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| Research progress of microRNA-125b in tumor |
| ZHAO Xueyu QIAN Yayun▲ |
| Department of Combine Traditional Chinese and Western Medicine, Yangzhou University School of Medicine, Jiangsu Province, Yangzhou 225009, China |
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Abstract Malignancy is one of the important factors leading to human death. The occurrence of malignant tumors is closely related to the abnormal expression of a particular gene. MicroRNA-125b (miR-125b) is a non-coding small RNA molecule that plays a pivotal role in different biological changes. More and more studies have shown that miR-125b may be an advanced biomarker for the diagnosis of certain specific malignancies and may be a potential new target for its medical treatment. According to the latest research results of the relationship between miR-125b and tumor, it is reviewed in the aspects of cell proliferation, apoptosis, invasion and metastasis and drug resistance.
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[1] Sun YM，Lin KY，Chen YQ. Diverse functions of miR-125 family in different cell contexts [J]. J Hematol Oncol，2013， 6（1）：6.
[2] Chaudhuri AA，So AY，Mehta A，et al. Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A [J]. Proc Natl Acad Sci USA，2012，109（11）：4233.
[3] Park D，Xiang AP，Mao FF，et al. Nestin is required for the proper self-renewal of neural stem cells [J]. Stem Cells，2010，28（12）：2162-2171.
[4] Rückerl D，Jenkins SJ，Laqtom NN，et al. Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo [J]. Blood，2012，120（11）：2307-2316.
[5] Luo X，Zhang L，Li M，et al. The role of miR-125b in T lymphocytes in the pathogenesis of systemic lupus erythematosus [J]. Clin Exp Rheumatol，2013，31（2）：263-271.
[6] Di LG，Garofalo M，Croce CM. MicroRNAs in cancer [J]. Annu Rev Pathol，2014，9（2）：287-314.
[7] Ryan BM，Robles AI，Harris CC. Genetic variation in microRNA networks：the implications for cancer research [J]. Nat Rev Cancer，2010，10（6）：389-402.
[8] He J，Jing Y，Li W，et al. Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis [J]. PloS One，2013，8（2）：e56 647.
[9] Wang F，Yu D，Liu Z，et al. MiR-125b functions as a tumor suppressor and enhances chemosensitivity to cisplatin in osteosarcoma [J]. Technol Cancer Res Treat，2016，15（6）：NP105.
[10] Zhao X，He W，Li J，et al. MiRNA-125b inhibits proliferation and migration by targeting SphK1 in bladder cancer [J]. Am J Transl Res，2015，7（11）：2346.
[11] Hofmann MH，Heinrich J，Radziwill G，et al. A short hairpin DNA analogous to miR-125b inhibits C-Raf expression，proliferation，and survival of breast cancer cells [J]. Mol Cancer Res，2009，7（10）：1635.
[12] Le MT，Teh C，Shyh-Chang N，et al. MicroRNA-125b is a novel negative regulator of p53 [J]. Genes Dev，2009， 23（7）：862-876.
[13] Liang L，Wong CM，Ying Q，et al. MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B [J]. Hepatology，2010，52（5）：1731.
[14] Shiiba M，Shinozuka K，Saito K，et al. MicroRNA-125b regulates proliferation and radioresistance of oral squamous cell carcinoma [J]. Br J Cancer，2013，108（9）：1817-1821.
[15] Wu S，Liu F，Xie L，et al. miR-125b suppresses proliferation and invasion by targeting MCL1 in gastric cancer [J]. Biomed Res Int，2015，2015：1-10.
[16] Bao Z，Huang G，Wang X，et al. HPV-16 E6 promotes cell growth of esophageal cancer via downregulation of miR-125b and activation of Wnt/β-catenin signaling pathway [J]. Int J Clin Exp Pathol，2015，8（10）：13 687.
[17] Bi Q，Tang S，Xia L，et al. Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF [J]. Plos One，2012，7（6）：e40 169.
[18] Zhao A，Zeng Q，Xie X，et al. MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression [J]. J Genet Genomics，2012，39（1）：29.
[19] Pearson AS，Spitz FR，Swisher SG，et al. Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells [J]. Clin Cancer Res，2000，6（3）：887.
[20] Zhou JN，Zeng Q，Wang HY，et al. MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4 [J]. Hepatology，2015，62（3）：801-815.
[21] Lee M，Kim EJ，Jeon MJ. MicroRNAs 125a and 125b inhibit ovarian cancer cells through post-transcriptional inactivation of EIF4EBP1 [J]. Oncotarget，2016，7（8）：8726-8742.
[22] Lan Y，Yiming M，Wenxiao H，et al. Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b [J]. J Biol Chem，2015，290（44）：26627.
[23] Li Q，Han Y，Wang C，et al. MicroRNA-125b promotes tumor metastasis through targeting tumor protein 53-induced nuclear protein 1 in patients with non-small-cell lung cancer [J]. Cancer Cell Int，2015，15（1）：1-10.
[24] Xie X，Hu Y，Xu L，et al. The role of miR-125b-mitochondria-caspase-3 pathway in doxorubicin resistance and therapy in human breast cancer [J]. Tumour Biol，2015， 36（9）：7185-7194.
[25] Tang XY，Wei Z，Min D，et al. miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism [J]. Drug Des Devel Ther，2016， 10（571）：571-583.
[26] Zhang Y，Huang S. Up-regulation of miR-125b reverses epithelial-mesenchymal transition in paclitaxel-resistant lung cancer cells [J]. Biol Chem，2015，15（4）：45-45.
[27] Nair VS，Maeda LS，Ioannidis JPA. Clinical outcome prediction by microRNAs in human cancer：a systematic review [J]. J Natl Cancer Inst，2012，104（7）：528.
[28] Gu L，Li H，Chen L，et al. MicroRNAs as prognostic molecular signatures in renal cell carcinoma：a systematic review and Meta-analysis [J]. Oncotarget，2015，6（32）：32 545-32 560.
[29] Brito BDL，Louren■o SV，Damascena AS，et al. Expression of stem cell-regulating miRNAs in oral cavity and oropharynx squamous cell carcinoma [J]. J Oral Pathol Med，2016， 45（9）：647-654. |
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