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2018 Vol. 15, No. 33
Published: 2018-11-25
 
 
4 The preventive effect of Huoxue Jiangtang Decoction on pancreatic β cell apoptosis and its influence on scrib protein expression in type 2 diabetes rats
LIU Deliang1 LI Huilin1 QU Xin1 ZHAO Hengxia1 CHU Shufang1 LIU Xuemei1 ZENG Lin2 ZHANG Xuewen2
Objective To investigate the preventive effect of Huoxue Jiangtang Decoction on pancreatic β cell apoptosis and its influence on scrib protein expression in type 2 diabetes mellitus rats. Methods The type 2 diabetes mellitus model was induced by high fat and high calorie diet and intravenous injection of low dose of Streptozotocin. By SPSS software, all model rats were divided into model group, herbal group, Metformin group, besides, normal group was added, 10 rats in each group. After treatment, the blood glucose, insulin and lipids were tested; the pancreatic β cell apoptosis was examined by terminal-deoxynucleoitidyl transferase mediated nick end labeling method; and scrib protein expression was detected by Western blot in extracted and purified pancreatic islet cells. Results Compared with model group, the levels of fasting blood-glucose, 2 h postprandial blood glucose, fasting insulin, 2 h postprandial insulin, insulin resistance index and total cholesterol, triacylglycerol, low density lipoprotein cholesterin in herbal group and Metformin group were all decreased, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01), while high density lipoprotein cholesterol had no obvious changes, the difference was not statistically significant (P ＞ 0.05). Compared with model group, the β cell apoptosis indices in herbal group and Metformin group were also decreased (P ＜ 0.01), meanwhile, the scrib protein expression in islet cells was increased significantly (P ＜ 0.01). Conclusion Huoxue Jiangtang Decoction treatment has the effects of regulating blood lipid, decreasing blood glucose, improving insulin resistance, which can effectively prevent β cell apoptosis. The mechanism may be related to the upregulation of scrib protein expression in islet cells.
2018 Vol. 15 (33): 4-7,12 [Abstract] ( 201 ) HTML (1 KB)  PDF (631 KB)  ( 150 )
8 The study of analgesic effect and mechanism of Yuanhu Zhitong Dropping Pills on dysmenorrhea model rats
FENG Yue1,2 ZHANG Zongpeng1,2 SHEN Xiuping1,2 HU Jinfang1,2
Objective To study the analgesic effect of Yuanhu Zhitong Dropping Pills on dysmenorrhea model rats and to discuss the possible mechanism. Methods Sixty female SPF grade Wistar rats were divided into control group, model group, small-dose (0.2 g crude drug/kg), low-dose (0.4 g crude drug/kg), medium-dose(0.8 g crude drug/kg), high-dose(1.6 g crude drug/kg) of Yuanhu Zhitong Dropping Pills group according to weight random block method, with 10 rats in each group. The model of dysmenorrhea was induced by intraperitoneal injection of oxytocin, and Yuanhu Zhitong Dropping Pills was administered by intragastric administration for 3 days after sensitized by intraperitoneal injection of estradiol benzoate. The effect of Yuanhu Zhitong Dropping Pills was observed by detecting latency stage and times of writhing response induced by dysmenorrhea, and the level of factors related to pain such as prostaglandin F2α and prostaglandin E2 in plasma were also detected. Results Compared with model group, the times of writhing response in low-dose , medium-dose, high-dose of Yuanhu Zhitong Dropping Pills group significantly decreased (P < 0.05 or P < 0.01), and the preclinical period of writhing response in low-dose, medium-dose, high-dose of Yuanhu Zhitong Dropping Pills group showed an extension trend, while the standard deviation was large due to individual differences, the differences were not statistically significant (P > 0.05). Compared with model group, the level of β-endorphin and prostaglandin E2 in medium-dose and high-dose of Yuanhu Zhitong Dropping Pills group increased significantly (P < 0.05 or P < 0.01), and the level of noradrenaline, 5-hydroxytryptamine, the ratio of prostaglandin F2α to prosta-glandin E2 decreased significantly (P < 0.05 or P < 0.01), the level of prostaglandin F2α in high-dose of Yuanhu Zhitong Dropping Pills group decreased significantly (P < 0.05). There was no statistically significant difference on the level of thromboxane B2 and 6-Keto-prostaglandin F1α between medium-dose, high-dose of Yuanhu Zhitong Dropping Pills group and model group (P > 0.05). Conclusion Yuanhu Zhitong Dropping Pills has significant analgesic effect on dysmenorrhea model rats with the dose of 0.8-1.6 g crude drug/kg. The multi-way analgesic effect is probably related to improved levels of pain-associated prostaglandins, monoamine transmitters, and β-endorphin in peripheral blood.
2018 Vol. 15 (33): 8-12 [Abstract] ( 268 ) HTML (1 KB)  PDF (563 KB)  ( 38 )
13 Study of anti-inflammatory effect and molecular mechanism of Yinyanjing Lotion
TAN Qian OUYANG Bo XIAO Zuoqi
Objective To investigate anti-inflammatory effect and molecular mechanism of Yinyanjing Lotion on allergic contact dermatitis (ACD) rats. Methods Fifty half male and half female SPF grade SD rats were randomly divided into 5 groups according to random number table method, including blank control group (purified water 50 μL), ACD model group (purified water 50 μL), positive control group (Dexamethasone Sodium Phosphate Injection 50 μL), low dose treatment group (Yinyanjing Lotion 50 μL) and high dose treatment group (2 times concentrated Yinyanjing Lotion 50 μL), with 10 rats in each group. The right ears were smeared with drugs twice a day for 10 days. The allergic reaction and swelling degree of the skin were observed, and the expression levels of phosphorylated extracellular regulated protein kinases (pERK1/2) and nuclear factor κB (NF-κB) were detected by immunohistochemistry and Western blot. Results Compared with the blank control group, the ear swelling degree of rats in the ACD model group was significantly increased (P < 0.01). Compared with the ACD model group, the ear swelling degree of rats in the high dose treatment group and low dose treatment group was significantly decreased (P < 0.01). Compared with the blank control group, the protein expression of pERK1/2 and NF-κB in the ACD model group was significantly up-regulated (P < 0.01). Compared with the ACD model group, the protein expression of pERK1/2 and NF-κB in the high dose treatment group and low dose treatment group was significantly down-regulated (P < 0.05 or P < 0.01). Conclusion Yinyanjing Lotion has an anti-inflammatory effect on ACD rats, and the mechanism may be achieved by inhibition of pERK1/2/NF-κB signaling pathway.
2018 Vol. 15 (33): 13-16 [Abstract] ( 187 ) HTML (1 KB)  PDF (648 KB)  ( 55 )
17 Effects of environmental estrogen on Notch signaling pathway in neonatal rat′s gubernaculum
WANG Guanghuan1 CHEN Kaihong1 ZHONG Jun1 WANG Fusheng1 XU Chengbin1 JIANG Xuewu2
Objective To explore the effect of diethylstilbestrol (DES) on Notch signaling pathway of chorda gubernaculum in offspring rats. Methods Forty-five healthy female SD rats aged 8-10 weeks were divided into the control group, experimental group 1 and 2 according to the random number table, with 15 rats in each group. The experimental group 1 and 2 were given DES 0.1 μg/(kg·d) and DES 25 μg/(kg·d) respectively. According to the conventional ratio of male to female 2∶1 cage. The day of offspring birth of each group was recorded as day 0 after birth (PD0). The chorda gubernaculum was taken at PD1 and PD7 respectively. The expressions of Notch1, Hes1, EGFR and TGF-α were analyzed by RT-PCR and Western blot imprinting. Results At PD1 and PD7, the mRNA expression of Notch1, Hes1, EGFR and TGF-α in the experimental group 1 were higher than those in the control group and the experimental group 2 (P < 0.05), while only TGF-α mRNA in the experimental group 2 was higher than that in the control group (P < 0.05). At PD1, the levels of Notch1, Hes1 and TGF-α protein in the experimental group 1 were higher than those in the control group, and the levels of Hes1 and EGFR at PD7 were increased (P < 0.05). Compared with control group, only the levels of Notch1, EGFR and Hes1 protein were in the experimental group 2 increased at PD1, and the levels of Notch1, Hes1 and EGFR protein were increased at PD7 (P < 0.05). Compared with the experimental group 1, only EGFR protein increased in the experimental group 2 at PD1, while Notch1, Hes1 and TGF-α protein increased at PD7 (P < 0.05). Conclusion Environmental estrogen can affect the expression of Notch signaling in gubernaculum of offspring rats, which may be one of the mechanisms of exogenous estrogen affecting the development and proliferation of gubernaculum.
2018 Vol. 15 (33): 17-20,24 [Abstract] ( 217 ) HTML (1 KB)  PDF (995 KB)  ( 125 )
21 Progress in the new approaches to regulation of muscle synthesis and metabolism
REN Guangxu1 YUAN Chao2
Skeletal muscle plays an important role in human health and disease. In many tumors, chronic heart failure and nutritional deficiency, the symptoms of muscular atrophy are characterized by loss of muscle mass and strength. Muscle atrophy seriously affects the quality of life, and even threatens the lives of patients. Although researchers have found that inflammation and nutritional health state can lead to muscle atrophy, the specific regulatory network is still not clear. Recent studies have revealed that gut microbes in the human body may also participate in the regulation of muscle synthesis. Therefore, we will review the recent progress in the study of the "gut muscle" axis and the molecular mechanisms involved.
2018 Vol. 15 (33): 21-24 [Abstract] ( 225 ) HTML (1 KB)  PDF (599 KB)  ( 95 )
25 General experiment study about regulating effect on OPG/RANK/RANKL system of ovariectomized osteoporosis rats by traditional Chinese medicine and acupuncture
ZHOU Jingying1 ZHOU Ning2 ZHANG Yiweng3 YANG Hongguang4 ZHAO Yingxia3
The pathogenesis of postmenopausal osteoporosis is closely related to the dysfunction of osteoprotegerin (OPG)/ receptor activator of nuclear factor κB (RANK)/ receptor activator of nuclear factor κB ligand (RANKL) system. Immature osteoblast secretes RANKL, which is combined with RANK, then it will stimulate the differentiation of osteoclast and inhibit its apoptosis, promoting bone absorption. Mature osteoblast secretes OPG, which will competitively combine RANKL with RANK, thus inhibit osteoclast differentiation and induce its apoptosis, reducing bone resorption. OPG/RANK/RANKL system can be regulated by traditional Chinese medicine and acupuncture, especially the traditional Chinese medicine and acupoints of tonifying kidney and spleen. This may be one of the mechanisms of traditional Chinese medicine and acupoints to prevent and treat postmenopausal osteoporosis.
2018 Vol. 15 (33): 25-27,35 [Abstract] ( 274 ) HTML (1 KB)  PDF (642 KB)  ( 149 )
28 Research advances for Stereotactic body radiation therapy in early stage Non-small cell lung cancer
DENG Xiaoxi GE Wei
Stereotactic radiotherapy (SBRT) has become the standard treatment for medically inoperable early non-small cell lung cancer (NSCLC), providing local tumor control effects comparable to surgery. For operable patients with early-stage NSCLC, the efficacy of SBRT is the same or even better than surgery. With the advancement of Phase Ⅱclinical trials, the understanding of the radiobiological characteristics of SBRT, treatment techniques and related methods, dose limits for normal organs/tissues, major factors affecting efficacy, SBRT-induced immune effects, and distant effects and other aspects is deeper, these provide a reliable basis for the clinical application of SBRT. This article reviews the recent advances in SBRT for NSCLC in these areas.
2018 Vol. 15 (33): 28-31,39 [Abstract] ( 298 ) HTML (1 KB)  PDF (625 KB)  ( 157 )
32 Nursing advances in the prevention and treatment of drug-induced phlebitis
HUANG Zhongli CHEN Lei ZHANG Jianqiang LIU Meizhen
Intravenous treatment of drugs was the main method of medical activities currently, and drug-induced phlebitis was the most common issue for paramedic. Phlebitis not only increases the suffering of the patients, but also increases their economic burden, and it also increases the difficulty in puncture for paramedic. This article mainly introduces the integrated Chinese and Western methods in treating and nursing for phlebitis, in order to help the nursing staff take effective and timely measures to accelerate the recovery of phlebitis, and reduce the disputes between nurses and patients.
2018 Vol. 15 (33): 32-35 [Abstract] ( 160 ) HTML (1 KB)  PDF (626 KB)  ( 153 )
36 The research progress on the pain treatment with Vitamin C
LIU Yao1 XIONG Miaomiao1 CHEN Yajie1 JIN Jun1 SHEN Wen2▲
Vitamin C (VitC), also known as ascorbic acid, is a highly effective antioxidant in the human body and plays an important role in many biosynthetic processes. VitC deficiency is highly prevalent in a variety of patients, such as patients with trauma, infection, and cancer. Many recent clinical studies have shown that intravenous high-dose VitC can prevent the occurrence of complex regional pain syndrome after fracture. It can also relieve the herpes zoster pain and reduce the incidence of postherpetic neuralgia. In addition, the high-dose VitC can reduce pain in patients with advanced cancer and extend their survival time. Many experts have proposed several mechanisms for relieving pain in VitC, but they are still controversial. All in all, VitC has shown a safe and effective effect in relieving acute and chronic pain.
2018 Vol. 15 (33): 36-39 [Abstract] ( 238 ) HTML (1 KB)  PDF (599 KB)  ( 116 )
40 Progress on the mechanism and application of tea in cosmetics and skin care
LIU Qian LIU Yaxuan XIAO Juan LUO Jie TAN Xiang TONG Chuan ZHOU Yi▲
As a traditional cosmetics and skin care product, tea is the most widely used raw material for botanical cosmetics currently. This article, connecting with the research literature on tea in recent years, reviews the history about cosmetology and skin care of tea, and summarizes the study advances in reducing weight of lipid-lowering, whitening, anti-aging, antibacterial, moisturizing and tea application status home and abroad. This article aims at providing theoretical basis for developing products with beauty and skin care benefits.
2018 Vol. 15 (33): 40-42 [Abstract] ( 243 ) HTML (1 KB)  PDF (586 KB)  ( 136 )
43 Research on constipation and psychological health in outpatient of general hospital
ZHANG Yinfeng1 WANG Yongzhi2 DU Yi2 ZHAO Jingjie2 LI Yangfan2 LI Li1,2▲
Objective To understand the constipation and mental health of outpatients in general hospital. Methods A total of 5000 patients from the Beijing Friendship Hospital, Capital Medical University from July 2013 to July 2014 were selected. Patients were diagnosed by Symptom Checklist-90 (SCL-90), and constipation patients were diagnosed according to the constipation standard established by RomeⅢ. Statistical analysis was performed on the relevant data using statistical software SPSS 18.0. Results A total of 4911 valid questionnaires were collected, the effective rate of the questionnaire was 98.22%; the number of constipation patients in general hospitals accounted for 19.04% of the total number of outpatients, including 77.65% of female constipation patients and 22.35% of males, female patients were significantly higher than males. The prevalence of different ages was also different. Among them, the age-complexity ratio of constipation patients in the middle-aged group of 45-59 years old was the highest, accounting for 42.67%. The prevalence rate of constipation in the elderly group over 60 years old was the highest, accounting for 48.12%; compared with the model, the factors such as depression, anxiety, paranoia, and somatization were statistically different (P < 0.01). Conclusion Patients with constipation in general hospitals account for a certain proportion of outpatients, and they have certain problems in mental and psychological aspects such as depression, anxiety and somatization.
2018 Vol. 15 (33): 43-46,55 [Abstract] ( 277 ) HTML (1 KB)  PDF (666 KB)  ( 62 )
47 Risk analysis of thrombosis in early diabetic nephropathy patients
SU Yang ZHANG Qian CUI Ronggang LI Juan TIAN Fengsheng
Objective To study the risk and influencing factors of thrombosis in patients with early diabetic nephropathy. Methods One hundred and twenty patients with type 2 diabetes that admitted to Endocrinology Department of Cangzhou Hospital of Integrated Chinese and Western Medicine("our hospital" for short) from May 2017 to May 2018 were selected, with 60 cases ACR<2.5 (male)/3.5 (female) mg/mmol as type 2 diabetes group (T2DM group), 60 cases ACR from 2.5 (male)/3.5 (female) mg/mmol to 30.0 mg/mmol as early diabetic nephropathy group (EDN group). And 30 cases of health check-up in our hospital were taken as the control group（NC group）. The metabolism indexes of each group were detected as fasting blood-glucose (FPG), postprandial 2 h plasma glucose (2hPBG), glycosylated hemoglobin (HbA1c), total cholestero (TC), low-density lipoprotein cholesterol (LDL-C), triacylglycerol (TG), and thrombelastogram (TEG) indexes as R value, K value, CI value, MA value, Angle angle value to assess the risk of thrombosis. Results Compared with the NC group, the levels of FPG, 2hPBG, HbA1c of T2DM group and EDN group increased (P ＜ 0.05); compared with the T2DM group, the levels of FPG, 2hPBG, HbA1c of EDN group increased (P ＜ 0.05). Compared with the NC group, the levels of TG, TC, LDL-C of T2DM group and EDN group increased (P ＜ 0.05), while there was no significant difference in the levels of TG, TC, LDL-C between T2DM group and EDN group (P ＞ 0.05). Compared with the NC group, the R value and K value of T2DM group and EDN group decreased, while the Angle value, MA value and CI value increased, and the differences were statistically significant (P < 0.05); compared with the T2DM group, the R value and K value of the EDN group decreased, while the Angle value, MA value and CI value increased, the differences were statistically significant (P < 0.05). Linear correlation analysis showed that ACR was negatively correlated with R value and K value (r = -0.423, -0.517, all P < 0.01), ACR was positively correlated with Angle value, MA value and CI value (r = 0.683, 0.742, 0.669, all P < 0.01). Logistic regression analysis showed that the course of diabetes, dyslipidemia, smoking history, and ACR increase were independent risk factors for thrombosis in patients with early diabetic nephropathy (OR = 2.423, 1.986, 2.103, 4.358, all P < 0.05). Conclusion Diabetics have a higher risk of blood clots than healthy adults before proteinuria. Patients with early diabetic nephropathy have a higher risk of thrombosis than those with simple diabetes. The risk of thrombosis in patients with diabetic nephropathy is related to the course of diabetes, smoking history, dyslipidemia, and elevated ACR.
2018 Vol. 15 (33): 47-50 [Abstract] ( 274 ) HTML (1 KB)  PDF (366 KB)  ( 140 )
51 Minimally invasive percutaneous nephrolithotomy combined with flexible cystoscopy for the treatment of complicated renal calculi and its impact on patients′ quality of life
CHEN Ligang1 YI Faxian1 CHEN Lijun2 WANG Guoqiang1
Objective To analyze the effect of minimally invasive percutaneous nephrolithotomy combined with flexible cystoscopy on the treatment of complicated renal calculi and its impact on patients′ quality of life. Methods Ninety-six patients with complicated renal calculi admitted to the Department of Urology, Inner Mongolia Medical University Hospital from July 2015 to February 2018 were divided into study group (48 cases) and control group (48 cases) by random number table method. The control group was treated with minimally invasive percutaneous nephroscopy, and the study group was treated with flexible cystoscopy combined with minimally invasive percutaneous nephroscopy. The intraoperative blood loss, operation time, hospital stay, calculus rate, complications, urokinase, creatinine level and quality of life score (somatic function, emotional function, social function, cognitive function score) were compared between the two groups. Results The bleeding volume, hospitalization time, first-stage stone clearing rate, second-stage stone clearing rate, and complication rate were lower in the study group than in the control group(all P < 0.05). After treatment, the urokinase in the study group was higher than the control group and the creatinine was lower than the control group (all P < 0.01); the physical function, emotional function, social function and cognitive function score of the study group were higher than the control group (all P < 0.01). Conclusion Minimally invasive percutaneous nephrolithotomy combined with flexible cystoscopy has significant curative effect for the treatment of complicated renal calculi, which can reduce the blood loss and shorten the length of hospital stay, and it has higher rate of stone clearance, less complications. It has less effect on renal function and the patients′ quality of life is high.
2018 Vol. 15 (33): 51-55 [Abstract] ( 292 ) HTML (1 KB)  PDF (402 KB)  ( 118 )
56 The clinical effect of massage manipulation combined with crawl training in the treatment of lumbar disc herniation
HE Tianxiang1 GU Fei1 KONG Lingjun2 XU Jun1 ZHANG Jun1
Objective To investigate the clinical effect of massage manipulation combined with crawl training on patients with lumbar disc herniation (LDH). Methods From June 2015 to December 2016, 60 cases of LDH were treated in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine ,which were randomly divided into control group and observation group by random number table method, with 30 cases in each group. Both groups were given massage manipulation, and the observation group was assisted with crawler training on the basis of massage manipulation. Visual analogue scale (VAS) score and Japanese orthopedic association (JOA) score were observed before and after treatment, and recurrence was observed 3 months after follow-up. Results After treatment, the VAS scores in the two groups were significantly lower than those before treatment, the differences were statistically significant (P ＜ 0.05), the VAS score of the observation group was significantly lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). The JOA scores of the two groups after treatment were higher than those before treatment, and the differences were statistically significant(P ＜ 0.05), and the observation group was more obviously than the control group in the JOA score increase, and the difference was statistically significant (P ＜ 0.05). The total effective rate of control group after treatment was 76.7 %, the total efficiency of the observation group was 86.6%, there was statistically significant difference between the two groups (P ＜ 0.05). In the two groups, the recurrence rate was measured by telephone back in 3 months after the treatment, the recurrence rate of control group was 43.3%, the observation group had a recurrence rate of 30.0%, the two groups had a statistical differences (P ＜ 0.05). Conclusion The combination of massage manipulation combined with crawler training for LDH patients is more significant in reducing VAS score and improving JOA score than simple massage manipulation, and has a lower recurrence rate.
2018 Vol. 15 (33): 56-59 [Abstract] ( 210 ) HTML (1 KB)  PDF (418 KB)  ( 66 )
60 Clinical research of electrical stimulation combined with pelvic floor function training for the treatment of postpartum pelvic floor dysfunction
ZHANG Yan1 MA Na1 ZOU Hongxia2
Objective To explore the clinical effect of electrostimulation combined with pelvic floor function training for postpartum pelvic floor dysfunction (PFD). Methods From October 2016 to November 2017, 89 puerperas who were admitted to Yan′an People′s Hospital were selected as study objects, and they were divided into control group (n = 44) and research group (n = 45) according to random number table method. Puerperas in the control group were trained with postpartum basic nursing and pelvic floor function, while the puerperas of research group were treated with electrical stimulation on the basis of control group. The clinical total effective rate of two groups after treatment were counted, the vaginal muscle strength of two groups before and after the treatment were detected, the female sexual function index (FSFI) and urine dynamics index of two groups before and after the treatment were detected. In addition, the prognosis of two groups 6 months after delivery were observed. Results The total clinical effective rate of the study group was higher than that of the control group (P < 0.05); compared with before treatment, the sustained systolic blood pressure and duration of the contraction of muscle fiber of pelvic floor type Ⅰ and type Ⅱ, FSFI score, Qmax and MUP of two groups after treatment significantly elevated (P < 0.05), while VT was shorten significantly (P < 0.05). The improvement of vaginal muscle, FSFI and urine dynamics index of research group after treafment were better than that of the control group (P < 0.05). The incidence of uterine prolapse, urinary incontinence, sexual dysfunction and PFD of the research group were significantly lower than that of the control group (P < 0.05). Conclusion Electrostimulation combined with pelvic floor function training can effectively treat PFD, which not only improve the quality of maternal sex, vaginal muscle strength and urine dynamics index, but also have a good prognosis. It is worthy of clinical application.
2018 Vol. 15 (33): 60-63,67 [Abstract] ( 262 ) HTML (1 KB)  PDF (563 KB)  ( 88 )
64 Relationship between homocysteine and threatened abortion， recurrent spontaneous abortion, secondary sterility
LI Menglan1 LIN Ning1 SHI Hui1 FENG Jie1 WU Yulin1 CUI Ting2▲
Objective To investigate the relationship between homocysteine (Hcy) and threatened abortion, recurrent spontaneous abortion, secondary sterility. Methods From January 2017 to April 2018, in the First Affiliated Hospital of Nanjing Medical University, 194 cases of threatened abortion were selected as threatened abortion group, 364 cases of recurrent spontaneous abortion were selected as recurrent spontaneous abortion group, 547 cases of secondary sterility were selected as secondary sterility group, 500 cases of pregnant women were selected as normal pregnant group and 500 cases of pre-pregnancy women were selected as normal non-gestational group. The level of plasma Hcy, the percentage of Hhcy of each group and the relationship between Hcy and threatened abortion, recurrent spontaneous abortion, secondary sterility were compared and analyzed. Results Compared with the normal non-gestational group, the plasma Hcy level, percentage of Hhcy were significantly lower in the normal pregnant women group, while significantly higher in the recurrent spontaneous abortion group and the secondary sterility group, the differences were statistically significant (P < 0.01), and those in the threatened abortion group were tend to increase, but without statistically significant difference (P > 0.05). Compared with the normal pregnant group, the plasma Hcy level and the percentage of Hhcy were significantly higher in the threatened abortion group, recurrent spontaneous abortion group and the secondary sterility group, the differences were statistically significant (P < 0.01). The high Hcy level was the risk factor of threatened abortion (OR = 1.994), recurrent spontaneous abortion (OR = 4.095) and secondary sterility (OR = 3.006). Conclusion The plasma Hcy level has relationship with the threatened abortion, recurrent spontaneous abortion and secondary sterility, and the increase of plasma Hcy level could be an important risk factor of these diseases, more attention should be paid for clinical diagnosis and treatment.
2018 Vol. 15 (33): 64-67 [Abstract] ( 233 ) HTML (1 KB)  PDF (504 KB)  ( 107 )
68 Clinical effect of combination therapy in the treatment of chronic pelvic inflammatory disease
WU Wei CHAI Shuhui DONG Junwei
Objective To study the clinical efficacy and prognosis of combination therapy for chronic pelvic inflammatory disease. Methods From November 2016 to November 2017, 89 patients with chronic pelvic inflammatory disease who were admitted to Chengde Hospital of Traditional Chinese Medicine were enrolled. The patients were divided into observation group (42 cases) and control group (47 cases) by random number table method. The control group was treated with simple Chinese medicine enema, the observation group was treated with abdominal acupuncture plus TDP, moxibustion, acupoint injection, and hammocks collaterals bloodletting and cupping therapy in addition. The clinical efficacy, clinical symptom scores, inflammatory factor levels, quality of life, and recurrence of patients in both groups were observed after treatment. Results The total effective rate of the observation group after treatment was higher than that of the control group (P < 0.01). After treatment, the clinical symptom scores of the two groups were significantly decreased, and those of the observation group were significantly lower than the control group (P < 0.01); the levels of IL-2 and IL-10 in the two groups increased significantly, and those in the observation group were higher than the control group (P < 0.05 or P < 0.01); the levels of TNF-α in the two groups were significantly decreased, and that in the observation group was lower than the control group (P < 0.05 or P < 0.01); the pain and discomfort scores of the observation group were significantly lower than those of the control group, the positive feeling, sleep status and overall health score were significantly higher than those the control group (P < 0.01). Six months follow-up after treatment showed that the relapse rate in the observation group was significantly lower than the control group (P < 0.05). Conclusion The clinical effect of combination therapy in treating chronic pelvic inflammatory disease is better than traditional Chinese medicine enema alone. It can improve clinical symptoms, inhibit inflammation, improve quality of life, and reduce disease recurrence. It has high clinical value.
2018 Vol. 15 (33): 68-71 [Abstract] ( 199 ) HTML (1 KB)  PDF (545 KB)  ( 132 )
72 Therapeutic effect of low-dose heparin in newborn with coagulation disorders
ZANG Lili WANG Zhao LI Xiaoxiang LI Lihua
Objective To investigate the therapeutic effect of low-dose heparin in newborn with coagulation disorders. Methods A total of 70 neonates with coagulation disorders treated in Department of Neonatology of Beijing Luhe Hospital, Capital Medical University from August 2016 to July 2017 were selected and were divided into control group (n = 35 cases) and observation group (n = 35 cases) according to random number table. The control group was given general treatment such as reasonable milking or parenteral nutrition support and appropriate blood product administration, the observation group was given a small dose of heparin sodium on the basis of the control group. The prothrombin time (PT), thrombin time (TT), fibrinogen (FBI), activated partial thromboplastin time (APTT), platelet count (PLT), and D-dimer (D-D) were determined at three different time points at 24, 48, and 72 h after treatment. The complications, cure rate, and mortality of the two groups were recorded, and the clinical efficacy, coagulation index, and prognosis of the two groups were compared. Results The effective rate of observation group 72 h after treatment was higher than the control group, the difference was statistically significant (P < 0.05). There was no statistically significant difference in the levels of PT, TT, FBI, APTT, PLT and D-D between the two groups before and 24 h after the treatment (P > 0.05). The levels of PT, TT, APTT and D-D in the observation group at 48 and 72 h after treatment were lower than those in the control group, the differences were statistically significant (P < 0.05); the levels of FBI and PLT in the observation group 72 h after treatment were higher than those in the control group, the differences were statistically significant (P < 0.05). The levels of PT, TT, APTT and D-D of the two groups after treatment showed a decreasing trend, which were lower than before treatment, the differences were statistically significant (P < 0.05). The levels of FBI and PLT of the observation group were higher than those of the control group, the differences were statistically significant (P < 0.05). The incidence rate of intracranial hemorrhage, pulmonary hemorrhage, gastrointestinal hemorrhage and mortality after treatment were all lower than those in the control group, the differences were statistically significant (P < 0.05). Conclusion The combination of low-dose heparin on the basis of conventional treatment can help improve clinical efficacy of neonatal coagulopathy, improve patients′ coagulation function, reduce the incidences of complications and mortality, and it is worthy of popularization and application.
2018 Vol. 15 (33): 72-75,79 [Abstract] ( 220 ) HTML (1 KB)  PDF (764 KB)  ( 104 )
76 Observation of the early stage safety of phacoemulsification combined with domestic foldable intraocular lens implantation
WU Jingming1 LI Yunfeng1 ZHAO Zhouting1 WANG Shuainan1 SONG Wulian2
Objective To evaluate the safety of early stage in phacoemulsification combined with domestic foldable intraocular lens (IOL) implantation. Methods From October to November 2017, 14 cases of cataract patients (18 eyes) who were treated in the Department of Ophthalmology in the 211th Hospital of PLA were implanted with A1-UV one-piece foldable IOL. Intraoperative complications were recorded. The patients were followed up at 1 day, 3 days, 1 week and 2 weeks after operation. The anterior chamber depth, corneal average curvature, non-contact intraocular pressure, corneal endothelial cell density and slit lamp microscopy were measured and recorded. The result was analyzed by SPSS 20.0. Results There were no significant differences in corneal mean curvature, anterior chamber depth and non-contact intraocular pressure among different follow-up times (F = 0.991, P = 0.418; F = 3.244, P = 0.092; F = 1.445, P = 0.229). The corneal endothelial cell density was significantly decreased at 1 d, 3 d, 1 week and 2 weeks after operation (F = 19.816, P ＜ 0.001). No patient developed exudation of the anterior chamber after operation. Only mild conjunctival edema occurred 1 day after operation, and recovered to the preoperative level 3 days after operation. Mild postoperative aqueous humor cells and corneal edema occurred 1 day to 3 days after operation, and recovered to the preoperative level 1 week after operation. Mild aqueous flashes and bulbar conjunctival congestion occurred 1 day to 1 week after operation, and returned to preoperative level 2 weeks after operation. Conclusion Phacoemulsification combined with domestic foldable IOL implantation has little perturbation to the human eye and quick postoperative recovery. Domestic A1-UV foldable IOL, HS-Ⅰ injector and SI-Ⅰ import head all have good biocompatibility and safety, which is worth of clinical promotion and application.
2018 Vol. 15 (33): 76-79 [Abstract] ( 219 ) HTML (1 KB)  PDF (341 KB)  ( 117 )
80 UPLC-MS/MS qualitative analysis and HPLC determination of flavonoids in leaves of Tetrastigma hemsleyanum
DENG Sishan1 LIU Hongxu1 MA Lihong1 WANG Tingting2 WANG Yaduan2 HUANG Xinping3
Objective Qualitative and quantitative analysis of the chemical constituents of flavonoids in the leaves of Tetrastigma hemsleyanum. Methods The chemical constituents in leaves of Tetrastigma hemsleyanum were identified by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The column was C18 Luna Omega (2.1 mm × 100 mm, 1.6 μm); the mobile phase was acetonitrile-water (50∶50, V/V); the flow rate was 0.4 mL/min; the column temperature was 35°C; the injection volume was 5 μL; full scan mode. The contents of five carbon glycosides in the leaves of Tetrastigma hemsleyanum were determined at the same time by high performance liquid chromatography (HPLC). The column was Ultimate XB C18 (250 mm×4.6 mm, 5 μm); the mobile phase was acetonitrile - 0.2% H3PO4 (10∶90, V/V); the flow rate was 1 mL/min; the detection wavelength was 350 nm; room temperature; injection volume was 20 μL. Results A total of 6 chemical components were identified in the leaves, and the retention time, spectrum and mass spectrometry information of the 5 flavonoids were consistent with the control, which were isohumullin, valerin, vitexin and rhamnoside, vitexin, isovite. The contents of the above five components in the samples from 8 different origin sources were determined by HPLC. The linear relationship of each component was good (r > 0.9997), and the recovery rate was between 95.0% and 105.0%. Conclusion The leaves of Tetrastigma hemsleyanum are mainly composed of two kinds of carbon flavonoids, valerin and vitexin. The method established in this study can qualitatively and quantitatively analyze the main chemical components in the leaves of Tetrastigma hemsleyanum and control the quality of the medicinal materials.
2018 Vol. 15 (33): 80-84,88 [Abstract] ( 210 ) HTML (1 KB)  PDF (983 KB)  ( 172 )
85 Rapid determination of Labetalol in breast milk by ultra performance liquid chromatography-tandem coupled with mass spectrometry
CHEN Yu1 ZHENG Xin2 CHEN Libo1 CHEN Feng1
Objective To establish an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for rapid determination of labetalol in breast milk. Methods The breast milk sample was precipitated by a methanol-acetonitrile mixed solution, and after centrifugation, the supernatant was centrifuged for injection. The column was Thermo Scientific Syncronis C18 (100 mm × 2.1 mm, 1.7 μm), the initial mobile phase was 0.2% formic acid solution-acetonitrile (80∶20, V/V), the flow rate was 0.2 mL/min, utilizing a gradient elution program. The MS/MS detection was performed under AJS ESI+ in MRM mode, quantitatived by external standard method. Results The linear range of Labetalol was 1.042-104.2 ng/mL (r = 0.9988)，with the low limit of quantitation of 1.042 ng/mL. Accuracy was 92.0%-104.8%, intra-batch and inter-batch relative standard deviations were both below 15%. The absolute recovery in breast milk was 82.2%-92.4%. Conclusion The method is simple, accurate, specific, and with high sensitivity, which can be used for concentration in breast milk monitoring of labetalol.
2018 Vol. 15 (33): 85-88 [Abstract] ( 226 ) HTML (1 KB)  PDF (593 KB)  ( 106 )
89 Clinical efficacy of Mannatide combined with Mesalazine in the treatment of ulcerative colitis
WANG Limei1 XIANG Yi2 WU Ying1 LIANG Cong1 BAI Junfang1
Objective To explore the clinical efficacy of Mannatide combined with Mesalazine in the treatment of patients with ulcerative colitis. Methods A total of 106 patients with ulcerative colitis admitted to Shaanxi Second Provincial People′s Hospital and the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from August 2014 to December 2017 were collected as observation objects, they were divided into observation group and control group according to the random number table method, with 53 cases in each group. The control group was given Mesalazine alone, while the observation group was given Mannatide combined with Mesalazine. The clinical effect and adverse reactions of the two groups were recorded. The peripheral blood immune indexes CD3+, CD4+, CD4+/CD8+, NK cells were detected by flow cytometry. The serum levels of matrix metalloproteinase (MMP) -1, MMP-2, MMP-9 were determined by enzyme-linked immunosorbent assay (ELISA). Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P < 0.05). The CD3+, CD4+, CD4+/CD8+, NK cells levels in two groups after treatment were significantly higher than those before treatment, which in the observation group were higher than those in control group, the differences were statistically significant (P < 0.05). The MMP-1, MMP-2, MMP-9 levels in two groups after treatment were significantly lower than those before treatment, which in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Mannatide combined with Mesalazine in the treatment of ulcerative colitis can improve clinical efficacy, immune functions and body repair ability, and it doesn′t increase the incidence of adverse reactions, it′s safe and reliable.
2018 Vol. 15 (33): 89-92,97 [Abstract] ( 197 ) HTML (1 KB)  PDF (505 KB)  ( 291 )
93 Effect of Butylphthalide combined with Naoxintong Capsules on cerebral infarction and its effect on blood flow velocity of collateral circulation
YANG Minhui1 LIU Aiqun2 XIANG Guanghong3
Objective To explore the curative effect of Butylphthalide combined with Naoxintong Capsules on cerebral infarction and its effect on blood flow velocity of collateral circulation. Methods One hundred and forty-seven patients with cerebral infarction admitted to Affiliated Haikou Hospital of Xiangya Medical College, Central South University and the Second People′s Hospital of Hunan Province from May 2015 to May 2018 were selected as the research subjects. The patients were divided into the control group (n = 73) and the study group (n = 74) according to random number table method. The control group was treated by Butylphthalide, and the study group was treated by Butylphthalide combined with Naoxintong Capsules. The clinical efficacy of the two groups after treatment was compared, the flow velocity of collateral circulation in the two groups [anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA)], serum inflammatory factor level [interleukin (IL) -6, IL-10, C reverse protein (CRP)] before and after treatment were compared, the occurrence of adverse reactions in the two groups during the treatment were observed. Results After treatment, the total clinical effective rate of the study group was 97.30%(72/74), which was significantly higher than 82.19%(60/73) of the control group, the difference was statistically significant (P < 0.05). The blood flow velocity of ACA and PCA of the two groups after treatment were lower than those before treatment, which of the study group was lower than those of the control group (P < 0.05); the blood flow velocity of MCA was higher than that before treatment, which of the study group was higher than that of the control group (P < 0.05). After treatment, the levels of IL-6, IL-10 and CRP of the two groups decreased compared with those before treatment, which of the study group were lower than those of the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P > 0.05). Conclusion Butylphthalide combined with Naoxintong Capsules is effective in the treatment of cerebral infarction. It can effectively improve the flow velocity of collateral circulation, reduce the level of inflammatory factors and does not increase the incidence of adverse reactions. It has a high clinical application value.
2018 Vol. 15 (33): 93-97 [Abstract] ( 211 ) HTML (1 KB)  PDF (489 KB)  ( 147 )
98 Experience of treating chronic kidney diseases from the Shanghai style famous doctor TONG Shaobo
WANG Jie CHEN Wenhao SUN Beibei JI Jing LI Yuting YU Hongji HE Liqun
TONG Shaobo is a famous doctor of Chinese medicine and the successor of Ding′s internal medicine of Shanghai. In the long term clinical work, TONG Shaobo proposes to grasp the following key points in treating chronic kidney disease： Firstly, it is important to adjust the Yin and Yang, and give consideration of the lung, spleen and kidney. Secondly, the outside and the inside of body should be paid attention to, and adjust the tri-jiao. Thirdly, it is essential to strengthen the body resistance to eliminate pathogenic factors. TONG Shaobo believes that chronic kidney disease is the evidence of the deficiency, most of which are integrated false and solid, especially the deficiency of the spleen and kidney is the basis, leading to the damp wet, phlegm, blood stasis and other solid pathogenic factors. These factors will in turn lead to the dysfunction of the body, and which is difficult to be cured. Therefore, TONG Shaobo formulates a series of rules of treatment, taking into account the three organs-lung, spleen and kidney, paying attention to the harmonization of Yin and Yang. His treating rules not only helps the positive Qi, but also takes into account the existence of the pathogenic factors. He formula a series of therapies and rules in treatment, and uses multiple methods according to different syndrome differentiation.
2018 Vol. 15 (33): 98-101,121 [Abstract] ( 238 ) HTML (1 KB)  PDF (738 KB)  ( 133 )
102 Department mining of Professor Pang He′s medication rule of treating lower extremity arteriosclerosis obliterans
LIU Yali LI Youshan YANG Bohua LIU Fengtong CHEN Lei HUANG Tianyi DU Yuqing
Objective To study Professor Pang′s drug using rule in the treatment of arteriosclerotic obliteration of lower extremity. Methods From December 2016 to January 2018, 204 cases of occlusive arteriosclerosis in Professor Pang′s outpatient in Dongzhimen Hospital, Beijing University of Chinese Medicine were selected. The 204 prescriptions were recorded via traditional Chinese medicine inheritance system, and the relevant results came out by the prescription analysis function of the system. Results Among the 204 prescriptions, 198 kinds of Chinese medicine drugs were used. The five drugs with the highest frequency were ligusticum wallichii, angelica sinensis, radix paeoniae rubra, salvia miltiorrhiza and lumbricus, and frequency of all the drugs were≥160. Drugs with the emergence frequency ≥120 were poria cocos, caulis spatholobi, astragalus membranaceus, woodlouse, gastrodia elata, pueraria lobata, panax notoginseng, radix angelicae pubescentis, cassia twig, loranthus parasiticus, honey-fried licorice root, radix paeoniae alba. Conclusion for the lower extremity arteriosclerotic obliteration Professor Pang′s treatment is to invigorate Qi and promote blood circulation to remove meridian obstruction, meanwhile, assisted with other medications to remove dampness, support poison, dredge collaterals, eradicate blood stasis.
2018 Vol. 15 (33): 102-105,125 [Abstract] ( 182 ) HTML (1 KB)  PDF (886 KB)  ( 171 )
106 Effect of “experienced ten needles for spleen and stomach” for chronic atrophic gastritis with intestinal metaplasia
WANG Huiqing1 XU Keke2 DAI Ming2
Objective To explore the effect of “experienced ten needles for spleen and stomach” for chronic atrophic gastritis (CAG) with intestinal metaplasia (IM). Methods Fifty patients with CAG with IM treated in the Department of Spleen and Stomach, Xinjiang Autonomous Region Hospital of Traditional Chinese Medicine from March 2016 to February 2018 were selected and they were randomly divided into treatment group and control group by random number table method, with 25 cases in each group. The control group was treated with Vitacoenzyme Tablets, 1.0 g per time, tid; Domperidone Tablets, 20 mg per time, tid; and Rabeprazole Sodium Enteric-coated Capsules, 20 mg per time, qd. The course was 8 weeks. Based on the treatment above, “experienced ten needles for spleen and stomach” was given to the treatment group, the acupuncture formula: both Tianshu, both Neiguan, both Zusanli, Shangwan, Zhongwan, Xiawan, Qihai. Treating for 20 minutes per time, 5 times a week and the treatment was continuous for 8 weeks. Gastroscopy、pathological biopsy of gastric mucosa and clinical efficacy were compared before and after treatment. Results After treatment, atrophy of gastric mucosa glands improved in the two groups than that before treatment significantly (P ＜ 0.01 or P ＜ 0.05), and the improvement in the treatment group was more remarkably than the control group (P ＜ 0.05). After treatment, the improvement of intestinal metaplasia in stomach mucosa in the two groups were significant (P ＜ 0.01), and the degree of improvement in the treatment group was greater than the control group (P ＜ 0.05). After treatment, TCM symptom scores (stomach pain, stomach distension, belching and acid regurgitation, noise in the stomach, eating less, stomach oppression in the stomach after meal) decreased than those before treatment in the two groups (P ＜ 0.01 or P ＜ 0.05), and the improvement of any symptom score was more significantly in the treatment group than that in the control group (P ＜ 0.01 or P ＜ 0.05). The clinical effective rate in the intervention group was 92%, which was higher than 64% in the control group (P ＜ 0.05). Conclusion The “experienced ten needles for spleen and stomach” has a definite clinical effect for CAG with IM, which is worthy of clinical application and promotion.
2018 Vol. 15 (33): 106-109 [Abstract] ( 232 ) HTML (1 KB)  PDF (750 KB)  ( 118 )
110 Study on dynamic management of digital resources of ancient Chinese medicine books
DING Kan ZHANG Lijun▲
This paper proposes a dynamic management plan for digital resources of ancient books of traditional Chinese medicine based on the digital construction process. From three aspects of the unit of resource management, the naming of resources and the metadata of traditional Chinese medicine resources, this paper introduces the experience of relevant management work, especially about the detailed description of the metadata of ancient Chinese medicine resources, and deduces the management efficacy from several management perspectives and the dynamic management classic scenes.
2018 Vol. 15 (33): 110-113 [Abstract] ( 180 ) HTML (1 KB)  PDF (713 KB)  ( 72 )
114 Efficacy of acupuncture at Renying point combined with Qufeng Jiedu Huoluo Decoction on peripheral facial paralysis
YANG Fang1,2 YAO Qinghua3
Objective To study the efficacy of acupuncture at Renying point combined with Qufeng Hiedu Huoluo Decoction in patients with peripheral facial paralysis. Methods A total of 93 patients with peripheral facial paralysis admitted to Hangzhou Lower Urban Integrated Traditional Chinese and Western Medicine Hospital from October 2014 to December 2017 were selected as study objects. They were randomly divided into control group (n = 46) and treatment group (n = 47) according to random number table method. The control group was treated with acupuncture at Renying point, the treatment group was treated with Qufeng Jiedu Huoluo Decoction combined with acupuncture at Renying point. The clinical efficacy of the two groups were compared. The serum level of malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) were measured by double sandwich enzyme-linked immunosorbent assay (ELISA), the House-Brackmann (H-B) score before and after treatment was evaluated, and the adverse reactions during treatment were recorded. Results The total efficacy rate of the treatment group was significantly higher than that of the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the level of serum MDA in the two groups were significantly lower than those before the treatment, which of the treatment group was lower than that of the control group; the level of serum SOD and NO were significantly higher than those before the treatment, and which of the treatment group were higher than those of the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the H-B score of the two groups were significantly lower than those before treatment, which of the treatment group was lower than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Acupuncture at Renying point combined with Qufeng Jiedu Huoluo Decoction for patients with peripheral facial paralysis has a good efficacy, it can obviously improve the level of serum MDA, SOD and NO, it is safe and worthy of clinical application.
2018 Vol. 15 (33): 114-117 [Abstract] ( 253 ) HTML (1 KB)  PDF (720 KB)  ( 105 )
118 A preliminary study on the theory system of traditional Chinese medicine for the treatment of vasculitis in Lingnan area by the combination of Maifusheng and nibbled method
LI Jianhua ZHOU Yiping ZHONG Jingfeng HUANG Chunfa
Vasculitis in Lingnan area has its distinctive characteristics. Therefore, the causes, pathogenesis and dialectical main points of the disease were analyzed from the local climate, soil and water, population constitution and other factors. And this paper summarizes the clinical experiences of the department of vasculitis in Guangzhou hospital of traditional Chinese medicine over 40 years in the treatment of vasculitis in Lingnan region. We initially establish the theory system and academic thought of Maifusheng combined with nibbled method in the treatment of vasculitis in Lingnan area.
2018 Vol. 15 (33): 118-121 [Abstract] ( 193 ) HTML (1 KB)  PDF (718 KB)  ( 252 )
122 Discussion on the treatment of phlegm and drinking disease by Linggan Wuwei Jiangxin Decoction and its associated prescription
LU Dan ZHANG Yan WANG Luying ZHANG Zhao
Linggan Wuwei Jiangxin Decoction comes from the Jingui Yaolüe a piece of Cough Phlegm Retention, it has the effect of warming lung to drink, and it is a prescription for treating cold drink and fu lung. Phlegm-drinking disease is a kind of disease caused by the abnormal movement of body fluid and the stop of liquid water in a certain part of the body. Clinical use of Linggan Wuwei Jiangxin Decoction for the treatment of phlegm-drinking disease is a trend and gets effect instantly. Linggan Wuwei Jiangxin Decoction is a kind of prescription based on the changes of symptoms, the treatment of phlegmy disease is more targeted and the effect is more obvious, but the analysis and application of such prescriptions in clinic are less. This paper analyzes the rules of the use of Linggan Wuwei Jiangxin Decoction and its associated prescription, further explains the advantages of this prescriptions in the treatment of phlegm-drinking disease, and illustrates the concrete embodiment of Zhang Zhongjingi′s thought of syndrome differentiation and treatment in phlegm-drinking disease.
2018 Vol. 15 (33): 122-125 [Abstract] ( 231 ) HTML (1 KB)  PDF (748 KB)  ( 44 )
126 The treatment experience about central nervous system demyelinating disease remission of Professor Wang Lixin from the hidden pathogen theory
DAI Yueman1 WANG Lixin2▲
Professor Wang Lixin has studied the demyelinating disease of central nervous system for many years. Based on the theory of "hidden pathogen", he has preliminarily constructed the syndrome differentiation system of the theory of hidden pathogen. Professor Wang takes the opinion that there was a close relationship between demyelinating disease of the central nervous system in remission stage and Yin-marrow deficiency, wind pathogen internal accumulating, Yang-marrow deficiency, and wind cold dampness internal accumulating. According to the patient′s four diagnostic data, comprehensive analysis of the etiology and pathogenesis, and using syndrome differentiation prescriptions, the treatment methods such as warming Yang engendering essence supplementing marrow, eliminating pathogen dredging collaterals, nourishing Yin supplementing marrow, eliminating pathogen activating collaterals and clearing heat are biult. These treatment methods have significant clinical effects.
2018 Vol. 15 (33): 126-129 [Abstract] ( 222 ) HTML (1 KB)  PDF (752 KB)  ( 138 )
130 Effect of head self-weight backward traction with acupotomy in the treatment of cervicogenic headache
HU Hua LI Liantai▲ LIU Yanwei XIE Shuangxi SUN Jianjun
Objective To investigate the clinical efficacy of head self-weight backward traction with acupotomy in the treatment of cervicogenic headache. Methods One hundred and twenty cases of patients with cervicogenic headache admitted to Affiliated Hospital of Chengde Medical University from March 2016 to March 2017 were selected and randomly divided into observation group (60 cases) and control group (60 cases) by fliping coins. The observation group was given the treatment of bedside head self-weight backward traction with acupotomy, and the control group was given acupotomy, the course was 4 weeks. Before and after treatment, X-ray examination of lateral cervical spine was taken, and the cervical curvature values were measured to observe the changes of cervical curvature before and after treatment. Before treatment and after treatment for 4 weeks, 3 months, the visual analogue scale (VAS) was performed respectively, the clinical efficacy of the two groups was observed and statistical analysis was carried out. Results After treatment for 4 weeks, the total effective rate of the observation group was significantly higher than that of the control group, the difference was highly statistically significant (P ＜ 0.01). After treatment for 3 months, the recurrence rate of cervicogenic headache of the observation group (3.33%) was lower than that of the control group (16.67%) (P ＜ 0.01). After treatment for 4 weeks, 3 months, the VAS scores of the two groups were all lower than those before treatment, which of the observation group were lower than those of the control group, the differences were highly statistically significant (P ＜ 0.01). After treatment for 4 weeks, the cervical curvature values of the two groups were higher than those before treatment, which of the observation group were higher than those of the control group (P ＜ 0.01). After treatment for 4 weeks, the total change rate of cervical curvature in the observation group was significantly higher than that in the control group, the difference was highly statistically significant (P ＜ 0.01). Conclusion The effect of head self-weight backward traction with acupotomy in the treatment of cervicogenic headache is significant, and the recurrence rate is low, which is worthy of clinical promotion.
2018 Vol. 15 (33): 130-133,141 [Abstract] ( 186 ) HTML (1 KB)  PDF (548 KB)  ( 110 )
134 Clinical effect of needle-knife in the treatment of cervical insomnia 
MA Hui1 LI Kang2 DONG Can2 ZHANG Cairong2
Objective To investigate the clinical effect of needle-knife in the treatment of cervical insomnia. Methods Ninety cases of patients with cervical insomnia treated in Department of Acupuncture and Moxibustion, Nanjing Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Department of Acupuncture and Moxibustion, Jiangsu Provincial Second Hospital of Traditional Chinese Medicine and Outpatient Department of Acupuncture and Moxibustion of Daishan Community Health Service Center of Yuhua District in Nanjing City from October 2014 to May 2016 were selected and divided into needle-knife group, drug group, needle-knife + drug group by random number table method, with 30 cases in each group. The therapeutic effects, Pittsburgh sleep quality index (PSQI) scores, visual analogue scale (VAS) and the satisfaction of patients in the three groups were compared. Results After treatment for two courses, there was no significant difference in the total effective rates among the three groups (P > 0.05). After treatment, the scores of daytime dysfunction, hypnotic, sleep disorder, sleep efficiency, sleeping time, fall-sleep time, sleep quality and total scores in the three groups were all lower than those before treatment, the differences were statistically significant (P ＜ 0.05), while there was no signficant difference among the three groups after treatment (P ＞ 0.05). After treatment, the scores of VAS in the three groups were significantly lower than those before treatment (P ＜ 0.05), and the VAS score in the needle-knife + drug group was significantly lower than that of drug group after treatment (P ＜ 0.05). After treatment, the degree of satisfaction in needle-knife group and needle-knife + drug group was higher than that of drug group, the difference was statistically significant (P ＜ 0.05). Conclusion The needle-knife therapy can improve the insomnia symptoms and the sleep quality of patients, which is worthy of clinical further promotion.
2018 Vol. 15 (33): 134-137 [Abstract] ( 197 ) HTML (1 KB)  PDF (530 KB)  ( 92 )
138 Clinical efficacy of ultrasound guided acupotomology in the treatment of knee osteoarthritis
LI Luning1 HU Guoqiang2 GAO Chengchao1 SUN Bichen3 TIAN Cuishi1 HU Kaibin4
Objective To investigate the clinical effect of ultrasound guided acupotomology in the treatment of knee osteoarthritis. Methods Sixty cases of patients with knee osteoarthritis in accordance with the inclusion criteria treated in Rehabilitation Department, Shijiazhuang Hospital of Traditional Chinese Medicine from November 2016 to March 2018 were selected as research objects, and they were divided into two groups by random number table method, with 30 cases in each group. The ultrasound guided acupotomology group was given therapy of ultrasound guided acupotomology, once every 5-6 days, for 2 weeks. The acupuncture group was given acupuncture therapy, five times each week, for 2 weeks. The visual analogue scale (VAS) was recorded before and after treatment for 2 weeks, and the efficacy of the two groups was recorded. Results After treatment, the VAS scores in both groups were significantly lower than those before treatment, and the score of ultrasound guided acupotomology group was significantly lower than that of acupuncture group, the differences were statistically significant (P ＜ 0.05). After treatment, the total effective rate of ultrasound guided acupotomology group was 90.0%, which was higher than that of acupuncture group (66.7%), the difference was statistically significant (P ＜ 0.05). Conclusion The clinical effect of ultrasound guided acupotomology in the treatment of knee osteoarthritis is better than that of acupuncture therapy, which can significantly improve clinical symptoms in short term.
2018 Vol. 15 (33): 138-141 [Abstract] ( 197 ) HTML (1 KB)  PDF (530 KB)  ( 99 )
142 Combined treatment of traditional Chinese and Western medicine for one case with polypoid choroidal vascular disease
HUANG Li ZHAO Yanqing XIANG Minhong▲ JIA Yuanling LI Qingsong WEN Hang
Polypoidal choroidal vasculopathy (PCV) is a kind of ocular retinal disease which seriously affects people′s visual function. In the continuous exploration, people's understanding of PCV is getting deeper and deeper not only in Western medicine treatment, but also in the field of traditional Chinese medicine (TCM). In this paper, the PCV patients are injected by Conbercep intravitreal injection with both eyes. The TCM differentiation combined treatment of replenishing qi and blood, tonifying liver eyesight and activating blood circulation was also given. The clinical therapeutic effect is better, and the advantages of combination of TCM and Western medicine in the treatment of PCV are fully reflected.
2018 Vol. 15 (33): 142-145,150 [Abstract] ( 190 ) HTML (1 KB)  PDF (1446 KB)  ( 134 )
146 Analysis of characteristics of patients admitted to Xinjiang Uygur Autonomous Region People′s Hospital
LIU Jia1 YANG Xu2 FANG Xian2,3
Objective To analyze the population, time and clinical features of emergency patients admitted to Xinjiang Uygur Autonomous Region People′s Hospital ("our hospital" for short), in order to provide the useful suggestion for reducing emergency damage to individuals and families. Methods From February 2009 to November 2016, patients with emergency treatment in our hospital were selected as the research object, descriptive epidemiology research method was adopted to analyze the basic information and injury characteristics of patients. Results In total, 16 102 cases were admitted to our hospital from February 2009 to November 2016, in which falls and traffic accidents accounted for 8506 cases (52.8%) and 4091 cases (25.4%) respectively. From February 2009 to December 2014, the number of emergencies increased significantly, and declined slowly from January 2015 to November 2016. Among the emergency inpatients admitted to our hospital, there were statistically significant differences in gender, nationality, age group, marital status and occupational distribution (P < 0.01). The majority of all kinds of emergencies were not clinically confirmed at the time of admission, with 7386 cases (45.9%), of which traffic accidents were the highest (2275 cases, 55.6%). The number of patients hospitalized between one and two weeks was the highest, with 6689 cases (41.5%), and the proportion of patients with falls was the highest (46.3%). There were 1105 cases (6.9%) with more than one month of hospitalization, with the highest proportion of patients with fire or burns (29.4%). The majority of patients were cured in hospital discharge and return, with 11 539 cases (71.6%), among which the number of people cured in falling down was the highest (72.2%). Conclusion Falls and traffic accidents were the major cause of emergency hospitalizations. Governmental-led interventions and comprehensive preventions should be taken to protect highrisk populations and reduce the occurrence of emergency effectively.
2018 Vol. 15 (33): 146-150 [Abstract] ( 204 ) HTML (1 KB)  PDF (748 KB)  ( 81 )
151 Diagnostic values of miR-21 and miR-423-5p in patients with valvular heart disease and heart failure
LI Yumei1 SHENG Hongbin2 XU Hengshi1
Objective To investigate the potential diagnostic value of serum miR-21 and miR-423-5p for heart failure (HF) due to heart valve disease (VHD). Methods From August 2014 to April 2016, in Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine, 60 VHD patients with HF were selected as VHD group, at the same period, 60 healthy persons were selected as control group. The levels of serum miR-21 and miR-423-5p were measured by qRT-PCR. The ROC curve was used analyse the clinical Value of miR-21 and miR-423-5p as VHD with biomarkers for diagnosis and prognosis of heart failure. Results The levels of miR-21 and miR-423-5p in sera of patients in VHD group were higher than control group, the differences were statistically significant (P < 0.05). The levels of miR-423-5p in sera of VHD patients with pulmonary hypertension (PH) were higher than VHD patients without PH, the differences were statistically significant (P < 0.05). ROC curve result showed that serum miR-21 and miR-423-5p had potential diagnostic values on HF due to VHD. Conclusion Serum miR-21 and miR-423-5p show potential diagnostic values on HF due to VHD. Moreover, serum miR-423-5p can be an effective biomarker for diagnosing VHD patients with PH.
2018 Vol. 15 (33): 151-154,162 [Abstract] ( 212 ) HTML (1 KB)  PDF (939 KB)  ( 58 )
155 Discussion on the development strategy of Guangxi Zhuang Yao medicine healthy pension tourism based on the status of Bama Yao autonomous county
GAO Haibin1 HUANG Guozhu1 JIANG Feng2 RUAN Qingting1 XIE Ye1
Health pension tourism of Zhuang Yao medicine is a transformation and innovation to the existing mode of the policy of providing for the aged in China. Guangxi Bama Yao Autonomous County ("Bama" for short) is known as "the world′s longevity village". Bama owns superior natural ecological environment, and it has rich Zhuang Yao medicine resources. Longevity culture has a long history here, and it is suitable for developing into a demonstration base of health endowment tourism. This paper explores the development of Zhuang Yao medical health and endowment tourism industry and the development prospects of the industry, mainly from the aspects of aging, health status, development prospects and development strategies. By analyzing the status quo of Chinese aging and the demand for old-age services, this paper proposes to develop Guangxi Zhuang Yao medicine healthy pension tourism with Zhuang Yao Medicine, aged services and tourism multi-industry integration model, and provides relevant development strategies and suggestions.
2018 Vol. 15 (33): 155-158 [Abstract] ( 191 ) HTML (1 KB)  PDF (730 KB)  ( 18 )
159 Analysis of the status of clinical pathway management in traditional Chinese medicine hospitals in China
LYU Jingru1,2 RUAN Song3 LIU Xiaoxing3 SUN Xiaojie1,2
This article elaborates the concepts of clinical pathway and clinical pathway of traditional Chinese medicine, the implementation significance of clinical pathway management and the policy background of its implementation in traditional Chinese medicine hospitals. The main part of this paper is made up of the current status of clinical pathway management and its supporting measures. Meanwhile, it also points out main problems existed and relative recommendations for further improvement. The results showed that the development of clinical pathway of traditional Chinese medicine is very fast, and it is well supported by many measures in some hospitals which contributes to the control of hospitalization expenditure and the improvement of health care quality. However, the lack of high quality clinical pathway, unbalanced information system construction, less motivation given by payment method and imperfect evaluation standard still limit the development of clinical pathway of traditional Chinese medicine. This status could be improved by studying traditional Chinese medicine experience hard, supporting information system construction of poor area, accelerating payment reform and standardizing evaluation system.
2018 Vol. 15 (33): 159-162 [Abstract] ( 206 ) HTML (1 KB)  PDF (733 KB)  ( 123 )
163 Thinking of training mode of continuing education in the primary medical staffs of critical care medicine of western Guangdong under the background of WeChat
DENG Liehua1 ZHANG Biao2 ZHONG Xian1 GAO Feng1 TONG Lin1▲
Currently, the continuing education training modes of critical care medicine have been unable to meet the needs of primary medical staff, and they are not compatible with the direction of reform and development of national health care. Although many training platforms based on network technology have been developed and applied, they take on have the limitation in time, space and resources. Therefore, a new training platform with mobility, comprehensiveness, high efficiency is a new idea to solve the problem of primary medical staff training of critical care medicineusing WeChat technology，which willbuild up a new model of continuing education of critical care medicine.
2018 Vol. 15 (33): 163-165,180 [Abstract] ( 201 ) HTML (1 KB)  PDF (690 KB)  ( 162 )
166 Textual quantitative analysis of healthcare reform policies on role of joint reform of medical service, medication and medical assurance in past ten years from perspective of policy tools
HU Zhimin LIU Xiaoxi XIE Yu
The new healthcare reform, which began in 2009, emphasizes on the joint reform of medical service, medication and medical assurance. This paper makes a textual quantitative analysis of 53 national-level healthcare reform policies in the past 10 years from both the perspectives of policy tools and three system dimensions of "three-medicine linkage". The results show the usage and evolution of policy tools in the aspects of supply, environment and demand, and preliminarily analyze the relationship between policy tools and the "three medicine linkage" system. From the perspective of policy tools, this study explores the path of development and change of healthcare reform policies in the past 10 years, and analyzes the effect of healthcare reform policies on the three systems of "three medical linkage" and the linkage relationship between the systems, which provides a useful reference for the further promotion of health care reform.
2018 Vol. 15 (33): 166-171 [Abstract] ( 242 ) HTML (1 KB)  PDF (849 KB)  ( 104 )
172 Analysis of scientific research papers published in our hospital from 2013 to 2017 and research on countermeasures
LIN Aicui1 LIU Chengyou2
Objective To analyze the trend characteristics of scientific research papers written by the staffs of Nanjing Hospital Affiated to Nanjing Medical University (hereinafter referred to as "our hospital") in the last 5 years, and provides references for the hospital to formulate relevant scientific research policies and promote the development of scientific research in the hospital. Methods The scientific research papers published by the staffs of the institute from 2013 to 2017 were obtained from our scientific technology management system of the institute, and the statistical analysis were conducted by descriptive statistics. Results From 2013 to 2017, the number of foreign papers published in our hospital has been increasing year by year. Moreover, the proportion of SCI papers with a score of 5 or above is increasing year by year, the proportion of papers in Chinese, Chinese medical association series journals, Peking University core journals showed a downward trend. In Chinese papers, the proportion of treatise is large, and the proportion of management, teaching and review consensus papers is low, and there is a downward trend. Conclusion While promoting scientific researchers to publish SCI papers, the hospital should also pay attention to the improvement of the level of publication of domestic papers, and promote the further improvement of the level of publication of papers from the aspects of system guidance, information service and writing guidance.
2018 Vol. 15 (33): 172-175 [Abstract] ( 220 ) HTML (1 KB)  PDF (734 KB)  ( 117 )
176 Conversion of the local coding database into the national clinical coding database of the classification of diseases
CUI Shengnan ZHAO Qing LIU Haimin WANG Yi
This article discusses the conversion of the local coding database into the national clinical coding database of the classification of diseases. The semi-automatic coding matching tool developed by the Medical Record Department of Peking Union Medical College Hospital was used to match, classify and note the codes of the two databases, and then classify the different matching types into different categories according to the situation of disease name and coding matching. After matching classification, the number of diseases codes shared by national clinical coding database and local coding database is 14 191, accounting for 90.14% of the total number of 15 743 of the local coding database. The Special disease codes in the local coding database is 1552, accounting for 9.86% of the total codes of local coding database. The coding of concordance library is classified according to different types after matching, which lays a foundation for the retrieval and utilization of historical database and the later work.
2018 Vol. 15 (33): 176-180 [Abstract] ( 374 ) HTML (1 KB)  PDF (1778 KB)  ( 138 )
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