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| Effect of self-made Shengui Baoxin Decoction on chronic heart failure and ventricular remodeling |
| SUN Xiaoyan1 YANG Lei2 ZHAO Dongpo1 FENG Qian1 |
1.The Third Department of Cardiology, the First Hospital of Zhangjiakou City, Hebei Province, Zhangjiakou 075000, China;
2.Department of Hematology, 81 Group Military Hospital of PLA Army, Hebei Province, Zhangjiakou 075000, China |
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Abstract Objective To investigate the effect of self-made Shengui Baoxin Decoction on chronic heart failure (CHF) and ventricular remodeling. Methods One hundred and thirty-seven CHF patients received in the First Hospital of Zhangjiakou City from August 2016 to May 2019 were divided into control group (n = 68) and study group (n = 69) by random number table method. Control group was given conventional treatment, while study group was given self-made Shengui Baoxin Decoction. The cardiac function index, clinical efficacy, serological index were compared between two groups. The occurrence of adverse reactions during treatment in two groups was recorded. Results Total clinical effective rate of study group was significantly higher than that of control group (P < 0.05). LVEF of two groups after 30 days of treatment was higher than that before treatment, LVEDD and LVESD of two groups after 30 days of treatment were shorter than those before treatment (P < 0.05), and the improvement of study group was significantly better than that of control group (P < 0.05). The levels of BNP and MMP-2 in two groups after 30 days of treatment were lower than those before treatment (P < 0.05), TIMP-1 in two groups after 30 days of treatment was higher than that before treatment (P < 0.05), and the improvement of study group was significantly better than that of control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion The self-made Shengui Baoxin Decoction can effectively reduce the levels of BNP and MMP-2, and improve the cardiac function of patients with CHF. It is safe and effective.
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