紫丹银屑胶囊联合雷公藤多苷治疗寻常性银屑病的临床研究

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Abstract Objective To investigate the clinical efficacy of Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside in the treatment of psoriasis vulgaris. Methods From January 2018 to January 2020, a total of 100 psoriasis vulgaris patients admitted to Qinghai Red Cross Hospital were selected and divided into control group (50 cases) and observation group (50 cases) by random number table method. The control group was treated with Tripterygium wilfordii multiglucoside, while the observation group was treated with Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside. The two groups were treated for 12 weeks. The clinical efficacy was evaluated after treatment. The psoriasis area and severity index (PASI) scores, visual analog score (VAS), dermatology life quality index (DLQI) scores, P-cadherin (P-cad), Trappin-2, neutrophils protease (NE), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) of the two groups were compared before and after treatment. The adverse reactions during treatment were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group (P ＜ 0.05). After treatment, the scores of PASI, VAS and DLQI, the P-cad, Trappin-2 and NE levels in the lesional tissue fluid in the two groups were lower than those before treatment (P ＜ 0.05), and the scores of PASI, VAS and DLQI, the P-cad, Trappin-2 and NE levels in the lesional tissue fluid in the observation group were lower than those in the control group (P ＜ 0.05). After treatment, the serum GSH-Px and SOD levels in the two groups were higher than those before treatment (P ＜ 0.05), and serum GSH-Px and SOD levels in the observation group were higher than those in the control group (P ＜ 0.05). There was no significant difference in adverse reactions incidence between the two groups during the treatment (P ＞ 0.05). Conclusion Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside in the treatment of psoriasis vulgaris has significant effect. It can significantly improve the clinical symptoms of patients, reduce the degree of skin lesions, improve the quality of life, lower the P-cad, Trappin-2 and NE levels in the lesion tissue fluid, and increase the serum GSH-Px and SOD levels, with good safety.

Key words： Psoriasis vulgaris Zidan Yinxie Capsules Tripterygium wilfordii multiglucosideon Efficacy

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	MA Xingmei1 LI Yuxiang2 MA Jie2 XIAO Jiehua3

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MA Xingmei1 LI Yuxiang2 MA Jie2 XIAO Jiehua3. Clinical effect of Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside in the treatment of psoriasis vulgaris[J]. 中国医药导报, 2020, 17(32): 135-138,143.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I32/135

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