|
|
|
| Clinical study on the value of brain natriuretic peptide combination with Tei index for the cardiac function of patients with viral hepatitis cirrhosis |
| WANG Likun1 ZHANG Sumei2 WU Xueliang3 YANG Jielin4 YANG Ruimin1 HAN Chao1 WANG Yicheng1 |
1.Department of Ultrasound, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of Ultrasound, Xuanhua District Hospital in Zhangjiakou City, Hebei Province, Zhangjiakou 075000, China;
3.Vascular Surgery Department, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
4.Department of Gastroenterology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China |
|
|
|
Abstract Objective To investigate the value of brain natriuretic peptide (BNP) combination with Tei index in evaluating the cardiac function of patients with viral hepatitis cirrhosis. Methods Eighty patients with viral hepatitis cirrhosis treated in Department of Gastroenterology, the First Affiliated Hospital of Hebei North University from December 2014 to December 2016 were selected and divided into compensatory stage group (Child A group 30 cases) and non compensatory stage (Child B group 25 cases and Child C group 25 cases) according into Child-Pugh liver function grading standard. Another 20 healthy volunteers were selected as the healthy control group. The plasma BNP level was detected by ELISA method and Tei index was detected by colour doppler imaging. Results The plasma BNP level in the Child B and the Child C group was higher than that in the Child A group and the control group; the plasma BNP level in the Child C group was higher than that in the control group, and there was significant difference (P ＜ 0.05). The Tei index of left ventricle and IRT/ET value in the Child B and the Child C group were higher than those in the Child A group and the control group. The Tei index of left ventricle and IRT/ET value in the Child C group were higher than those in the control group, and there were also significant differences (P ＜ 0.05). While there was no difference in Tei index and IRT/ET value of right ventricle in all the groups (P ＞ 0.05). The plasma BNP and Tei index were consistent in assessing cardiac function in patients with viral hepatitis cirrhosis (r = 0.655, P ＜ 0.01). Multiple stepwise regression analysis showed that the Tei index of left ventricle was independent risk factor of plasma BNP (P ＜ 0.01). Conclusion The plasma BNP combination with Tei index could accurately assess the changes of cardiac function in patients with viral hepatitis cirrhosis and provide a scientific reference for clinical treatment and monitoring.
|
|
|
|
|
|
[1] 徐爱强，张丽.中国病毒性肝炎血清流行病学调查的回顾与意义[J].中华预防医学杂志，2017，51（6）：457-461.
[2] Marchetta S，Delwaide J，Lancellotti R，et al. Cirrhotic cardiomyopathy：a brief overview [J]. Rev Med Liege，2015， 70（2）：86-91.
[3] Mocarzel LO，Bicca J，Jarske L，et al. Cirrhotic Cardiomyopathy：Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome [J]. Case Rep Gastroenterol，2016，10（3）：531-537.
[4] Liu D，Hu K，Herrmann S，et al. Value of tissue Doppler-derived Tei index and two-dimensional speckle tracking imaging derived longitudinal strain on predicting outcome of patients with light-chain cardiac amyloidosis [J]. Int J Cardiovasc Imaging，2017，33（6）：837-845.
[5] Gaggin HK，Chen-Tournoux AA，Christenson RH，et al. Rationale and design of the ICON-RELOADED study：International Collaborative of N-terminal pro-B-type Natriuretic Peptide Re-evaluation of Acute Diagnostic Cut-Offs in the Emergency Department [J]. Am Heart J，2017， 192（11）：26-37.
[6] 中华医学会肝病学分会，中华医学会感染病学分会.慢性乙型肝炎防治指南（2015更新版）[J].中华肝脏病杂志，2015，23（12）：881-891.
[7] Kamath PS，Wiesner RH，Malinchoc M，et a1. A model to predict survival in patients with end-stage liver disease [J]. Hepatology，2001，33（2）：464-470.
[8] Clerico A，Zaninotto M，Passino C，et al. New issues on measurement of B-type natriuretic peptides [J]. Clin Chem Lab Med，2017，56（1）：32-39.
[9] 郑穗谨，彭兰芬，刘国珍，等.血浆脑钠肽及Tei指数与妊娠高血压综合征患者关系的研究[J].中国医药导报，2013，10（7）：42-43，46.
[10] 李小鹏，余珊珊，李路，等.肝硬化患者左心功能变化与终末期肝病模型评分的相关性研究[J].南方医科大学学报，2015，35（4）：557-561.
[11] Somani PO，Contractor Q，Chaurasia AS，et al. Diastolic dysfunction characterizes cirrhotic cardiomyopathy [J]. Indian Heart J，2014，66（6）：649-655.
[12] Radaeva EV，Govorin AV，Chistyakova MV. Features of structural and functional changes of the myocardium in patients with chronic viral hepatitis[J].Vestn Ross Akad Med Nauk，2014，（11/12）：24-30.
[13] Goroshi M，Chand D. Myocardial Performance Index（Tei Index）：A simple tool to identify cardiac dysfunction in patients with diabetes mellitus [J]. Indian Heart J，2016， 68（1）：83-87.
[14] Terada T，Mori K，Inoue M，et al. Mitral annular plane systolic excursion/left ventricular length（MAPSE/L）as a simple index for assessing left ventricular longitudinal function in children [J]. Echocardiography，2016，33（11）：1703-1709.
[15] 黄晓玲，陈柏梁，仇烨，等.血清肌钙蛋白I、血浆脑钠肽联合心脏Tei指数评估窒息新生儿心肌损伤及心功能[J].中华实用儿科临床杂志，2014，29（14）；1112-1114.
[16] 杨朝美，李逊，马珍，等.血清BNP、hs-CRP、IMA与冠状动脉粥样硬化性心脏病患者的相关性研究[J].中国实验诊断学，2015，19（7）：1077-1079.
[17] 王朝燕，禹露.BNP联合心肌酶谱检测在冠心病危险分层和冠脉搭桥术疗效中预测作用[J].河北医学，2016， 22（3）：374-378.
[18] Liu S，Ngo DT，Chong CR，et al. Suppression of neutrophil superoxide generation by BNP is attenuated in acute heart failure： a case for 'BNP resistance [J]. Eur J Heart Fail，2015，17（5）：475-483.
[19] 范亚娟，褚雯，梁雅君，等.扩张型心肌病患者Tei指数与血浆脑钠肽的关系[J].中国医学影像学杂志，2015， 23（6）：449-452.
[20] 李娜，裴峰，丁晶，等.Tei指数联合B型脑钠肽评价高血压患者左室重构和心功能[J].中国老年学杂志，2014， 34（18）：5135-5137.
[21] 张达，吴彩军，姜维，等.左心室Tei指数对脓毒性心肌病患者心功能和预后的评估价值[J].中华急诊医学杂志，2017，26（5）：577-580.
[22] 邓翼业，韦德湛.Tei指数评价先天性肺囊腺瘤样畸形胎儿心功能的应用价值[J].中国当代医药，2016，23（12）：79-82.
[23] 徐志远，谢锋，梁惠玲.慢性心力衰竭患者血清NT-proBNP和cTnⅠ联合检测及临床意义分析[J].中国医药科学，2018，8（1）：241-243. |
|
|
|
