, most of the cultivation of application-oriented undergraduate nursing talents in traditional Chinese medicine focus on skill training, but lack of continuity and environment for the professional ethics education. It is difficult for the graduates to meet the "high-quality" standard. The core of "craftsman spirit" is to improve the quality. It can provide research ideas for the cultivation of application-oriented nursing talents. This paper taking the content of "craftsman spirit" as the starting point, find out the relationship between "craftsman spirit" and the cultivation of application-oriented undergraduate nursing talents in traditional Chinese medicine, explore the feasibility and the positive effects of "craftsman spirit" implantation. Through the analysis of the cultivation path, the practical significance of "crafstman spirit" for improving the quality of talents development is illustrated in this paper and provide references for the cultivation of application-oriented undergraduate nursing talents in traditional Chinese medicine.
2017 Vol. 14 (34): 132-136 [Abstract] ( 285 ) HTML (1 KB)  PDF (623 KB)  ( 143 )
137 The design and application of flipped classroom combined with WeChat public platform in surgical probation
ZHENG Kailian ZHANG Xin ZHOU Weizheng YUAN Liangxi LI Jia WANG Yan ZHAO Zhiqing JIN Gang
Objective To discuss the design and application effects of flipped classroom teaching method combined with WeChat public platform in surgical probation. Methods From March to May 2017, 90 medical undergraduates of the grade 2014 five-year clinical medicine undergraduate professional on probation in the Department of General Surgery of Changhai Hospital were enrolled as teaching objects and divided into the traditional group and the educational reform group by random number table, with 45 cases in each group. The traditional group was given traditional teaching methods and the educational reform group was given flipped classroom combined with WeChat teaching methods. The scores of theories and skills test were compared between the two groups. The standardized questionnaire designed by experts of the medical department was used to evaluate the teaching effect, learner's ability, learning attitude and learning methods and the medical humanistic consciousness. Results There was no statistically significant difference in the scores of theoretical examination between the two groups (P ＞ 0.05). In the skill test, there were no statistically significant differences in the scores of love concept, strain capacity during operation, operation steps, overall quality of operation, aseptic concept, aseptic operation skill and record writing between the two groups(P ＞ 0.05), the scores of learning attitude, operation readiness and coordination aspects in the educational reform group were higher than those of the traditional group, with statistically significant differences (P ＜ 0.05). The questionnaire survey showed that understanding and memorying the theoretical knowledge, learning initiative and enthusiasm, clinical thinking judgment, theory combined with practical application, learning efficiency and learning atmosphere in the educational reform group were all better than those of the traditional group, with statistically significant differences(P ＜ 0.05). Conclusion The teaching mode of flipped classroom combined with WeChat platform in surgical probation is feasible and more effective than the traditional teaching mode in improving teaching effectiveness.
2017 Vol. 14 (34): 137-140,150 [Abstract] ( 274 ) HTML (1 KB)  PDF (1024 KB)  ( 127 )
141 Evaluation of medical service economics and satisfaction analysis after trans-provincial trusteeship of a public hospital
YANG Zhe1 ZHANG Shihua1 REN Xiaoyan1 TU Bin2 HE Zhijun3 LI Lingui1
Compare and analyze the changes before and after the trusteeship from the aspects of hospital cost, financial input, business income, insurance compensation, economic management benefits, and employee benefits. And the satisfaction of Baihe County Hospital of Traditional Chinese Medicine in Shaanxi Province was analyzed by Likert scale score, in order to provide policy suggestions for the public hospital. It is observed that the balance of business is income and the expenditure has been improved after trusteeship. The cost of insurance for the insured is higher than the self-funded patients, and the welfare of the staffs has been significantly improved. The lowest satisfaction of managers is the distribution system, the second is the personnel system. The lowest satisfaction of workers is the salary and welfare treatment, the satisfactions of future development and work environment are high. The service attitude of medical staff is significantly improved in patients′ satisfaction.
2017 Vol. 14 (34): 141-145 [Abstract] ( 240 ) HTML (1 KB)  PDF (632 KB)  ( 158 )
146 Thinking and practice of advancing with time and conserving hospital spirit
WANG Jianmin HUA Lei ZhANG Guojun
Hospital spirit is the soft power of hospital development and the important way to enhance the hospital cohesion and cultural charisma as well as integrate multiple value concept and further promote smoothly the implementation of comprehensive reform of medicine separation. With the changing environment inside and outside the hospital and the continuous development of the times, we must advance with time, enrich and perfect the hospital spirit. Taking Xuanwu Hospital Capital Medical University as an example, the paper introduces the necessity of conserving hospital spirit, practice exploration, results and thinking experience with the background of new era and management requirements.
2017 Vol. 14 (34): 146-150 [Abstract] ( 234 ) HTML (1 KB)  PDF (581 KB)  ( 167 )
156 Analysis of the strategy of hospital management and operation
LI Anzhou
The management of hospital is a series of behavior from hospital′s internal which of focus on planning, organization, coordination, and controlling. The operation is the plan which connects the internal and the external of the hospital, in order to realize the maximization of the business volume and the benefit. This paper makes a survey on the special visits and investigations of the third-grade class-A hospitals in He′nan Province. To explore the way and the relationship of the management and operation. The decision-makers of the hospital plays a key role in the process of the development of the hospital, which provide reliable evidence for hospital operation and management.
2017 Vol. 14 (34): 156-159 [Abstract] ( 275 ) HTML (1 KB)  PDF (621 KB)  ( 88 )
160 Effects of PDCA cycle nursing management on self-efficiency, secondary infection for elderly patients with advanced lung cancer treated with chemotherapy
HAN Jizhen1 Amina·Quhai2 Ayiguli·Maimaiti3 YU Xiangyou4
Objective To observe the effects of PDCA cycle nursing management on self-efficiency, secondary infection and nursing quality in elderly patients with advanced lung cancer treated with chemotherapy. Methods 52 elderly patients with advanced lung cancer who received chemotherapy in the First Department of VIP Service, Cancer Hospital Affiliated to Xinjiang Medical University (“our department” for short) from January 2012 to December 2014 were collected as the control group, and 64 elderly patients with advanced lung cancer who received chemotherapy in our department from January 2015 to December 2016 were collected as the observation group. The control group was given to conventional nursing intervention, while the observation group was given to PDCA cycle nursing management. General Self-efficiency Scale (GSES) and self-made questionnaire were employed to assess self-efficiency and nursing quality respectively. Retrospectively analyzing their clinical materials, self-efficiency, secondary infection and nursing quality were compared between the two groups then. Results After intervention, in comparison with the control group, the GSES score of the observation group was significantly increased and the incidence of secondary infection was significantly decreased (P < 0.05 or P ＜ 0.01). Self-made questionnaire showed that the scores of service attitude, professional skill and health education in the observation group was significantly increased compared with the control group (P < 0.05). Conclusion PDCA cycle nursing management has good application effect in elderly patients with advanced lung cancer treated with chemotherapy. And it can increase self-efficiency, reduce incidence of secondary infection and promote nursing quality.
2017 Vol. 14 (34): 160-162,166 [Abstract] ( 265 ) HTML (1 KB)  PDF (533 KB)  ( 93 )
163 Effects of comprehensive nursing intervention on perioperative nursing in patients with rectal cancer underwent Dixon
LI Lei CHEN Aijing CHEN Pengju ZHANG Jie▲
Objective To explore the applying values of comprehensive nursing intervention in perioperative period of rectal cancer patients underwent Dixon. Methods From February 2012 to January 2016, 86 patients with rectal cancer in Peking University Cancer Hospital were selected and divided into observation group and control group by envelope method, with 43 cases in each group. All patients were treated with Dixon, and the control group was treated with the perioperative routine nursing, while the observation group was treated with comprehensive nursing care based on the control group. The prognosis and nursing satisfaction of the two groups were recorded. Results The exhaust time, defecation time and postoperative hospital stay in the observation group were significantly less than that those in the control group (P < 0.05). At discharge, the nursing satisfaction of the observation group was significantly higher than that of the control group (P < 0.05). One month after operation, occurrence of complications in the observation group was significantly lower than that of the control group (P < 0.05). Conclusion The comprehensive nursing intervention can be conducive to the rehabilitation of patients, reduce the incidence of complications, and improve nursing satisfaction of patients, which is applied in perioperative nursing in patients with rectal cancer underwent Dixon.
2017 Vol. 14 (34): 163-166 [Abstract] ( 277 ) HTML (1 KB)  PDF (521 KB)  ( 94 )
167 Effect of community health education combined nursing intervention on patients with limb dysfunction after stroke
LI Xiujuan1 GU Ting2 HE Qing3
Objective To explore the effect of community health education combined nursing intervention on patients with limb dysfunction after stroke. Methods Ninety patients with limb dysfunction were enrolled in the First People′s Hospital of Xuzhou from July 2015 to July 2016. They were divided into control group and study group according to the different nursing methods, with 45 cases in each group. The control group was treated with routine care, while the study group was treated with community health education joint nursing intervention. They were treated for 6 months. Before and after intervention, the neurological function, limb recovery and quality of life in the two groups were compared. Results Before the intervention, there were no significant differences in the neurological score, the athletic ability and the quality of life score between the two groups ( P > 0.05). After intervention, the neurological score and grading of life quality of the study group were lower than those of the control group, and the athletic ability of the limbs was significantly higher than that of the control group (P < 0.05). Conclusion The combination of community health education combined with nursing intervention can improve the recovery of limb function and neurological function, improve the efficiency of treatment and improve the quality of life of patients with postoperative stroke. It is worthy to be popularized and applied.
2017 Vol. 14 (34): 167-169,177 [Abstract] ( 364 ) HTML (1 KB)  PDF (562 KB)  ( 132 )
170 Influence of comprehensive psychological intervention on depressive mood, life health quality and neurotransmitter in patients with recurrent depression
TANG Wenjuan1 QIAN Yiping2▲ GU Kangying3 CHEN Xuefei4
Objective To study the influence of comprehensive psychological intervention on depressive mood, life health quality and neurotransmitter in patients with recurrent depression. Methods From April 2014 to June 2015, 80 patients with recurrent depression in the Third People's Hospital of Huai'an City were divided into control group (40 cases) and observation group (40 cases) by random number table. Patients in the control group were treated with routine clinical intervention, while those in observation group were treated with comprehensive psychological intervention combined with routine clinical intervention. The scores of depressive and life quality and the serum content of monoamine neurotransmitter in the two groups were compared. Results Before the intervention, there were no significant differences in the scores of depressive and life quality and the serum content of monoamine neurotransmitter between the two groups (P > 0.05). After intervention, the scores of depressive in the observation group were lower than those in the control group, the scores of life quality in the observation group were higher than those in control group, the levels of NE, 5-HT, DA in the observation group were higher than those in control group (P < 0.05). Conclusion Comprehensive psychological intervention can relieve depression and improve the quality of life in patients with recurrent depression.
2017 Vol. 14 (34): 170-173 [Abstract] ( 243 ) HTML (1 KB)  PDF (550 KB)  ( 121 )
174 Effect of evidence-based nursing intervention on the prognosis of children with ventricular tachycardia
SHAO Xiumin LIU Ming
Objective To investigate the influence of evidence-based nursing intervention on the prognosis of children with ventricular tachycardia, in order to provide evidence for clinical application. Methods From January 2015 to December 2016, 400 children with ventricular tachycardia in Beijing Children′s Hospital were divided into observation group and control group by envelope method, with 200 cases in each group. The observation group was treated with evidence-based intervention nursing mode, while the control group was treated with routine nursing intervention. The time of treatment, the incidence of adverse reactions, satisfaction, clinical efficacy rate and the quality of life in the two groups were compared. Results The treatment time and the incidence of adverse reactions in the observation group were significantly lower than those in the control group (P < 0.05). The satisfaction, clinical efficacy rate and the quality of life in the observation group were significantly higher than those in the control group (P < 0.05). Conclusion The prognosis of the children with ventricular tachycardia can be improved and the clinical satisfaction rate can be improved by treated with adopting the evidence-based nursing model.
2017 Vol. 14 (34): 174-177 [Abstract] ( 229 ) HTML (1 KB)  PDF (521 KB)  ( 274 )
178 Influence of immediate family involvement nursing on prognosis and psychological status of patients with dysphagia after stroke
LI Yi
Objective To explore the influence of participation in immediate family care on the prognosis, quality and psychological status of patients with dysphagia after stroke. Methods From January 2015 to December 2016, 100 patients with dysphagia after stroke in Beijing Tiantan Hospital were divided into observation and control group by envelope method. The control group was treated with conventional care intervention, while the observation group was treated with the participation of the immediate family nursing intervention. Before and after treatment, the patients were assessed by Watian drinking water test, and the curative effect was compared. Before and after nursing, the patient′s physical ability was assessed by mini Fugl-Meyer Integral, the patient′s life ability was evaluated by the Barthel index method, the psychological status of patients were assessed by SAS and SDS, the quality of life of patients was assessed by SS-QOL. Results The effect of the observation group was significantly higher than that of the control group (P < 0.01). The scores in the observation group were significantly better than those in the control group (P < 0.05). After nursing, the scores of Watian drinking, Barthel, Fugl-Meyer, SAS, SDS and SS-QOL in the observation group were significantly better than those in the control group (P < 0.05). The levels of total protein, albumin and hemoglobin in the observation group were significantly higher than those of the control group (P < 0.01). Conclusion The adoption of immediate relatives participation nursing mode can effectively improve the prognosis quality and psychological status of patients with dysphagia after stroke.
2017 Vol. 14 (34): 178-181 [Abstract] ( 243 ) HTML (1 KB)  PDF (684 KB)  ( 113 )
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