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| Effect of aerobic exercise combined with folic acid on cognitive function, serum cytokines and Hcy in patients with Alzheimer′s disease |
| ZHANG Shanshan1 JI Yifei1 PU Chao2 LONG Jifa1 LIU Pingping1 ZHANG Yi1 |
1.Department of Neurology, the Second Clinical Medical College of North Sichuan Medical College Nanchong Central Hospital, Sichuan Province, Nanchong 637000, China;
2.Department of Orthopaedics, the Second Clinical Medical College of North Sichuan Medical College Nanchong Central Hospital, Sichuan Province, Nanchong 637000, China |
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Abstract Objective To implore the effect of aerobic exercise combined with folic acid on cognitive function, serum cytokines and homocysteine (Hcy) in patients with Alzheimer′s disease (AD). Methods From May 2016 to January 2018, 86 cases with AD who treated in Nanchong City Central Hospital of Sichuan Province were selected. They were divided into control group and observation group according to the random number table method, with 43 cases in each group. Control group was treated with Donepezil Hydrochloride combine with aerobic exercise training, while observation group was treated with folic acid on the basis of control group. Both groups were treated for 3 months. Mini-mental state scale (MMSE) and the Alzheimer′s disease rating scale-cognitive sub-table (ADAS-cog) were used to evaluate the cognitive function of the patients. Serum levels of Hcy, interleukin-6 (IL-6), IL-1β and tumor necrosis factor-α (TNF-α) before and after treatment were compared between two groups. Results There was no significant difference in MMSE scores and ADAS-cog scores between two groups before treatment (P > 0.05). After treatment, MMSE scores in two groups were higher than those before treatment, and observation group were higher than control group. ADAS-cog scores of two groups were lower than those before treatment, and observation group was lower than control group, with statistically significant differences (all P < 0.05). There was no significant difference in serum cytokine levels and serum Hcy levels between two groups before treatment (P > 0.05). After treatment, serum levels of IL-6, TNF-α and IL-1β in two groups were lower than those before treatment, and observation group were lower than control group, with statistically significant differences (all P < 0.05). The serum Hcy level in observation group was lower than that before treatment, and observation group was lower than control group, with statistically significant difference (all P < 0.05). Conclusion Folic acid combined with aerobic exercise training can more effectively improve the cognitive function of AD patients, which may be related to the down-regulation of serum Hcy levels and the suppression of secretion of pro-inflammatory cytokines.
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