老年患者胆汁培养病原菌分布及耐药性分析

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Abstract Objective To investigate the distribution and drug resistance of pathogenic bacteria from bile specimens of elderly patients, in order to provide guidance for clinical rational use of antibiotics. Methods Identification of bacteria and antibiotic susceptibility tests were performed on the strains isolated from elderly patients in Shengjing Hospital of China Medical University ("our hospital" for short) from January 2014 to December 2016, and the results were analyzed retrospectively. Results There were 268 strains of pathogenic bacteria from bile specimens, including 191 strains of Gram-negative bacteria and 73 strains of Gram-positive strains and 4 strains of fungi, of which the top 6 pathogens were Escherichia coli, Enterococcus faecium, Klebsiella pneumoniae, Enterococcus faecalis, Acinetobacter baumannii and Pseudomonas aeruginosa. The drug resistance rates of Escherichia coli and Klebsiella pneumoniae to Carbapenems, Aminoglycosides, Cefepime, Ceftazidime, Cefotetan, Piperacillin-tazobactam were lower than 50.00%. The drug resistance rate of Acinetobacter baumannii to Imipenem was 86.67%, while to Tigecycline and Amikacin were lower. The resistant rate of Pseudomonas aeruginosa to Cefepime and Ceftazidime was 14.29% and 38.46% respectively. The drug resistance rates of Enterococcus faecium to many antibiotic drugs were higher than Enterococcus faecalis. Both of them were sensitive to Linezolid, Tigecycline, Vancomycin. Conlusion The most common pathogens from bile specimens of elderly patients in our hospital are Gram-negative strains, Amikacin may be the first choice antibiotics. For infection of the Enterococcus spp,Vancomycin and Linezolid have higher antimicrobial activities. The antimicrobial agents should be chosen reasonably according to the results of the drug susceptibility to improve the effect of the treatment.

Key words： Elderly Bile culture Pathogenic bacteria Drug resistance

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	ZHANG Wenjing1 YU Boxin1 ZHANG Yajie2 WANG Jiahe1

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ZHANG Wenjing1 YU Boxin1 ZHANG Yajie2 WANG Jiahe1. Analysis of the distribution and drug resistance of pathogenic bacteria from bile specimens of elderly patients[J]. 中国医药导报, 2017, 14(34): 106-109,131.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I34/106

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