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| Clinical effect of Erxian Decoction in adjuvant treatment of postmenopausal women with hypertension and its effect on estrogen and Kupperman score |
| XIANG Xiaojue SUN Tengfei ZHANG Yunxia WU Jing |
| Department of Cardiovascular Medicine, Wenzhou Hospital of Traditional Chinese Medicine, Zhejiang Province, Wenzhou 325000, China |
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Abstract Objective To investigate clinical effect of Erxian Decoction in adjuvant treatment of postmenopausal women with hypertension and its effect on estrogen and Kupperman score. Methods Randomized controlled clinical trial method was used, 68 postmenopausal women with hypertension treated in outpatient and ward of Wenzhou Traditional Chinese Medicine Hospital from June 2016 to December 2018 were selected and divided into two groups with random number table, control group (34 cases) was treated with Benazepril, and intervention group (34 cases) was treated with Erxian Decoction on the basis of Benazepril. Observed for 8 weeks, blood pressure, estrogen levels, Kupperman scores of two groups before and after treatment were recorded and curative effect between two groups was compared. Results After treatment, systolic and diastolic blood pressure levels of two groups were lower than those before treatment, intervention group was significantly lower than control group, the differences were statistically significant (P < 0.05). After treatment, estradiol level in intervention group was higher than that before treatment and in control group, the differences were statistically significant (P < 0.05). After treatment, level of FSH in intervention group was lower than that before treatment and in control group, the difference was statistically significant (P < 0.05). After treatment, Kupperman scores of two groups were lower than those before treatment, and intervention group was significantly lower than control group, the differences were statistically significant (P < 0.05). Total effective rate of intervention group was higher than that of control group, the difference was statistically significant (P < 0.05). Conclusion Erxian Decoction can further reduce systolic and diastolic blood pressure of postmenopausal women with hypertension on the basis of Benazepril treatment. It can also regulate estrogen level and improve Kupperman score.
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