急性主动脉夹层患者血清中D-二聚体、MMP-9水平变化及临床意义

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Abstract Objective To investigate the changes and clinical significance of serum D-dimer and matrix metalloproteinase-9 (MMP-9) in patients with acute aortic dissection (AAD). Methods From January 2014 to October 2016, 104 patients with AAD admitted in the Central Hospital of Wuhan ("our hospital" for short) as AAD group, 96 patients with myocardial infarction as myocardial infarction group and 100 healthy people carried the physical examination in our hospital at the same period were selected as control group. According to the prognosis, all the AAD patients were divided into survival group (82) and death group (22). Levels of D-dimer and MMP-9 in different groups of venous blood were compared, and the correlation between the levels of serum D-dimer, MMP-9 and clinical aortic risk score in AAD patients was analyzed. Results The levels of serum D-dimer and MMP-9 in AAD group were significantly higher than those of the myocardial infarction group and control group, and the myocardial infarction group was significantly higher than those in the control group, and the differences were statistically significant (P < 0.05). The levels of serum D-dimer and MMP-9 in the death group were significantly higher than those in the survival group, and the differences were statistically significant (P < 0.01). Pearson correlation analysis showed that levels of serum serum D-dimer and MMP-9 were positively correlated with risk score (r = 0.672, 0.568, all P < 0.05). Conclusion The levels of D-dimer and MMP-9 in the patients with AAD are significantly increased. The higher the level of D-dimer and MMP-9, the higher the risk of death, closely monitoring the two indicators has important application value in the diagnosis and prognosis of clinical AAD.

Key words： Acute aortic dissection D-dimer Matrix metalloproteinase-9 Myocardial infarction

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	MENG Shaozhi1 LIU Qijuan2▲

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MENG Shaozhi1 LIU Qijuan2▲. Changes of serum D-dimer and MMP-9 levels in patients with acute aortic dissection and their clinical significance[J]. 中国医药导报, 2018, 15(25): 144-147.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I25/144

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