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| Clinical effect of Estradiol Valerate, Mifepristone and Misoprostol combined with curettage in the treatment of missed abortion |
| XIA Jie JI Ying LIU Minglan |
| Department of Gynecology and Obstetrics, Rugao People’s Hospital, Jiangsu Province, Rugao 226500, China |
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Abstract Objective To observe clinical effect of Estradiol Valerate (Progynova) combined with Mifepristone, Misoprostol and curettage in the treatment of missed abortion. Methods Eighty-two patients with missed abortion treated in Department of Gynecology and Obstetrics of Rugao People’s Hospital in Jiangsu Province from October 2017 to December 2019 were selected and divided into control group (40 cases) and observation group (42 cases) according to different treatment methods. Control group was treated with Mifepristone combined with Misoprostol in sequence, while observation group was treated with Mifepristone and Misoprostol in the same way as control group. The patients in both groups were treated with Progynova three days before and one day after operation. The time of uterine curettage, intraoperative blood loss, smooth entry of uterine dilator, postoperative vaginal bleeding time, menstrual recovery time, re-curettage rate and incidence of abortion syndrome were observed in two groups. Endometrial receptivity was evaluated by ultrasonography at three months after operation, and ovarian reserve function was observed. Results The time of curettage, postoperative vaginal bleeding and menstrual recovery time in observation group were shorter than those in control group, the amount of intraoperative blood loss in observation group was less than that in control group, the incidence of re-curettage and induced abortion syndrome in observation group were lower than those in control group, the differences were statistically significant (P < 0.05). There was no significant difference in number seven uterine dilator entering smoothly between two groups (P > 0.05). Three months after operation, the endometrial thickness of observation group was thicker than that of control group, the pulsatility index and blood flow resistance index of observation group were lower than those of control group, and Salle score of observation group was higher than that of control group (P < 0.05). Three months after operation, the levels of serum luteinizing hormone and follicle stimulating hormone in observation group were lower than those in control group, and the level of anti Mullerian hormone in observation group was higher than that in control group (P < 0.05). Conclusion Progynova combined with Mifepristone, Misoprostol and curettage have significant clinical effect on missed abortion, and can improve endometrial receptivity and ovarian reserve function of missed abortion patients.
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