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2018 Vol. 15, No. 25 Published: 2018-09-05

	4	Effect of moxibustion on wound repair in rats with pressure injuries
		YU Jie1 SUN Zhongren2 LI Hongling3 ZHAO Hui2
		Objective To observe the effect of moxibustion on wound repair in rats with pressure injuries. Methods The models of rats with pressure ulcers which belonged to stage 2-3 were established by using self-made devices of pressure ulcers. The models of 70 SD female rats with skin ischemia reperfusion injury were randomly divided into model group and moxibustion group. There were 35 rats in each group. Each group was divided into 5 subgroups including 1 d, 3 d, 5 d, 7 d and 10 d according to the length of intervention time. Seven experimental rats were included in each subgroup. The blank group was given shaving disinfection, tied together with other groups of rats given only conventional iodophor intervention. The model group was only given conventional iodophor intervention. The moxibustion group was given iodophor intervention at first and direct moxibustion intervention to the local tissue of pressure ulcer with cyclotron operation, with moxibustion once a day and 15 minutes each time. The wound area was measured respectively after five time-points (1 d, 3 d, 5 d, 7 d and 10 d after intervention or treatment) before drawing. HE staining was used to observe the pathological changes of the pressure ulcer. Results There were no significant differences in the wound healing rates between the groups in the 1 d after intervention(P > 0.05). Compared with the model group, the wound healing rates of moxibustion group were significantly higher at the four time-points including 3 d, 5 d, 7 d and 10 d after treatment. At the same time-points, there were significant differences between the two groups (P < 0.01). Compared with the model group, the granulation tissues in the wounds of rats which belonged to moxibustion group with pressure ulcers had obvious advantages both in the time-points and the growth states. There were granulation tissues at the third day after treatment in the moxibustion group, while those of model group appeared about at the seventh day after iodophor intervention. Simultaneously, the wound contraction rates of pressure ulcers were faster in the moxibustion group which had more evident area reductions. Pathological changes of pressure ulcers were observed by HE staining that the peaks of the inflammatory infiltrations which existed in the moxibustion group had appeared in advance compared with the model group. Meanwhile, fibroblasts appeared earlier, having more numbers and obvious degrees of hyperplasia. The occurrence time of granulation tissues was earlier in the moxibustion group. Hence, neovascularization which belonged to moxibustion group formed earlier than that of model group. The epidermal structures of rats in the moxibustion group recovered in advance. Conclusion Moxibustion can promote the wound healing effectively in rats with pressure injuries.
		2018 Vol. 15 (25): 4-8,12 [Abstract] ( 265 ) HTML (1 KB) PDF (852 KB) ( 74 )

	9	Construction of lentivirus-mediated RNAi vector targeting vasodilator-stimulated phosphoprotein
		WANG Jing1 WEI Lei2 QIU Kun1
		Objective To construct the lentiviral RNA interference expression vector targeting vasodilator-stimulated phosphoprotein (VASP) gene. Methods The pre-constructed pcDNA6.2-miRVASP was identified by DNA sequencing and the positive clones were screened. The miRVASP fragment was cloned into destination vector pLenti6/V5-DEST by Gateway techology, including BP and LR reaction, RNA interference lentiviral vector pLenti6/V5-miRVASP targeting VASP gene was constructed. Then the 293FT cells were co-transfected with the plasmid lentiviral expression vector pLenti6/V5-miRVASP and lentiviral packaging mix. The virus particles were collected and infected into gastric cancer BGC-823 cells. Results The constructed lentiviral expression vector pLenti6/V5-miRVASP was introduced into E.coli Stbl3 for amplification. DNA sequencing results showed that the constructed vector was exactly as expected. BGC-823 cells were infected with the collected lentiviral stocks carrying the miRVASP expression cassette. The results showed that a large number of cells could express strong green fluorescence, demonstrated that the packaged lentiviral stocks could infect BGC-823 cells. Conclusion The RNA interference lentiviral vector targeting VASP gene is successfully constructed and packaged as the lentiviral stocks to successfully infect BGC-823 cells, which lay the foundation for the further study of the role of VASP in gastric cancer metastasis in vivo.
		2018 Vol. 15 (25): 9-12 [Abstract] ( 236 ) HTML (1 KB) PDF (679 KB) ( 118 )

	13	Experimental study of autologous platelet-rich plasma in combination with calcium phosphate cement in repairing vertebral bone defect
		GUO Ying1,2 JIA Lianshun2 WU Weimin3 ZHANG Lijun4 XING Guo1 PENG Bo5 WU Bo4
		Objective To observe the effect of the mixture of autologous platelet-rich plasma (PRP) and calcium phosphate cement (CPC) in repairing vertebral bone defect. Methods 18 goats were included in this experiment. A 6 mm×10 mm cylindrical bone defect was prepared on the side of lumbar vertebral body(L1-L6) of each sheep. The experiment was divided into three groups according to different filling methods: the experimental group was filled by CPC in combination with PRP, the control group was filled with CPC, and the sham operation group was not filled. 6 goats were randomly executed after surgery for 1, 3, 6 months, then the bone healing conditons were observed by imaging examination. Results All animals successfully completed surgery and survived. The platelet count in PRP was about 5 times more than that in whole blood, and the contents of growth factors [platelet derived growth factor (PDGF), transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF)] in PRP were significantly higher than those in the whole blood (P ＜ 0.05). In all time points after surgery, new bone formation and cement absorption could be observed in both experimental group and control group, but the experimental group was more obvious, while no significant bone repair sign could be seen in sham operation group. Conclusion PRP can release a large number of growth factors, and show great properties of osteoinductive and osteogenesis when combined with CPC. The composite is effective for the treatment of vertebral bone defect.
		2018 Vol. 15 (25): 13-16,28 [Abstract] ( 218 ) HTML (1 KB) PDF (959 KB) ( 70 )

	17	Effects of alcohol extract of Waternut Herb on behavior and hippocampal inflammatory media in mice with Alzheimer disease
		ZHONG Lili1，2 ZHANG Weijia3 LIU Xu4 SUN Zhongren5
		Objective To investigate the effects of alcohol extract of Waternut Herb on learning ability, memory ability, learning and memory retention ability of mice with Alzheimer disease, and the effects of interleukin (IL)-1β and tumor necrosis factor-α (TNF-α) in hippocampal inflammation media. Methods Forty-eight male C57BL/6 mice were divided into six groups according to the random number table method: model group, normal group, Donepezil group, and high, medium, low dose of alcohol extract of Waternut Herb group, with 8 mice in each group. Alzheimer disease model was induced by bilateral intracere broventricular injection of Aβ1-42 (80 pmol/μL). Each group of rats was given intragastric administration once a day. The mice in Donepezil group were given 0.000 92 g/(kg·d) by gavage. The mice in the high, medium, low dose of alcohol extract of Waternut Herb group were given 3.96, 1.98, 0.99 g/(kg·d) by gavage, respectively. While the mice in the normal group and model group were given intragastric administration with continuous saline, treatment for 35 days. The Morris water maze was used to detect the changes of behavior in Alzheimer disease mice. The levels of IL-1β and TNF-α in hippocampus of Alzheimer disease mice were determined by enzyme-linked immunosorbent assay. Results The incubation period and swimming distance of mice in the model group were increased. At the same time, the target residence time was shortened and the number of cross-platforms was reduced, it took a long time to find the underwater platform of the water maze system, compared with the normal group, the abnormal behavior in the model group was significantly increased (P ＜ 0.05). Compared with the normal group, the levels of IL-1β and TNF-α of the inflammatory mediators of the hippocampus in model group were significantly increased (P ＜ 0.05). Compared with the model group, the behavior of mice in the high and medium doses of alcohol extract of Waternut Herb group was significantly improved, and the levels of IL-1β and TNF-α in the hippocampus were significantly decreased, the differences were statistically significant (P ＜ 0.05). Conclusion Alcohol extract of Waternut Herb can improve the learning ability and memory impairment of mice, reduce the inflammatory response and relieve blood-brain barrier injury, and plays an important role in the treatment of Alzheimer disease.
		2018 Vol. 15 (25): 17-20 [Abstract] ( 209 ) HTML (1 KB) PDF (603 KB) ( 129 )

	21	Preparation and characterization of reference products for assay kit of IgG of poliomyelitis
		TAN Zhenguo YANG Rong LUO Fangyu XIE Zhongping LI Hua XIE Tianhong YIN Xiaoxiao LONG Runxiang▲
		Objective Referance products were developed for assay kit of IgG of poliomyelitis to make it possible to reliably control quality of the assay kits in evaluating their properties. Methods Serum was confirmed through a neutralization test to obtain the serum which met requirements. Twenty-two samples were collected for each type of reference products, including 10 positive reference products, 10 negative ones, 1 reference product with the minimum detection limit and 1 precise reference product. Results The conformity ratio of type Ⅰ, Ⅱ and Ⅲ negative reference products of IgG of poliomyelitis was not below 9/10. The conformity ratio of positive reference products was not lower than 8/10, the coefficient of variation of precise reference was not higher than 15%, and the coefficient of variation of precise reference products was not lower than 1/8. The reference products were placed at 37℃ for 5 days. They were still quite stable after 5 repetitive freezing and thawing. Conclusion The prepared reference products of assay kit for IgG of poliomyelitis were tested to be qualified in all tests and could be used for quality control over such assay kits.
		2018 Vol. 15 (25): 21-24 [Abstract] ( 242 ) HTML (1 KB) PDF (462 KB) ( 125 )

	25	Study on the technology of enzyme-assisted homogenate extraction method for the extraction of procyanidins from seedpod of lotus
		WANG Jianmei GAO Hong XU Qiaona ZHANG Yuzhen YU Le ZHANG Shuning CHEN Fei
		Objective To research on extraction process of proanthocyanidins from seedpod of lotus with homogenate extraction method. Methods Taking the proanthocyanidins yield of seedpod of lotus as the evaluation index, single factor test was used to investigate the effect of volume fraction of solvent extraction, ethanol extraction time, extraction times and solid-liquid ratio on the extraction of procyanidins from seedpod of lotus. The orthogonal tests of four factors and three levels were carried out with ethanol volume fraction, material liquid ratio, extraction time and blank as the object of study. The optimum extraction process parameters were determined. Results The results showed that the optimum process conditions were as followed, the volume fraction of ethanol was 60%, the extraction time was 3 min, and the liquid material ratio was 40∶1. Conclusion With this condition, the proanthocyanidins yield of seedpod of lotus is 8.12%. Compared with the traditional extraction method, the flash method has the advantages of high efficiency and less time.
		2018 Vol. 15 (25): 25-28 [Abstract] ( 185 ) HTML (1 KB) PDF (471 KB) ( 239 )

	29	Advances in brain functional magnetic resonance imaging of acupuncture at sanyinjiao point
		LI Xiaoling1 CAI Li′na2 WANG Feng2 CAO Danna1 XU Yufei1 LIU Xiaohui2 ZHANG Kunyu2 KANG Qi2
		Acupuncture at sanyinjiao point is widely used in clinical practice, but its mechanism lacks objective basis. With the development of functional magnetic resonance imaging technology, the central mechanism of acupuncture is going to be revealed, which has become a hot research field in recent years. After collecting and analyzing the literature of the brain functional magnetic resonance imaging of acupuncture at the point of sanyinjiao, and comparing the brain functional imaging study of the body in different functional states, it is found that the main content of the study is mainly focused on the differences of the brain regions activated by acupuncture the single point and group points in the physiological and pathological conditions. Under physiological conditions, acupuncture at sanyinjiao point activates specific brain regions, confirming that acupuncture points have relative specificity. The brain activation area of acupuncture group points is not a simple superposition of acupuncture points. Although there is overlap, it also exists difference. Under pathological conditions, acupuncture at sanyinjiao point is used to treat diseases through multiple brain regions synergistic regulation and central network.
		2018 Vol. 15 (25): 29-31,35 [Abstract] ( 223 ) HTML (1 KB) PDF (439 KB) ( 68 )

	32	Research progress of cell autophagy mediated by mammalian target of rapamycin associated with tumor
		ZHANG Haoran QIAO Xuxu BI Minghong
		Autophagy capacity may correlate with malignant transformation and differentiation of cancer cells. The mammalian target of rapamycin (mTOR) has close relationship with autophagy, which can play an important role through regulating the autophagic activity on cancer genesis and progression. So far mTOR inhibitors (inhibiting targets of signaling pathways) have potential in the future for cancer therapy, the development of mTOR inhibitors represents an important field in anticancer research. This article summarizes the relationship between mTOR signaling pathway and tumor in autophagy pathways, and the current status of the development of mTOR inhibitors, it hopes to provide information for studies on cancer research and targets for tumor therapy.
		2018 Vol. 15 (25): 32-35 [Abstract] ( 207 ) HTML (1 KB) PDF (428 KB) ( 88 )

	36	Application evaluation of multimethod combined with WeChat teaching in obstetrics and gynecology teaching for eight-year-program medical students
		LI Jia LIU Shujuan CHEN Biliang YANG Hong ZHANG Wei
		Objective To evaluate the application and effect of multimethod combined with WeChat teaching in gynecology and obstetrics eight-year-program teaching. Methods In the Fourth Military Medical University, from May to July 2017, 20 eight-year-program medical students were selected as the experimental group, and from May to July 2016, 21 eight-year-program medical students were selected as the control group. The experimental group was given multimethod combined with WeChat teaching method, while the control group was given traditional teaching method. After teaching, examination and questionnaire investigation were used to evaluate the application and effect of the teaching methods. Results The theoretical knowledge results, case analysis scores and comprehensive performance results in the experimental group were higher than the control group, the differences were statistically significant (P < 0.05). Students in the experimental group generally believed that on the basis of WeChat combined with multimethod teaching model could effectively improve the learning interest and learning efficiency, promote mastery of the teaching content, and increase the communication between teachers and students and they could accept this teaching mode. Conclusion Multimethod combined with WeChat teaching method can fully promote the learning interest of students, break through traditional classroom restriction, deepen knowledge understanding, strengthen self-study ability, and effectively improve teaching effect.
		2018 Vol. 15 (25): 36-39 [Abstract] ( 204 ) HTML (1 KB) PDF (648 KB) ( 67 )

	40	Application of MOOC combined with LBL teaching mode in food safety and food poisoning teaching
		LIU Wenbin1 XU Ting2
		Objective To investigate the application of massive open online course(MOOC) combined with lecture-based learning (LBL) in food safety and food poisoning teaching and to evaluate its effect. Methods A total of 80 students with preventive medicine and related majors in Grade 2013 from Army Medical University (the Third Military Medical University) were selected and randomly divided into traditional LBL teaching group and MOOC combined with LBL teaching group, with 40 students in each group. Traditional LBL teaching and MOOC combined with LBL teaching were used for course teaching respectively. Questionnaire and grade statistics were used to analyze teaching effect. Results The subjective questions results, objective questions results and average results of the students′ theoretical examination in the MOOC combined with LBL teaching group were obviously higher than the traditional LBL teaching group, the differences were statistically significant (P < 0.01). The teaching satisfaction in the MOOC combined with LBL teaching group was obviously higher than the traditional LBL teaching group, the difference was statistically significant (P < 0.01). The academic record, practical ability, analytical and problem solving skills in the MOOC combined with LBL teaching group were significantly better than the traditional LBL teaching group, the differences were statistically significant (P < 0.01). Conclusion MOOC combined with LBL teaching method not only improves the quality in course teaching of food safety and food poisoning, but also improves students′ examination results, and helps students improving their autonomous learning ability and comprehensive quality.
		2018 Vol. 15 (25): 40-43 [Abstract] ( 246 ) HTML (1 KB) PDF (649 KB) ( 112 )

	44	Application of PDCA cycle in standardized training of general surgery residents
		CAO Feng ZHAO Ye ZHENG Yamin LI Fei▲
		Objective To evaluate the application of PDCA cycle in standardized training of general surgery residents. Methods Sixty-two students received standardized training in General Surgery Department of Xuanwu Hospital， Capital Medical University from September 2014 to August 2017 were selected and divided into the experimental group and the control group by random number table method, with 31 students in each group. PDCA cycle method and the traditional teaching method were used in the experimental group and the control group respectively. Objective structured clinical examination （OSCE） and student satisfaction survey were used to evaluate teaching efficacy. Results Scores of the medical history collection and physical examination, case analysis, basic operation skills and auxiliary examination results in the OSCE examination of the experimental group were higher than those of the control group (P < 0.01). The scores of rationality in the curriculum design, teaching skills, knowledge and analytical problem solving skills of students′ satisfaction to the teaching manner were higher than those of the control group (P < 0.01). Conclusion PDCA cycle is helpful to improve the quality of standardized training for general surgery residents.
		2018 Vol. 15 (25): 44-47 [Abstract] ( 255 ) HTML (1 KB) PDF (648 KB) ( 65 )

	48	Application of flipped classroom based on micro-lecture in medical diagnostic imaging
		REN Cui YUAN Huishu LANG Ning
		Objective To evaluate the application effect of flipped classroom based on micro-lecture in medical radiology teaching. Methods Fifty eight-year medical program students of grade 2012 in Peking University Third Hospital were recruited. The study was carried out from May to June 2016. The students were randomly divided into the experimental group and the control group, with 25 students in each group. The experimental group received the mixed teaching method (micro-lecture and flipped classroom), while the control group received the traditional teaching method. 10 hours' classes on central nervous system imaging diagnosis were carried out. The students' evaluations of the teaching methods were investigated by questionnaire at the end of the classes. The scores of central nervous system image reading examination between the two groups were compared. Results The self-learning ability, communication ability, knowledge mastery and application ability of the students received flipped teaching method based on micro-lecture were improved. The average test score of the experimental group [(87.84±0.93) points] was significantly higher than the control group [(79.88±2.71) points] (P ＜ 0.05). Conclusion The flipped classroom based on micro-lecture is a scientific and effective teaching model, which can improve the teaching effect of imaging diagnostics.
		2018 Vol. 15 (25): 48-50 [Abstract] ( 192 ) HTML (1 KB) PDF (638 KB) ( 71 )

	51	Application of case-based learning method in the teaching of occupational therapy for sports rehabilitation major undergraduates
		LI Ping WEN Xiaoni
		Objective To explore the effect and feasibility of the case-based learning （CBL） method applied in occupational therapy teaching. Methods Thirty-seven undergraduates in Grade 2013 of Sports Rehabilitation in Xi′an Physical Education University from September 2016 to January 2017 were selected as control group, and they were taught in traditional teaching method; thirty-six undergraduates in Grade 2014 from September 2017 to January 2018 were selected as CBL group, and they were taught with CBL. The teaching efficacy was compared between the two groups. Results The clinical practice results, theoretical results, and total results of the CBL group were higher than those of the control group, the differences were statistically significant （P ＜ 0.05）. Conclusion The CBL method plays an important role in cultivating students′ clinical thinking ability, and at the same time, it enhances the autonomous learning ability and improves the comprehensive ability. Thus, this method is worth promoting widely in the teaching of occupational therapy.
		2018 Vol. 15 (25): 51-53,62 [Abstract] ( 244 ) HTML (1 KB) PDF (667 KB) ( 59 )

	54	Problems and countermeasures on the training of youth ophthalmologist
		YE Zi LI Chaohui
		This paper introduces the current situation of cataract surgery in China, summarizes the problems in the training of young ophthalmologists, and offers the strategy to develop young ophthalmologists by intelligence and information system, to discuss the feasibility of using the latest computer vision processing technology to take video data processing and ophthalmic surgery analysis, in order to design surgical tools and simulation training system for young ophthalmologists training through eye surgery video data in the future.
		2018 Vol. 15 (25): 54-58 [Abstract] ( 205 ) HTML (1 KB) PDF (653 KB) ( 69 )

	59	Discussion and reform of clinical medicine teaching in the age of big data
		DOU Weijia WANG Jingjie LIU Zhenxiong
		With the advent of the age of big data, there are unprecedented impacts and changes in all fields of society, and clinical medicine teaching is no exception. Therefore, how to meet the challenge in the new situation is an urgent problem to be discussed. Only combining the features of clinical medicine teaching with the characteristics of big data and making both teacher and student seize the moment in the age of big data, we can better teach the clinical medicine and train medical students who can adapt to the new era of digital medicine.
		2018 Vol. 15 (25): 59-62 [Abstract] ( 255 ) HTML (1 KB) PDF (647 KB) ( 166 )

	63	Analysis of iodine nutritional status in patients with abnormal thyroid function
		WANG Fengling1 HOU Zhenjiang1 LIU Yuzhi1 DAI Rongqing1 CHEN Lixin2
		Objective To explore the characteristics of iodine nutritional status in patients with abnormal thyroid function in Cangzhou. Methods A total of 1024 patients with abnormal thyroid function in Department of Endocrinology in Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine in Hebei Province ("our hospital for short") from March 2015 to December 2017 were selected as study group. They were divided into 4 groups according to the diagnostic criteria of thyroid diseases, which were hyperthyroidism group, ubclinical hyperthyroidism group, hypothyroidism group and subclinical hypothyroidism group. At the same time, 130 normal adults taken physical examination in our hospital at the same time were collected as control group. The urine iodine and thyroid function [free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropic hormone (TSH)] were detected. The iodine nutritional status in all subgroups of study group and control group was analyzed. Results The levels of median urinary iodine (MUI) in all subgroups in ascending order were subclinical hyperthyroidism group, hyperthyroidism group, control group, hypothyroidism group and subclinical hypothyroidism group. The iodine nutrition in study group and control group were in the proper state. But the range of urine iodine levels was large, and the difference of urine iodine levels among different individuals was large. The levels of MUI in hyperthyroidism group and subclinical hyperthyroidism group were more than 200 μg/L, and the patients were in a state of excess iodine nutrition. The percentage of iodine deficiency, proper iodine, iodine excess in hyperthyroidism group and subclinical hyperthyroidism group had statistically significant differences compared with those of hypothyroidism group and subclinical hypothyroidism group (P ＜ 0.05), the percentage of iodine deficiency, proper iodine, iodine overbalance in all subgroups of study group had statistically significant differences compared with those of control group (P ＜ 0.05). Conclusion Iodine nutrition levels are associated with thyroid function. Both patients with abnormal thyroid function and healthy people need to pay attention to the state of iodine nutrition. Individualized iodine intake should be guided by the results of urine iodine. Blind iodine supplementation should be avoided. It is of great significance for the prevention and treatment of thyroid diseases.
		2018 Vol. 15 (25): 63-66 [Abstract] ( 267 ) HTML (1 KB) PDF (565 KB) ( 61 )

	67	Clinical efficacy of Aidi Injection combined with VAD chemotherapy program in patients with multiple myeloma
		TANG Hongxia1 WANG Mengying2 TUO Jing1 CUI Yisen1 WEN Jianwei1
		Objective To study the clinical efficacy and safety of Aidi Injection combined with VAD chemotherapy program in patients with multiple myeloma (MM). Methods A total of 60 patients with MM admitted to Neijiang Traditional Chinese Medicine Hospital of Sichuan Province from January 2015 to January 2018 were enrolled in this study. The subjects were divided into the control group and the treatment group according to the random number table method, with 30 cases in each group. The control group was treated with VAD chemotherapy program, the treatment group was treated with Aidi Injection combined with VAD chemotherapy program. Four weeks were a course of treatment, the two groups were treated for 3 courses. The clinical efficacy of the two groups were evaluated and compared. The serum M protein, β2-microglobulin, hemoglobin, myeloma cells and peripheral blood CD3+,CD4+,CD8+of the two groups before and after treatment were compared. The adverse reactions of the two groups during the treatment were recorded and compared. Results The total effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the M protein, β2-microglobulin and the content of myeloma cells of the two groups were significantly less than those before treatment (P ＜ 0.05), the hemoglobin content was significantly greater than those before treatment (P ＜ 0.05), and the changes in the treatment group were significantly greater than those in the control group (P ＜ 0.05). After treatment, the levels of CD3+, CD4+ in peripheral blood of the treatment group were significantly higher than those before treatment (P ＜ 0.05), while the level of CD8+ in peripheral blood of the treatment group was significantly lower than that before treatment (P ＜ 0.05), and the levels of CD3+, CD4+ in peripheral blood of the treatment group were significantly higher than those of control group, while the level of CD8+ in peripheral blood of the treatment group was significantly lower than that of control group (P ＜ 0.05). There was no significant difference of the adverse reactions between the two groups during the treatment (P ＞ 0.05). Conclusion Aidi Injection combined with VAD chemotherapy program in patients with MM has good efficacy and safety, which can also improve the immune function of patients. It is worthy of clinical promotion and application.
		2018 Vol. 15 (25): 67-70,74 [Abstract] ( 217 ) HTML (1 KB) PDF (592 KB) ( 64 )

	71	Clinical study of interventional therapy for acute lower extremity arterial embolism
		HE Jingliang LIANG Zhihui LI Liang LIU Jinglei
		Objective To investigate the clinical efficacy of interventional therapy for acute lower extremity arterial embolism. Methods From June 2016 to June 2017, in PLA Bethune International Peace Hospital, 60 patients with acute arterial embolism of lower extremity were selected, according to the treatment methods, they were divided into two groups, 30 cases in the control group were treated with large cavity catheter sucking thrombus, and 30 cases in the experiment group were treated with large cavity catheter sucking thrombolytic thrombolysis plus catheter thrombolytic therapy. The treatment effect, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and D-Dimer (D-D) level of the two groups were compared, and the recurrence rate and amputation rate of the two groups were observed. Results After treatment, the total effective rate of experiment group was significantly higher than that of control group, the difference was statistically significant (P < 0.05). After treatment, the levels of APTT and PT in the two groups were higher than those before treatment, and those in the experiment group were significantly higher than those of control group, the differences were statistically significant (P < 0.05), and the levels of FIB and D-D in the two groups were significantly lower than those before treatment, and those in the experiment group were significantly lower than those of control group, the differences were statistically significant (P < 0.05). After treatment, the incidence of embolic recurrence in the experiment group was lower than that of control group, the difference was statistically significant (P < 0.05). There was no significant difference in amputation rate between the experiment group and control group (P > 0.05). Conclusion The clinical effect of large cavity catheter suction thrombolysis plus catheter thrombolysis for patients with acute lower extremity arterial embolization is remarkable, and the complications are few, the clinical effect is better than that of the simple use of large cavity catheter suction thrombolytic therapy, and it can be popularized.
		2018 Vol. 15 (25): 71-74 [Abstract] ( 231 ) HTML (1 KB) PDF (609 KB) ( 73 )

	75	The relationship between serum ferritin and bone density of female check-ups
		ZHANG Dihui HUANG Zexin LUO Bin
		Objective To explore the relationship between serum ferritin (Fer) and bone density (BMD), bone metabolism in physical examination. Methods A total of 104 cases of female volunteers from February 2017 to October 2017 in Physical Examination Center of Guangdong Province Traditional Chinese Medical Hospital were selected. According to the age, they were divided into elder group (age≥50, n = 67) and young group (age＜50, n = 37). According to the menopausal status, they were divided into the postmenopausal group (n = 58) and the non-menopausal group (n = 46). According to the bone mass, they were divided into the normal bone mass group (femoral neck and lumbar T value≥-1 SD, n = 40) and the bone mass reduction group (femoral neck and lumbar T value＜-1 SD, n = 64). The levels of serum Fer, BMD and bone metabolism index [alkaline phosphatase (ALP), type Ⅰ collagen amino terminal extension of the peptide (P1NP) and β-degradation products (β-CTX)] of the volunteers with different age and different bone mass were compared, meanwhile the effect of menstruation on serum Fer, BMD and bone metabolism indices was analyzed. In addition, the correlation between serum Fer and the levels of BMD and bone metabolism index was analyzed. Results The levels of Fer, ALP, P1NP and β-CTX of the elder group were obviously higher than the young group, while the BMD of hip and L1-4 and total femoral were significantly lower than the young group, and the differences were statistically significant (P ＜ 0.05). Compared with bone mass reduction group, the levels of Fer, ALP, P1NP and β-CTX of normal bone mass group significantly decreased, but the BMD of hip and L1-4 and total femoral significantly increased, and the differences were statistically significant (P ＜ 0.05). The levels of Fer, ALP, P1NP and β-CTX of menopausal group were significantly higher than those of the non-menopausal group, while the BMD levels of the hip, L1-4 and the total femur were significantly lower than those in the non-menopausal group. There was a negative correlation between serum Fer and BMD levels of hip, L1-4 and the total femur (r = -0.698, -0.714, -0.682, P ＜ 0.05), but a positive correlation with ALP, P1NP and β-CTX in serum (r = 0.732, 0.725, 0.619, P ＜ 0.05). Conclusion The female serum Fer level is affected by age and menstruation, which is closely related to BMD and bone metabolism index, and it can act as an important indicator for predicting the decline of bone mass.
		2018 Vol. 15 (25): 75-78 [Abstract] ( 238 ) HTML (1 KB) PDF (613 KB) ( 129 )

	79	Effects of the Glutamine on inflammatory response and lung injury in liver cancer patients after the hepatectomy
		WANG Hui1 BIAN Haopeng2 CHENG Qi3 LI Li4
		Objective To study the effect of the Glutamine on inflammatory response and lung injury in liver cancer patients after the hepatectomy. Methods A total of 101 liver cancer patients after the hepatectomy in Central Hospital, the First Hospital of Shijiazhuang City from January 2014 to January 2017 were selected and they were divided into the control group (n = 50) and the treatment group (n = 51) according to random number table method. The treatment group was treated with Glutamine, and the control group was treated with normal saline in the same volume. Both groups were treated for 7 days. The serum Interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), glutamic-pyruvic transaminase (ALT), glutamic oxalacetic transaminase (AST) and proportion of peripheral blood CD3+, CD4+, CD8+ of the two groups were compared before and after treatment. The MLIS and APACHE Ⅱ scores of the two groups were compared before and after treatment. Results After treatment, the levels of serum IL-1, TNF-α of the two groups were significantly lower than those before treatment, and those of the treatment group were significantly lower than the control group (P ＜ 0.05). After treatment, the MLIS and APACHE II scores of the two groups were significantly lower than those before treatment, and scores of the treatment group were significantly lower than the control group (P ＜ 0.05). After treatment, the serum ALT, AST of the two groups were significantly higher than those before treatment, while the indices of the treatment group were significantly lower than the control group (P ＜ 0.05). After treatment, the proportions of peripheral blood CD3+, CD4+ of the two groups were significantly higher than those before treatment, the proportion of peripheral blood CD3+, CD4+, CD8+ of the two groups were significantly lower than those before treatment, and the changes of the treatment group were significantly better than the control group (P ＜ 0.05). Conclusion Application of Glutamine in liver cancer patients with hepatectomy, can inhibit the inflammatory response, reduce the lung injury degree, improve the liver and immune function, and it is worthy clinical promotion.
		2018 Vol. 15 (25): 79-82 [Abstract] ( 232 ) HTML (1 KB) PDF (605 KB) ( 62 )

	83	Clinical study of three vascular suturation techniques in autogenous arteriovenous fistula operation
		OUYANG Bin ZHANG Haifeng PAN Ningfeng ZHAO Feng YANG Dengyuan XING Chuanming
		Objective To improve the success rate of arteriovenous fistula operation by studying the clinical effect of three different vascular suturation techniques: continuous suture,continuous-discontinuous suture and discontinuous suture. Methods A total of 98 patients that underwent autogenous arteriovenous fistula operation in Nanjing Central Hospital from September 2015 to May 2017 were selected. In the same operation condition, they were randomly divided into three groups according to different vascular suturation technique: continuous suture group (32 cases), continuous-discontinuous suture group (33 cases) and discontinuous suture group (33 cases). Then, the one-time success rate of operation, the fistula patency rate postoperative 24 hours, 3 months, 6 months, the diameter of anatomosis and the blood flow change of fistula postoperative 1 month, 3 months, 6 months were compared among the three groups, and statistical analysis was made to analyze the data. Results The one-time success rate of operation among the three groups had statistically significant difference (P ＜ 0.05). The one-time success rate of continuous-discontinuous suture group was higher than those of continuous suture group and discontinuous suture group that had statistically significant differences (P ＜ 0.05). The fistula patency rate in the continuous-discontinuous suture group was higher than the continuous suture group postoperative 3 months and 6 months (P ＜ 0.05). The fistula patency rate in the discontinuous suture group was higher than the continuous suture group postoperative 24 hours, 3 months and 6 months (P ＜ 0.05). The fistula patency rate had difference among the three groups (P < 0.05). The diameter of anatomosis in the continuous-discontinuous suture group and discontinuous suture group were longer than the continuous suture group postoperative 1, 3 and 6 months (P ＜ 0.01); the diameter of anatomosis in the discontinuous suture group was longer than the continuous-discontinuous suture group postoperative 1 month and 6 months (P ＜ 0.05); the diameter of anatomosis among the three groups had high statistically significant difference (P < 0.01). The blood flow of fistula in the continuous-discontinuous suture group was higher than the continuous suture group postoperative 1, 3 and 6 months (P ＜ 0.05); the blood flow of fistula in discontinuous suture group was higher than the other two groups postoperative 1 month and 6 months (P ＜ 0.05); the blood flow of fistula among the three groups postoperative 1, 3, 6 months had statistically significant difference (P < 0.01). Conclusion The continuous-discontinuous suture is a good suturation manner that combines the advantages of continuous suture and discontinuous suture, and it is a good technique for vascular anastomosis in internal arteriovenous fistula.
		2018 Vol. 15 (25): 83-86,95 [Abstract] ( 239 ) HTML (1 KB) PDF (1002 KB) ( 161 )

	87	Association of TRPV1 gene polymorphism with opioid requirements in patients with advanced lung cancer
		WANG Dan1 WU Chengfeng1 SHEN Wen2▲
		Objective To investigate the relationship between transient receptor potential vanilloid 1 (TRPV1) gene polymorphisms and opioid requirements in patients with advanced lung cancer. Methods Peripheral venous blood samples were collected from 191 patients with advanced lung cancer (stages Ⅲ and Ⅳ) (lung cancer group) and 52 healthy controls (healthy control group) in Affiliated Hospital of Xuzhou Medical University from December 2016 to May 2017. The genotypes of rs222747 and rs8065080 of TRPV1 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Part of samples were randomly selected and verified by direct sequencing method. Visual analogue scale (VAS) was used to evaluate the pain of patients and morphine equivalents were used to compare the requirements of opioids for patients with different genotypes. Results Three genotypes were detected in lung cancer group and healthy control group: rs222747 (CC, GC, GG) and rs8065080 (CC, TC, TT). There was no significant difference in the genotype and allele distribution of rs222747 between the lung cancer group and healthy control group (P > 0.05). The distribution of genotypes and alleles of the rs8065080 between the lung cancer group and the healthy control group were statistically significant(P < 0.05). There was no significant difference in the 24 h-opioids doses, weight-adjusted-24 h-opioids doses, weight-surface area-adjusted-24 h-opioids doses between the genotypes and alleles of rs222747 in the lung cancer group with pain(P > 0.05). Conclusion There is insufficient evidence that the rs222747 polymorphisms of TRPV1 are associated with the requirement of opioids in advanced lung cancer patients with pain.
		2018 Vol. 15 (25): 87-90 [Abstract] ( 287 ) HTML (1 KB) PDF (694 KB) ( 197 )

	91	Influences of perioperative temperature protection on brain oxygen metabolism and oxidative stress in the elderly patients with gastrointestinal surgery
		MA Kun1 MI Meiyan2 MA Pengyu3 YANG Yunliang3 ZHAO Jianhui3
		Objective To investigate the influences of perioperative temperature protection on brain oxygen metabolism and oxidative stress in the elderly patients with gastrointestinal surgery. Methods The clinical case data of 105 cases of elderly patients with gastrointestinal surgery from January 2016 to November 2017 in the Fourth Hospital of Shijiazhuang were retrospectively analyzed, including of routine perioperative treatment as routine group (51 cases) and routine perioperative + heat treatment as study group (54 cases). The body temperature (Temp), heart rate (HR) and mean arterial pressure (MAP) were compared before anesthesia (T1), after 15 mins of operation (T2), immediately after operation (T3) and 2 h after operation (T4), as well as the blood oxygen partial pressure (PjvO2), blood oxygen saturation (SjvO2), blood oxygen content (CjvO2) and lactate in jugular vein blood (JVL) and serum levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the occurrence of chills and irritability and postoperative recovery time were observed. Results The values of Temp, HR and MAP of the study group had no obvious fluctuation (P > 0.05), of which the routine group at T2, T3 and T4 were significantly lower than those at T1 (P < 0.05), of which the routine group at T3 and T4 were significantly lower than those at T2 (P < 0.05). Except T1, the Temp of the study group were significantly higher than those of the routine group (P < 0.05), and the HR and MAP of the study group were significantly lower than those of the routine group (P < 0.05). Except T1, the PjvO2, SjvO2, CjvO2, SOD and GSH-Px of the study group were significantly higher than those of the routine group (P < 0.05), and the JVL and MDA of the study group were significantly lower than those of the routine group (P < 0.05). The incidence rates of chills and irritability of the study group were significantly lower than those of the routine group (P < 0.01), and the recovery time after operation of the study group was significantly shorter than that of the routine group (P < 0.01). Conclusion Perioperative temperature protection can maintain the stability of the life signs of the elderly patients with gastrointestinal surgery, obviously improve the brain oxygen metabolism and oxidative stress response, reduce the occurrence of chills and irritability and shorten the recovery time.
		2018 Vol. 15 (25): 91-95 [Abstract] ( 400 ) HTML (1 KB) PDF (601 KB) ( 128 )

	96	Effects of Dexmedetomidine on hemodynamics and recovery during Sevoflurane anesthesia in children with supraventricular tachycardia
		GUAN Yuan PANG Xiaolin ZHANG Dongya▲
		Objective To investigate the effects of Dexmedetomidine on hemodynamics and restlessness during Sevoflurane anesthesia in children with supraventricular tachycardia. Methods A total of 63 cases of supraventricular tachycardia children who were treated with radiofrequency ablation in Beijing Huaxin Hospital, the First Affiliated Hospital of Tsinghua University from January 2013 to August 2017 were selected and divided into group A, B and C according to the random number table method, with 21 cases in each group. Before operation, children in group A were intravenously injected Dexmedetomidine 0.3 μg/kg, children in group B were injected Dexmedetomidine intravenously 0.5 μg/kg, and children in group C (control group) were injected with normal saline. The mean arterial pressure (MAP) and heart rate(HR) of T0, T1, T2, T3, T4 and T5 were observed and compared. The operation time, waking time, extubation time after treatment in 3 groups were recorded. The PAED scale and Watcha score were used to assess restlessness after awakening in these children. The incidence of > 15 min in the restless duration was recorded. Adverse reactions after the operation were recorded. Results Compared with T0, the MAP and HR from T3 to T5 in the group A and C increased with statistically significant differences (P < 0.05), and the differences on the MAP and HR in the group B at each time point was no statistically significant (P < 0.05). Compared with the group C, the MAP and HR from T3 to T5 in group A and B was decreased significantly (P < 0.05), and the MAP and HR in the group B was significantly lower than those of the group A. The scores of PEAD, Watcha and restless duration > 15 min in group A and B was lower than that in group C, and the scores group B was lower than that in group A, the differences of were statistically significant (P < 0.05). After treatment, the incidence of total adverse reactions in group A (23.80%) and group B (9.52%) were lower than that in group C (57.14%), and adverse reactions in group B were significantly lower than that in group A (P < 0.05). Conclusion Dexmedetomidine can effectively alleviate the restlessness in the awakening period of Sevoflurane in children with supraventricular tachycardia, improve hemodynamic changes, reduce the adverse reactions.
		2018 Vol. 15 (25): 96-99 [Abstract] ( 223 ) HTML (1 KB) PDF (589 KB) ( 64 )

	100	Comparison of Mivacurium and Cisatracurium on histamine release in otorhinolaryngologic short-term operation
		ZHANG Xiaodong WANG Huiming QI Jiao SHANG Ying WEN Jing
		Objective To quantitatively compare the effects between Mivacurium and Cisatracurium on histamine release in otorhinolaryngologic short-term operation. Methods A total of 120 short-term operation patients from January 2016 to January 2017 in the Second Hospital of Baoding were selected, and they were divided into group A and B according to the random number table method, with 60 cases in each group. The patients received Mivacurium 0.2 mg/kg (group A) and Cisatracurium 0.15 mg/kg (group B) respectively. After intravenous anesthesia, before injecting the muscle relaxant (T1) and 4 min (T2), 7 min (T3) after injecting, blood samples were collected to test plasma histamine by Elias method. Mean arterial pressure (MAP), heart rate (HR), SpO2(%) and related side-effects were recorded. Results The patients in group A had significantly increased plasma histamine compared with those in group B (P < 0.05). No statistically significant differences in HR, MAP, SpO2 and side-effects were found between the two groups (P > 0.05). Conclusion For otorhinolaryngologic short-term operations, Mivacurium caused higher plasma histamine compared with Cisatracurium, while there is no significant difference in side-effects between them.
		2018 Vol. 15 (25): 100-103 [Abstract] ( 214 ) HTML (1 KB) PDF (586 KB) ( 69 )

	104	Study of the value of superior vena cava deformation index in volumetric treatment of liver transplantation and the effect on postoperative recovery
		ZHANG Peicai CHEN Yong LI Binfei
		Objective To investigate the application of superior vena cava deformation index in volumetric therapy of liver transplantation and the effect on postoperative recovery. Methods A total of 60 liver transplantation patients from January 2016 to December 2017 in the Zhongshan People′s Hospital were collected as the study subjects, and they were divided into study group (n = 30) and routine group (n = 30) according to the principles of randomness and control. The volumetric treatment was monitored by the value of superior vena cava deformation index in the study group, while that was monitored by routine methods such as the CVP, ABP, and Swan-Ganz floating catheters in routine group. The volume of operation and postoperative recovery were recorded. Results The total amount of intraoperative fluid infusion, intraoperative colloid fluid volume, intraoperative lens fluid volume in the study group were less than those in the conventional group, the defecation time, degassing time, fluid intake time and length of stay shorter were than those in the conventional group, the differences were statistically significant (P < 0.01). After surgery, the intra-abdominal pressures increased significantly compared with those before surgery in the two groups, and the study group was lower than that in the routine group, the differences were statistically significant (P < 0.05 or P < 0.01). The incidence of postoperative complications in the study group was 6.67%, lower than that in routine group (16.67%), the difference was statistically significant (P < 0.05). Conclusion The application of superior vena cava deformation index can better guide the volumetric treatment of liver transplantation. The total amount of intraoperative fluid infusion and postoperative complications are reduced. Postoperative deflation and defecation, rapid recovery of eating are promoted.
		2018 Vol. 15 (25): 104-107 [Abstract] ( 202 ) HTML (1 KB) PDF (582 KB) ( 83 )

	108	Clinical observation of Oxycodone hydrochloride in patient-controlled intravenous analgesia after off-pump coronary artery bypass grafting
		TIAN Lijuan SHI Sheng ZHANG Zhe▲ CHEN Lei▲
		Objective To observe the clinical effects of Oxycodone hydrochloride on postoperative analgesia after off-pump coronary artery bypass grafting (CABG) in order to optimize the prescription of analgesic pump. Methods Clinical data of off-pump CABG patients in Fuwai Hospital Chinese Academy of Medical Science from October 2015 to April 2016 were retrospectively analyzed. According to the prescription of postoperative analgesic pump, the patients were divided into Oxycodone group (group O) and Sufentanil group (group S) with 50 cases in each group. The analgesic pump in group O was composed of Oxycodone (0.8 mg/kg) and tropisetron (5 mg), and the analgesic pump formula in group S was Sufentanil (1.5 μg/kg) and tropisetron (5 mg). Patient controlled intravenous analgesia (PCIA) began at the end of surgery. The arterial systolic blood pressure (SBP), the arterial diastolic blood pressure (DBP) and the heart rate (HR) were collected at 30 min before extubation(T1), the moment of extubation(T2), 3 h after extubation (T3), and 24 h after extubation(T4)． Pain and sedative scores at each time points of T2 to T4, additional postoperative analgesics, length of postoperative mechanical ventilation, length of intensive care unit (ICU) stay and analgesic related complications were collected. Results At the time point of T2, the HR and SBP of group O were higher than those of group S, the differences were statistically significant (P < 0.05). At the time point of T2, the SBP, DBP, and HR of group O and the SBP of group S were increased significantly compared to the time point of T1 with statistical significance (P < 0.05). There was no significant difference between groups in pain and sedative score, additional postoperative analgesics, length of postoperative mechanical ventilation, length of intensive care unit (ICU) stay and analgesic related complications (P > 0.05). Conclusion Oxycodone hydrochloride is safe and effective for postoperative analgesia in patients undergoing off-pump CABG. There is no significant difference in the clinical analgesic effect between the two prescriptions (0.8 mg/kg Oxycodone and 1.5 μg/kg Sufentanil) of analgesia pumps, and the anesthesiologist should choose them according to their own experience and the patients′ condition.
		2018 Vol. 15 (25): 108-111 [Abstract] ( 217 ) HTML (1 KB) PDF (588 KB) ( 54 )

	112	Effect of qigong practice wuqinxi on the motor function of elderly patients with stroke hemiplegia
		TANG Linxia GONG Bomin SHI Zhenwen WANG Bin
		Objective To investigate the effect of qigong practice wuqinxi on the motor function of elderly patients with stroke hemiplegia. Methods Sixty elderly patients with stroke hemiplegia admitted to Encephalopathy Department of Shanghai Municipal Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from November 2015 to August 2016 were selected as research objects, and they were assigned to experimental group and control group by random number table method, with 30 cases in each group. The experimental group were given routine rehabilitation training and organized health qigong wuqinxi, once a day, 1 hour each time, 5 times each week, for 20 weeks; the control group received routine rehabilitation training, such as enhancing the muscle, passive joint motion, and so on, once a day, 5 times each week, but the patients in the control group did not receive the group training of qigong practice wuqinxi or individual planned exercise rehabilitation. The motor function was compared by Fugl-Meyer assay (FMA) method before treatment and after treatment for 20 weeks. Results There were no significant differences of FMA score between the two groups before treatment (P ＞ 0.05). After treatment for 20 weeks, the FMA scores in both groups were significantly higher than those before treatment, which of experimental group were significantly higher than those in the control group, with statistically significant differences (P ＜ 0.05). Conclusion The modified wuqinxi can significantly improve the motor function of elderly patients with stroke hemiplegia, which is fit for the patients to exercise.
		2018 Vol. 15 (25): 112-115 [Abstract] ( 241 ) HTML (1 KB) PDF (439 KB) ( 171 )

	116	Bibliometric analysis of acupoint massage in the treatment of post-stroke dysphagia
		WU Qian1 ZHAO Limei1 GUO Limin1 YANG Siyuan1 JIA Yuan1 MENG Fanjie2
		Objective To explore the research status and trend of acupoint massage in the treatment of post-stroke dysphagia in China, and provide thought and basis for further research. Methods A computer search was conducted for the relevant literatures published by CNKI, VIP, Wanfang and CBM from the construction of the database to April 30, 2018, and descriptive statistical analysis was conducted on the research types, published journals, authors, key words, institutions and fund funding of the literature. Results A total of 65 literatures were finally selected, except 1 dissertation, the remaining 64 literatures were published in 56 journals. Literatures were mainly based on clinical research literature. The common therapy was comprehensive therapy. Lianquan, fengchi, yifeng, jiache were commonly used acupoints. Conclusion Acupoint massage is a hot topic in future research in the treatment of post-stroke dysphagia, but the quantity and quality of the literature need to be improved. It is an important direction in the future to make standard plan of acupoint massage and explore the best combination of comprehensive therapy.
		2018 Vol. 15 (25): 116-118,131 [Abstract] ( 222 ) HTML (1 KB) PDF (880 KB) ( 72 )

	119	The effect of transvaginal color Doppler ultrasound on the pregnancy outcome of pregnancy of unknown location women with early pregnancy
		SUN Qian1 MU Kexiao2
		Objective To explore the detection results of the corpus luteum blood flow in pregnancy of unknown location (PUL) by transvaginal color doppler ultrasound and its prediction effect on pregnancy outcome. Methods A total of 120 PUL patients admitted to the West Campus of Qingdao Municipal Hospital from January 2014 to January 2017 were enrolled in the study. According to the pathological findings of the surgery, there were 58 cases of ectopic pregnancy group and 62 cases of intrauterine pregnancy group. In the intrauterine pregnancy group, 32 cases of premature pregnancy and 30 cases of premature intrauterine abortion were confirmed. The echo type and blood flow classification of the corpus luteum and the resistance index (RI), pulsatile index (PI) and peak systolic flow velocity (PSV) between the two groups were compared. The predictive value of Receiver operator characteristic curve (ROC) on ectopic pregnancy and intrauterine pregnancy abortion was analyzed. Results The blood classification of the intrauterine pregnancy group was significantly better than that of the ectopic pregnancy group, the difference was statistically significant (P ＜ 0.05). The RI and PI of luteal blood flow in the intrauterine pregnancy group were lower than those in the ectopic pregnancy group, while the PSV in the ectopic pregnancy group was significantly higher than that in the ectopic pregnancy group (P ＜ 0.05).The area of the luteal blood flow RI, PI, and PSV for predicting ectopic pregnancy was 0.884, 0.711, 0.867. The luteal blood flow RI of the patients with intrauterine early pregnancy was lower than patients with early pregnancy abortion, while the PSV was significantly higher than patients with early pregnancy abortion (P ＜ 0.05). The area under the curve of RI and PSV for predicting intrauterine pregnancy abortion was 0.829 and 0.830 respectively. Conclusion Transvaginal color Doppler ultrasound can identify the pregnancy position of PUL patients as early as possible, and have higher predictive value for ectopic pregnancy and intrauterine pregnancy abortion.
		2018 Vol. 15 (25): 119-122 [Abstract] ( 221 ) HTML (1 KB) PDF (714 KB) ( 65 )

	123	Correlation analysis between brain parenchymal changes and cognitive dysfunction in children with type 1 diabetes mellitus
		ZHU Chen XUN Chong▲ ZHANG Xiaojun ZHANG Xinrong
		Objective To study the effect of type 1 diabetes (T1D) on the brain parenchyma changes and cognitive function in children. Methods Forty children with T1D admitted in the Department of Childhood Endocrinology and Metabolism, the Affiliated Children′s Hospital of Nanjing Medical University (“our hospital” for short) from January to December 2017 were included as the T1D group. Another 40 children examined in our hospital for physical examination were involved in non T1D group. Both groups were detected blood HbA1c before and after MRI. All children enrolled in the study were underwent IQ tests and evaluated brain developmental-related scores by professionals. Resting state functional magnetic resonance (rsfMRI) scans were performed on both groups. The rsfMRI data were preprocessed by SPM8 software, and the seed connection ICA analysis was performed by GIFT software. Pearson correlation test was used to analyze the correlation. Results There was no significant difference in IQ levels between the two groups (P ＞ 0.05). For the brain performance, learning, memory and treatment ability, the scores of children with T1D were lower than those in non T1D group, but there was no significant difference (P ＞ 0.05), considering lack of samples and/or young age. The brain connections in the T1D group increased, including the left frontal lobe, the left anterior wedge anterior, the right cerebellum and the left anterior superior gyrus. There was no correlation between these abnormal connections and HbA1c level, brain cognitive function (P ＞ 0.05). Conclusion The connections of brain regions in children with T1D increase, but there is no significant correlation between HbA1c level, cognitive function and these abnormal connections. It may be related to the factors such as small sample size and short observing time.
		2018 Vol. 15 (25): 123-126 [Abstract] ( 236 ) HTML (1 KB) PDF (605 KB) ( 58 )

	127	Clinical study on the value of brain natriuretic peptide combination with Tei index for the cardiac function of patients with viral hepatitis cirrhosis
		WANG Likun1 ZHANG Sumei2 WU Xueliang3 YANG Jielin4 YANG Ruimin1 HAN Chao1 WANG Yicheng1
		Objective To investigate the value of brain natriuretic peptide (BNP) combination with Tei index in evaluating the cardiac function of patients with viral hepatitis cirrhosis. Methods Eighty patients with viral hepatitis cirrhosis treated in Department of Gastroenterology, the First Affiliated Hospital of Hebei North University from December 2014 to December 2016 were selected and divided into compensatory stage group (Child A group 30 cases) and non compensatory stage (Child B group 25 cases and Child C group 25 cases) according into Child-Pugh liver function grading standard. Another 20 healthy volunteers were selected as the healthy control group. The plasma BNP level was detected by ELISA method and Tei index was detected by colour doppler imaging. Results The plasma BNP level in the Child B and the Child C group was higher than that in the Child A group and the control group; the plasma BNP level in the Child C group was higher than that in the control group, and there was significant difference (P ＜ 0.05). The Tei index of left ventricle and IRT/ET value in the Child B and the Child C group were higher than those in the Child A group and the control group. The Tei index of left ventricle and IRT/ET value in the Child C group were higher than those in the control group, and there were also significant differences (P ＜ 0.05). While there was no difference in Tei index and IRT/ET value of right ventricle in all the groups (P ＞ 0.05). The plasma BNP and Tei index were consistent in assessing cardiac function in patients with viral hepatitis cirrhosis (r = 0.655, P ＜ 0.01). Multiple stepwise regression analysis showed that the Tei index of left ventricle was independent risk factor of plasma BNP (P ＜ 0.01). Conclusion The plasma BNP combination with Tei index could accurately assess the changes of cardiac function in patients with viral hepatitis cirrhosis and provide a scientific reference for clinical treatment and monitoring.
		2018 Vol. 15 (25): 127-131 [Abstract] ( 228 ) HTML (1 KB) PDF (609 KB) ( 40 )

	132	The evaluation of PET/CT and enhanced CT in the target area of NSCLC radiotherapy and the analysis of patient survival function
		CHEN Shan HUANG Jie
		Objective To study the value of 18F-FDG PET/CT and enhanced CT in the delineation of radiotherapy target area for non-small cell lung cancer (NSCLC) and its effect on progression free survival time (PFS) and total survival time (OS). Methods Seventy-eight cases diagnosed as NSCLC treated with radiotherapy in Renmin Hospital of Wuhan University (“our hospital” for short) from January to December 2013 and the radiotherapy target area was delineated with enhanced CT that were enrolled in the enhanced CT group, while 78 NSCLC cases from January to December 2014 treated with radiotherapy in our hospital and the radiotherapy target area was delineated with 18F-FDG PET/CT, that were enrolled in the PET/CT group. The data of the two groups were preserved and compared. Adverse reaction rate of the two groups were compared. Follow-up results of 3 years and evaluation of the quality of life, PFS, OS were compared between the two groups. Results The total effective rate in the PET/CT group (32.05%) was higher than that in the enhanced CT group (14.10%), and the total effective rate of the PET/CT group was higher than the enhanced CT group (P ＜ 0.01). Adverse reaction rate and the incidence degree in the PET/CT group were lower than that in the enhanced CT group (P ＜ 0.05). The lungs V5, V20, V30 in the PET/CT group were better than the enhanced CT group (P ＜ 0.05). After 3 years of follow up, the quality of life in the PET/CT group was better than the enhanced CT group (P ＜ 0.01). PFS, OS in the PET/CT group were longer than the enhanced CT group (P ＜ 0.05). Detection rate of lesions via enhanced CT was lower than using PET/CT (P ＜ 0.05). The gross tumor volume (GTV) was smaller in the PET/CT group, and the maximum uptake value (SUVmax) was smaller in the PET/CT group than the enhanced CT group. Conclusion It is more precisely to use PET/CT to delineate the radiation field, that can improve the accuracy and reduce partial radiation quantity. It will reduce adverse incidence degree and improve the prognosis, so as to extend PFS and OS.
		2018 Vol. 15 (25): 132-136 [Abstract] ( 267 ) HTML (1 KB) PDF (652 KB) ( 83 )

	137	Application of CT coronary angiography and digital subtraction angiography in the diagnosis of acute coronary syndrome
		FU Wei1 LIU Jichang1 YAN Jidong1 YUE Qinghong1 WANG Guisheng2
		Objective To study the application of CT coronary angiography and digital subtraction angiography （DSA） in the clinical diagnosis of acute coronary syndrome. Methods Twenty-eight patients with acute coronary syndrome admitted in Veterans Hospital of Liaocheng City from January 2016 to October 2017 were selected as subjects. All the patients were given CT coronary angiography and DSA examination, and the diagnostic precision of two methods were compared. Results CT coronary angiography results showed that there were 26 cases of acute coronary syndrome, the true positive rate was 92.86%, the true negative rate was 100%, the diagnostic sensitivity was 100%, and the specificity was 89.29%. DSA results showed that there were 24 cases with acute coronary syndrome, true positive rate was 78.57%, the true negative rate was 100%, the diagnostic sensitivity was 100%, and the specificity was 82.14%. The sensitivity and true negative rate of the two detection methods had no statistically significant difference (P ＞ 0.05). The positive rate and specificity of CT coronary angiography were higher than those of DSA, and the difference was statistically significant (P ＜ 0.05). In addition, the number of plaques examined by CT coronary angiography was less than DSA. There was no significant deifference of calcified plaque and non calcified plaque detection rate by CT coronary angiography or DSA (P ＞ 0.05). Conclusion In the diagnosis process acute coronary syndrome, CT coronary angiography method is easy to handle and and it has high accuracy, that can be used widely in clinic, so as to provide more effective protection for patients.
		2018 Vol. 15 (25): 137-139,143 [Abstract] ( 234 ) HTML (1 KB) PDF (840 KB) ( 156 )

	140	The effect of Linezolid combined with Ambroxol Hydrochloride on ventilator-associated pneumonia and serum PSP/sTREM-1 levels
		GONG Gu1 HU Zhansheng2
		Objective To analyze the effect of Linezolid combined with Ambroxol Hydrochloride on Ventilator associated pneumonia (VAP) and its effect on serum PSP/sTREM-1 levels. Methods A total of 90 patients with VAP admitted in Jinzhou Central Hospital from October 2016 to October 2017 were collected and they were divided into observation group and control group according to the random number table method, with 45 cases in each group. The control group was treated with Linezolid, while the observation group was treated with Linezolid and Ambroxol Hydrochloride. Both groups were treated for 7 days. The clinical efficacy, clinical indices, serum inflammatory factors, PSP and sTREM-1 levels were compared between the two groups. Results After treatment, the total effective rate, pathogen clearance rate, sputum suction times, mechanical ventilation time, the time of ICU hospitalization, and the serum inflammatory factor levels in the observation group were significantly better than those in the control group (P ＜ 0.05). Compared with before treatment, the serum levels of PSPN and TREM-1 in the two groups significantly decreased after treatment, and the levels of PSPN and TREM-1 in the observation group were significantly lower than those in the control group (P ＜ 0.05). Conclusion The combination of Linezolid and Ambroxol Hydrochloride has a significant effect in the treatment of VAP, that can effectively improve the antibacterial efficacy, reduce serum PSP and sTREM-1 levels, so as to improve inflammatory response and prognosis.
		2018 Vol. 15 (25): 140-143 [Abstract] ( 197 ) HTML (1 KB) PDF (398 KB) ( 74 )

	144	Changes of serum D-dimer and MMP-9 levels in patients with acute aortic dissection and their clinical significance
		MENG Shaozhi1 LIU Qijuan2▲
		Objective To investigate the changes and clinical significance of serum D-dimer and matrix metalloproteinase-9 (MMP-9) in patients with acute aortic dissection (AAD). Methods From January 2014 to October 2016, 104 patients with AAD admitted in the Central Hospital of Wuhan ("our hospital" for short) as AAD group, 96 patients with myocardial infarction as myocardial infarction group and 100 healthy people carried the physical examination in our hospital at the same period were selected as control group. According to the prognosis, all the AAD patients were divided into survival group (82) and death group (22). Levels of D-dimer and MMP-9 in different groups of venous blood were compared, and the correlation between the levels of serum D-dimer, MMP-9 and clinical aortic risk score in AAD patients was analyzed. Results The levels of serum D-dimer and MMP-9 in AAD group were significantly higher than those of the myocardial infarction group and control group, and the myocardial infarction group was significantly higher than those in the control group, and the differences were statistically significant (P < 0.05). The levels of serum D-dimer and MMP-9 in the death group were significantly higher than those in the survival group, and the differences were statistically significant (P < 0.01). Pearson correlation analysis showed that levels of serum serum D-dimer and MMP-9 were positively correlated with risk score (r = 0.672, 0.568, all P < 0.05). Conclusion The levels of D-dimer and MMP-9 in the patients with AAD are significantly increased. The higher the level of D-dimer and MMP-9, the higher the risk of death, closely monitoring the two indicators has important application value in the diagnosis and prognosis of clinical AAD.
		2018 Vol. 15 (25): 144-147 [Abstract] ( 366 ) HTML (1 KB) PDF (502 KB) ( 64 )

	148	Analysis of combined antibacterial of extensively drug-resistant Acinetobacter baumannii in vitro
		MA Dongmei TAO Qingchun QI Hongwei
		Objective To study antibacterial effect of Shuanghuanglian combined with minocycline and Piperacillin /Taz-obactam and Cefoperazone / Sulbactam on extensively drug-resistant Acinetobacter baumannii in vitro. Methods A total of 30 strains extensively drug-resistant Acinetobacter baumannii were collected from clinical specimens from October 2016 to June 2017 in Beijing University of Chinese Medicine Third Affiliated Hospital. The minimum inhibitory concentration (MIC) of Shuanghuanglian and minocycline, Piperacillin / Tazobactam, Cefoperazone / Sulbactam (Cefoperazone / Sulbactam) in 30 strains extensively drug-resistant Acinetobacter baumannii was tested by the broth dilution method, and the partial inhibitory concentration (FIC) index was calculated, and the combined bacteriostasis effect of Chinese and Western medicine was determined. Results The FIC index of Shuanghuanglian combined with minocycline: 0.5-1 accounted for 6.7%, >1-2 accounted for 63.3%, and >2 accounted for 30.0%; the FIC index of Shuanghuanglian combined with Piperacillin / Tazobactam: 0.5-1 accounted for 16.7%, >1-2 accounted for 83.3%; the FIC index of Shuanghuanglian combined with Cefoperazone / Sulbactam: ≤ 0.5 accounted for 23.3%, 0.5-1 accounted for 73.3%, >1-2 accounted for 3.3%. Conclusion Shuanghuanglian combined with minocycline and Piperacillin / Tazobactam has a non-independent and antagonistic effect on the extensively drug-resistant Acinetobacter baumannii, and the combined antibacterial effect in vitro is poor. The combined antibacterial effect of Shuanghuanglian combined with Cefoperazone / Sulbactam is better.
		2018 Vol. 15 (25): 148-151 [Abstract] ( 227 ) HTML (1 KB) PDF (744 KB) ( 127 )

	152	Diagnostic value of combined detection of tumor markers in lung cancer
		XIE Chaohui1 FANG Kun2▲
		Objective To investigate the diagnostic value of combined detection of carcinoembry onic antigen (CEA), neuron-specific enolase (NSE), cytokeratin-19-fragment (CYFRA21-1), pro-gastrin-releasing peptide (ProGRP), and squamous cell carcinoma antigen (SCC-Ag) in lung cancer. Methods A total of 158 patients with lung cancer in the Chengdu First People′s Hospital from January to December 2017 were selected as lung cancer group(there were 51 cases of squamous cell carcinoma group, 72 cases of adenocarcinoma group and 35 cases of small cell carcinoma group), and 50 healthy persons during the same period were selected as health group. The levels of CEA, NSE, CYFRA21-1, ProGRP, and SCC-Ag in serum were detected respectively. Logistic regression receiver operating characteristic curve were applied to analyze the data and evaluate the diagnostic values. Results The concentrations of CEA, NSE, CYFRA21-1, ProGRP and SCC-Ag in lung cancer group were significantly higher than those in the healthy group (P < 0.01). The serum levels of NSE and ProGRP were the highest in small cell carcinoma group. The concentration of CEA was the highest in adenocarcinoma group, while that of SCC-Ag and CYFRA21-1 in squamous cell carcinoma group. The levels of five markers in lung cancer patients with stage Ⅲ-Ⅳ were significantly higher than those with stage Ⅰ-Ⅱ, the differences were statistically significant (P < 0.01). The area under the curve of combined detection Logistic regression model was 0.925, which was significantly higher than that of single test. Conclusion The combined of 5 serum tumor markers can improve the accuracy of lung cancer diagnosis.
		2018 Vol. 15 (25): 152-155 [Abstract] ( 245 ) HTML (1 KB) PDF (523 KB) ( 144 )

	156	Influence of individualized and human culture nursing on complications of cardiac interventional therapy
		GAO Yan1 CAO Yukun2 WANG Tao3
		Objective To explore the effect of personalized and humanistic nursing on the complications of cardiac interventional therapy. Methods From January to December 2017, in Baoji Central Hospital, 170 hospitalized patients underwent cardiac interventional therapy technique were selected, according to random number table method, they were divided into traditional nursing group (85 cases) and individual character humanistic nursing group (85 cases). The traditional nursing group was given routine nursing heart operations, individual character humanistic nursing group was given the personalization and humanization nursing measures on the basis of conventional nursing. The pain, anxiety and sleep quality in the two groups after operation for 2 weeks were compared, and the postoperative complications were statistically analyzed. Results After nursing, the scores of visual analogue scale (VAS), HAMA anxiety scale (HAMA) and Pittsburgh sleep quality index (PSQI) in two groups were significantly lower than before nursing, and the VAS scores, HAMA scores and PSQI scores in individual character humanistic nursing group were significantly lower than those of traditional nursing group, the differences were statistically significant (P < 0.05). The incidence of cardiac complications and non-cardiac complications in individual character humanistic nursing group were significantly lower than those of traditional nursing group, the differences were statistically significant (P < 0.05). Conclusion Humanistic nursing personality comprehensive considers the needs for interventional heart surgery patients with various personalized care, and from the perspective of humanistic care, it reduces the pain patients maximally, improves the prognosis of disease recovery, decreases the incidence of complications after cardiac interventional therapy.
		2018 Vol. 15 (25): 156-159 [Abstract] ( 196 ) HTML (1 KB) PDF (626 KB) ( 160 )

	160	Effect of FOCUS-PDCA model on quality of life and activity of daily living for elder patients with sarcopenia
		XING Jiwei WU Yanyan CHAI Yuan JIN Baolian CAO Yan WU Xuejuan CUI Wei NIU Xiaochen
		Objective To observe the influence of FOCUS-PDCA model on quality of life and activity of daily living for elder patients with sarcopenia. Methods From July 2015 to March 2017, in Beijing Friendship Hospital, Capital Medical University, 169 elder patients with sarcopenia were selected, they were divided into control group (85 cases) and observation group (84 cases) according to the random number table. The control group was given nutrition and exercise education, the observation group was given the FOCUS-PDCA model based on the control group. The quality of life and activity of daily living in two groups were evaluated and compared before and after the intervention for 3 months by Spitzer quality of index and Modified Barthel Idex. Results There was no statistically significant difference on 5 dimension score of living condition, mobility, life feeling, general health, family support, and total scores about quality of life in control group before and after intervention (P > 0.05); the each dimension score and total scores of quality of life in observation group were higher after intervention than before intervention, and these were higher than those in control group, the differences were statistically significant (P < 0.05). There was no statistically significant differences in 10 item scores (personal hygiene, bathing, eating, dressing, large, urine control, toilet, up and down stairs, bed/chair transfer, ground walking) and total scores of ADL in control groups before and after intervention (P > 0.05); and the 10 item score and total scores of ADL in observation group after intervention were higher than before intervention, and these were higher than control group, the differences were statistically significant (P < 0.05). Conclusion FOCUS-PDCA model can improve quality of life and activity of daily living for elder patients with sarcopenia.
		2018 Vol. 15 (25): 160-163,177 [Abstract] ( 200 ) HTML (1 KB) PDF (656 KB) ( 129 )

	164	Effect of doctor and nurse integration combined with enhanced recovery after surgery on hypoproteinemia in patients with liver cancer after hepatectomy
		YU Qiu XU Xiaoping ZHAO Min LIU Yingyan PENG Xiangqun▲
		Objective To study the effect of medical and nursing integration combined with enhanced recovery after surgery (ERAS) on hypoproteinemia in hepatectomy patients. Methods From August 2014 to January 2017, in Hu'nan Provincial People′s Hospital, 78 patients with hypoproteinemia after hepatectomy were selected, according to the random number method, they were divided into the control group and observation group, with 39 cases in each group. The control group was given doctor and nurse integration, the observation group was given doctor and nurse integration combined with enhanced recovery. The improvement of fatigue feeling, complications, negative emotion score, nutrition index and insulin-like growth factor-1 (IGF-1) and alanine aminotransferase (ALT) level in the two groups after intervention were analyzed. Results After intervention, the fatigue feeling rate, body weight and grip strength in two groups improved compared with before intervention, and the fatigue feeling rate in observation group was lower than control group, body weight and grip strength in observation group were stronger than control group, the differences were statistically significant (P < 0.05). The time of intestinal exhaust time, defecate, restore complete oral diet in observation group was less than control group, the differences were statistically significant (P < 0.05). After intervention, the level of prealbumin, transferrin, albumin in two groups increased, and the level of prealbumin, transferrin, albumin in observation group were higher than control group, the differences were statistically significant (P < 0.05). After intervention, the levels of IGF-1 in two groups were higher than before intervention, the levels of ALT were lower than before intervention, and the levels of IGF-1 and ALT in observation group were better than control group, the differences were statistically significant (P < 0.05). After intervention, self-rating anxiety scale (SAS), self-rating depression scale (SDS) scores in two groups were reduced comprared with before intervention, and those in observation group were lower than control group, the differences were statistically significant (P < 0.05). The satisfaction score in observation group was higher than control group, the difference was statistically significant (P < 0.05), but there was no statistical difference in the incidence of complications between two groups (P > 0.05). Conclusion Patients with hypoproteinemia after liver cancer treated with the combination of medical care and ERAS concept can reduce the fatigue, improve the body nutrition level, lower the serum IGF-1 level, reduce the negative emotions of patients, and improve the patient satisfaction.
		2018 Vol. 15 (25): 164-168 [Abstract] ( 196 ) HTML (1 KB) PDF (636 KB) ( 70 )

	169	Effects of cognitive behavioral nursing on neurological function and quality of life in patients with cerebral hemorrhage
		ZHOU Jingjing GU Yudan
		Objective To explore the effects of medical expulsive treatment combined with cognitive behavioral nursing on neurological function and the quality of life in patients with cerebral hemorrhage. Methods From July 2015 to July 2017, in Affiliated Hospital of Nantong University, 110 cerebral hemorrhage patients were selected, according to random number table method, they were divided into control group and test group, with 55 cases in each group. The control group was given routine nursing intervention, and the test group was given cognitive behavior intervention on the basis of routine nursing intervention. The movement function, life activity, nervous function and quality of life changes of two groups before and after nursing intervention were compared. Results After nursing intervention, Fugl-Meyer assessment (FMA) score and life activity Barthel index of the patiens in two groups improved significantly (P < 0.05), and FMA score and modified Barthel index of the patients in test group were significantly higher than control group (P < 0.05). After nursing intervention, the score of national institute of health stroke scale (NIHSS) of the patients in two groups reduced significantly (P < 0.05), Glasgow outcome score (GOS) incerased significantly (P < 0.05), and the NIHSS score in the test group was significantly lower than the control group (P < 0.05), the GOS score level was significantly higher than the control group (P < 0.05). After nursing intervention, the life scores of QLQ-30 rating scale of the patients in the two groups after intervention increased significantly (P < 0.05), and the physical function, role function, emotional function, cognitive function, social function and overall health of QLQ-30 rating scale of the patients in the test group were significantly higher than the control group (P < 0.05). Conclusion Medical expulsive treatment with cognitive behavioral nursing therapy can effectively improve the level of cognition, the patients' medication adherence and neurologic status, promote the recovery of motor function and activities of life skills, provide guarantee for recovery of the patients' life.
		2018 Vol. 15 (25): 169-172 [Abstract] ( 206 ) HTML (1 KB) PDF (623 KB) ( 59 )

	173	Research on Delphi method in establishing clinical training target system for graduate students of nursing master degree
		SU Ting TANG Wanzhen
		Objective To explore an effective system for clinical training objectives of graduates with master of nursing specialist (MNS). Methods On the basis of literature review, group discussion and expert interview, MNS training objective system consultation form was initially formed. 30 patients were selected by purpose sampling, and two rounds of consultation were established by Delphi method. Results In the two rounds of expert consultations, experts′ positive coefficients were 100.00% and 93.33%. The authoritative coefficients of experts were 0.87 and 0.87, respectively. The Kendall′s W coefficients were 0.132 and 0.235 (P < 0.01). The evaluation system included 3 primary indicators, 25 secondary indicators. Conclusion The higher nursing teaching in China can be deepened by the MNS clinical training target system constructed by this study. The psychological quality and ideological attitude of MNS in our country have been improved, and clinical practice skills and theoretical knowledge can be more deeply understood by MNS. At the same time, scientific research has been deepened by MNS to promote the improvement of the comprehensive quality of MNS in China.
		2018 Vol. 15 (25): 173-177 [Abstract] ( 219 ) HTML (1 KB) PDF (638 KB) ( 86 )

	178	Intervention result and self-protection status survey of occupational musculoskeletal injury for nurses
		LI Furu ZHU Yun
		Objective To approach the intervention effect and self-protection status survey of occupational musculoskeletal injury (OMSI) for nurses. Methods From March 2015 to August 2016, in the Fifth Affiliated Hospital of Xinjiang Medical University, the data of 300 nurses were analyzed, according to appearing OMSI or not, they were divided into control group (200 persons) and detection group (OMSI, 100 persons), they were given self protection training. The general information, hazards logistic regression model for OMSI variable and assignment of two group nurses were detected. The OMSI acknowledge score, pain duration, seizure frequency of OMSI nurses before and after self-protection measures were detected. Results There were statistically significant differences in age, working years, marital status, exercise habit, shift work situation, the department, title of two groups (P < 0.05). Logistic regression analysing showed the age, working years, marital status, exercise habit, shift work situation, department, title were influnce factors of OMSI appearing (P < 0.05), the regular exercise was risk factor of OMSI, the age, working years, department, title were protective factors of OMSI (P < 0.05). After self-protection intervention, the OMSI cognitive score of nurses was higher than before intervention, the pain duration time, seizure frequency were lower than before intervention, the differences were statistically significant (P < 0.05). Conclusion The age, working years, marital status, exercise habit, shift work situation, department, title are significant factors of OMSI，the effective interventions can increase OMSI acknowledge score of nurses, decrease pain duration, seizure frequency.
		2018 Vol. 15 (25): 178-181 [Abstract] ( 207 ) HTML (1 KB) PDF (835 KB) ( 60 )

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