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Progress in the new approaches to regulation of muscle synthesis and metabolism |
REN Guangxu1 YUAN Chao2 |
1.Institute of Food and Nutrition Development, Ministry of Agriculture, Beijing 100081, China;
2.China National Food Industry (Group) Corp, Beijing 100062, China |
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Abstract Skeletal muscle plays an important role in human health and disease. In many tumors, chronic heart failure and nutritional deficiency, the symptoms of muscular atrophy are characterized by loss of muscle mass and strength. Muscle atrophy seriously affects the quality of life, and even threatens the lives of patients. Although researchers have found that inflammation and nutritional health state can lead to muscle atrophy, the specific regulatory network is still not clear. Recent studies have revealed that gut microbes in the human body may also participate in the regulation of muscle synthesis. Therefore, we will review the recent progress in the study of the "gut muscle" axis and the molecular mechanisms involved.
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