甲状腺功能异常患者碘营养状态的评估分析

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Abstract Objective To explore the characteristics of iodine nutritional status in patients with abnormal thyroid function in Cangzhou. Methods A total of 1024 patients with abnormal thyroid function in Department of Endocrinology in Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine in Hebei Province ("our hospital for short") from March 2015 to December 2017 were selected as study group. They were divided into 4 groups according to the diagnostic criteria of thyroid diseases, which were hyperthyroidism group, ubclinical hyperthyroidism group, hypothyroidism group and subclinical hypothyroidism group. At the same time, 130 normal adults taken physical examination in our hospital at the same time were collected as control group. The urine iodine and thyroid function [free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropic hormone (TSH)] were detected. The iodine nutritional status in all subgroups of study group and control group was analyzed. Results The levels of median urinary iodine (MUI) in all subgroups in ascending order were subclinical hyperthyroidism group, hyperthyroidism group, control group, hypothyroidism group and subclinical hypothyroidism group. The iodine nutrition in study group and control group were in the proper state. But the range of urine iodine levels was large, and the difference of urine iodine levels among different individuals was large. The levels of MUI in hyperthyroidism group and subclinical hyperthyroidism group were more than 200 μg/L, and the patients were in a state of excess iodine nutrition. The percentage of iodine deficiency, proper iodine, iodine excess in hyperthyroidism group and subclinical hyperthyroidism group had statistically significant differences compared with those of hypothyroidism group and subclinical hypothyroidism group (P ＜ 0.05), the percentage of iodine deficiency, proper iodine, iodine overbalance in all subgroups of study group had statistically significant differences compared with those of control group (P ＜ 0.05). Conclusion Iodine nutrition levels are associated with thyroid function. Both patients with abnormal thyroid function and healthy people need to pay attention to the state of iodine nutrition. Individualized iodine intake should be guided by the results of urine iodine. Blind iodine supplementation should be avoided. It is of great significance for the prevention and treatment of thyroid diseases.

Key words： Urinary iodine Iodine nutrition status Hyperthyroidism Subclinical hyperthyroidism Hypothyroidism Subclinical hypothyroidism

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	WANG Fengling1 HOU Zhenjiang1 LIU Yuzhi1 DAI Rongqing1 CHEN Lixin2

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WANG Fengling1 HOU Zhenjiang1 LIU Yuzhi1 DAI Rongqing1 CHEN Lixin2. Analysis of iodine nutritional status in patients with abnormal thyroid function[J]. 中国医药导报, 2018, 15(25): 63-66.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I25/63

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