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2020 Vol. 17, No. 8
Published: 2020-03-15
 
 
4 Experimental study on effect of Yunpi Rougan Recipe on motilin and somatostatin in rats with constipation type irritable bowel syndrome
LIU Mengru1 QIU Renjing1 TIAN Yaozhou2 LI Hui2，3
Objective To explore the effect of Yunpi Rougan Recipe on the expression of motilin (MOT) and somatostatin (SS) in serum and colon tissues of rats with constipation type irritable bowel syndrome (IBS-C). Methods Twelve Wistar rats were selected as normal group, IBS-C model was established by ice water gavage in the other 60 rats. After the successful modeling, the rats were divided into IBS-C model group, Mosapride group and low, medium and high dose of traditional Chinese medicine group according to the random number table method, with 12 rats in each group. Normal group and IBS-C model group were given equal volume distilled water, Mosapride group was given 1.35 mg/(kg·d) suspension, low, medium and high dose of traditional Chinese medicine groups was given 12.2, 24.4, 48.8 g/(kg·d) respectively. The expression of MOT and SS in serum and colon tissue of rats were measured by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry. Results After molding, compared with normal group, the number of fecal particles in IBS-C model group decreased (P < 0.05). After administration, compared with normal group, the number of fecal particles in IBS-C model group decreased (P < 0.05); compared with the IBS-C model group, the number of fecal particles in Mosapride group and low, medium and high dose of traditional Chinese medicine groups increased (P < 0.05 or P < 0.01). After modeling, compared with normal group, the fecal water content of IBS-C model group decreased (P < 0.01). After administration, compared with normal group, the fecal water content of IBS-C model group decreased (P < 0.05); compared with IBS-C model group, the fecal water content of low, medium and high dose of traditional Chinese medicine groups increased (P < 0.01). Compared with normal group, the intestinal propulsion rate of IBS-C model group was significantly decreased (P < 0.05); compared with IBS-C model group, the intestinal propulsion rate of Mosapride group and low, medium and high dose of traditional Chinese medicine groups was significantly increased (P < 0.05 or P < 0.01). Compared with normal group, the content of serum MOT in IBS-C model group decreased, and SS increased (P < 0.05); compared with IBS-C model group, the content of serum MOT in Mosapride group, middle and high dose of traditional Chinese medicine groups increased, and SS decreased (P < 0.05). Compared with normal group, the MOD value of the colon tissue of IBS-C model group was significantly decreased (P < 0.05), and the MOD value of SS was significantly increased (P < 0.05); compared with the IBS-C model group, the MOD value of mot was significantly decreased (P < 0.05), and the MOD value of SS was significantly decreased (P < 0.05). Conclusion Yunpi Rougan Recipe may regulate gastrointestinal hormones to improve intestinal propulsion rate and defecation by regulating the expression of MOT and SS in rat serum and colon tissues.
2020 Vol. 17 (8): 4-8,16 [Abstract] ( 198 ) HTML (1 KB)  PDF (747 KB)  ( 143 )
9 Effects of acteoside on behavior and hormone changes of APP/PS1 double transgenic mice
CHEN Jiayuan1 GAO Li2 LUO Jianan2 LI Jianmei2 YAN Ming2▲
Objective To investigate the effects of acteoside on behavior and hormone changes of APP/PS1 double transgenic mice. Methods Ten mice of C57 BL/6J were selected as control (group A). 50 healthy APP/PS1 double transgenic mice were randomly divided into group B (model), group C (Donepezil), group D (low dose of acteoside), group E (medium dose of acteoside), group F (high dose of acteoside), 10 mice in each group. After 120 days of continuous administration, O maze test was carried out, and Aβ1-40 content in hippocampus of mice and the hormone content in serum and pituitary gland were determined. Results Compared with group A, the distance and time of arm opening in group B were significantly shortened (P < 0.05); compared with group B, the distance and time of arm opening in group D were significantly lengthened (P < 0.01), and the distance of arm opening in group E was lengthened (P < 0.05). Compared with group A, the content of Aβ1-40 in group B increased significantly (P < 0.01); compared with group B, the content of Aβ1-40 in group E decreased significantly (P < 0.01). Compared with group A, the content of adrenocorticotropic hormone in group B was significantly increased (P < 0.05); compared with group B, the content of adrenocorticotropic hormone in group C and group F was significantly decreased, and the content of cortisol in group F was significantly decreased (P < 0.05). Compared with group B, follicle-stimulating hormone content in pituitary gland of group D decreased significantly (P < 0.05). Compared with group A, thyroid-stimulating hormone content of group B was significantly decreased (P < 0.05); compared with group B, thyroid-stimulating hormone content of group C, group E and group F was significantly increased (P < 0.05 or P < 0.01). Compared with group A, growth hormone content in pituitary of group B decreased significantly (P < 0.05); compared with group B, growth hormone content of group C, group E and group F increased significantly (P < 0.05 or P < 0.01). Conclusion Acteoside can improve the anxiety emotion of APP/PS1 double transgenic mice, protect the cerebral neural circuit and improve the memory ability by regulating the content of Aβ1-40 and the hormone secretion.
2020 Vol. 17 (8): 9-12 [Abstract] ( 141 ) HTML (1 KB)  PDF (809 KB)  ( 55 )
13 Effect and mechanism of curcumin and its analogues on inhibiting CCl4 induced hepatic fibrosis in rats
WANG Zikai* MAO Yongbin* KONG Li ZHONG Xing SUN Xiaowen WU Dan YUAN Xiaohuan
Objective To study the effect and mechanism of curcumin and its analogues on CCl4 induced hepatic fibrosis in rats. Methods Forty male Wistar rats were randomly divided into model, normal curcumin, H8 low and high dose groups, with 8 rats in each group according to body weight. The model group, curcumin group and H8 group were intraperitoneally injected with 40% CCl4 olive oil to replicate the liver fibrosis model. After 8 weeks, the curcumin group, H8 low and high dose groups were given the corresponding drugs by gavage, and intraperitoneal injection of 40% CCl4 olive oil once for 4 weeks. After sacrificed the rats, blood biochemical indicators were measured, pathological morphological changes were observed by HE and Masson staining of liver tissue, while Col1, fibronectin (FN), transforming growth factor-β (TGF-β), and α-smooth muscle actin (Α-SMA) mRNA were measured by QPCR. Results The alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum glutamyl transpeptidase (GGT), liver coefficient, Col1, FN, TGF-β, α-SMA mRNA in the model group were significantly higher than those in the control group, and the differences were highly statistically significant (P ＜ 0.01). In the curcumin group, the serum ALT, AST, GGT, liver coefficient, Col1, FN, TGF-β, and α-SMA mRNA in the H8 low and high-dose groups were significantly lower than those in the model group, and the differences were statistically significant (P ＜ 0.05). Conclusion Curcumin and its analogue H8 have therapeutic and protective effects on CCl4 induced liver fibrosis in rats, and H8 has better effects than curcumin.
2020 Vol. 17 (8): 13-16 [Abstract] ( 196 ) HTML (1 KB)  PDF (881 KB)  ( 142 )
17 Expression and clinical significances of NLRP3 inflammasomes and oxidative stress in placenta of patient with neonatal hypoxic-ischemic encephalopathy
WEI Tingyan1,2 YANG Jie3 ZENG Yuting4 HUANG Qiting4 LIU Yujun4
Objective To investigate the expression and oxidative stress of NLRP3 inflammasomes in the placenta of neonates with hypoxic-ischemic encephalopathy (HIE), and to investigate the clinical significance of NLRP3 inflammasome and oxidative stress in HIE. Methods From July 2010 to May 2019, 30 cases of HIE placental tissue (HIE group) and 30 cases of normal placental tissue (normal group) were selected from Zengcheng District People′s Hospital, Guangzhou, NLRP3 expression was detected by immunohistochemistry. The concentrations of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in 10 fresh placental tissues, placental tissues of the two groups were pathologically evaluated. Results The number of villi with cytosygotrophoblast nodules and cytotrophoblast cells in the placenta tissues of neonates in HIE group was higher than that of normal group (P ＜ 0.05). The number of villi with cytosomal membrane was less than that of normal group (P ＜ 0.05). The expression level of NLRP3 in HIE group neonatal placenta was significantly higher than that in normal group, and the difference was statistically significant (P ＜ 0.05). SOD activity in HIE group was lower than that in normal group (P ＜ 0.05), and MDA content was higher than normal group (P ＜ 0.05). NLRP3 was negatively correlated with SOD activity (r = -0.63, P = 0.00), while positively correlated with MDA content (r = 0.74, P = 0.00). Conclusion There is a significant increase in the expression of NLRP3 inflammasomes in the placenta of neonates with HIE and abnormal oxidative stress, both of which are correlated, which may be the cause of neonatal HIE.
2020 Vol. 17 (8): 17-20 [Abstract] ( 234 ) HTML (1 KB)  PDF (570 KB)  ( 57 )
21 Research progress of SGLT-2 inhibitors in the treatment of diabetic nephropathy
XU Qi FU Jia HAN Rui
Sodium-glucose transporter-2 (SGLT-2) is upregulated in patients with diabetes, and it is responsible for approximately 90% of the reabsorption of urine glucose in the proximal tubules. SGLT-2 inhibitor is a new type of hypoglycemic agent which can reduce the expression of hypoxia-inducible factor-1 protein and kidney injury molecule-1, and improve the activation of the renin-angiotensin-aldosterone system, while reduce the generation of oxidative stress. It can also protect the kidneys by reducing blood sugar, blood pressure, uric acid and improving lipid metabolism. In addition, SGLT-2 inhibitors combined with angiotensin-converting enzyme inhibitor are used to treat patients with type 2 diabetes combined with chronic kidney disease. SGLT-2 inhibitors have good safety in patients with diabetic nephropathy, but we need to pay attention to the increased risk of urinary tract infections of Dapagliflozin, and at the same time be alert to the risk of acute kidney injury of Canagliflozin and Dapagliflozin. This article reviews the effects of SGLT-2 inhibitors on the kidney and its clinical application in the treatment of diabetic nephropathy in order to provide new treatment options for diabetic nephropathy.
2020 Vol. 17 (8): 21-24 [Abstract] ( 317 ) HTML (1 KB)  PDF (586 KB)  ( 129 )
25 Advance in studies on the protective effect of Tetramethylpyrazine on vascular endothelial injury
LI Fangfang ZHANG Qi
The degree of vascular endothelial injury is closely related to the development of cardiovascular diseases such as hypertension. Many kinds of cardiovascular diseases, such as hypertension, coronary heart disease and atherosclerosis, will present different degrees of vascular endothelial injury, and the protection of injured endothelial cells is the key to the prevention and treatment of cardiovascular diseases. Tetramethylpyrazine is a kind of alkaloid extracted from Chinese herbal medicine Ligusticum chuanxiong Hort.. It has biological activity and many pharmacological effects. Its pharmacological effects include, delaying endothelial cell apoptosis, promoting angiogenesis, anti-inflammatory, antioxidant, etc. It can be used to treat the changes in vascular structure and function caused by hypertension. This article reviews the research progress of Tetramethylpyrazine against vascular endothelial injury in hypertension, and provides scientific basis for the clinical application of Tetramethylpyrazine in the treatment of cardiovascular and cerebrovascular diseases.
2020 Vol. 17 (8): 25-28 [Abstract] ( 177 ) HTML (1 KB)  PDF (577 KB)  ( 106 )
29 Research progress on identification and quality evaluation of Lonicerae Flos
LI Mantian1,2 AO Dongmei2 CHEN Jun1 LIU Sai1 XU Changqing1 XU Rong1 DING Lingling2
As a common traditional Chinese medicine, Lonicerae Flos is also a homologous product of medicine and food. In the market circulation, it not only has the legal source stipulated in the Chinese pharmacopoeia, but also has folk medicinal varieties and mixed products. In order to standardize the quality of Lonicerae Flos and establish a stable and controllable quality evaluation method, this paper tries to summarize the research status of quality control of Lonicerae Flos from the aspects of qualitative identification and quantitative analysis in recent years, so as to provide a basis for the improvement and optimization of quality control and evaluation methods of Lonicerae Flos.
2020 Vol. 17 (8): 29-32 [Abstract] ( 212 ) HTML (1 KB)  PDF (604 KB)  ( 96 )
33 Research progress of Wnt/LRP6 signaling pathway on synaptic function in alzheimer′s Disease
WANG Su1 LI Yiping1 XIE Ning2
Alzheimer′s disease (AD) is one of the most common dementias currently. AD is characterized by the formation of senile plaques by the deposition of β amyloid in the brain, and the main pathological manifestations of neurofibrillary tangles and loss of neurons caused by excessive phosphorylation of Tau protein, accompanied by neuroinflammatory changes and cognitive impairment. There have been extensive studies to prove that synaptic dysfunction and synaptic loss are pathological manifestations of AD in the early stage. Aβ has direct toxic effect on the synapse, but the type of signaling pathway through which Aβ affects the synapse needs further study. The Wnt/β-catenin signaling pathway plays an important role in the functional and morphological integrity of synaptic connections in the adult brain through the common wnt-lrp6 locus. On this basis, this paper explores the underlying mechanism of AD susceptibility in order to reveal new therapeutic targets and methods.
2020 Vol. 17 (8): 33-35,47 [Abstract] ( 228 ) HTML (1 KB)  PDF (975 KB)  ( 61 )
36 Progress in establishment of malignant transformation model of human gastric mucosal epithelial cells
WANG Xia DONG Mengjia
China is a high incidence area of digestive tract tumors. Early diagnosis and early treatment are an important means to reduce the mortality of gastric cancer. The establishment of malignant transformation model of gastric mucosal epithelial cells is one of the important methods to study early gastric cancer. Currently model inducers include nitrosoguanidine, Helicobacter pylori, chenodeoxycholic acid, ochratoxin A, non-coding transcriptional regulatory gene expression and so on. There is no established standard for model development. This paper summarizes the malignant transformation model of gastric mucosa epithelial cells published in recent years, and introduces the methods of model preparation, related morphology, molecular expression difference and its pathogenic principle, so as to provide reference for further experimental research.
2020 Vol. 17 (8): 36-38,59 [Abstract] ( 198 ) HTML (1 KB)  PDF (966 KB)  ( 46 )
39 Pharmacological effects and application prospects of cordycepin
ZHOU Yanli1，2 XU Jianyi2 WANG Hongjuan2 LIU Rui1，3 ZHANG Jingzhao1，3 ZHAO Xin1，3 TANG Xudong1，3
Cordycepin is a nucleoside antibiotic isolated from Cordyceps militaris, which has a variety of biological activities, such as antibacterial, antiviral, anti-inflammatory, immune regulation, anti-tumor, hypoglycemic and anti-aging, etc. Cordycepin has a certain therapeutic effect on lung, liver, kidney, stomach and other diseases. It can also be used as cosmetics, health products and animal husbandry. With the deepening of research, the pharmacological effect of cordycepin has been gradually explored, and its mechanism has become increasingly clear. In this paper, we summarize the research and application of cordycepin in recent years, which lays a foundation for further study of cordycepin.
2020 Vol. 17 (8): 39-42 [Abstract] ( 165 ) HTML (1 KB)  PDF (585 KB)  ( 388 )
43 Prevalence study on the perceived professional benefits of nurses in emergency department of grade-A tertiary hospital in Shanghai
ZHANG Jian1,2 YANG Xin1 JIANG Jinxia3 TIAN Meimei4 DONG Hanqiong1
Objective To investigate the status of the perceived professional benefits of nurses in emergency department of grade-A tertiary hospital in Shanghai, and to analyze the influencing factors, so as to provide theoretical basis for enhancing the perceived professional benefits of nurses. Methods From February to March 2019, the general data questionnaire which was independently designed and nurses′ perceived professional benefit questionnaire were used to investigate 208 nurses in emergency department of 2 grade-A tertiary hospitals in Shanghai. Results The total score of nurses′ perceived professional benefits were (120.18±13.91) points, and the score index was 82.88%. Among all dimensions, the highest score index was good nurse-patient relationship (85.57%) and the lowest score index was the positive career perception (78.16%). The working years, monthly income, technical titles, voluntary job hunting to be nurses have an impact on the perceived professional benefits of nurses in emergency department (P ＜ 0.05). Conclusion The perceived professional benefits of nurses in emergency department of grade-A tertiary hospitals in Shanghai are on the upper middle level in this survey. The influencing factors of nurses′ perceived professional benefits should be taken into account and targeted intervention measures should be formulated to enhance their perceived professional benefits.
2020 Vol. 17 (8): 43-47 [Abstract] ( 310 ) HTML (1 KB)  PDF (646 KB)  ( 107 )
48 Effect of mindfulness training on sleep quality of officers and soldiers during military parade
LI Wenjuan1 ZHAO Chunhai2 SHI Xiufang1 CHI Yuhao1 SU Xiaoguang3
Objective To explore the effect of mindfulness training on sleep quality of officers and soldiers during large-scale military task training. Methods From September 2018 to June 2019, a total of 403 officers and soldiers from a grassroots unit who were about to perform large military missions were selected as officers and soldiers group, and they were divided into control group (197 cases) and research group (206 cases) according to random number table method. During the same period, the patients with insomnia were selected as the insomnia group (48 cases) and normal healthy persons as the normal group (142 people). The control group received routine psychological intervention only. Based on this, the study group received mindfulness training intervention. The pittsburgh sleep quality index scale (PSQI) scores of officers and soldiers group, insomnia group, and normal groups were compared before training, while the PSQI scores of the control and study groups were compared before and after training. Results Before training, the PSQI scores of the officers and soldiers group were significantly higher than those of the normal group, and the differences were highly statistically significant (P ＜ 0.01). Except for sleep efficiency, other PSQI scores before training in the inmate group were significantly lower than those in insomnia group, and the differences were highly statistically significant (P ＜ 0.01). There was no significant difference in PSQI scores between the study group and the control group before training (P ＞ 0.05). After training, the PSQI scores of the two groups were significantly lower than before training, while the study group were lower than those of the control group, and the differences were highly statistically significant (P ＜ 0.01). Conclusion During the large-scale military mission training, although it affected the sleeping quality of officers and soldiers to a certain extent, it has not yet reached the level of insomnia. After a period of mindfulness training, the sleep quality of officers and soldiers performing tasks has been significantly improved.
2020 Vol. 17 (8): 48-51,63 [Abstract] ( 134 ) HTML (1 KB)  PDF (665 KB)  ( 104 )
52 The elements of academic English teaching syllabus for PhD students with the background of traditional Chinese medicine
GAO Lianli1 XU Weiming2 LIN Tingxiu1 WU Fang1 HU Chunyu1 SONG Chunsheng1 MA Xiaobei1
Objective To confirm the elements of the academic English teaching syllabus for PhD students with the background of traditional Chinese medicine based on students need. Methods A total of 74 PhD students by general recruitments and in-service PhD students in 2014 in the Graduate School of China Academy of Chinese Medical Sciences were surveyed. The questionnaire was designed under the guideline of the theories of teaching English to speakers of other languages (TESOL) and English for academic purposes (EAP). Statistical analysis was conducted using factor analysis and principal component analysis. Results A total of 53 PhD students completed the survey. Six basic elements of the English teaching syllabus for Chinese PhD students, including “learning principles” “writing principles” “expression principle” “learning attitude principles” “testing principles” and “teaching test principles”. Conclusion When setting up an English teaching course outline for PhD students of Chinese medicine, we should make full use of the “learning principles” and pay attention to writing as the center of gravity and translation to facilitate writing. Apply the problem-oriented learning and teaching model to solve the problems of the “testing principle” elements. In addition, the outline setting should reflect Chinese medicine characteristics.
2020 Vol. 17 (8): 52-55 [Abstract] ( 178 ) HTML (1 KB)  PDF (593 KB)  ( 125 )
56 Localization and reliability and validity of parental stressor scale for children in neonatal intensive care unit
LI Guoxi JIANG Xun WANG Ailing▲
Objective To translate the parental stressor scale of neonatal intensive care unit (NICU), and to evaluate the reliability and validity of the Chinese version. Methods The English version of the parental stressor scale of NICU was translated, back translated, cross-culturally adjusted, pre-investigated and other processes to form a Chinese version. The convenient sampling method was used to select the parents of 118 children who were hospitalized in the NICU of the Tangdu Hospital of the Air Force Military Medical University from June 2018 to June 2019. The questionnaire was surveyed, while the reliability and validity of the scale were evaluated. Results The Chinese version of the parental stressor scale of the NICU has 3 dimensions and 25 entries. The correlation coefficient between each item and the total score were 0.339-0.589 (P ＜ 0.05), and the decision value were 3.652-8.883 (P ＜ 0.05). The total content validity was 0.961, while the content validity of the three dimensions were 0.989, 0.924, 1.000, respectively, and the content validity of each item were 0.843-1.000. Exploratory factor analysis extracted a total of three common factors with a characteristic root＞1, the cumulative contribution rate was 67.136%. The total Cronbach′α coefficient of the scale was 0.856, the Cronbach′α coefficients of each dimension were 0.841, 0.815, 0.774, respectively, the half-fold reliability was 0.825. Conclusion The parental stressor scale of Chinese NICU has better reliability and validity. It can be used as a survey tool to evaluate the exposure of parents with stressors in the NICU and to understand the psychological characteristics of parents.
2020 Vol. 17 (8): 56-59 [Abstract] ( 203 ) HTML (1 KB)  PDF (646 KB)  ( 150 )
60 Analysis of the secondary resistance in Helicobacter pylori
LIUFU Junye LI Junda HU Guihua SHEN Jian′gang HUANG Jinwen QIU Jiahua FU Zhaoxia
Objective To investigate the secondary drug resistance of Helicobacter pylori (Hp) to six commonly used antibiotics, and to provid a basis for clinicians to rationally choose antibiotics and rationally formulate remedial plans for eradication of Hp. Methods A total of 120 patients with positive 13C breath test after Hp eradication were randomly selected from the Longhua District People′ Hospital of Shenzhen City. Gastroscopy was performed on the mucosa of the gastric antrum and on the minor curvature of the gastric body for Hp isolation and culture. The obtained Hp strain was tested for the drug sensitivity of Amoxicillin, Clarithromycin, Furazolidone, Doxycycline, Levofloxacin, Metronidazole. Results A total of 97 strains of Hp were successfully isolated and cultured, and those who were positive for the rapid urease test were successfully cultured. The positive rate of Hp culture were not related to gender, age, and 13C-urea breath test (P ＞ 0.05). The secondary drug resistance rates of Hp to Metronidazole, Amoxicillin, Clarithromycin and Furazolidone were 100.0%, 75.2%, 30.9%, and 1.0%, respectively. No strains resistant to Doxycycline or Levofloxacin were detected; the single drug resistance rate was 14.4%, the dual drug resistance rate was 65.0%, the triple drug resistance rate was 19.6%, while the quadruple drug resistance rate was 1.0%. Hp secondary resistance rates were not related to gender, age, and 13C-urea breath test results (P ＞ 0.05). Conclusion The remediation eradication of Hp should be individualized eradication treatment under the guidance of drug susceptibility test. Positive urease test is a reliable method to increase the positive rate of Hp culture.
2020 Vol. 17 (8): 60-63 [Abstract] ( 238 ) HTML (1 KB)  PDF (657 KB)  ( 106 )
64 Effect of Yangxin Granules combined with Western medicine in the treatment of unstable angina pectoris and its influence on vascular endothelial function and inflammatory factors
WANG Haitao YANG Bo YANG Jingna PEI Lili
Objective To explore the effect of Yangxin Granules combined with Western medicine in the treatment of unstable angina pectoris (UAP) and its influence on vascular endothelial function and inflammatory factors. Methods One hundred and fifty-eight patients with UAP admitted to Qinhuangdao Muncipality Traditional Chinese Medicine Hospital from January 2017 to January 2019 were selected and divided into single group and treatment group according to the random number table method. 79 patients in single group were treated with Western medicine, and 79 patients in treatment group were treated with Yangxin Granules + Western medicine, and they were treated for 2 weeks. Therapeutic efficacy, traditional Chinese medicine symptoms scores, vascular endothelial damage function and serum cytokines levels were observed in two groups. Results After treatment, the effect in treatment group was significantly better than single group (P < 0.05). After treatment, the scores of chest distress, chest pain, palpitation, fatigue, self perspiration, dizziness, pallor and mental fatigue in two groups were significantly lower than those before treatment (P < 0.05), and the scores in treatment group were lower than those in single group (P < 0.05). After treatment, the levels of nitric oxide and prostacyclin in two groups were significantly higher than those before treatment (P < 0.05), the levels of plasma endothelin and thromboxane A2 were significantly lower than those before treatment (P < 0.05), and the change range in treatment group was larger than that in single group (P < 0.05). After treatment, the levels of IL-6, intercelluar adhesion molecule-1, homocysteine and matrix metalloproteinase-9 in two groups were significantly lower than those before treatment (P < 0.05), and those in treatment group were lower than those in single group (P < 0.05). Conclusion Yangxin Granules combined with Western medicine has exact efficacy in treating UAP. And it can significantly relieve symptoms of angina pectoris, improve ischemic performance of electrocardiogram, protect vascular endothelial function and inhibit expression of serum cytokines.
2020 Vol. 17 (8): 64-67 [Abstract] ( 228 ) HTML (1 KB)  PDF (578 KB)  ( 141 )
68 Effect of Sakubatrevalsartan in the treatment of heart failure in the elderly with left ventricular ejection fraction reduction
QI Jie ZHUO Liu′an WU Feixue WEI Wenwen
Objective To observe the effect of Sakubatrevalsartan in the treatment of heart failure in the elderly with left ventricular ejection fraction (LVEF) reduction. Methods 89 elderly patients with heart failure were selected from Liuzhou People′s Hospital from June 2017 to December 2018, they were divided into control group (n = 44) and study group (n = 45) by random number table method. Control group was treated with routine Western medicine, and study group was treated with Sakubatrevalsartan on the basis of control group. Clinical efficacy, cardiac function, renal function and adverse reactions were compared between two groups. Results After treatment, total effective rate of study group was significantly higher than that of control group (P < 0.05). The walking distance of 6 minutes after treatment in two groups was longer than that before treatment, left ventricular end diastolic dimension was shorter than that before treatment, LVEF was higher than that before treatment, heart rate was slower than that before treatment, and the improvement in study group was significantly better than that in control group (P < 0.05). After treatment, blood urea nitrogen and serum creatinine of two groups were lower than before treatment, estimated glomerular filtration rate was higher than before treatment, and the improvement of study group was significantly better than that of control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Sakubatrevalsartan can effectively improve the cardiac and renal function of elderly patients with heart failure due to the reduction of LVEF, with definite curative effect and good safety, and has certain clinical application value.
2020 Vol. 17 (8): 68-71 [Abstract] ( 232 ) HTML (1 KB)  PDF (577 KB)  ( 101 )
72 Effect of self-made Shengui Baoxin Decoction on chronic heart failure and ventricular remodeling
SUN Xiaoyan1 YANG Lei2 ZHAO Dongpo1 FENG Qian1
Objective To investigate the effect of self-made Shengui Baoxin Decoction on chronic heart failure (CHF) and ventricular remodeling. Methods One hundred and thirty-seven CHF patients received in the First Hospital of Zhangjiakou City from August 2016 to May 2019 were divided into control group (n = 68) and study group (n = 69) by random number table method. Control group was given conventional treatment, while study group was given self-made Shengui Baoxin Decoction. The cardiac function index, clinical efficacy, serological index were compared between two groups. The occurrence of adverse reactions during treatment in two groups was recorded. Results Total clinical effective rate of study group was significantly higher than that of control group (P < 0.05). LVEF of two groups after 30 days of treatment was higher than that before treatment, LVEDD and LVESD of two groups after 30 days of treatment were shorter than those before treatment (P < 0.05), and the improvement of study group was significantly better than that of control group (P < 0.05). The levels of BNP and MMP-2 in two groups after 30 days of treatment were lower than those before treatment (P < 0.05), TIMP-1 in two groups after 30 days of treatment was higher than that before treatment (P < 0.05), and the improvement of study group was significantly better than that of control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion The self-made Shengui Baoxin Decoction can effectively reduce the levels of BNP and MMP-2, and improve the cardiac function of patients with CHF. It is safe and effective.
2020 Vol. 17 (8): 72-75 [Abstract] ( 279 ) HTML (1 KB)  PDF (578 KB)  ( 104 )
76 Relationship between aVR T wave shape of electrocardiogram and the degree of coronary artery lesions in patients with ST-segment elevation myocardial infarction
YAN Jiesong ZHOU Dong TANG Xiangrui GUO Hongyi ZHAO Kuan
Objective To study the relationship between the aVR T wave shape of electrocardiogram and the degree of coronary artery lesions in patients with ST-segment elevation myocardial infarction. Methods One hundred and seven patients with ST-segment elevation myocardial infarction treated in 3201 Hospital Affiliated to Medical College of Xi′an Jiaotong University from January 2016 to January 2019 were divided into group A (positive electrocardiogram aVR T wave shape, 41 cases) and group B (non-positive electrocardiogram aVR T wave shape, 66 cases) according to the different electrocardiogram aVR T wave shape at admission. The basic data, the level of each laboratory examination index and the number of coronary artery lesion of two groups were compared. Logistic regression analysis was used to analyze the positive influence factors of aVR T wave shape. Results Left ventricular ejection fraction (LVEF) of group A was lower than that of group B, while the serum brain natriuretic peptide (BNP) and troponin I (cTnI) levels of group A were higher than those of group B (P < 0.05). There was significant difference in the total number of coronary artery lesions between two groups (P < 0.05). Logistic regression analysis showed that LVEF (OR = 0.337, 95%CI: 0.173-0.656) was the protective factor of aVR T wave postive in patients with ST-segment elevation myocardial infarction (P < 0.05), while BNP (OR = 1.715, 95%CI: 1.278-2.30), cTnI (OR = 1.535, 95%CI: 1.218-1.935), the multiple vessel lesions (OR = 2.275, 95%CI: 1.536-3.369) were the independent risk factors of aVR T wave postive in patients with ST-segment elevation myocardial infarction (P < 0.05). Conclusion aVR T wave positive is the risk factor of multi vessel lesions in patients with ST-segment elevation myocardial infarction. Close monitoring of aVR T wave can evaluate the degree of coronary artery lesions in patients with ST-segment elevation myocardial infarction.
2020 Vol. 17 (8): 76-79 [Abstract] ( 218 ) HTML (1 KB)  PDF (577 KB)  ( 85 )
80 The value of circulating blood ANRIL in the early diagnosis of acute myocardial infarction
HUANG Ying ZHANG Yun NONG Wenzheng LAN Biyang PAN Rubao ZHANG Dingmin
Objective To investigate the value of circulating ANRIL in the early diagnosis of acute myocardial infarction (AMI). Methods Blood samples were collected from 50 AMI patients (experimental group) and 30 patients with coronary angiography normally (control group) from November 2016 to June 2018 in Affiliated Ethnic Hospital of Guangxi Medical University (hereinafter referred to as “our hospital”). Quantitative real-time fluorescence polymerase chain reaction (qRT-PCR) was used to detect the levels of circulating ANRIL at different time intervals (0-6 h, 12 h, 24 h, 7 d and 14 d) after the onset of symptoms of AMI. And the level of plasma cTnT was detected by using electrochemiluminescence． Results There was no significant difference in age, gender, smoking, diabetes, LDL-C, SBP, DBP and Cr between two groups (P ＞ 0.05). There was significant difference in cTnT between two groups (P < 0.05). Compared with control group, the expression level of ANRIL and cTnT in the plasma of AMI patients increased significantly (P < 0.05). In experimental group, the expression level of ANRIL began to increase at the time of admission, decreased after reaching the peak at 12 h, and decreased to the normal range at 7 d. CTnT had a very long diagnostic window period, it started to rise significantly at 6-12 h, then decreased at 24 h, and falled to the normal range at 14 d. ROC analysis showed that when the expression value of ANRIL in 6 h was 3.65 times (the highest value) of the normal control, the sensitivity was 91.9%, the specificity was 91.1%, which was the best diagnostic node; when the cTnT value increased to the highest value of 24 h, the sensitivity and specificity of AMI diagnosis was 91.8%, 92.4% respectively. Conclusion The expression of circulating ANRIL in AMI patients increases significantly and changes dynamically with the course of disease. Compared with cTnT, circulating ANRIL has earlier time window and peak time. It has good early sensitivity and specificity for the diagnosis of AMI.
2020 Vol. 17 (8): 80-83 [Abstract] ( 252 ) HTML (1 KB)  PDF (645 KB)  ( 78 )
84 Effect of aerobic exercise combined with folic acid on cognitive function, serum cytokines and Hcy in patients with Alzheimer′s disease
ZHANG Shanshan1 JI Yifei1 PU Chao2 LONG Jifa1 LIU Pingping1 ZHANG Yi1
Objective To implore the effect of aerobic exercise combined with folic acid on cognitive function, serum cytokines and homocysteine (Hcy) in patients with Alzheimer′s disease (AD). Methods From May 2016 to January 2018, 86 cases with AD who treated in Nanchong City Central Hospital of Sichuan Province were selected. They were divided into control group and observation group according to the random number table method, with 43 cases in each group. Control group was treated with Donepezil Hydrochloride combine with aerobic exercise training, while observation group was treated with folic acid on the basis of control group. Both groups were treated for 3 months. Mini-mental state scale (MMSE) and the Alzheimer′s disease rating scale-cognitive sub-table (ADAS-cog) were used to evaluate the cognitive function of the patients. Serum levels of Hcy, interleukin-6 (IL-6), IL-1β and tumor necrosis factor-α (TNF-α) before and after treatment were compared between two groups. Results There was no significant difference in MMSE scores and ADAS-cog scores between two groups before treatment (P > 0.05). After treatment, MMSE scores in two groups were higher than those before treatment, and observation group were higher than control group. ADAS-cog scores of two groups were lower than those before treatment, and observation group was lower than control group, with statistically significant differences (all P < 0.05). There was no significant difference in serum cytokine levels and serum Hcy levels between two groups before treatment (P > 0.05). After treatment, serum levels of IL-6, TNF-α and IL-1β in two groups were lower than those before treatment, and observation group were lower than control group, with statistically significant differences (all P < 0.05). The serum Hcy level in observation group was lower than that before treatment, and observation group was lower than control group, with statistically significant difference (all P < 0.05). Conclusion Folic acid combined with aerobic exercise training can more effectively improve the cognitive function of AD patients, which may be related to the down-regulation of serum Hcy levels and the suppression of secretion of pro-inflammatory cytokines.
2020 Vol. 17 (8): 84-87 [Abstract] ( 232 ) HTML (1 KB)  PDF (510 KB)  ( 43 )
88 Comparison of effect of early enteral nutrition and delayed enteral nutrition on postoperative patients with severe craniocerebral trauma
QIN Shu GU Yudan FEI Yaya GONG Peipei JI Xiaoliang
Objective To investigate the effect of early enteral nutrition and delayed enteral nutrition on postoperative patients with severe craniocerebral trauma. Methods A total of 106 cases with severe craniocerebral trauma who treated in Affiliated Hospital of Nantong University from June 2017 to June 2019 were enrolled. They were divided into control group and observation group groups according to the random number table method, with 53 cases in each group. Enteral nutrition was started in control group from 48 h to 5 d after operation, and enteral nutrition was started in observation group from 24 h to 48 h (excluding 48 h) after operation. Nutritional status, postoperative complication, ICU stay time and glasgow outcome score (GOS) before intervention and after 10 d intervention were compared between two groups. Results There was no significant difference in hemoglobin, albumin and prealbumin between two groups before intervention (P > 0.05). The levels of hemoglobin, albumin and prealbumin after 10 d intervention in observation group were higher than before intervention and control group , and the differences were statistically significant (P < 0.05). The incidence of postoperative diarrhea, pulmonary infection and constipation in observation group were lower than those in control group, and the differences were statistically significant (P < 0.05). The time of admission to the intensive care unit was shorter than that of control group, the GOS scores at the time of discharge of observation group were higher than those of control group, and the differences were statistically significant (P < 0.05). Conclusion Early enteral nutrition can improve nutritional status, reduce the incidence of complications and promote the relief of patients with severe craniocerebral injury. It is worth promoting.
2020 Vol. 17 (8): 88-91 [Abstract] ( 183 ) HTML (1 KB)  PDF (503 KB)  ( 136 )
92 Effect of evaluation-based optimal treatment on metabolic syndrome in schizophrenia
XI Lingyan1 JIN Guixing2▲ QIAO Jingshuang1 HUANG Xiuqin1 ZHANG Suyun1 ZHANG Qian1
Objective To explore the effect of evaluation-based optimal treatment on metabolic syndrome (MS) in schizophrenia. Methods From March 2017 to March 2018, 120 cases with schizophrenia who diagnosed and treated in Hengshui Mental Hospital were selected. According to the random number table method, they were divided into study group and control group, with 60 cases in each group. Study group was taking Risperidone Tablets, and those with poor curative effects switched to Olanzapine. Control group was given Risperidone Tablets. Psychopathological symptoms were assessed using the negative and positive symptom scale (PANSS), and adverse drug reactions were assessed using the treatment emergent symptom scale (TESS). Fasting blood glucose (FBG), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) levels were recorded and compared between two groups. Results There was no significant difference in scores of positive symptoms, negative symptoms, general psychopathology and PANSS between two groups before treatment (P > 0.05). The scores of positive symptoms, negative symptoms, general psychopathology and PANSS at the end of the 4th week of treatment in two groups were lower than those before treatment, and the scores of positive symptoms and PANSS in study group were lower than those in control group, with statistically significant differences (all P < 0.05). The scores of positive symptoms, negative symptoms, general psychopathology and PANSS at the end of the 8th week of treatment in two groups were lower than those before treatment and the end of the 4th week of treatment, and the scores of general psychopathology and PANSS in study group were significantly lower than those in control group, with statistically significant differences (all P < 0.05). There was no significant difference in MS detection rate between two groups at different times (P > 0.05). There was no significant difference in body mass index (BMI), FBG, systolic blood pressure (SBP), diastolic pressure (DBP) and HDL-C between two groups before treatment (P > 0.05). TG level in study group was higher than that in control group, and the difference was statistically significant (P < 0.05). FBG and SBP levels at the end of the 4th week of treatment in study group were higher than before treatment, while BMI and HDL-C levels in control group were higher than before treatment, the levels of FBG and DBP in study group were higher than those in control group, with statistically significant differences (all P < 0.05). SBP level at the end of the 8th week of treatment in study group was lower than that at the end of the 4th week of treatment, TG level was higher than that at the 4th week of treatment, and FBG level was higher than that before treatment, BMI and DBP levels in control group were higher than those before treatment, TG and HDL-C levels in study group were higher than those in control group, with statistically significant differences (all P < 0.05). Compared with the 2th weekend of treatment, TESS scores in both groups were decreased at the 4th and 8th weeks of treatment; compared with the treatment group at the end of the 4th week, both groups had lower TESS scores at the end of the 8th week, and study group was lower than control group, with statistically significant differences (all P < 0.05). Conclusion The optimal treatment model based on evaluation is used to treat schizophrenia, which has better efficacy than traditional treatment model and has similar effects on metabolic syndrome.
2020 Vol. 17 (8): 92-96 [Abstract] ( 153 ) HTML (1 KB)  PDF (486 KB)  ( 44 )
97 Effect of Kanggongyan Tablets combined with Recombinant Human Interferon α2b Gel in the treatment of chronic cervicitis
ZHOU Rui GAO Yanhong TIAN Mengdie
Objective To investigate the clinical efficacy of Kanggongyan Tablets combined with Recombinant Human Interferon α2b Gel in the treatment of chronic cervicitis. Methods From March 2018 to June 2019, 198 cases of chronic cervicitis who admitted to Liaoning Health Industry Group Fuxin Mine General Hospital were selected. They were divided into control group (n = 99, Recombinant Human Interferon α2b Gel treatment) and study group (n = 99, Kanggongyan+Recombinant Human Interferon α2b Gel treatment) according to the random number table method. The course of treatment was 2 weeks. The clinical efficacy, immunoglobulin (Ig) M, IgG, IgA, hypersensitive C-reactive protein (hs-CRP), interleukin-10 (IL-10) and vascular endothelial growth factor (VEGF), natural killer T cells (NKTs) of two groups were compared, and the adverse reactions were recorded. Results The total clinical effective rate of study group was significantly higher than that of control group (P < 0.05). There was no significant difference in the indexes of immune function between two groups before treatment (P > 0.05). After treatment, the levels of IgM, IgG and IgA in two groups were higher than those before treatment, and study group was higher than control group (P < 0.05). There was no significant difference in serum inflammatory factors and cytokines between two groups before treatment (P > 0.05). After treatment, the levels of hs-CRP, IL-10 and VEGF in two groups were lower than those before treatment, and study group was lower than control group (P < 0.05), the level of NKTs was higher than that before treatment, and study group was higher than control group (P < 0.05). There was no difference in the total incidence of adverse reactions between two groups (P > 0.05). Conclusion Kanggongyan Tablets combined with Recombinant Human Interferon α2b Gel are effective in treating chronic cervicitis. It can significantly improve immune function, reduce inflammatory reaction, and has a high safety. Clinical treatment can be used for reference.
2020 Vol. 17 (8): 97-100 [Abstract] ( 253 ) HTML (1 KB)  PDF (373 KB)  ( 96 )
101 Clinical effect of Icotinib Hydrochloride Tablets combined with whole-brain radiotherapy in the treatment of brain metastasis of non-small cell lung cancer
LI Wenge GE Wei
Objective To investigate the short-term efficacy and safety of Icotinib Hydrochloride Tablets (Conmana) combined with whole-brain radiotherapy in the treatment of advanced non-small cell lung cancer with brain metastasis. Methods The clinical data of 142 patients with non-small cell lung cancer with brain metastasis admitted to the Renmin Hospital of Wuhan University from February 2013 to February 2016 were retrospectively analyzed. According to the treatment approaches, they were divided into 51 cases in the group of Icotinib Hydrochloride Tablets combined with whole-brain radiotherapy, 51 cases in the group of Icotinib Hydrochloride Tablets and 40 cases in the group of whole-brain radiotherapy. In the Icotinib Hydrochloride Tablets combined with whole-brain radiotherapy group, whole-brain radiotherapy was performed simultaneously with oral administration of Icotinib Hydrochloride Tablets. The radiotherapy dose was 40-50 Gy/20-25 F, and the radiotherapy was completed within one month. Icotinib Hydrochloride Tablets were taken orally once a day at the beginning of radiotherapy, and the dose was 125 mg, 3 times a day. In the Icotinib Hydrochloride Tablets group, one Icotinib Hydrochloride Tablet was taken orally every day at a dose of 125 mg, 3 times a day. The whole-brain radiotherapy group received a radiotherapy dose of 40-50 Gy/20-25 F. The radiotherapy was completed within one month. In the three groups, the drug of parients was discontinued until the disease progressed or an intolerable toxic reaction occurred, and the progression-free survival time was calculated from the start of treatment until the disease progressed. Chi-square test was used to analyze whether there were significant differences in objective response rate, disease control rate and incidence of adverse reactions among the three groups of patients, and Kaplan-Meier test was used to analyze whether there were significant differences in progression-free survival among the three groups of patients. Results The objective response rate and disease control rate of Icotinib Hydrochloride Tablets combined with whole-brain radiotherapy group were higher than those of the Icotinib Hydrochloride Tablets group and the whole-brain radiotherapy group, the differences were statistically significant (all P ＜ 0.05). There was no significant difference in the objective response rate and disease control rate between the Icotinib Hydrochloride Tablets group and the whole-brain radiotherapy group (P ＞ 0.05). Median progression-free survival in the Icotinib Hydrochloride Tablets combined with whole-brain radiotherapy group was higher than that in the Icotinib Hydrochloride Tablets group and higher than that in the whole-brain radiotherapy group, the differences were statistically significant (all P ＜ 0.05). The median progression-free survival time of the Icotinib Hydrochloride Tablets group was not significantly different from that of the whole-brain radiotherapy group (P ＞ 0.05). The one-year survival rate of Icotinib Hydrochloride Tablets combined with whole-brain radiotherapy group was 66.7% higher than that of the Icotinib Hydrochloride Tablets group (41.2%) and the whole-brain radiotherapy group (37.5%), with statistically significant differences (all P ＜ 0.05). There was no significant difference in the incidence of adverse reactions among the three groups of parients (P ＞ 0.05). Conclusion Icotinib Hydrochloride Tablets combined with whole-brain radiotherapy can significantly improve the disease control rate and progression-free survival time of patients with tolerable adverse reactions.
2020 Vol. 17 (8): 101-105 [Abstract] ( 171 ) HTML (1 KB)  PDF (605 KB)  ( 110 )
106 Meta-analysis on the effect of colorectal cancer screening in China
YUAN Ping MA Xingfan
Objective To systematically evaluate the effectiveness of screening for colorectal cancer in China by questionnaire survey combined with fecal occult blood tests. Methods Computer search was conducted on CNKI, WanFang, PubMed, EBSCO and other Chinese and foreign language databases, supplemented by reference tracing and manual search methods, to find literatures with a population of more than 5000 in the primary screening population of colorectal cancer. The retrieval time was from the database construction to June 2016. R3.3.1 software was used for meta-analysis. The screening effect was analyzed by the initial screening positive rate, the detection rate and early diagnosis rate of colorectal lesions and the detection rate of colorectal cancer, and the detection rate of colorectal lesions was analyzed by stratification. Results In the end, 28 articles were included, and a total of 3 398 895 people were screened. Meta-analysis results showed that the initial screening positive rate was 14% [95%CI (11%-19%), P ＜ 0.0001]. The detection rate of colorectal lesions was 16% [95%CI (12%-19%), P ＜ 0.0001], and the early diagnosis rate was 93% [95%CI (92%-95%), P ＜ 0.0001]. The detection rate of colorectal cancer was 1% [95%CI (1%-2%), P ＜ 0.0001]. Stratified analysis of the detection rate of colorectal lesions found that: urban (17%) was higher than rural (8%), the South (15%) was slightly higher than the North (12%), the results of opportunistic colorectal cancer screening based on physical population (13%) were slightly lower than those of the natural community population (16%). Conclusion The questionnaire survey combined with the sequential screening method of fecal occult blood for colorectal cancer can increase the positive rate of initial screening, suitable for areas with poor compliance with colonoscopy.
2020 Vol. 17 (8): 106-112 [Abstract] ( 213 ) HTML (1 KB)  PDF (1745 KB)  ( 134 )
113 Predictive value of IL-6 combined with NLR on the prognosis of patients with triple negative breast cancer after sugery
LIU Junling1 ZHOU Ge2 GUO Hongbin2
Objective To investigate the predictive value of interleukin-6（IL-6） combined with neutrophil/lymphocyte ratio (NLR) on the prognosis of patients with triple negative breast cancer after surgery. Methods A total of 540 patients with triple negative breast cancer who underwent radical mastectomy in Liaoyang City Central Hospital of Liaoning Province from January 2015 to December 2017 were selected as subjects. Serum IL-6 level of the patients was detected by enzyme-linked immunosorbent assay, and the number of neutrophils and lymphocytes were detected by hematology analyzer, and the NLR value was calculated. Logistic regression was used to analyze the risk factors of poor prognosis of triple negative breast cancer. Receiver operating curve (ROC) was used to evaluate the predictive value of serum IL-6 and NLR to the prognosis of patients. The prognosis of the patients was followed up after discharge. Results By the end of follow-up, 141 patients had poor prognosis, the incidence was 26.11%. The poor prognosis of triple negative breast cancer was correlated with TNM stage, NLR and IL-6 levels (P ＜ 0.05). Logistic regression analysis showed that NLR (OR = 3.652, 95%CI：1.804-7.918, P = 0.000) and IL-6 levels (OR = 2.361, 95%CI：2.169-2.770, P = 0.006) were risk factors for poor prognosis of triple negative breast cancer (P ＜ 0.05). ROC curve showed that the cutoff value of IL-6 was 128.06 ng/mL, the sensitivity was 71.67% and the specificity was 70.83%, the cutoff value of NLR was 2.61, the sensitivity was 75.31% and the specificity was 79.65%. Conclusion Increased levels of NLR and serum IL-6 are risk factors for poor prognosis in triple negative breast cancer. Combined testing for NLR and serum IL-6 can improve sensitivity and specificity and predict poor prognosis in patients.
2020 Vol. 17 (8): 113-116 [Abstract] ( 210 ) HTML (1 KB)  PDF (534 KB)  ( 89 )
117 Analysis of clinical characteristics and prognostic factors of different molecular types of young breast cancer
AI Yongbiao YUAN Jie LI Wenfang WANG Qun
Objective To investigate the clinicopathological characteristics and prognostic differences of patients with different molecular types of breast cancer at the age of 35 and below, and to analyze the prognostic factors. Methods The clinical data of 89 cases of young breast cancer patients (≤35 years old) treated in Taihe Hospital of Shiyan City, Hubei Province from February 2007 to January 2014 were retrospectively analyzed, and the clinicopathological characteristics and prognostic factors were analyzed. Results There were 86 cases of surgical treatment and 3 cases of salvage treatment in young breast cancer patients. Surgery in patients with Luminal A type 21 cases, 16 cases of Luminal B type, HER-2 overexpression was found in 11 cases, triple negative breast cancer 38 cases, invasive ductal carcinoma in 73 cases, clinical staging Ⅱ period 54.6% and Ⅲ period was 24.4%. There was no significant difference in tumor size, clinical stage, Ki67, lymph node metastasis and other indicators in different molecalar types (P ＞ 0.05). There was no statistically significant difference in recurrence, metastasis and survival rate between 3 and 5 years of follow-up (P ＞ 0.05). Tumor size, lymph node metastasis, Ki67, age and clinical stage were the main factors influencing the prognosis of young breast cancer (P ＜ 0.05). Lymph node metastasis, tumor size and clinical stage were independent risk factors for prognosis (P ＜ 0.05). Conclusions The majority of young breast cancer patients are triple negative, and the clinical stage is late. Tumor size and lymph node metastasis have a great influence on the prognosis, so early diagnosis and early treatment are needed to improve the prognosis. However, the effect of molecular typing on the prognosis needs to be further studied.
2020 Vol. 17 (8): 117-120 [Abstract] ( 227 ) HTML (1 KB)  PDF (531 KB)  ( 51 )
121 Effect of epidermal growth factor receptor tyrosine kinase inhibitor combined with 125I radioactive seed implantation in the treatment of non-small cell lung cancer
SHE Hua CHEN Kai
Objective To investigate the efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIS) combined with 125I radioactive seed implantation in the treatment of non-small cell lung cancer (NSCLC). Methods From June 2015 to May 2017, 70 patients with NSCLC from Department of Radiology, Affiliated Hospital of Xiangnan University were selected. According to the different treatment methods, they were divided into the control group (35 cases) and the observation group (35 cases). The patients in the control group were treated with EGFR-TKIS, and the observation group was treated with 125I radioactive seed implantation on the basis of the control group. The curative effect, the adverse reaction and the survival rate of the two groups were compared, and the Karnofsky performance starus score (KPS score) before and after treatment was compared. Results The effective rate and local control rate in the observation group were significantly higher than those in the control group (all P ＜ 0.05). There was no significant difference in pneumothorax, diarrhea, adverse reaction of skin and the rate of bone marrow suppression between the two groups (P ＞ 0.05). Follow-up was conducted for 30 months, 26 cases died in the control group and 18 cases in the observation group. The 1 year survival rate and 2 years survival rate in the observation group were significantly higher than those in the control group (P ＜ 0.05). The non-progression survival time was significantly higher than that in the control group (P ＜ 0.05). After 3 months of treatment, the Karlman score in the observation group was significantly higher than that in the control group (P ＜ 0.05). Conclusion EGFR-TKIS combined with 125I radioactive seed implantation can improve the therapeutic effect and local control rate of NSCLC patients, improve the 1 year and 2 years survival rate and progression-free survival time of patients, improve the quality of life of patients after treatment, and do not increase the risk of treatment.
2020 Vol. 17 (8): 121-124 [Abstract] ( 221 ) HTML (1 KB)  PDF (533 KB)  ( 34 )
125 Effect of acupuncture combined with exercise relearning rehabilitation therapy on the recovery of nerve function and limb motor function in patients with cerebral ischemic stroke
JING Fuquan1 SUN Sa1 WANG Zengliang2
Objective To observe the effect of acupuncture on nerve function and limb motor function recovery in patients with cerebral ischemic stroke by acupoints of whole body, warm acupuncture of abdominal acupoints and exercise relearning rehabilitation therapy. Methods A total of 90 patients with cerebral ischemic stroke admitted to the First Affiliated Hospital of Xinjiang Medical University from February 2017 to February 2019 were selected. A randomized controlled study was conducted to divide the patients into treatment group and control group according to the random number table, with 45 patients in each group. Before the test, all patients were treated with Western medicine, including blood pressure control, improvement of brain circulation, stabilization of vital signs and prevention of complications. In the treatment group, acupuncture and moxibustion combined with exercise relearning rehabilitation therapy were used as the main treatment, and acupuncture and moxibustion were treated once a day and 10 times as a course of treatment. The control group was given rehabilitation treatment alone, 10 times of rehabilitation treatment for 1 course of treatment, and the patients in the two groups received a total of 2 courses of treatment. The nerve defect function and motor function were evaluated by the nerve defect function rating scale 1995 (CSS) and the international general motion function Fugl-Meyer assessment (FMA), and the clinical efficacy of the two groups of patients was compared. Results There was no significant difference in FMA score and CSS score between the two groups before treatment (P ＞ 0.05). After treatment, FMA score in both groups was higher than before treatment, while CSS score was lower than before treatment. FMA score in the treatment group was higher than that in the control group, while CSS score was lower than that in the control group, with statistically significant differences (P ＜ 0.05). The total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The improvement of nerve function and limb motor function in patients with ischemic stroke by acupuncture and moxibustion combined with cerebral exercise relearning rehabilitation therapy is superior to rehabilitation therapy alone, and is worthy of further promotion and application in clinic.
2020 Vol. 17 (8): 125-129 [Abstract] ( 291 ) HTML (1 KB)  PDF (706 KB)  ( 316 )
129 Analysis on the clinical characteristics and influencing factors of senile viral complicated bacterial pneumonia
HAN Fan1,2 ZHONG Guofu1,2 YE Ye1,2 ZHENG Min′an1,2 WANG Dawei1,2,3 LIU Yuntao1,2,3,4▲
Objective To identify the clinical characteristics and related influencing factors of senile viral bacterial pneumonia by comparing it with simple bacterial infectious pneumonia. Methods A case-control trial was designed to study elderly patients with pneumonia diagnosed in the emergency treatment, observation, comprehensive ward hospitalization department of Guangdong Provincial Hospital of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from January 2016 to June 2018. The patients who were clearly diagnosed as respiratory virus infection by etiology were in the viral complicated bacterial pneumonia group. The patients were matched by age and gender at 1∶1, and the elderly patients with simple bacterial infection diagnosed in our hospital at the same time were selected as the simple bacterial pneumonia group, with 70 cases in each group. The basic clinical information, previous medical history, clinical symptoms and signs, laboratory examination results and pathogenic indicators of patients in the two groups were collected. The clinical characteristics and related influencing factors of senile viral complicated bacterial pneumonia were studied by intergroup comparison and logistic regression. Results Parainfluenza virus, influenza virus B and influenza virus A were the main infectious agents of senile pneumonia. The proportion of diabetes mellitus, cerebrovascular disease and malignant tumor in the viral complicated bacterial pneumonia group was higher than that in the simple bacterial pneumonia group, the incidence rate of cough and shortness of breath was lower than that of bacterial pneumonia group, the average body temperature was higher than that of bacterial pneumonia group, the abnormal proportion of white blood cell count, neutrophils, calcitonin, hypersensitive C-reactive protein, blood lactic acid, carbon dioxide partial pressure in arterial blood, total bilirubin, prothrombin time, international standardized ratio, D-Dimer and other indicators were higher than those of the simple bacterial pneumonia group, the abnormal proportion of red blood cell count and hemoglobin were lower than those in the simple bacterial pneumonia group, and the differences were statistically significant (all P ＜ 0.05). Correlation analysis showed that patients with diabetes, associated with shortness of breath, abnormal blood carbon dioxide partial pressure, abnormal blood lactic acid, and abnormal total bilirubin may be associated with viral complicated bacterial pneumonia, while abnormal hemoglobin may be associated with simple bacterial pneumonia (P ＜ 0.05). Conclusion Parainfluenza virus and influenza virus are the main pathogens of senile viral complicated bacterial pneumonia patients. Diabetes may increase the risk of senile viral complicated bacterial pneumonia. Associated with shortness of breath, blood carbon dioxide partial pressure, blood lactic acid, total bilirubin and other abnormalities, may indicate the possibility of viral complicated bacterial pneumonia.
2020 Vol. 17 (8): 129-133,143 [Abstract] ( 173 ) HTML (1 KB)  PDF (742 KB)  ( 74 )
134 Analysis of risk factors for repeated hospitalization and death in newly increased elderly hemodialysis patients
GENG Lei1 WU Weihua1 HUANG Chaoyue1 LIU Jian1,2
Objective To explore the risk factors of repeated hospitalization in the first year after starting dialysis and its correlation with long-term death in new elderly hemodialysis patients. Methods From July 2013 to June 2018, 166 patients aged ≥60 years old who started dialysis treatment in the hemodialysis room of the Affiliated Hospital of Southwest Medical University were screened out. According to the frequency of hospitalization in the first year after the start of regular dialysis, the patients were divided into non-hospitalization group (57 cases), hospitalization for 1-2 times (71 cases), hospitalization for 3 times or more (38 cases). The laboratory data, complications, all-cause mortality, etc. of patients in the three groups before starting dialysis were compared, and the orderly logistic regression model and COX regression model were respectively used to explore the hospitalization frequency and risk factors of death of the patients. Results A total of 242 hospitalizations were made in 166 patients in the first year after the start of dialysis, with 58 deaths due to all causes by June 2019. The main causes of hospitalization were infectious diseases, cardiovascular events and complications related to vascular access. The main causes of death were cardiovascular events, severe infections and cerebrovascular accidents. Multivariate logistic regression analysis showed that old age, low immunoreactive parathyroid hormone (iPTH), high B natriuretic peptide (BNP), low albumin and low hemoglobin were associated with increased hospitalization risk (P ＜ 0.05), and COX regression analysis showed that hospitalization frequency, low iPTH, high BNP and low albumin were risk factors for death of patients in the first year after the start of dialysis (P ＜ 0.05). Conclusion Low iPTH, low proteinemia and high BNP before dialysis are risk factors for hospitalization and long-term death of patients.
2020 Vol. 17 (8): 134-138 [Abstract] ( 217 ) HTML (1 KB)  PDF (728 KB)  ( 110 )
139 Clinical effect of hyaluronic acid repair biofilm combined with Loratadine Tablets in the treatment of atopic dermatitis
LIU Wenfang1 ZHAO Zishen2 ZHANG Haixiang2
Objective To observe the clinical effect of hyaluronic acid repair biofilm combined with Loratadine Tablets in the treatment of atopic dermatitis and the effect on serum interleukin（IL）-2 and IL-4 levels. Methods One hundred and sixty patients with atopic dermatitis who were admitted to Cangzhou People′s Hospital from January 2017 to February 2018 were collected and divided into the control group and the observation group according to the random number table method, with 80 cases in each group. The control group was treated with Loratadine Tablets (10 mg/ time, 1 time/d). The observation group was given hyaluronic acid repair biofilm for skin care on the basis of treatment of the control group, once in the morning and once in the evening, after 4 weeks of continuous treatment. Scoring atopic dermatitis index (SCORAD), visual analogue scale (VAS), sebum content, cuticle water content, scale human tissue kallikelin 5 (KLK5), transepidermal water loss (TEWL), immature cornified envelope in scales (CE), serum IL-2, IL-4 and clinical efficacy were compared between the two groups. Results There was no significant difference in SCORAD and VAS scores before treatment between the two groups (P ＞ 0.05). Compared with before treatment, the SCORAD and VAS scores of the two groups were significantly decreased after treatment, and the SCORAD and VAS scores in the observation group were significantly lower than that in the control group, the differences were highly statistically significant (all P ＜ 0.01). There was no significant difference in sebum content, cuticle water content, KLK5 in scales, TEWL and immature CE ratio in scales between the two groups before treatment (P ＞ 0.05). Compared with before treatment, sebum content, cuticle water content and KLK5 in scales in the two groups were significantly increased after treatment, while the proportion of TEWL and immature CE in scales was significantly reduced, and the sebum content, cuticle water content and KLK5 in scales in the observation group were significantly higher than those in the control group, while the proportion of TEWL and immature CE in scales was significantly lower than that in the control group after treatment, the differences were highly statistically significant (all P ＜ 0.01). There was no significant difference in serum IL-2 and IL-4 between the two groups before treatment (P ＞ 0.05). Compared with the two groups before treatment, the serum IL-2 level significantly increased and IL-4 level significantly decreased in the two groups after treatment, and the serum IL-2 level in the observation group was significantly higher than that in the control group, while the serum IL-4 level was significantly lower than that in the control group after treatment, the differences were highly statistically significant (all P ＜ 0.01). Conclusion Hyaluronic acid repair biofilm combined with Loratadine Tablets can significantly improve the clinical symptoms, skin barrier function and clinical efficacy of atopic dermatitis patients, and its possible mechanism is related to the regulation of Th1/Th2 cytokine balance.
2020 Vol. 17 (8): 139-143 [Abstract] ( 284 ) HTML (1 KB)  PDF (676 KB)  ( 99 )
144 High risk factors for short-term recurrence of idiopathic granulomatous mastitis
REN Yun1 XU Jianzhong1 YANG Haibo2 ZHANG Jindan1
Objective To analyze the clinical characteristics and treatment of idiopathic granulomatous mastitis (IGM) with recurrence in the short term (within 1 year) after cure. Methods Seventy patients with pathologically confirmed IGM admitted to the department of breast surgery of Changzhi People′s Hospital of Shanxi Province and Shanxi Dayi Hospital from January 2017 to June 2018 were selected as the study subjects, among which 42 cases were treated with combination therapy (drugs + surgery) and 28 cases were treated with surgical treatment alone. Patients were divided into the relapsing group (14 cases) and the non-relapsing group (56 cases) according to whether they had relapsed within 1 year of cure. The clinical characteristics and treatment methods of the two groups were compared. Results There were statistically significant differences in body mass index with or without abscess fluid and with or without fistula (sinus tract) between the two groups (P ＜ 0.05). There was no significant difference in age, lactation time and mass size between the two groups (P ＞ 0.05). After multi-factor analysis, surgery alone and high body mass index were independent risk factors for recurrence (P ＜ 0.05). The risk of recurrence in patients who received surgical treatment alone was 7.8 times higher than that in patients receiving combined treatment, and the risk of recurrence in obese patients was 1.3 times higher than that in other patients. Conclusion Patients with obesity, breast abscesses and fistula (sinus tract) formation, and surgical treatment alone have a higher risk of short-term recurrence. Surgical treatment alone and obesity are independent risk factors for recurrence after treatment.
2020 Vol. 17 (8): 144-147 [Abstract] ( 143 ) HTML (1 KB)  PDF (707 KB)  ( 61 )
148 Expression level and the diagnostic value of glial cell line-derived neurotrophic factor and Nod-like receptor protein 3 inflammatory in patients with depression
TIAN Haihua1 LIU Jimeng2 XU Guoan2 LI Guangxue2 WAN Xiaohan2,3 ZHANG Jiao2,3 GAO Shugui2
Objective To investigate the changes of glial cell-derived neurotrophic factor (GDNF) and nod-like receptor protein 3 (NLRP3) inflammasome in major depressive disorder patients and analyze the diagnostic value. Methods A total of 100 patients with major depressive disorder admitted to the Department of Affective Disorder, Ningbo Kangning Hospital (“our hospital” for short) from January 2018 to June 2019 were selected as the depression group. A total of 60 healthy people underwent routine physical examination in our hospital during the same period were selected as the control group. The expression of serum GDNF and NLRP3 inflammasome were compared between the two groups of patients and patients with depression of different severity. The correlation between the severity of depression and the diagnostic efficacy of GDNF and NLRP3 inflammasome single test and combined test in diagnosing depression were calculated. Results The level of GDNF in the depression group was significantly lower than that of the control group, and the serum NLRP3 level of the inflamatome was significantly higher than that of the control group, with statistically significant differences (all P ＜ 0.05). The levels of GDNF and NLRP3 in patients with depression of different severity were statistically significant differences (P ＜ 0.05). Compared with the mild depression group, the GDNF level in the moderate depression group and the severe depression group were decreased and the NLRP3 inflammasome was increased, the differences were statistically significant (all P ＜ 0.05). Compared with the moderate depression group, the GDNF level in the severe depression group were decreased and the NLRP3 inflammasome was increased, the differences were statistically significant (all P ＜ 0.05). The expression level of GDNF was negatively correlated with the severity of depression (r = -0.603, P ＜ 0.05), while the expression level of serum NLRP3 inflamosome was positively correlated with the severity of depression (r = 0.762, P ＜ 0.05). The sensitivity and specificity of combined detection of GDNF and NLRP3 inflammasome in diagnosing depression were significantly higher than that of single detection of GDNF and NLRP3 inflammasome and the combined detection has good specificity. Conclusion The abnormal expression of GDNF and serum NLRP3 inflammarosome is closely related to the occurrence and development of depression, and the combined detection of GDNF and NLRP3 inflammarosome is helpful for the diagnosis and condition evaluation of depression.
2020 Vol. 17 (8): 148-151 [Abstract] ( 191 ) HTML (1 KB)  PDF (769 KB)  ( 79 )
152 Application effect of acupuncture and modern rehabilitation exercise therapy in the cerebral vascular disease of upper limb with spasmodic pattern
ZHANG Qian1,2 QIN Hai1 SONG Yingnan1 GAO Lijuan3
Objective To evaluate the effect of acupuncture combined with modern rehabilitation exercise therapy in patients with cerebral vascular disease of upper limb spasmodic cerebrovascular disease. Mothods From January 2018 to June 2019, a total of 50 cases of cerebrovascular patients with spasm pattern admitted to Department of the Second Acupuncture and Moxibustion, the Second Affiliated Hospital, Heilongjiang University of Chinese Medicine were selected and they were divided into treatment group and control group by random number table method, with 25 cases in each group. The control group was treated with Eperisone Hydrochloride Tablets combined with modern rehabilitation exercise therapy, while the treatment group was treated with acupuncture combined with modern rehabilitation exercise therapy. The results of modified Ashworth scale and muscle strength scale were compared between the two groups before and after treatment. Results Compared with before treatment, there were statistically significant differences in the scores of modified Ashworth scale and muscle strength scale between the two groups after treatment (all P ＜ 0.05). After treatment, there were statistically significant differences in the scores of the modified Ashworth scale and the muscle strength scale between the two groups (all P ＜ 0.05). After treatment, the total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Acupuncture combined with modern rehabilitation exercise therapy and Eperisone Hydrochloride Tablets combined with modern rehabilitation exercise therapy can improve the spasm mode of upper limb on the affected side of cerebrovascular patients, but the effect of acupuncture combined with modern rehabilitation exercise therapy on the affected side of upper limb spasm mode of cerebrovascular patients is significant.
2020 Vol. 17 (8): 152-155,159 [Abstract] ( 178 ) HTML (1 KB)  PDF (731 KB)  ( 221 )
156 Glucose metabolism status and the correlation with diet in adolescents  with phenylketonuria
ZUO Xuemei JIN yuqi QIU Hainan
Objective To investigate the relationship between glucose metabolism and diet control in adolescents with phenylketonuria (PKU). Methods A total of 96 PKU patients for regular reexamination in Chengde Maternal and Child health Care Hospital (“our hospital” for short) were selected from September 2016 to March 2019, and they were divided into PKU group (phenylalanine concentration in 240-600 μmol/L was good control group, and phenylalanine concentration ＞600 μmol/L was poorly control group), 100 healthy adolescents of the same age who came to our hospital for physical examination in the same period were selected as the control group. The relationship between dietary status, Phe control level and insulin resistance and the risk factors of diabetes mellitus in PKU group were analyzed. Results The daily carbohydrate intake, incidence of abnormal glucose tolerance, fasting glucose, blood glucose level at 2 h after meal and homeostasis insulin resistance index (HOMA-IR) in the well-controll group (64 cases) were higher than those in the poorly controll group (32 cases), with statistically significant differences (all P ＜ 0.05). Daily carbohydrate intake was positively correlated with HOMA-IR, while Phe control level was negatively correlated with HOMA-IR (all P ＜ 0.05). High daily carbohydrate intake was an independent risk factor for abnormal glucose tolerance and diabetes in adolescents (OR = 1.048, P ＜ 0.05), and Phe control level was a protective factor (OR = 0.992, P ＜ 0.05). Conclusion The risk of abnormal glucose tolerance and insulin resistance in adolescents with PKU may be associated with higher carbohydrate intake.
2020 Vol. 17 (8): 156-159 [Abstract] ( 172 ) HTML (1 KB)  PDF (667 KB)  ( 81 )
160 Clinical experience of professor Li Yueting in preventing and treating stone recurrence after gallbladder-preserving cholecystolithotomy
HU Ziyan1，2 HAO Shaodong1，2 LI Yueting1，2
There is a certain rate of stone recurrence after minimally invasive gallbladder-preserving cholecystolithotomy. Professor Li Yueting believes that the location of the stone recurrence after gallbladder-preserving cholecystolithotomy is mainly in the liver and gallbladder, and it is related to spleen, stomach, intestines and other viscera. Its pathogenesis is related to the failure to distribute freely of liver and gallbladder, abnormal ascension and descension of spleen and stomach, fuqi obstruction of gallbladder and intestines. Clinic treatment is mainly consisted of dispersing stagnated liver qi for promoting bile flow, activating qi and purging fu organs, combined with the methods of reconciling spleen and stomach, promoting blood circulation and removing blood stasis. When making formula and description, he not only pays attention to the application of “liver” treatment for liver-discharging first, but also to the treatment of “gallbladder” for the purpose of protecting the gallbladder, and to the treatment of the “intestines”, which is intended to clear the bile excretion from the clinical experience that “the intestinal excretion is also the bile drain”, and thus achieve its clinical effects.
2020 Vol. 17 (8): 160-163 [Abstract] ( 307 ) HTML (1 KB)  PDF (572 KB)  ( 23 )
164 Systematic evaluation and meta-analysis of effect of Radix Bupleuri medication in the treatment of cardiac neurosis
WANG Yiru1，2 WEI Jing1 LIU Ping1▲
Objective To systematically evaluate clinical effect and safety of Radix Bupleuri medication in the treatment of cardiac neurosis. Methods Randomized controlled trials about Radix Bupleuri medication treating cardiac neurosis were collected from CNKI, WanFang, VIP and PubMed database from library built until June 1, 2019. Studies were selected according to the inclusion, exclusion and quality. Observation group was treated with Radix Bupleuri medication, and control group did not include that. Review Manager 5.3 software was used to analyze. Results Thirty-four studies involving 3269 cases were included. Meta-analysis showed that compared with control group, Radix Bupleuri medication could increase the effective rate of clinical syndromes improvement [OR = 4.08, 95%CI (3.35, 4.97), P < 0.000 01], reduce self-rating anxiety scale score [MD = -6.68, 95%CI (-11.46, -1.90), P = 0.006], Hamilton anxiety scale score [MD = -2.85, 95%CI (-4.20, -1.50), P < 0.0001], self-rating depression scale score [MD = -14.45, 95%CI (-26.47, -2.42), P = 0.02] and Hamilton depression scale [OR = -2.12, 95%CI (-3.54, -0.70), P = 0.003]. There were less adverse events in Radix Bupleuri medication group [OR = 0.25, 95%CI (0.09, 0.75), P = 0.01]. The differences were statistically significant. Conclusion Radix Bupleuri medication can improve clinical symptoms of cardiac neurosis patients and cause less adverse reactions. As the low quality of included studies, more well-designed randomized controlled trials are required to prove this conclusion.
2020 Vol. 17 (8): 164-169,181 [Abstract] ( 218 ) HTML (1 KB)  PDF (2311 KB)  ( 104 )
170 Clinical effect of Erxian Decoction in adjuvant treatment of postmenopausal women with hypertension and its effect on estrogen and Kupperman score
XIANG Xiaojue SUN Tengfei ZHANG Yunxia WU Jing
Objective To investigate clinical effect of Erxian Decoction in adjuvant treatment of postmenopausal women with hypertension and its effect on estrogen and Kupperman score. Methods Randomized controlled clinical trial method was used, 68 postmenopausal women with hypertension treated in outpatient and ward of Wenzhou Traditional Chinese Medicine Hospital from June 2016 to December 2018 were selected and divided into two groups with random number table, control group (34 cases) was treated with Benazepril, and intervention group (34 cases) was treated with Erxian Decoction on the basis of Benazepril. Observed for 8 weeks, blood pressure, estrogen levels, Kupperman scores of two groups before and after treatment were recorded and curative effect between two groups was compared. Results After treatment, systolic and diastolic blood pressure levels of two groups were lower than those before treatment, intervention group was significantly lower than control group, the differences were statistically significant (P < 0.05). After treatment, estradiol level in  intervention group was higher than that before treatment and in control group, the differences were statistically significant (P < 0.05). After treatment, level of FSH in intervention group was lower than that before treatment and in control group, the difference was statistically significant (P < 0.05). After treatment, Kupperman scores of two groups were lower than those before treatment, and intervention group was significantly lower than control group, the differences were statistically significant (P < 0.05). Total effective rate of intervention group was higher than that of control group, the difference was statistically significant (P < 0.05). Conclusion Erxian Decoction can further reduce systolic and diastolic blood pressure of postmenopausal women with hypertension on the basis of Benazepril treatment. It can also regulate estrogen level and improve Kupperman score.
2020 Vol. 17 (8): 170-173 [Abstract] ( 145 ) HTML (1 KB)  PDF (607 KB)  ( 70 )
174 Professor Ti Guixiang′s skillful treatment for 3 cases of refractory palmar hyperhidrosis
PENG Yanwen LYU Pin TI Guixiang
Sweat is the product of human activity, blood circulation and metabolism. Palmar hyperhidrosis is a common clinical disease in traditional Chinese medicine, which is often seen in young women. The treatment effect of Western medicine is not good enough, and the experience of diagnosis and treatment in traditional Chinese medicine is rarely reported. Professor Ti Guixiang believes that palmar hyperhidrosis is a kind of perspiration syndrome. In addition to the conventional thinking, such as invigorating qi, nourishing yin, clearing away damp heat, etc., the prescription should follow the ancient rather than the ancient, with flexible thinking and overall grasp. For example, if young women need to consider whether the patients are easy to be nervous, anxious, insomnia, etc., the method of soothing the liver and calming the nerves should be taken into consideration or emphasized. If the sweating of the patient is limited, the sweating of the hand alone is obvious, and there is no abnormal sweating of other parts of the body, the sweating method can be used to make the sweating of the whole body as usual, then the sweating of the hand can be solved. There are 3 cases of refractory hand sweating syndrome attached.
2020 Vol. 17 (8): 174-177 [Abstract] ( 514 ) HTML (1 KB)  PDF (571 KB)  ( 121 )
178 Comparison of efficacy and prognosis of Roxadustat Capsules and recombinant human erythropoietin in the treatment renal anemia
LI Hongbin1 LIANG Jun1 MA Qiang2▲
Objective To investigate the efficacy and prognosis of Roxadustat Capsules and recombinant human erythropoietin (rhEPO) in the treatment of maintenance hemodialysis (MHD) with renal anemia. Methods A total of 56 cases with MHD renal anemia who admitted to Beijing East District First People′s Hospital from July to October 2019 were selected as the subjects. They were divided into control group and study group by random number table method, with 28 cases in each group. Two groups were treated with Ferrous Succinate Tablets orally, and control group was treated with rhEPO, while study group was treated with Roxadustat Capsules. They were treated for 3 months. Anemia indicators [red blood cell count (RBC), hemoglobin (Hb), hematocrit (Hct)] and iron metabolism indexes [serum ferritin (SF), transferrin saturation (TSAT), transferrin (TRF), hepcidin (Hepc)] were compared between two groups before and after 3 months of treatment, and the adverse reactions were recorded. Results There was no significant difference in the levels of RBC, Hb and Hct between two groups before treatment（P > 0.05）；after 3 months of treatment, the levels of RBC, Hb, Hct were significantly higer than those before treatment, and study group was higher than control group, and the differences were statistically significant（all P < 0.05）. There was no significant difference in the levels of SF, TSAT, TRF and Hepc between two groups before treatment（P > 0.05）. After 3 months of treatment, the levels of SF, TSAT an TRF were significantly higer than those before treatment, the levels of Hepc were lower than those before treatment. The levels of SF, TSAT and TRF in study group were significantly higer than those in control group, the levels of Hepc in study group were lower than those in control group, and the differences were statistically significant（all P < 0.05）. The adverse reactions in study group were lower than those in control group, and the differences were statistically significant（P < 0.05）. Conclusion Compared with rhEPO, Roxadustat Capsules has better efficacy in the treatment of patients with MHD renal anemia, and it can significantly correct the symptoms of anemia, increase the utilization rate of iron in the body, and has higher safety and application value.

 
2020 Vol. 17 (8): 178-181 [Abstract] ( 2146 ) HTML (1 KB)  PDF (382 KB)  ( 180 )
186 Discussion on the psychological support service model and negative emotion regulation function of family members of esophageal cancer patients under the perspective of social work
CHENG Shiwei WANG Wei
Objective To explore and analyze the negative emotion regulation function of the family′s psychological support service model of esophageal cancer patients under the social work perspective. Methods The families of 142 patients with esophageal cancer from the Department of Thoracic Surgery，Liaoning Cancer Hospital from January 2015 to January 2018 were selected as the study subjects，all patients′ family members were divided into observation group and control group according to the random number table method，with 71 cases in each group. Control group only received health education，including distribution of brochures and general knowledge dissemination. The observation group received implemented subthreshold psychological service support on the basis of the control group. The mental toughness，negative emotional changes and quality of life scores of the families of the two groups were compared. Results After intervention，the scores and total scores of fortitude，optimism and strength of family members of patients in the two groups were higher than before intervention，and the observation group was higher than the control group，with statistically significant differences （P ＜ 0.05）. After intervention，the cognitive reappraisal，expression inhibition score and total score of the families of patients in the two groups were higher than before intervention，and the observation group was higher than the control group，with statistically significant differences （P ＜ 0.05）. After intervention，the scores and total scores of physical function，role function，cognitive function，emotional function and social function of family members of patients in the two groups were all higher than before intervention，and the observation group was higher than the control group，with statistically significant differences （P ＜ 0.05）. Conclusion The application of the psychological support service model for the family members of patients with esophageal cancer from the perspective of social work can effectively improve the mental toughness of the family members of patients，play an effective role in regulating negative emotions，and improve the quality of life of the family members of patients.
2020 Vol. 17 (8): 186-189,封三 [Abstract] ( 202 ) HTML (1 KB)  PDF (582 KB)  ( 268 )
190 Professor Wang Xiaomin′s experience in treating tumor from “poison”
ZHANG Jiahui1,2 WANG Xiaomin2▲ YANG Yong2 YU Mingwei2
The word “poison” has a wide range of definitions in ancient Chinese medicine literature, and it refers to the property of medicine, the etiology, pathology and disease, and it can also be used as a verb or an adjective. “Poison” in tumor mainly refers to cancer poison, phlegm poison, blood stasis poison and turbid poison. In the course of traditional Chinese medicine treatment, it can be treated from the aspects of poison challenge, detoxification, detoxification and so on. Although they are all used for the treatment of poison, the direction of “poison” is different, and the methods and theories of clinical application are also different. This article will explain the understanding and application of “poison” in the treatment of tumors by traditional Chinese medicine.
2020 Vol. 17 (8): 190-193 [Abstract] ( 170 ) HTML (1 KB)  PDF (457 KB)  ( 112 )
194 Research on the current situation of conditional knowledge of “double-qualified” nursing teachers in universities
WANG Yanni QIAO Tingting
Objective To investigate the conditional knowledge of “Double-qualified” nursing teachers in universities．Methods From March to August 2019, a questionnaire survey was conducted among 240 “double-qualified” nursing teachers in a medical school in Xinjiang. The regression analysis was carried out by taking the conditional knowledge of teachers as the independent variable and the age, teaching age, educational background and professional title as the dependent variables. Results The study found that the scores of self-possessed conditional knowledge of “double-qualified” nursing teachers were not very high. The analysis results showed that there was no significant relationship between teachers′ conditional knowledge and their age, but it was positively correlated with teachers′ teaching age and professional title. The longer the teaching age was, the higher the professional title was, the richer the teachers′ conditional knowledge was（P ＜ 0.05）. Conclusion In order to improve the teaching ability of teachers, the school should provide special training of conditional knowledge for “double-qualified” nursing teachers, establish a teacher training base, and provide systematic training in teaching for each “double-qualified” nursing teacher. “Double-qualified” clinical nursing teachers should remember their teacher identity, spend more time in the role of teachers, actively participate in training, and strive to become a knowledge structure of “double-qualified” nursing teacher.
2020 Vol. 17 (8): 194-封三 [Abstract] ( 135 ) HTML (1 KB)  PDF (578 KB)  ( 113 )
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