参苏温肺汤加减对慢性鼻窦炎患者的肺功能及炎症因子的影响

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Abstract Objective To investigate the effect of Modified Shensu Wenfei Decoction on pulmonary function and inflammatory factors in patients with chronic sinusitis. Methods Eighty-eight patients with chronic sinusitis admitted to Lishui Hospital of Traditional Chinese Medicine from January 2018 to January 2020 were selected. All patients were randomly divided into two groups, with 44 cases in each group. The control group was given Fluticasone Propionate combined with Prednisone, and the observation group was treated with Modified Shensu Wenfei Decoction on the basis of control group. After 4 weeks of treatment, the clinical efficacy, incidence of adverse reactions, lung indexes (forced vital capacity [FVC], forced expiratory volume in one second [FEV1], FEV1/FVC), inflammatory cytokines (interleukin-17 [IL-17], interleukin-1β [IL-1β], interferon-gamma [IFN-γ], tumor necrosis factor-α [TNF-α]) levels were compared between the two groups before and after treatment. Results The total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05); after treatment, the levels of FEV1, FVC and FEV1/FVC in the observation group were significantly higher than those in control group, the differences were statistically significant (P ＜ 0.05); after treatment, the levels of IL-17, IL-1β, IFN-γ and TNF-α in the observation group were significantly lower than those in control group, the differences were statistically significant (P ＜ 0.05); after treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Modified Shensu Wenfei Decoction in the treatment of chronic sinusitis can significantly improve the inflammatory levels and pulmonary function, with high safety, which is worthy of clinical promotion and application.

Key words： Modified Shensu Wenfei Decoction Chronic sinusitis Pulmonary function Inflammatory factors Clinical efficacy

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LIU Ying XU Jianyou. Effect of Modified Shensu Wenfei Decoction on pulmonary function and inflammatory factors in patients with chronic sinusitis[J]. 中国医药导报, 2020, 17(32): 144-147.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I32/144

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