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| Effects of the Glutamine on inflammatory response and lung injury in liver cancer patients after the hepatectomy |
| WANG Hui1 BIAN Haopeng2 CHENG Qi3 LI Li4 |
1.The Second Department of Intensive Care Unit, Central Hospital, the First Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050011, China; 2.Department of General Surgery, Central Hospital, the First Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050011, China;
3.Department of Functional, Central Hospital, the First Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050011, China;
4.Department of Neurology, Central Hospital, the First Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050011, China |
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Abstract Objective To study the effect of the Glutamine on inflammatory response and lung injury in liver cancer patients after the hepatectomy. Methods A total of 101 liver cancer patients after the hepatectomy in Central Hospital, the First Hospital of Shijiazhuang City from January 2014 to January 2017 were selected and they were divided into the control group (n = 50) and the treatment group (n = 51) according to random number table method. The treatment group was treated with Glutamine, and the control group was treated with normal saline in the same volume. Both groups were treated for 7 days. The serum Interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), glutamic-pyruvic transaminase (ALT), glutamic oxalacetic transaminase (AST) and proportion of peripheral blood CD3+, CD4+, CD8+ of the two groups were compared before and after treatment. The MLIS and APACHE Ⅱ scores of the two groups were compared before and after treatment. Results After treatment, the levels of serum IL-1, TNF-α of the two groups were significantly lower than those before treatment, and those of the treatment group were significantly lower than the control group (P ＜ 0.05). After treatment, the MLIS and APACHE II scores of the two groups were significantly lower than those before treatment, and scores of the treatment group were significantly lower than the control group (P ＜ 0.05). After treatment, the serum ALT, AST of the two groups were significantly higher than those before treatment, while the indices of the treatment group were significantly lower than the control group (P ＜ 0.05). After treatment, the proportions of peripheral blood CD3+, CD4+ of the two groups were significantly higher than those before treatment, the proportion of peripheral blood CD3+, CD4+, CD8+ of the two groups were significantly lower than those before treatment, and the changes of the treatment group were significantly better than the control group (P ＜ 0.05). Conclusion Application of Glutamine in liver cancer patients with hepatectomy, can inhibit the inflammatory response, reduce the lung injury degree, improve the liver and immune function, and it is worthy clinical promotion.
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