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2020 Vol. 17, No. 32
Published: 2020-11-15
 
 
4 Analysis of clinical characteristics and prognostic factors in patients with non-small cell lung cancer with brain metastasis
YANG Siqi1 YAO Yi1,2 SONG Qibin1,2▲
Objective To explore the clinical characteristics and prognostic factors in patients of non-small cell lung cancer with brain metastasis. Methods A total of 9411 patients with organ metastasis of non-small cell lung cancer from January 2000 to January 2005 were collected by SEER*stat software. The clinical characteristics of 4299 patients with brain metastasis and 5112 patients without brain metastasis were compared by chi-square test and binary logistic regression. Kaplan-Meier method was used to analyze the clinical and pathological characteristics that possible influencing factors of brain metastasis. Log-Rank method was used to test the difference of survival rate. Multivariate Cox regression model was used to analyze the independent risk factors that affect the long-term prognosis of non-small cell lung cancer patients with brain metastasis. The Nomogram figure was constructed by R software version 3.4.4 using independent risk factors affecting long-term prognosis, and the predictive value of the model was evaluated by calculating the consistency index (C-index). Results The results of binary logistic regression showed that age (OR=1.284, 95%CI：1.243-1.326, P ＜ 0.001), gender (OR=0.785, 95%CI：0.731-0.843, P ＜ 0.001), pathological type (OR=0.622, 95%CI：0.575-0.673, P ＜ 0.001), N stage (OR=1.094, 95%CI：1.058-1.131, P ＜ 0.001) were independent risk factors for brain metastasis. The results of multivariate Cox regression showed that age (HR=1.25, 95%CI：1.210-1.290, P ＜ 0.001), race (HR=0.865, 95%CI：0.823-0.909, P ＜ 0.001), gender (HR=0.827, 95%CI：0.774-0.884, P ＜ 0.001), histological grade (HR=1.198, 95%CI：1.133-1.267, P ＜ 0.001), pathological type (HR=0.740, 95%CI：0.682-0.803, P ＜ 0.001), Tumor stage (HR=1.078, 95%CI：1.054-1.104, P ＜ 0.001), N stage (HR=1.078, 95%CI：1.044-1.114, P ＜ 0.001), bone metastasis (HR=0.917, 95%CI：0.850-0.989, P < 0.05), liver metastasis (HR=0.742,95%CI：0.673-0.819, P ＜ 0.001) were independent prognostic factors of non-small cell lung cancer patients with brain metastasis. The C-index was calculated as 0.643. Conclusion The incidence of brain metastasis is higher in young women, adenocarcinoma and patients with early N stage. The prognosis of elderly white male patients with high histological grade, squamous cell carcinoma, late Tumor stage and N stage, bone metastasis and liver metastasis is poor. The clinical model has a medium predictive value.
2020 Vol. 17 (32): 4-8,16 [Abstract] ( 124 ) HTML (1 KB)  PDF (673 KB)  ( 115 )
9 Based on AGREE Ⅱ depression clinical practice guidelines for the adult population quality evaluation research
MA Huaping1 HAN Zhenyun2 HU Wenyue1 LIN Jingfeng1 LIU Ganlu1 WANG Zhenyi1
Objective To evaluate the quality of clinical practice guidelines for depression with adults, and to provide reference for the formulation or update of adult depression guidelines in the future. Methods The document database and guide database were searched by computer, and the retrieval time was from January 1, 2015 to January 31, 2020, The application of clinical guideline research and evaluation system (AGREE Ⅱ) to evaluate the quality of guidelines. Results A total of four English guidelines were included, all of which were evidence-based guidelines, the included guidelines scored low in the fields of “participants” “application” and “conscientiousness”, with the scores being 57.9%, 66.0% and 66.7%, respectively; they scored higher in the areas of “scope and purpose” “clarity” and “independence”, at 75.5%, 79.2%, and 79.2%, respectively. The overall quality of the four guides is high, two Grade A recommendations, two Grade B recommendations. Conclusion The overall quality of the inclusion guidelines is high, however, the quality in the field of “participants” “application” and “conscientiousness” are relatively low, so we should better improve the content of adult depression guidelines in the future.
2020 Vol. 17 (32): 9-12 [Abstract] ( 132 ) HTML (1 KB)  PDF (727 KB)  ( 99 )
13 Relationship between differential gene expression in pure oxygen and air pulmonary ventilation relating to lung injury
CHEN Chao1 LI Yuntao2 ZHANG Hongbo3 SHEN Liang4 NIE Xiaohu2 WEI Pengxiang5
Objective To explore the relationship between differential gene expression in pure oxygen and air pulmonary ventilation relating to lung injury. Methods Five Rattus norvegicus rats were randomly assigned to the experiment group (pure oxygen ventilations, n = 3) and the control group (air ventilation, n = 2). The R software was used to analyze the differential gene expression of lung tissues between the two groups, and functional enrichment was used to analyze differential gene function, protein-protein interactions were constructed to visualize and visualize the protein network of differential genes. Results There were 140 differential genes expressed in the lung tissues of  two groups. The differential gene function was mainly enriched in mitochondria, mitochondrial respiratory chain complex Ⅰ, activation of homologous dimer proteins, intercellular connection and exosomes, among which mitochondria respiratory chain complex Ⅰ was a low-expression gene, which include NDUFB3, NDUFA4, NDUFB1, NDUFB9, NDUFB10, NDUFC1 and NDUFC2, respectively. Conclusion Lung injury under high oxygen content ventilation mainly inhibits the synthesis of ATP in mitochondrial respiratory chain complex Ⅰ. NDUFA4, NDUFB1, NDUFB3, NDUFB9, NDUFB10, NDUFC1, and NDUFC2 genes are the major differential genes in oxidative stress injury and play an important role in lung injury.
2020 Vol. 17 (32): 13-16 [Abstract] ( 88 ) HTML (1 KB)  PDF (683 KB)  ( 116 )
17 Expression of IFN-γ and IL-4 in colorectal cancer and their relationship with clinical stage
FANG Xianlei1,2 ZENG Liping1,2 LI Na1 XIANG Sha2 WU Shihui2 LU Xiaomin2 ZHANG Chang1,2 Liang LU1
Objective To investigate the expression of T helper (Th)1 cytokine interferon-γ (IFN-γ) and Th2 cytokine interleukin-4 (IL-4) in colorectal cancer tissues and explore its relationship with clinical stage. Methods The intestinal tissue samples of 61 patients with colorectal cancer admitted to the First Affiliated Hospital of Hu′nan University of Medicine from January 2016 to August 2018 were collected as colorectal cancer group. According to the clinical stage, they were devided into clinical stage Ⅰ (16 cases)， clinical stage Ⅱ (20 cases)， clinical stage Ⅲ (15 cases)， clinical stage Ⅳ (10 cases). In addition, 5 cases (20 cases in total) of paracancer tissues 10 cm away from the edge of the cancer tissues were collected as the control group. The immunohistochemistry was used to detect the expression of IFN-γ and IL-4 in tissues. Then the mean integrated optical density (MIOD) of the positive staining fraction of each group was analyzed, and the expression differences of IFN-γ and IL-4 among all groups were compared. Results The higher the tumor stage, the weaker the positive degree of IFN-γ expression. The higher the tumor stage, the stronger the IL-4 positive. IL-4 MIOD value in clinical stage Ⅳ colorectal cancer tissue was higher than that in clinical stageⅠ-Ⅲ and the control group, IL-4 MIOD values in the clinical stage Ⅱ-Ⅲ colorectal cancer tissue  were higher than those in clinical stage Ⅰ and the control group, IL-4 MIOD value in the clinical stage Ⅰ colorectal cancer tissue was higher than that in the control group, and the differences were statistically significant (all P < 0.05). IFN-γ MIOD value in clinical stage Ⅳ colorectal cancer tissue was lower than that in the clinical stage Ⅰ-Ⅲ and the control group, IFN-γ MIOD value in the clinical stage Ⅲ colorectal cancer tissue was lower than that in the clinical stage Ⅰ-Ⅱ and the control group, IFN-γ MIOD value in the clinical Ⅱ colorectal cancer tissue was lower than that in the clinical stage Ⅰ and the control group, IFN-γ MIOD value in the clinical stage Ⅰ colorectal cancer tissue was lower than that in the control group, and the differences were statistically significant (all P < 0.05). Conclusion The expression of cytokine IFN-γ is decreased in colorectal cancer tissues, and the expression of IL-4 is increased, which are closely related to the clinical pathological stage of patients.
2020 Vol. 17 (32): 17-19,28 [Abstract] ( 174 ) HTML (1 KB)  PDF (594 KB)  ( 91 )
20 Changes and clinical significance of serum sTWEAK and MMP-9 levels in patients with acute ST-segment elevation myocardial infarction
WANG Peng1 WANG Gang2 ZHANG Chunhe1 ZHANG Aimin1 MA Xiao1 ZUO Ruiju1
Objective To investigate the changes of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and matrix metalloproteinase-9 (MMP-9) in serum in patients with acute ST-segment elevation myocardial infarction (STEMI), and to evaluate their prognostic value. Methods From January to December 2018, 100 STEMI patients admitted to Cangzhou People’s Hospital, Hebei Province were selected as STEMI group, 100 stable angina patients as stable group, 100 unstable angina patients as unstable group and 100 patients without coronary atherosclerotic heart disease as the common group. The general data and the levels of sTWEAK and MMP-9 in each group were compared. STEMI patients were divided into a non-MACE group (61 cases) and MACE group (39 cases) according to whether major adverse cardiovascular events (MACE) occurred after 6 months of follow-up. sTWEAK and MMP-9 levels were compared between the non-MACE group and the MACE group. The related factors of MACE in STEMI patients were analyzed. The diagnostic value of sTWEAK and MMP-9 on prognosis of STEMI patients was analyzed by receiver operating characteristic. Results The STEMI group had higher serum sTWEAK and MMP-9 levels than the other groups (P ＜ 0.05). The serum levels of sTWEAK and MMP-9 in MACE group were higher than those in non-MACE group (P ＜ 0.05). Logistic analysis showed that sTWEAK (OR = 2.159, 95%CI [1.134, 4.109], P = 0.019) and MMP-9 (OR = 1.102, 95%CI [1.018, 1.193], P = 0.017) were independent predictors of MACE in STEMI patients. The area under the curve (AUC) of predicting MACE in STEMI patients by sTWEAK was 0.985, 95%CI (0.963, 1.000), the cutoff value was 78.57 pg/mL, the sensitivity and specificity were 89.70% and 100.00%, respectively. The AUC of predicting MACE in STEMI patients by MMP-9 was 0.773, 95%CI (0.684, 0.863), the cutoff value was 644.13 μg/L, the sensitivity and specificity were 100.00% and 16.00%, respectively. Conclusion The serum levels of sTWEAK and MMP-9 are high in patients with STEMI, and the high levels of sTWEAK and MMP-9 are independent risk factors for prognosis of MACE.
2020 Vol. 17 (32): 20-23,39 [Abstract] ( 206 ) HTML (1 KB)  PDF (1048 KB)  ( 76 )
24 Effects of homoharringtonine on proliferation and DNA damage related protein expression in leukemia K562 cells
KE Bo1 YU Juhong2 TU Liyan2 CHENG Hongbo1
Objective To study the effects of homoharringtonine (HHT) on proliferation and DNA damage related protein expression in human leukemic K562 cells. Methods Human leukemia K562 cells were cultured in vitro, and divided into HHT group and control group. HHT group was further divided into HHT subgroups with different concentrations of 5×10-9, 1×10-8, 5×10-8 and 1×10-7 mol/L. The effects of HHT at different concentrations  on the proliferation of K562 cells were detected by CCK-8 method. The effects of different HHT concentrations on K562 cells proliferation (rabbit anti human cyclin D1 [Cyclin D1] and rabbit anti human nuclear protein MKI67 [KI-67]) and the expression of DNA damage (rabbit anti human histone H2AX phosphorylation [γ-H2AX] and phosphorylated rabbit anti human ataxia telangiectasia mutated protein kinase [p-ATM]) relative protein were analyzed by Western blot. Results HHT significantly inhibited human leukemic K562 cells, with HHT inhibition rates (4.70±0.45)%, (9.80±0.35)%, (34.00±0.29)%, and (41.00±0.64)% at different concentrations (5×10-9, 1×10-8, 5×10-8 and 1×10-7 mol/L), respectively. Compared with the control group, Cyclin D1 protein expression could be down-regulated in 5×10-9, 1×10-8, 5×10-8 and 1×10-7 mol/L HHT groups, and the differences were statistically significant (all P ＜ 0.05). Compared with the control group, Ki-67 expression levels in 5×10-8 and 1×10-7 mol/L HHT group were significantly down-regulated, with statistically significant differences (all P ＜ 0.05). Compared with the control group, the upregulation of the expression of γ-H2AX proteins were induced in 5×10-8 and 1×10-7 mol/L HHT groups, with statistically significant differences (all P ＜ 0.05). Compared with the control group, p-ATM levels were increased in the 1×10-8, 5×10-8 and 1×10-7 mol/L HHT groups, with statistically significant differences (all P ＜ 0.05). Conclusion HHT can inhibit the proliferation of leukemic K562 cells by down-regulating the expression of proliferation-related proteins, and may induce cell DNA damage.
2020 Vol. 17 (32): 24-28 [Abstract] ( 157 ) HTML (1 KB)  PDF (799 KB)  ( 86 )
29 Research overview on application and mechanism of traditional Chinese medicine external therapy for photosensitivity disorders
WANG Zixuan1 LI Guanru2 SUN Liyun1▲
Photosensitivity disorders, a group of common and frequent skin disease, is characterized by various lesions on the skin caused by sun exposure. Chinese medicine believes that the main causes of this disease are the internal retention of damp-heat, deep multiple abscess due to summer heat-dampness and heat-toxicity. In clinical treatment, syndrome differentiation and treatment, integrated traditional Chinese and Western medicine, external Chinese medicine and non-drug therapy are often used. Recently, giving that the extremely irritating and side effects of oral medicine, application of traditional Chinese medicine external treatment had gradually increased in photosensitivity disorders treatment. Traditional Chinese medicine external treatment has the advantages of convenient use, high safety, minor irritation, less side effects, curative effects, with widely application and development prospect. Meanwhile, the mechanism of traditional Chinese medicine external therapy in photosensitivity disorders still needs further research.
2020 Vol. 17 (32): 29-32 [Abstract] ( 120 ) HTML (1 KB)  PDF (603 KB)  ( 92 )
33 Research progress of mistletoe in the treatment of liver cancer
LIU Shuang CAO Zhengmin LYU Wenliang▲
Liver cancer is one of the most harmful malignant tumors in clinic. Its morbidity and mortality rate remain high in China for a long time, which seriously affects the patients’ life, health and quality of life. In the process of prevention and treatment of liver cancer, mistletoe, as a specific drug against liver cancer, plays a huge role with its multi-channel and multi-target treatment characteristics. From the perspective of traditional Chinese medicine, mistletoe has the functions of tonifying the liver and kidney, strengthening the muscles and bones, removing wind and activating collaterals, detoxifying and eliminating carbuncle. It can cut the opportunity of liver cancer’s deficiency, toxin and stasis through the function of strengthening the body and removing pathogenic factors. From the perspective of Western medicine, mistletoe extracts, such as mistletoe agglutinin, mistletoe toxin peptide and mistletoe total base, can induce cell apoptosis and regulate the immune system liver cancer plays a certain role in the treatment. In this paper, from the perspective of the combination of traditional Chinese and Western medicine, according to the relevant literature at home and abroad in recent years, the role of mistletoe in the treatment of liver cancer is summarized to a certain extent.
2020 Vol. 17 (32): 33-35,43 [Abstract] ( 88 ) HTML (1 KB)  PDF (591 KB)  ( 139 )
36 Research progress of diagnostic molecular probes for ovarian cancer
MING Lan CHENG Kai CHEN Yu YANG Rui▲ CHEN Daozhen▲
Ovarian cancer is the most fatal gynecological malignancy because it is found at an advanced stage. Therefore, it is imminent to find a new diagnostic method that can accurately diagnose ovarian cancer at an early stage. Molecular probe technology has unique advantages in accurate diagnosis because of its high specificity and strong sensitivity, and has become a hot spot in the field of accurate diagnosis of ovarian cancer. In this paper, the progress of molecular probe technology in the accurate diagnosis of ovarian cancer is briefly reviewed from the perspective of ovarian cancer specific targets and different modalities, and the future application and development are prospected.
2020 Vol. 17 (32): 36-39 [Abstract] ( 92 ) HTML (1 KB)  PDF (578 KB)  ( 87 )
40 Overview of Zuogui Pills in the treatment of gynecological diseases
ZHAO Panting CUI Xiaoping
Traditional Chinese medicine believes that kidney qi is prosperous, Tiangui is mature, Ren Tong Chong Sheng is the basic condition of women’s menstruation and reproductive development, and nourishing kidney and tonifying kidney is an important principle for recuperating Chong Ren qi and blood and treating gynecological diseases. Zuogui Pills, as a classic prescription for tonifying the kidney, has the effect of nourishing yin and tonifying the kidney, filling essence and marrow, nourishing the essence and blood of Chong Ren and maintaining the normal physiological function of women. Modern pharmacological studies have also confirmed that Zuogui Pills has hormone-like effects, which can promote reproduction, improve endocrine environment, enhance immunity and delay aging. Compared with hormone replacement therapy in Western medicine, Zuogui Pills has higher safety, fewer side effects and is easy to be accepted by patients. In recent years, the application rate in gynecological diseases is increasing day by day. This article intends to review its application in gynecological diseases from the aspects of clinical application and experimental research.
2020 Vol. 17 (32): 40-43 [Abstract] ( 122 ) HTML (1 KB)  PDF (566 KB)  ( 73 )
44 Research progress on non-human primate models of Parkinson’s disease
SONG Jingyang1 CHE Xiangyuan1 XING Hongxia2
Parkinson’s disease (PD) is a common neurodegenerative disease in middle-aged and elderly people. Nowadays, medical science can only delay its progress but cannot cure it. The successful establishment of PD experimental animal model that can simulate the pathogenesis similar to humans is the key link to solve these problems. As for animal models, all kinds of experimental animals have advantages and disadvantages. However, since the physiological and biochemical mechanisms of non-human primates are very similar to those of humans, PD model of non-human primates has become an ideal target. This paper summarizes and analyzes the existing PD animal models, the classical 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) non-human primate PD animal models, and the new PD non-human primate models, so as to discuss the key issues to be considered in the establishment of animal models and the direction of improvement. It is hoped that more scientific modeling methods and more advanced evaluation methods can be found through this review, which will provide some references for the selection and establishment of animal models.
2020 Vol. 17 (32): 44-47 [Abstract] ( 172 ) HTML (1 KB)  PDF (577 KB)  ( 71 )
48 Current situation and influencing factors of sexual knowledge among university students in Zhuhai City, Guangdong Province
CHEN Yu’an1 XIAO Yao2▲ LUO Qianyi1
Objective To study the status quo of college students’ sexual knowledge and its influencing factors, and to provide certain references for schools and related departments to carry out college students’ reproductive health education. Methods Using simple random sampling, a total of 1550 undergraduate students in six colleges and universities in Zhuhai City, Guangdong Province from January to June 2018 were surveyed by an anonymous questionnaire. The economic status, knowledge of sex in different genders, grades, and lovers of college students were analyzed. Results In this study, 1550 questionnaires were sent out, 1550 questionnaires were returned, and 1503 valid questionnaires were returned. The effective response rate was 96.97%. There were statistically significant differences in the degree of mastery of sex knowledge among college students in different genders, educational backgrounds, and lovers (P ＜ 0.05). There were statistically significant differences in the cognitive scores of college students with different educational backgrounds, grades, and monthly disposable costs (P ＜ 0.05). There were no statistically significant difference in the cognitive scores of college students of different genders and lovers (P ＞ 0.05). The results of multiple linear regression analysis showed that educational background was a relevant factor affecting the scores of college students’ sexual knowledge (P ＜ 0.05). After excluding the influence of other research factors, comparing the average cognitive scores of sex knowledge between undergraduates and junior college students, the difference was highly statistically significant (P ＜ 0.01), and the estimated regression coefficient was -8.749. Conclusion The current level of knowledge of reproductive health and contraception among college students in Zhuhai City, Guangdong Province is generally low. Colleges and universities should offer relevant courses to strengthen the level of sexual knowledge of college students, while improve and broaden the channels for schools to provide contraceptives and contraceptive services.
2020 Vol. 17 (32): 48-51,55 [Abstract] ( 78 ) HTML (1 KB)  PDF (681 KB)  ( 146 )
52 Effect of Wenxin Granules combined with Amiodarone in the treatment of chronic heart failure with atrial fibrillation in the elderly
LI Lan HOU Liangping JIA Dongxia ZHENG Hang HUANG Qiangpei YANG Xianzheng LIU Sitai
Objective To investigate the effect of Wenxin Granules combined with Amiodarone in the treatment of chronic heart failure (CHF) with atrial fibrillation in the elderly. Methods A total of 106 CHF patients with atrial fibrillation admitted to Sichuan Mianyang 404 Hospital from February 2017 to September 2019 were selected and divided into control group and study group by random number table method, with 53 cases in each group. Patients in the control group were treated with Amiodarone, while the study group was added with Wenxin Granules. The efficacy, cardiac function index, related serum indexes and adverse reactions during treatment were compared between the two groups. Results After treatment, the total clinical effective rate of the study group was higher than the control group (P ＜ 0.05). After treatment, left ventricular ejection fraction and cardiac index in two groups were higher than before treatment, and those in the study group were higher than those in the control group (P ＜ 0.05). After treatment, left ventricular end diastolic diameter, left ventricular end systolic diameter, C-reactive protein (CRP), cystatin (CysC), endothelin-1 (ET-1), and brain natriuretic peptide (BNP) in the two groups decreased compared with those before treatment, and those in the study group were lower than those in the control group (P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Wenxin Granules combined with Amiodarone in the treatment of CHF with atrial fibrillation in the elderly has definite curative effect. It can effectively improve the cardiac function and serum CysC, BNP, CRP and ET-1 levels, and has a good safety.
2020 Vol. 17 (32): 52-55 [Abstract] ( 221 ) HTML (1 KB)  PDF (451 KB)  ( 28 )
56 Effects of Propranolol combined with Isosorbide Nitrate on the levels of Obestatin, tPAI-1 and Fractalkine in patients with coronary heart disease and angina pectoris
DENG Jing1 WANG Chunlian1▲ WEN Junjie2 WU Bin1
Objective To investigate the effect of Propranolol combined with Isosorbide Nitrate on patients with coronary heart disease and angina pectoris, and the effect on levels of Obestatin, tissue-plasminogen activator inhibitor-1 (tPAI-1) and irregular chemokines (Fractalkine). Methods A total of 126 patients with coronary heart disease and angina pectoris who were treated in Guang’an People’s Hospital, Sichuan Province from April 2018 to April 2019 were selected and divided into control group and treatment group according to the random number table method, with 63 cases in each group. The control group was treated with Isosorbide Nitrate. The treatment group was treated with Propranolol combined with Isosorbide Nitrate. Both groups received continuous treatment for 14 days. The incidence of angina pectoris was observed. The cardiac functions of the two groups were examined, the serum and other relevant indicators levels were detected, and the therapeutic effect of the two groups was compared. Results After treatment, the number and duration of angina pectoris attacks in the treatment group were lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The level of left ventricular posterior wall thickness in the treatment group was lower than that in the control group, the levels of left ventricular ejection fraction and cardiac output in the treatment group were higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The level of serum glutathione peroxidase in the treatment group was higher than that in the control group, while lipid peroxide, malondialdehyde, Obestatin, tPAI-1, Fractalkine levels were all lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The total effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Patients with coronary heart disease and angina pectoris treated with Pronalolol combined with Isosorbide Nitrate can improve the occurrence of angina pectoris, improve the cardiac function and antioxidant capacity, and improve the levels of serum Obestatin, tPAI-1 and Fractalkine.
2020 Vol. 17 (32): 56-59 [Abstract] ( 131 ) HTML (1 KB)  PDF (479 KB)  ( 99 )
60 Effect of Lamotrigine combined with cerebral hemispheric ring insular lobe transection in patients with valproic acid ineffective epilepsy
LI Chouzhong1 WEI Ling2 YUAN Baowen3▲ HU Xiao4
Objective To observe the effect of Lamotrigine combined with cerebral hemisphere ring insular lobe transection in the treatment of patients with valproic acid ineffective epilepsy. Methods A total of 86 patients with valproic acid ineffective epilepsy who were diagnosed and treated at Guizhou Provincial People’s Hospital from January 2017 to June 2018 were selected as the research objects. A total of 43 patients with valproic acid ineffective epilepsy who received Lamotrigine treatment were divided into the drug addition group, and another 43 patients with valproic acid ineffective epilepsy who received Lamotrigine addition combined with cerebral hemisphere ring lobe insula transection were divided into the Lamotrigine disconnection group. The effective rate of treatment, Wechsler intelligence scale for children (WISC) scores, hippocampal hydrogen ion magnetic resonance spectroscopy imaging parameters and adverse reactions were compared between the two groups. Results The effective rate of treatment in the Lamotrigine disconnection group was higher than that of the drug addition group, and the difference was statistically significant (P ＜ 0.05). The WISC scores of the two groups after treatment were higher than those before treatment, and the lamotrigine group was higher than that in the drug addition group,  and the differences were statistically significant (P ＜ 0.05). After treatment, N-acetylaspartate acid (NAA) and NAA/(choline[Cho]+creatine[Cr]) of the two groups were higher than before treatment, while Cho and Cr were lower than before treatment, and NAA and NAA/(Cho+Cr) in the Lamotrigine dicconnection group were higher than those in the drug addition group, Cho, Cr were lower than those in the drug addition group, and the differences were statistically significant (P ＜ 0.05). The adverse reaction rate of the Lamotrigine dicconnection group was lower than that of the drug addition group, and the difference was statistically significant (P ＜ 0.05). Conclusion The addition of Lamotrigine combined with cerebral hemisphere ring insular lobe transection has a definite effect in the treatment of patients with valproic acid ineffective epilepsy, with fewer adverse reactions, and has a significant effect in improving patients’ cognitive function and hippocampal tissue metabolism.
2020 Vol. 17 (32): 60-63 [Abstract] ( 104 ) HTML (1 KB)  PDF (473 KB)  ( 67 )
64 Clinical effect of Pramipexole and Escitalopram in the treatment of patients with Parkinson’s disease and depression
YANG Xu1 ZHANG Yi1 LIU Pingping1 QU Zhanli1 HE Dongmei1 LU Taoli2 MA Ying3
Objective To explore the clinical effect of Pramipexole and Escitalopram in the treatment of Parkinson’s disease (PD) with depression. Methods A total of 120 patients with Parkinson’s disease and depression admitted to Nanchong Central Hospital in Sichuan Province from January 2018 to December 2019 were selected as the research objects. They were divided into observation group A (treated with Pramipexole), observation group B (treated with Escitalopram, 40 cases), and control group (treated with Medobar, 40 cases) by random number table method. The Hamilton depression (HAMD), unified Parkinson’s disease rating scale (UPDRS), the scores of the 39 Parkinson’s disease questionnaire (PDQ-39) and the incidence of adverse reactions of each group were analyzed. Results After treatment, the HAMD scores of the three groups were compared, and the difference was statistically significant (P ＜ 0.05). Among them, the observation group A and the observation group B were lower than the control group, and the differences were statistically significant (P ＜ 0.05). The HAMD of observation group A and observation group B were lower than before treatment, and the differences were statistically significant (P ＜ 0.05). The UPDRS and PDQ-39 scores of observation group A and observation group B were lower than those before treatment, and the differences were statistically significant (P ＜ 0.05). The UPDRS and PDQ-39 scores of observation group A and observation group B were lower than those of control group, and the differences were statistically significant (P ＜ 0.05). The total clinical effective rate of the three groups was compared, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions among the three groups (P ＞ 0.05). Conclusion Pramipexole and Escitalopram can effectively improve the depression of patients with Parkinson’s disease, and the therapeutic effect of Pramipexole is better than that of Escitalopram, which can significantly improve the symptoms of depression in patients and improve the quality of life of patients.
2020 Vol. 17 (32): 64-67 [Abstract] ( 102 ) HTML (1 KB)  PDF (474 KB)  ( 98 )
68 Correlation analysis of osteopontin levels with inflammatory factors and severity of Alzheimer’s disease
LIU Ting1,2 LI Dan1,2 LIU Jia1,2 MA Na1,2 MENG Xinling1,2
Objective To analyze the correlation of osteopontin (OPN) levels with inflammatory factors and severity of Alzheimer’s disease. Methods A total of 30 patients with AD and mild cognitive impairment (MCI) who were diagnosed and treated in the First Department of Encephalopathy in Affiliated Chinese Medicine Hospital of Xinjiang Medical University from November 2016 to March 2019 were included in the study, served as AD group and MCI group respectively, while another 30 patients with non-inflammatory neuropathy (OND) were selected during the same period, served as the control group. The clinical baseline data and serum OPN, interleukin-1β (IL-1β), IL-6, IL-17A, transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-α (TNF-α) level were compared, while the Pearson correlation model was used to analyze the correlation between the patient’s serum OPN levels and inflammation indicators and condition. Results The mini-mental state examination (MMSE) score of the AD group was higher than that of the MCI group and the control group, and the differences were statistically significant (P ＜ 0.05). TNF-α and OPN in AD group were significantly higher than those in MCI group and control group, and the differences were statistically significant (P ＜ 0.05). Multivariate linear regression showed that OPN and TNF-α levels were influence factor MMSE (t = 3.195, 3.545, P ＜ 0.05). Correlation analysis showed that OPN level was positively correlated with TNF-α level (r = 0.749, P ＜ 0.05). Conclusion The levels of OPN and TNF-α in AD patients are negatively correlated with the severity of the patient’s condition, and OPN may increase the expression level of TNF-α, thereby making the severity of the patient’s condition progress.
2020 Vol. 17 (32): 68-71 [Abstract] ( 126 ) HTML (1 KB)  PDF (503 KB)  ( 89 )
72 Clinical effect of Estradiol Valerate, Mifepristone and Misoprostol combined with curettage in the treatment of missed abortion
XIA Jie JI Ying LIU Minglan
Objective To observe clinical effect of Estradiol Valerate (Progynova) combined with Mifepristone, Misoprostol and curettage in the treatment of missed abortion. Methods Eighty-two patients with missed abortion treated in Department of Gynecology and Obstetrics of Rugao People’s Hospital in Jiangsu Province from October 2017 to December 2019 were selected and divided into control group (40 cases) and observation group (42 cases) according to different treatment methods. Control group was treated with Mifepristone combined with Misoprostol in sequence, while observation group was treated with Mifepristone and Misoprostol in the same way as control group. The patients in both groups were treated with Progynova three days before and one day after operation. The time of uterine curettage, intraoperative blood loss, smooth entry of uterine dilator, postoperative vaginal bleeding time, menstrual recovery time, re-curettage rate and incidence of abortion syndrome were observed in two groups. Endometrial receptivity was evaluated by ultrasonography at three months after operation, and ovarian reserve function was observed. Results The time of curettage, postoperative vaginal bleeding and menstrual recovery time in observation group were shorter than those in control group, the amount of intraoperative blood loss in observation group was less than that in control group, the incidence of re-curettage and induced abortion syndrome in observation group were lower than those in control group, the differences were statistically significant (P < 0.05). There was no significant difference in number seven uterine dilator entering smoothly between two groups (P > 0.05). Three months after operation, the endometrial thickness of observation group was thicker than that of control group, the pulsatility index and blood flow resistance index of observation group were lower than those of control group, and Salle score of observation group was higher than that of control group (P < 0.05). Three months after operation, the levels of serum luteinizing hormone and follicle stimulating hormone in observation group were lower than those in control group, and the level of anti Mullerian hormone in observation group was higher than that in control group (P < 0.05). Conclusion Progynova combined with Mifepristone, Misoprostol and curettage have significant clinical effect on missed abortion, and can improve endometrial receptivity and ovarian reserve function of missed abortion patients.
2020 Vol. 17 (32): 72-75 [Abstract] ( 150 ) HTML (1 KB)  PDF (532 KB)  ( 74 )
76 Analysis of allergic reaction in children with adenoid hypertrophy
XU Sheng1 CHU Hanqi2 GUAN Hongxia1▲
Objective To analyze the clinical characteristics of allergy indicators (screening of Eosinophils [EOS] and serum allergens) in children with adenoid hypertrophy (AH). Methods A retrospective analysis of 303 inpatients admitted to Department of Otolaryngology at Maternal and Child Health Hospital of Hubei Province from October 2017 to July 2019 with AH as the first diagnosis. According to whether it was accompanied by allergic rhinitis (AR), it was divided into AH group (215 cases) and AH+AR group (88 cases). Peripheral blood was drawn from all children for EOS percentage and serum allergen screening. Results EOS and total IgE in AH+AR group were significantly higher than those in AH group (P < 0.05). The positive rate of allergens in AH+AR group was 29.04%, of which the most common allergens were house dust mite (81.82%), dust mite (68.18%), mold mixture (17.05%) and alternaria alternata (13.64%). The positive rate of a single allergen was 26.14%, and the positive rate of two allergens was 60.23%. There were up to nine types of allergens in the same child. Conclusion Allergic reaction may be one of the pathogenic factors in children with AH. The allergens in children with AH are mainly house dust mites, and the positive degree is more common in mild to moderate.
2020 Vol. 17 (32): 76-78,95 [Abstract] ( 86 ) HTML (1 KB)  PDF (878 KB)  ( 54 )
79 Hemostatic effects of dilute and recovered autologous blood transfusions during a cesarean section in placenta previa and their effects on maternal and infant outcomes
NIE Xin1 DING Jie1 SUN Caifeng2▲
Objective To investigate the effect of dilute and recovered autologous blood transfusions during a cesarean section in placenta previa and their effects on maternal and infant outcomes. Methods From January 2017 to February 2020, 80 puerpera with dangerous placenta previa who underwent cesarean section in Department of Obstetrics and Gynecology of Changzhou Maternity and Child Health Hospital of Nanjing Medical University were selected. According to different methods of autologous blood transfusion, they were divided into dilution group (diluted autologous blood transfusion) and recovered group (recovered autologous blood transfusion). Maternal peripheral venous blood before the blood collection (T1), blood collection (T2), immediately after the closing abdomen (T3) and 24 h after surgery (T4) four times respectively were collected, and hemoglobin (Hb) of maternal was detected using automatic blood cell analyzer, prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (Fg) were detected by solidification method. The hemostatic effect, maternal and infant outcome and complication rate of two groups were compared. Results There were no significant differences in blood separation and intraoperative blood loss between two groups (P ＞ 0.05). The overall analysis showed that there were no significant differences in PT and Fg between two groups in terms of time, inter group and interaction (P > 0.05). There were significant differences in APTT and Hb between two groups in terms of time (P < 0.05), but there were no significant differences in APTT and Hb between two groups in inter group and interaction (P > 0.05). Further pairwise comparison, intra group comparison: APTT in two groups was T3, T4, T2, T1 from long to short (P < 0.05), and Hb from high to low was T1, T2, T3, T4 (P < 0.05). Comparison between groups: there were no significant differences in PT, APTT, Fg and Hb between two groups (P > 0.05). There were no significant differences in one-minute Apgar score, five-minute Apgar score and umbilical artery blood pH between two groups (P > 0.05). The incidence of transfusion complications in recovered group was lower than that in diluted group (P < 0.05). Conclusion Dilute and recovered autologous blood transfusions have no significant difference in hemostatic effects and effects on infant outcomes during the risk of cesarean section in puerpera with dangerous placenta previa, but recovered autologous blood transfusions have fewer complications and higher safety.
2020 Vol. 17 (32): 79-82,99 [Abstract] ( 98 ) HTML (1 KB)  PDF (883 KB)  ( 87 )
83 Characteristics and risk factors of Mycoplasma Pneumoniae Pneumonia mixed infection in children
SUN Hui GUO Yanmei LI Jun’e HUO Ximin XU Meixian
Objective To investigate the characteristics and risk factors of mixed infection of Mycoplasma Pneumoniae Pneumonia (MPP) in children. Methods Six hundred and fifteen MPP children hospitalized in Hebei Children’s Hospital from June 2016 to June 2018 were selected. Blood routine, C-reactive protein (CRP), Chlamydia/Mycoplasma IgM and sputum bacterial culture were performed in all patients. Results Among 615 children with MPP, 489 cases were in single infection group and 126 cases in mixed infection group. In mixed infection group, 72 cases in mixed virus group, 33 cases in mixed bacteria group, 21 cases in mixed Chlamydia group. There were significant differences in age, fever > 10 days and extrapulmonary complications among four groups (P < 0.05). There was no significant difference in gender and wheezing between single infection group and mixed infection groups (P > 0.05). There were significant differences in WBC, NEU and CRP among single infection group and mixed virus group, mixed bacteria group, mixed Chlamydia group (P < 0.01). The levels of WBC and CRP in mixed bacteria group were higher than those in single infection group (P < 0.05), and NEU level in mixed virus group was lower than that in single infection group (P < 0.05). Multivariate logistic analysis showed that age (OR = 0.732, P < 0.01) was a protective factor for mixed virus infection, and extrapulmonary complication (OR = 1.429, P < 0.05) was independent risk factor for mixed virus infection. Age (OR = 0.548, P < 0.01) was a protective factor for mixed bacterial infection. Fever > 10 days (OR = 3.593, P < 0.05) and WBC (OR = 2.593, P < 0.05) were independent risk factors for mixed bacterial infection. Age (OR = 3.392, P < 0.01) was an independent risk factor for mixed Chlamydia infection. Conclusion The detection rate of MPP mixed infection is lower in this area. The younger the age is, the higher the detection rate of MPP mixed infection is. The main pathogen of mixed infection is virus, followed by bacterial infection. The children are mainly mixed virus and bacterial infection. The older children should be alert to the mixed Chlamydia infection. The length of fever and the increase of WBC should be paid attention to bacterial infection.
2020 Vol. 17 (32): 83-86 [Abstract] ( 119 ) HTML (1 KB)  PDF (545 KB)  ( 75 )
87 Meta-analysis of efficacy of Ganfule combined with TACE in the treatment of hepatocellular carcinoma
YAN Yuanzhi1 TANG Heng1 YOU Jing2
Objective To systematically evaluate the effect of Ganfule combined with transcatheter arterial chemoembolization (TACE) on hepatocellular carcinoma. Methods PubMed, Medline, EMBase, Cochrane Library, CBM, CNKI, WanFang and VIP databases were all searched by computer, and the retrieval time was set up until December 2019. Randomized controlled trial of Ganfule combined with TACE in the treatment of hepatocellular carcinoma were screened. Meta-analysis was performed using RevMan5.3 software. Results A total of 11 studies were included in the analysis. Meta analysis showed that the effective rate of the experimental group was higher than that of the control group (OR = 2.05, 95%CI: 1.41, 2.97, P = 0.0001). The alanine aminotransferase level in the experimental group was lower than that in the control group (MD = -53.86, 95%CI: -73.33, -34.38, P < 0.000 01). The level of gamma-glutamyltransferase in the experimental group was lower than that in the control group (MD = -142.46, 95%CI: -152.88, -132.04, P < 0.000 01). The alpha fetal protein level of experimental group was lower than the control group (MD = -46.18, 95%CI: -55.70, -36.67, P < 0.000 01). The half-year survival rate in the experimental group was higher than that in the control group (OR = 3.65, 95%CI: 1.57, 8.51, P = 0.003). The one-year survival rate in the experimental group was higher than that in the control group (OR = 2.09, 95%CI: 1.47, 2.96, P < 0.0001). The two-year survival rate in the experimental group was higher than that in the control group (OR = 2.12, 95%CI: 1.21, 3.72, P = 0.008). Conclusion Compared with TACE alone, Ganfule combined with TACE in the treatment of hepatocellular carcinoma has a better clinical effect, which is worthy of promotion and application.
2020 Vol. 17 (32): 87-91 [Abstract] ( 104 ) HTML (1 KB)  PDF (1636 KB)  ( 81 )
92 Characteristics of ultrasound and BRAFV600E gene mutation in papillary thyroid micropapillary carcinoma with cervical lymph node metastasis
ZHONG Lichang1 GU Liping1 MA Fang1 XIONG Miao2
Objective To analyzed ultrasonographic images of papillary thyroid micropapillary carcinoma (PTMC) with cervical lymph node metastasis and characteristics of BRAFV600E gene mutation. Methods A total of 127 cases of PTMC admitted to the East Branch of Shanghai Sixth People’s Hospital, Affiliated to Shanghai Jiaotong University from June 2013 to June 2017 were selected as study subjects. According to the presence or absence of cervical lymph node metastasis, they were divided into PTMC cervical lymph node metastasis group (61 cases) and PTMC non-cervical lymph node metastasis group (66 cases). The ultrasound characteristics and BRAFV600E gene mutation were compared between the two groups. Results There were significant differences in nodule maximum diameter, whether nodule contact with thyroid capsule, nodule shape, calcification, aspect ratio between PTMC cervical lymph node metastasis group and PTMC non-cervical lymph node metastasis group (all P < 0.05). The positive rate of BRAFV600E gene mutation in the PTMC cervical lymph node metastasis group was higher than that in the PTMC non-cervical lymph node metastasis group (P < 0.05). Conclusion In PTMC patients, cervical lymph node metastasis is likely to occur if the nodules show ultrasonic signs such as nodule maximum diameter > 5 mm, nodule contact with thyroid capsule, irregular shape of nodules, aspect ratio≥1, nodules with microcalcification, and BRAFV600E gene mutation positive.
2020 Vol. 17 (32): 92-95 [Abstract] ( 103 ) HTML (1 KB)  PDF (531 KB)  ( 64 )
96 The value of prophylactic use of pegylated recombinant human granulocyte colony-stimulating factor in breast cancer receiving adjuvant chemotherapy
HUANG Miao1 TIAN Wuguo2 HAO Shuai2
Objective To investigate the value of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in preventing chemotherapy-induced neutropenia in breast cancer and the influence on quality of life. Methods A total of 160 patients with breast cancer treated in Daping Hospital, Army Medical University from January 2018 and June 2019 were selected as study odjects. According to the random number method, they were divided into the experimental group (80 cases) and the control group (80 cases). All patients received a six cycle TEC chemotherapy programme, on this basis, the experimental group was prophylactic use of PEG-rhG-CS, while the control group was prophylactic use of recombinant human granulocyte colony-stimulating factor (rhG-CSF). The efficacy and safety of the two groups were compared. The quality of life scale (FACT-B) was compared between the two groups. Results The incidence of febrile neutropenia between the two groups was not statistically significant (P > 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). After chemotherapy, physiological status, social/family status, emotional status, functional status, additional attention status and total score of the experimental group were all higher than those of the control group, with statistically significant differences (all P < 0.05). Conclusion Prophylactic use of PEG-rhG-CSF can effectively prevent the occurrence of neutropenia and FN in breast cancer chemotherapy, and is more conducive to maintaining a higher quality of life.
2020 Vol. 17 (32): 96-99 [Abstract] ( 106 ) HTML (1 KB)  PDF (528 KB)  ( 32 )
100 Analysis of malignant tumor composition and change trend of inpatients in a provincial grade A of level Ⅲ hospital from 2016 to 2018
HUANG Xiantao1 JING Chao2 ZHAO Lijuan3 TANG Xueqin4 PAN Limin5 WANG Chenyu6 XUE Jun7
Objective To study the malignant tumor composition and change trend of inpatients in a provincial grade A of level Ⅲ hospital from 2016 to 2018 of Zhangjiakou of Hebei Province. Methods From 2016 to 2018, 14 431 inpatients of malignant tumor in a provincial grade A of level Ⅲ hospital of Zhangjiakou, Hebei Province were selected as the study objects, the basic information of all patients was collected and sorted out, and the composition and change trend of malignant tumors of inpatients from 2016 to 2018 were analyzed. Results The gender and age distribution of inpatients with malignant tumors from 2016 to 2018 were compared, and the difference was statistically significant (P < 0.05). In 2017 and 2018, there were statistically significant differences in pulmonary malignant tumors, ovarian malignant tumors, and thyroid malignant tumors compared with 2016 (all P < 0.05); and the difference between 2018 and 2016 was statistically significant (P < 0.05). From 2016 to 2018, there was a statistically significant difference in the number of inpatients with malignant tumor undergoing surgery (P < 0.05). Conclusion From 2016 to 2018, the total number of inpatients of malignant tumors in a provincial grade A of level Ⅲ hospital in Zhangjiakou of Hebei Province showed a decreasing trend, in which there are significant differences in patients’ gender, age and disease type, and the number of patients receiving surgical treatment increased year by year. The situation of prevention and control of malignant tumors is severe. Therefore, it is necessary to attract the attention of relevant departments and take corresponding prevention and control measures to better protect the city and surrounding areas residents’ health.
2020 Vol. 17 (32): 100-103 [Abstract] ( 71 ) HTML (1 KB)  PDF (525 KB)  ( 17 )
104 Correlation study between sarcopenia and osteoporosis in postmenopausal female
MIAO Ketuan1 XU Bing2 WANG Xiaofeng2▲ WANG Guanhua2 XUE Yangyang3 LIN Zongzhuang4
Objective To investigate the correlation between sarcopenia and osteoporosis (OP) in postmenopausal female. Methods A total of 117 postmenopausal female volunteers over 45 years old who attended Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medical University were selected from January to December 2018. According to the bone mineral density (BMD), they were divided into OP group and non-OP group (Non-OP group). The general condition of the patients were recorded. A dual-energy X-ray absorptiometer was used to measure the BMD of the L1-4 lumbar and hips, the appendicular skeletal muscle mass (ASM), and the appendicular fat mass (AFM), as well as the muscle strength and walk velocity. The appendicular skeletal muscle mass index (ASMI) was calculated. Linear correlation analysis was used to analyze the correlation between ASM, AFM, ASMI and BMD, and logistic regression analysis was used to analyze the correlation between sarcopenia and OP. Results The BMD of L1-4 lumbar was positively correlated with ASM, ASMI, walk velocity, muscle strength and body mass index (r = 0.487, 0.361, 0.468, 0.287, 0.368, all P ＜ 0.05). The BMD of hip was positively correlated with ASM, ASMI, walk velocity, muscle strength and body mass index (r = 0.377, 0.345, 0.370, 0.276, 0.380, all P ＜ 0.05). There were no significant correlation between the BMD of L1-4 lumbar and hip with AFM (all P ＞ 0.05). There were 16 patients with sarcopenia (13.7%). Logistic regression analysis showed that sarcopenia was a risk factor for osteoporosis (P < 0.05). Conclusion BMD is closely related to sarcopenia in postmenopausal women. BMD is positively correlated with ASM, muscle strength and walk velocity but not with AFM. The incidence of sarcopenia increases significantly with the decrease of BMD and the increase of age.
2020 Vol. 17 (32): 104-107,111 [Abstract] ( 127 ) HTML (1 KB)  PDF (542 KB)  ( 99 )
108 Analysis of related factors of fatty liver in patients with schizophrenia
AN Bang1 ZHAO Shanshan1 GAO Huirong1 TANG Shuyu1 JIA Yingxia1 YANG Xiaobo2

Objective To explore the related factors of schizophrenic patients with fatty liver. Methods A total of 300 schizophrenic patients admitted to Xianyang Central Hospital of Shaanxi Province from January 2018 to December 2019 were selected as study subjects. According to the diagnosis results of fatty liver, they were divided into the fatty liver group and the non-fatty liver group, with 150 patients in each group. The basic data and clinical data of the two groups were compared and analyzed, and single factor analysis and multi-factor logistic regression analysis were used to explore the risk factors of fatty liver in schizophrenia. Results There were significant difference in body mass index (BMI), disease course, history of hyperlipidemia, application of antipsychotic drugs (APS) between two groups (P ＜ 0.05). Multi-factor logistic regression analysis showed that BMI, disease course, history of hyperlipidemia, types of APS were independent risk factors of fatty liver in schizophrenics(P ＜ 0.05). Conclusion There is a high incidence of fatty liver in schizophrenics during the treatment. The incidence of fatty liver is affected by the degree of obesity, the course of disease, the history of hyperlipidemia and the use of APS.

 
2020 Vol. 17 (32): 108-111 [Abstract] ( 168 ) HTML (1 KB)  PDF (518 KB)  ( 31 )
112 Observation of curative effect of different infection prevention programs in patients with liver cirrhosis and upper gastrointestinal bleeding with severe hepatic insufficiency
PAN Xiaojun1* LI Xiang2* GUAN Bin1 CAI Haifeng1
Objective To study the effect of different infection prevention programs in the treatment of patients with liver cirrhosis and upper gastrointestinal bleeding with severe hepatic insufficiency. Methods From October 2018 to December 2019, a total of 60 patients in Wuxi No. 5 People’s Hospital, Jiangsu Province with liver cirrhosis and upper gastrointestinal bleeding who were admitted to the Intensive Care Unit and Child-Pugh graded as C were included. According to the random number table method, they were divided into the control group and the observation group, with 30 cases in each group. All patients were treated with conventional treatment for upper gastrointestinal bleeding of liver cirrhosis. At the same time, the control group was given third-generation cephalosporin, and the observation group was given β-lactamase inhibitor to prevent infection. The incidence of secondary infection, time of secondary infection, length of hospitalization, mortality, and rebleeding rate in the two groups were observed. Results The incidence of secondary infection in the observation group was lower than that of the control group, the time of secondary infection was later than that of the control group, and the length of hospitalization was shorter than that of the control group, the differences were statistically significant (all P ＜ 0.05). There were no statistically differences in the mortality and rebleeding rate between the two groups after the medication (all P ＜ 0.05). Among the 60 patients, secondary infection occurred in 17 cases, but non-secondary infection occurred in 43 cases. The rebleeding rate of secondary infected persons was higher than that of non-secondary infected persons, and the difference was highly statistically significant (P ＜ 0.01). Conclusion Choosing a relatively reasonable infection prevention treatment plan based on the evaluation of pathogenic bacteria, drug resistance, and its own special pathophysiological factors is positive for patients with liver cirrhosis and upper gastrointestinal bleeding to reduce the incidence of secondary infection, shorten the length of hospitalization, and reduce the rate of rebleeding.
2020 Vol. 17 (32): 112-115 [Abstract] ( 137 ) HTML (1 KB)  PDF (518 KB)  ( 20 )
116 Comparative study of Shugan Jieyu Capsules and Sertraline in treatment of mild and moderate depression in the elderly
ZHANG Xia1 LI Yunxia1 ZHANG Yan1 ZHANG Yuanyuan2 SUN Zhonghua1▲
Objective To observe the clinical efficacy, adverse reactions and safety of Shugan Jieyu Capsules and Sertraline in the treatment of mild and moderate depression in the elderly. Methods Seventy-five cases of mild and moderate depression patients from April 2016 to October 2019 in the Department of Rehabilitation Medicine of the People’s Liberation Army Hospital, 984th and the Department of Hongshankou Outpatient of Jingbei Medical District of Chinese PLA General Hospital were selected, all patients in line with the Chinese classification and diagnostic criteria for mental disorders, aged ≥60 years, first onset cases. According to the random number table method, they were divided into the treatment group (Shugan Jieyu Capsules) with 38 cases and the control group (Sertraline) with 37 cases, a total of eight weeks of treatment and observation. The Hamilton Depression Scale 17 (HAMD-17), reduction rate, and treatment emergent symptom scale (TESS) were used to evaluate the efficacy and adverse reactions before treatment and at the end of the second, fourth and eighth week of treatment. Results The differences of time points and interaction between the two groups were highly statistically significant (all P ＜ 0.01), while the difference between the two groups was not statistically significant (P ＞ 0.05). Intra-group comparison: compared with before treatment, HAMD-17 scores in both groups decreased at two, four, and eight weeks after treatment, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Comparison between groups: there was no statistically significant difference between the two groups in the same period (all P ＞ 0.05). There was no significant difference in total effective rate between the two groups (P ＞ 0.05). The incidence of adverse reactions in the treatment group was lower than that in the control group, with statistically significant difference (P ＜ 0.05). Conclusion Shugan Jieyu Capsules has the same efficacy as Sertraline in the treatment of mild and moderate depression in the elderly, and the adverse reactions are significantly less than Sertraline. It is an ideal choice for the treatment of mild and moderate depression in the elderly.
2020 Vol. 17 (32): 116-119 [Abstract] ( 186 ) HTML (1 KB)  PDF (550 KB)  ( 86 )
120 Professor Ding Zhiguo’s experience in treating hyperthyroidism based on the theory of “facilitating the stagnant wood”
GE Yaxue1 QI Shuo2 CHEN Xiaoheng2 LI Zhe2 LI Huilong2 LIU Meijun1 DING Zhiguo2
Hyperthyroidism is a common endocrine and metabolic disease, which belongs to the category of “goiter disease” in traditional Chinese medicine. Western medicine currently uses 131I, antithyroid drugs, surgical resection, etc. as the main methods of treatment for hyperthyroidism, but with potential serious side effects and the risk of recurrence or persistent hyperthyroidism, which often become the important factors to limit the therapeutic effect of this disease. Based on the traditional Chinese medicine characteristics of “holistic concept, differentiation and treatment based on syndrome differentiation”, Professor Ding Zhiguo proposes the theory of “Yeben Xiangying”. He believes that the cause of hyperthyroidism is closely related to mood, and liver depression and qi stagnation are the important reasons for the occurrence and development of this disease. Starting from the liver, “facilitating the stagnant wood”, soothing the liver, clearing the liver, calming the liver, nourishing the liver, maintaining the smooth of qi movement, in order to “achieve it”.
2020 Vol. 17 (32): 120-123 [Abstract] ( 108 ) HTML (1 KB)  PDF (677 KB)  ( 164 )
124 Experience of Professor Liu Weisheng in treating esophageal cancer
TIAN Wanpeng LI Liuning LIU Weisheng
Esophageal cancer is a tumor disease with a high incidence in China, which has a complicated course and diversified treatment methods. Professor Liu Weisheng distinguishes and treats esophageal cancer according to the stage of the patients’ condition, emphasizes full-course management and integrates Chinese and Western medicine. According to the early, middle and late stages of patients with esophageal cancer, Professor Liu establishes the methods of soothing the liver and regulating qi, reducing phlegm and removing blood stasis, supplementing qi and nourishing blood, warming the spleen and kidney. According to the different methods of surgery, radiotherapy and chemotherapy, there are also differences in adjusting qi and blood, clearing heat and detoxifying, strengthening spleen and stomach, tonifying qi and producing blood. At the same time, Professor Liu Weisheng pays attention to the combination of attacking pathogens and strengthening healthy qi, diseases differentiation and syndromes differentiation, that achieves “survival with tumor”, prolongs the overall survival period, improves the quality of life, and achieves better clinical efficacy.
2020 Vol. 17 (32): 124-127 [Abstract] ( 289 ) HTML (1 KB)  PDF (701 KB)  ( 188 )
128 Discussion on the relationship between inflammatory response of plaque in coronary artery disease and yin-yang of traditional Chinese medicine
WANG Yiru1 WEI Jing2 LIU Ping1▲
The local inflammatory response of coronary artery disease plaques presents a state of immune imbalance, which is macroscopically consistent with the imbalance of yin-yang. This paper explores the relationship between coronary heart disease plaques and yin-yang based on the contradictory restriction of yin-yang, the mutual interaction of yin-yang, and the balance and mutual transformation of yin-yang. The following conclusion is drawn: prevention and treatment of coronary artery disease should pay attention to adjust the inflammatory response of systemic and local patches, make “inflammation suppression” and “proinflammatory” to achieve stable and the best condition, which is consistent with the governing body balance of yin-yang theory of traditional Chinese medicine, so as to reduce coronary artery disease of chronic inflammation, stable plaques, alleviate the disease process, provide new way for the traditional Chinese medicine treatment of coronary artery disease.
2020 Vol. 17 (32): 128-130 [Abstract] ( 119 ) HTML (1 KB)  PDF (663 KB)  ( 55 )
131 Effect of Jiawei Huangqi Guizhi Wuwu Decoction combined with rehabilitation training in the treatment of shoulder-hand syndrome after stroke
LIU Wei LI Bo LIU Jingfeng
Objective To investigate the effect of Jiawei Huangqi Guizhi Wuwu Decoction combined with rehabilitation training in the treatment of shoulder-hand syndrome (SHS) after stroke. Methods Ninety-six patients with SHS after stroke admitted to Beijing Hepingli Hospital from October 2017 to October 2019 were selected, they were divided into control group and study group according to the random number table method, with 48 cases in each group. The control group was given routine rehabilitation training, on basis of control group, the study group was given Jiawei Huangqi Guizhi Wuwu Decoction. The clinical efficacy, SHS scale (SHSS), Fugl-Meyer assessment (FMA), visual analogue scale (VAS), serum calcitonin gene-related peptide (CGRP), substance P (SP), bradykinin (BK) and adverse reactions were compared between the two groups. Results After treatment, the total clinical effective rate of the study group was significantly higher than that of the control group (P ＜ 0.05). After treatment, SP and BK in the two groups were lower than those before treatment, CGRP was higher than that before treatment (P ＜ 0.05). After treatment, SP and BK in the study group were lower than those in the control group, CGRP was higher than that in the control group (P ＜ 0.05). After treatment, the scores of SHSS and VAS in the two groups were lower than those before treatment, and the FMA was higher than that before treatment (P ＜ 0.05). After treatment, the scores of SHSS and VAS in the study group were lower than those in the control group, and the FMA was higher than that in the control group (P ＜ 0.05). During the treatment period no obvious adverse reactions were observed in the control group and one case of gastrintestinal discomfort occurred in the study group. Conclusion Jiawei Huangqi Guizhi Wuwu Decoction combined with rehabilitation training in the treatment of patients with SHS after stroke can effectively improve the clinical symptoms, the effect is significant, which may be related to the increase of CGRP content and the decrease of BK and SP levels.
2020 Vol. 17 (32): 131-134 [Abstract] ( 79 ) HTML (1 KB)  PDF (674 KB)  ( 103 )
135 Clinical effect of Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside in the treatment of psoriasis vulgaris
MA Xingmei1 LI Yuxiang2 MA Jie2 XIAO Jiehua3
Objective To investigate the clinical efficacy of Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside in the treatment of psoriasis vulgaris. Methods From January 2018 to January 2020, a total of 100 psoriasis vulgaris patients admitted to Qinghai Red Cross Hospital were selected and divided into control group (50 cases) and observation group (50 cases) by random number table method. The control group was treated with Tripterygium wilfordii multiglucoside, while the observation group was treated with Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside. The two groups were treated for 12 weeks. The clinical efficacy was evaluated after treatment. The psoriasis area and severity index (PASI) scores, visual analog score (VAS), dermatology life quality index (DLQI) scores, P-cadherin (P-cad), Trappin-2, neutrophils protease (NE), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) of the two groups were compared before and after treatment. The adverse reactions during treatment were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group (P ＜ 0.05). After treatment, the scores of PASI, VAS and DLQI, the P-cad, Trappin-2 and NE levels in the lesional tissue fluid in the two groups were lower than those before treatment (P ＜ 0.05), and the scores of PASI, VAS and DLQI, the P-cad, Trappin-2 and NE levels in the lesional tissue fluid in the observation group were lower than those in the control group (P ＜ 0.05). After treatment, the serum GSH-Px and SOD levels in the two groups were higher than those before treatment (P ＜ 0.05), and serum GSH-Px and SOD levels in the observation group were higher than those in the control group (P ＜ 0.05). There was no significant difference in adverse reactions incidence between the two groups during the treatment (P ＞ 0.05). Conclusion Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside in the treatment of psoriasis vulgaris has significant effect. It can significantly improve the clinical symptoms of patients, reduce the degree of skin lesions, improve the quality of life, lower the P-cad, Trappin-2 and NE levels in the lesion tissue fluid, and increase the serum GSH-Px and SOD levels, with good safety.
2020 Vol. 17 (32): 135-138,143 [Abstract] ( 104 ) HTML (1 KB)  PDF (701 KB)  ( 178 )
139 Clinical effect of Professor Lin Jiakun’s “ways to decrease yang qi” in the treatment of chronic obstructive pulmonary disease with syndrome of phlegm-heat obstructing lung
ZHAO Yi1 HAN Shiwei2▲ LIN Jiakun1
Objective To explore the clinical efficacy of Professor Lin Jiakun’s “ways to decrease yang qi” in the treatment of chronic obstructive pulmonary disease with syndrome of phlegm-heat obstructing lung. Methods A total of 72 cases of chronic obstructive pulmonary disease patients with syndrome of phlegm-heat obstructing lung admitted to Respiratory Department, ICU, and Emergency Department of Pingxiang Hospital of Traditional Chinese Medicine (TCM)from January 2019 to July 2020 were selected and randomly divided into study group and control group by random number table method, with 36 cases in each group. The control group was routinely treated with antispasmodic, antiasthmatic, anti-inflammatory, and phlegm-resolving drugs. The study group was added with “ways to decrease yang qi” Chinese medicine prescription on the basis of control group. The related indexes of lung function, 36-item short form health survey (SF-36), clinical efficacy, TCM syndrome scores, and adverse reactions were compared between the two groups. Results After treatment, the arterial blood oxygen partial pressure (PO2), forced expiratory volume in the first second (FEV1), forced vital capacity (FVC) in the two groups were significantly higher than those before treatment, carbon dioxide partial pressure (PCO2) was significantly lower than that before treatment; after treatment, the PO2, FEV1, FVC in the treatment group were significantly higher than those in the control group, and PCO2 was significantly lower than that in the control group (P ＜ 0.05). After treatment, the SF-36 scores of the two groups were significantly higher than those before treatment, which of the treatment group was higher than that of control group (P ＜ 0.05). The total effective rate of treatment group was higher than that in the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the TCM syndrome scores in the two groups were lower than those before treatment, which of the treatment group was higher than that of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The application of “ways to decrease yang qi” in the treatment of chronic obstructive pulmonary disease with syndrome of phlegm-heat obstructing lung has significant clinical effect, without increasing the incidence of adverse reactions, which can significantly improve the quality of life and clinical symptoms, and it is worthy of promotion.
2020 Vol. 17 (32): 139-143 [Abstract] ( 83 ) HTML (1 KB)  PDF (685 KB)  ( 134 )
144 Effect of Modified Shensu Wenfei Decoction on pulmonary function and inflammatory factors in patients with chronic sinusitis
LIU Ying XU Jianyou
Objective To investigate the effect of Modified Shensu Wenfei Decoction on pulmonary function and inflammatory factors in patients with chronic sinusitis. Methods Eighty-eight patients with chronic sinusitis admitted to Lishui Hospital of Traditional Chinese Medicine from January 2018 to January 2020 were selected. All patients were randomly divided into two groups, with 44 cases in each group. The control group was given Fluticasone Propionate combined with Prednisone, and the observation group was treated with Modified Shensu Wenfei Decoction on the basis of control group. After 4 weeks of treatment, the clinical efficacy, incidence of adverse reactions, lung indexes (forced vital capacity [FVC], forced expiratory volume in one second [FEV1], FEV1/FVC), inflammatory cytokines (interleukin-17 [IL-17], interleukin-1β [IL-1β], interferon-gamma [IFN-γ], tumor necrosis factor-α [TNF-α]) levels were compared between the two groups before and after treatment. Results The total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05); after treatment, the levels of FEV1, FVC and FEV1/FVC in the observation group were significantly higher than those in control group, the differences were statistically significant (P ＜ 0.05); after treatment, the levels of IL-17, IL-1β, IFN-γ and TNF-α in the observation group were significantly lower than those in control group, the differences were statistically significant (P ＜ 0.05); after treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Modified Shensu Wenfei Decoction in the treatment of chronic sinusitis can significantly improve the inflammatory levels and pulmonary function, with high safety, which is worthy of clinical promotion and application.
2020 Vol. 17 (32): 144-147 [Abstract] ( 214 ) HTML (1 KB)  PDF (674 KB)  ( 24 )
148 Application effect of standardized pharmaceutical care model in the whole process management of cancer pain
QIAN Jun YANG Peng DENG Huaidong
Objective To explore the application effect of standardized pharmaceutical care model in the whole process management of cancer pain. Methods A total of 123 patients with cancer pain who were admitted to Panzhihua Integrated Traditional Chinese and Western Medicine Hospital, Sichuan Province from March 2016 to May 2019 were selected as research objects and divided into control group (61 cases) and study group (62 cases) according to the random number table method. The control group only used drugs according to doctor’s orders. The study group was given standardized pharmaceutical care model management. After one month of intervention, the pain, quality of life and improvement situation of medication compliance in the two groups were observed. Adverse reactions during the intervention were recorded. Results The numerical rating scoring (NRS) scores of two groups were lower after one week and one month of intervention than before intervention, and the NRS scores after one month of intervention were lower than those after one week of intervention, the NRS score of the study group was lower than that of the control group one week  and one month after intervention (P ＜ 0.05). After one month of intervention, scores of emotion, sleep, daily life, relationship with others, interest in life, walking ability and daily work in two groups all decreased compared with that before intervention, and those in the study group were lower than those in the control group (P ＜ 0.05). After one month of intervention, the scores of Chinese version eight items morisky medication adherence scale in two groups were higher than those before intervention, and the study group was higher than the control group (P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The standardized pharmaceutical care model management for cancer pain patients can significantly improve their compliance with medication, effectively improve their clinical symptoms and quality of life,  and also ensure the safety of medication for patients with high clinical application value.
2020 Vol. 17 (32): 148-151 [Abstract] ( 193 ) HTML (1 KB)  PDF (359 KB)  ( 71 )
152 Comparison of the effect of local citrate anticoagulation and systemic heparin anticoagulation on CRRT in ARDS patients with AKI
LU Wei1 YAN Xianliang2 LIU Li3 LU Haiyan3 ZHANG Gaofeng3 ZHANG Xiaonan3
Objective To compare the efficacy of local citrate anticoagulation and systemic heparin anticoagulation on continuous renal replacement therapy (CRRT) in acute respiratory distress syndrome (ARDS) patients with acute kidney injury (AKI). Methods A total of 36 patients with ARDS complicated with AKI who underwent CRRT between March 2017 and September 2018 in the Department of Intensive Medicine of Suzhou Municipal Hospital were divided into heparin group (18 cases) and citrate group (18 cases) by random number table method. The renal function (serum creatinine [Cr], blood urea nitrogen [BUN]), blood coagulation-related indexes (activated partial thromboplastin time [APTT], prothrombin time [PT], platelet count), filter useful life and occurrence of adverse reactions were compared before and after treatment between the two groups. Results There were no significant differences in the renal function and blood coagulation-related  indexes before and after treatment between the two groups (all P ＞ 0.05). After treatment, BUN and Cr levels, platelet accounts after treatment in the two groups were lower than before treatment, while PT and APTT were longer than before treatment, the differences were statistically significant (all P ＜ 0.05). After treatment, the platelet account of heparin group was lower than that of the citrate group, and PT and APTT were longer than the citrate group, the differences were statistically significant (all P ＜ 0.05). The filter useful life of heparin group was shorter than that of the citrate group, the difference was statistically significant (P ＜ 0.05). There were no adverse events during the treatment in both groups. Conclusion In the CRRT treatment of ARDS complicated with AKI, the local application of citrate has better anticoagulant effect, which can prolong the life of the filter and is safer.
2020 Vol. 17 (32): 152-155 [Abstract] ( 168 ) HTML (1 KB)  PDF (366 KB)  ( 60 )
156 Nursing practice of extracorporeal membrane oxygenation combined with intra aortic balloon pulsation in selective high risk percutaneous coronary intervention
YANG Li1 ZHANG Yamin1 GAO Haokao1 LIAN Kun1 HAN Peng2▲
Objective To explore the nursing measures of extracorporeal membrane oxygenation (ECMO) combined with Intra aortic balloon pulsation (IABP) in percutaneous coronary intervention (PCI). Methods From May 2018 to April 2020, 43 patients who underwent high-risk coronary PCI with circulation support of ECMO combined with IABP in the Department of Cardiovascular Medicine, the First Affiliated Hospital of PLA Air Force Medical University of the People’s Liberution Army (Xijing Hospital) were continuously included, mainly summarizing the general nursing of perioperative patients, ECMO and IABP instrument and related complications. Results A total of 43 high-risk PCI patients were successfully implanted with ECMO and IABP during operation and removed ECMO half an hour after PCI. Except three patients died in hospital, the other 40 patients were successfully removed ECMO and recovered and discharged. The ECMO running time was (7.67±3.79) h, the IABP auxiliary time was 44.50 (24.25, 72.00) h, and the hospitalization time was (13.79±5.08) d. Malignant arrhythmia occurred in five cases during operation and complications occurred in seven cases after operation. Conclusion ECMO combined with IABP assisted high-risk PCI is an important guarantee to ensure the successful and effective implementation of high-risk PCI.
2020 Vol. 17 (32): 156-159,168 [Abstract] ( 100 ) HTML (1 KB)  PDF (652 KB)  ( 60 )
160 Application of assessment methods for active pain in patients undergoing total hip arthroplasty
LI Xiaoqin HU Guihua ZHAO Guifeng ZHAO Qinghua LIU Yubao
Objective To explore the application effect of assessment methods for active pain in patients undergoing total hip arthroplasty. Methods A total of 80 patients who underwent primary unilateral total hip replacement due to femoral neck fracture in Liuhe Hospital Affiliated to Yangzhou University Medical College from April 2017 to March 2020 were selected as study subjects. According to the random number table method, the patients were divided into control group and observation group, 40 cases in each group. Routine pain nursing assessment and intervention were carried out in the control group, and postoperative pain management was conducted in the observation group on the basis of the control group combined with active pain assessment methods. The numerical rating scale (NRS) score of functional activity at 24 h after operation, satisfaction with analgesia management, frequency of functional activity within 24 h after operation, time of first getting out of bed activity, and hip function score at three days and one week after operation were compared between the two groups. Results The NRS score of the observation group was lower than that of the control group at the time point of functional activity 24 h after operation (P ＜ 0.05). The satisfaction score of analgesia management was higher than that of the control group (P ＜ 0.05). The frequency of functional activity within 24 h after operation was higher than that of the control group, the time of getting out of bed for the first time was earlier than that of the control group (P ＜ 0.05). Overall analysis found that: Harris rating group comparison, time point comparison and interaction difference were statistically significant (all P ＜ 0.05), further pairwise comparison and intra-group comparison: compared with preoperative comparison, Harris score was improved three days and one week after surgery in both groups, and the differences were statistically significant (P < 0.05), comparison between groups: Harris scores of the observation group three days and one week after operation were higher than that of the control group (P ＜ 0.05). Conclusion The application of assessment methods for active pain in total hip arthroplasty can effectively improve the quality of postoperative pain management and promote the recovery of postoperative hip function.
2020 Vol. 17 (32): 160-163,176 [Abstract] ( 113 ) HTML (1 KB)  PDF (654 KB)  ( 71 )
164 Establishment and application of disease management pathway in patients with ischemic stroke
ZHU Li1 CAO Xiaolin2 LI Hongyan3 LI Ping2▲
Objective To develop a standardized management path for ischemic stroke and evaluate its practicability and reliability. Methods A non-randomized controlled study was conducted to divide 112 patients admitted to the Neurology Department of a Third-grade A general Hospital in Xinjiang from January to August 2019 into two groups by convenient sampling method. From January to June 2019, 56 patients were treated as the control group and received routine nursing care. From June to August 2019, 56 patients in the intervention group received disease management pathway care. The scores of national institutes of health stroke scale (NIHSS), barthel index rating scale (BI) and satisfaction survey were evaluated respectively in the two groups. Results NIHSS scores of both groups at discharge were lower than those at admission, and NIHSS scores of the intervention group were lower than those of the control group (P ＜ 0.05), overall analysis showed that the differences in intergroup comparison, time point comparison and interaction were statistically significant (P ＜ 0.05). Further pairwise comparison and intra-group comparison: the BI score at discharge, one, three and six months after discharge was statistically significant compared with that at admission (P ＜ 0.05). Comparison between groups: the BI scores of the intervention group at discharge, one, three and six months after discharge were all higher than those of the control group (P ＜ 0.05), satisfaction score of the intervention group was higher than that of the control group (P ＜ 0.05). Conclusion The establishment and application of the disease management pathway of ischemic stroke has effectively improved the limb dysfunction of patients and enhanced their daily activity ability and satisfaction with life. It has feasibility and safety in clinical nursing.
2020 Vol. 17 (32): 164-168 [Abstract] ( 94 ) HTML (1 KB)  PDF (1102 KB)  ( 119 )
169 Effect of nursing intervention based on behavior change theory on compliance behavior and nutritional status of diet management in maintenance hemodialysis patients
SHI Zhenzhen TANG Jingfeng ZHUANG Jing
Objective To explore the effect of nursing intervention based on behavior change theory in diet management of maintenance hemodialysis patients (MHD). Methods A total of 112 patients with MHD admitted to the Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University from January 2017 to December 2018 were selected. According to the dialysis time, they were divided into treatment group (January to December 2018) and control group (January to December 2017), with 56 cases in each group. The control group was given routine diet management intervention, and the treatment group was combined with intervention based on behavior change theory. Followed up for six months, the diet management compliance behavior, serum nutrition index and nutritional status of the two groups were compared. Results The scores of dietary management compliance such as fluid restriction in the two groups were significantly higher than that before intervention in the same group (P ＜ 0.05 or P ＜ 0.01). The scores of fluid restriction, potassium uptake management, self-care and difficulties in the treatment group were significantly higher than those in the control group, with statistically significant differences (P ＜ 0.05 or P < 0.01). The nutritional indexes of total protein (TP), albumin (ALB) and prealbumin (PA) in the two groups were significantly higher than those before intervention (P ＜ 0.05 or P ＜ 0.01); TP, ALB and PA levels in treatment group were significantly higher than those of the control group, and the differences were statistically significant (P ＜ 0.05); the incidence of malnutrition in the treatment group was significantly lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The nursing intervention based on behavior change theory is helpful to promote the formation of MHD patients’ diet management compliance behavior, improve serum nutrition indicators, and reduce the incidence of malnutrition during hemodialysis.
2020 Vol. 17 (32): 169-172 [Abstract] ( 123 ) HTML (1 KB)  PDF (623 KB)  ( 77 )
173 Application of HFMEA in prevention of pulmonary infection in patients with severe craniocerebral injury after tracheotomy
SONG Lingxia ZHANG Yongmei▲ ZHOU Ting
Objective To investigate the effect of healthcare failure mode and effect analysis (HFMEA) on the prevention of pulmonary infection in patients with severe craniocerebral injury after tracheotomy. Methods A total of 100 patients with severe craniocerebral injury who underwent tracheotomy in Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University from January to December 2018 were selected as the experimental group, HFMEA nursing management mode was implemented. A total of 100 patients with severe craniocerebral injury undergoing tracheotomy from January to December 2017 were selected as the control group, and routine nursing management mode was implemented. The incidence of pulmonary infection and patient satisfaction were compared between the two groups. Results The incidence of pulmonary infection in the experimental group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05); the satisfaction of the experimental group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The HFMEA model was used to analyze the causes of pulmonary infection in patients with severe craniocerebral injury after tracheotomy, and the improvement scheme was formulated and implemented, which could effectively reduce the incidence of infection.
2020 Vol. 17 (32): 173-176 [Abstract] ( 99 ) HTML (1 KB)  PDF (628 KB)  ( 74 )
177 The reform characteristics of the National Key Research and Development Program of China and the management practice of scientific research projects under the new situation
LI Mengdan1 LIU Yunyong1 PIAO Haozhe2▲
The new design of projects of the National Key Research and Development Program of China has brought new requirements and challenges to management staff. Relevant supporting policies optimize the management process and the performance management ultimately endowed the researchers with more autonomy. From the perspective of the project manager, this article combines the specific projects and actual management problems in Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, and proposes to build a dynamic management model that is guided by goals, through organizational management, schedule arrangement, fund supervision, and quality control. Further explore the performance management plan and put forward a five-level project quality control and research integrity construction plan. Ultimately, the importance of the project management department is clearly defined, project risks are accurately identified, scientific research enthusiasm is fully mobilized, and new policies are maximized. Hope to provide reference for other project managers.
2020 Vol. 17 (32): 177-180 [Abstract] ( 78 ) HTML (1 KB)  PDF (661 KB)  ( 195 )
181 Effect of family pharmacist responsibility system on compliance and prognosis of patients with atrial fibrillation taking Warfarin
DING Xiaoli1 WANG Song1 ZHOU Chunqiao1 WANG Hu1 LIU Hailin1 ZHANG Xuelin1 LIU Huanyun2
Objective To study the effect of family pharmacist responsibility system on compliance and prognosis of patients with atrial fibrillation (AF) taking Warfarin. Methods A total of 120 patients with AF admitted to the First People’s Hospital of Chongqing Liang Jiang New Area from June 2017 to June 2019 as the research objects, they were divided into the control group (56 cases) and the observation group (64 cases) according to a random number table method. Patients in the control group were given regular health education and follow-up, and the observation group implemented a family pharmacist responsibility system. The scores of the Warfarin anticoagulation knowledge questionnaire, the medication compliance questionnaire, the standard rate of the international normalized ratio (INR) and the occurrence of complications of patients were compared between the two groups after one year of intervention. Results The scores of Warfarin anticoagulant knowledge questionnaire, medication compliance questionnaire and the standard rate of INR at one year after discharge in observation group were higher than those in the control group (all P < 0.05). The incidence of bleeding and thrombosis complications in the observation group were lower than those in the control group (P < 0.05). Conclusion Family pharmacist responsibility system could significantly improve the awareness, treatment compliance of Warfarin anticoagulant and the standard rate of INR in AF patients, and can reduce the incidence of bleeding and thrombotic complications.
2020 Vol. 17 (32): 181-184 [Abstract] ( 127 ) HTML (1 KB)  PDF (542 KB)  ( 123 )
185 Based on Marx’s theory of social division of labor，three principles of undergraduate vocational education for rehabilitation medicine majors in colleges of traditional Chinese medicine
ZENG Xuelu LI Baoqin WANG Qiuying GUO Qian
The specialty of rehabilitation medicine has the characteristics of multi-discipline, extensiveness and sociality, and it is also a subject with strong application. Therefore, it is of practical significance for the research and talent cultivation of the vocational education of rehabilitation medicine majors. At present, there is a certain contradiction between the number of rehabilitation professionals of traditional Chinese medicine and the social rehabilitation needs. We should strengthen the vocational education for undergraduate rehabilitation professionals in higher traditional Chinese medicine education, and improve the overall quality of rehabilitation professionals of traditional Chinese medicine, it is an important measure to transform the theory and knowledge of rehabilitation medicine specialty into professional abilities. Therefore, on the basis of the three principles of “specialization of labor” “industrialization of labor” and “regional division of labor” based on Marx’s social division of labor theory, this paper analyzes the necessity of the vocational education of rehabilitation medicine in higher education of traditional Chinese medicine, to perfect and develop the education of rehabilitation medicine in higher education of traditional Chinese medicine.
2020 Vol. 17 (32): 185-187 [Abstract] ( 78 ) HTML (1 KB)  PDF (486 KB)  ( 20 )
188 Application and thinking of grid management in hospital fire safety management
HONG Yang1 ZHOU Yisi2 LI Kai3
The promotion of hospital fire safety grid management is a new mode of fire protection development in the new period, and it is the innovation embodiment of optimizing fire safety management mode. Through fire safety grid management practices, the hospital divides hospital administrative areas into cell grids, and establishes a set of management system, in order to improve fire safety management of the hospital. The final purpose is to implement that someone tube transverse to the edge, longitudinal what someone, all-round, multi-dimensional management, which reaches a solid, efficient and curative fire safety goal.
2020 Vol. 17 (32): 188-192 [Abstract] ( 96 ) HTML (1 KB)  PDF (665 KB)  ( 445 )
193 Discussion on the effect of construction of Chinese medical culture in transforming Western hospitals into hospitals of integrated traditional Chinese and Western medicine
HUO Yingming1 SHAO Guiqiang2
Taking the transformation of Wujing Hospital of Shanghai Minhang District into Shanghai Minhang Hospital of Integrated Traditional Chinese and Western Medicine (“our hospital” for short) as an example, this paper explores the importance of strengthening the construction of traditional Chinese medical culture in the process of functional transformation of Western medicine hospitals. Our hospital has been strengthening the connotative construction of “Yueyang-Minhang” medical treatment combination, constantly inheriting and promoting traditional Chinese medical culture to advance the hospital culture with Chinese medical characteristics, which lays a solid foundation for the overall transformation of hospital functions. This paper introduces the successful experience and existing problems of the hospital’s Chinese medical culture construction, and proposes further improvement and optimization methods. That general hospitals of Western medicine facilitate Chinese medical cultural construction is one of the critical elements of successful tranformation into hospitals of integrated traditional Chinese and Western medicine. The purpose of this paper is to provide theoretical basis and practical reference for further improving cultural construction of other hospitals.
2020 Vol. 17 (32): 193-196 [Abstract] ( 221 ) HTML (1 KB)  PDF (568 KB)  ( 81 )
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