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2018 Vol. 15, No. 21
Published: 2018-07-25
 
 
4 Evaluation of diagnosis value of plasma miRNA-21 and miRNA-142-5p in renal cell carcinoma
LI Qian1 JIANG Fujin2 WEN Rumin1 WANG Wentian3
Objective To investigate the clinical values of plasma miRNA-21 and miRNA-142-5p expression levels in the diagnosis of renal cell carcinoma (RCC). Methods Blood samples of patients with RCC and bebign renal disease from July 2015 to October 2017 in the Second People′s Hospital of Huai′an were collected, there were 55 cases and 49 cases respectively. The expression levels of plasma miRNA-21 and miRNA-142-5p were determined by fluorescence quantitative PCR in these patients. The correlations between the two miRNAs levels in plasma and clinicopathological characteristics of patients with RCC were analyzed. The diagnostic performance of each miRNA to distinguish RCC from benign renal disease was evaluated by the receiver operating characteristic (ROC) curve analysis. Results The levels of plasma miRNA-21 and miRNA-142-5p in RCC patients were higher than those in benign renal disease (P < 0.01). There was no significant correlation between plasma miRNA-142-5p levels and clinicopathological characteristics of RCC patients (P > 0.05), whereas the expression levels of plasma miRNA-21 was correlated with clinical stages (P < 0.05). There was no significant correlation between the expression of miRNA-21 and miRNA-142-5p in the plasma of 55 patients with RCC (P > 0.05). The area under ROC curve of the two miRNAs were 0.826 (95%CI:0.794-0.912) and 0.805 (95%CI:0.744-0.919). The sensitivity and specificity were 81.8% and 83.7% for miRNA-21, and 80.0% and 77.6% for miRNA-142-5p, respectively, for diagnosing RCC. And the sensitivity was increased to 87.3% with miRNA-21 in combination with miRNA-142-5p, despite slightly decreased specificity which was 75.5%. Conclusion These findings demonstrated that plasma miRNA-21 and miRNA-142-5p may serve as a promising biomarker in the diagnosis of RCC.
2018 Vol. 15 (21): 4-7,18 [Abstract] ( 242 ) HTML (1 KB)  PDF (608 KB)  ( 63 )
8 Mitochondrial DNA ND1 and ND4 mutation in liver and captured hepatocytes of mice after long-term nucleoside analogues exposure
ZHANG Wei1* QIAO Luxin1,2* DING Wei1 CHEN Dexi1,2 ZHANG Yulin1▲
Objective To investigate whether long-term use of nucleoside analogues (NAs) can lead to damage of DNA (mtDNA) ND1 and ND4 regions in liver mitochondria of mice. Methods According to the simple random method, twenty-five 7-weeks-old female Balb/c mice were divided into 5 groups, with 5 cases in each group. The control group received double-distilled water by intraperitoneal injection 5 days per week for 3 months. The each test group was respectively given D4T 50 mg/kg, AZT 100 mg/kg,3TC 50 mg/kg,or DDI 50 mg/kg by intraperitoneal injection per day,5 days per week for 3 months. Single liver cell was captured from mouse liver tissues by laser capture microdissection. The products of mtDNA ND1 and ND4 region PCR amplicons were cloned and sequenced in mice liver cells. Results The mean distance to the reference sequence of mtDNA ND4 in the captured hepatocytes of AZT, D4T and 3TC groups were longer than that in the control group, the differences were statistically significant (P < 0.01). The mean mtDNA ND4 dN of the captured hepatocytes in the AZT group was higher than that in the control group, the difference was statistically significant (P < 0.05). The mean distance to the reference sequence of mtDNA ND1 in the captured hepatocytes of AZT and 3TC groups were longer than that in the control group, the differences were statistically significant(P < 0.01). The mean mtDNA ND1 dS of the liver tissue in the DDI group was higher than that in the control group, the difference was statistically significant (P < 0.05). The mean mtDNA ND1 dS of AZT and 3TC groups were higher than that in the control group, the differences were statistically significant(P < 0.05). Conclusion Long-term exposure to nucleoside analogue can result in mtDNA ND1 and ND4 regions lesion in mouse hepatocytes.
2018 Vol. 15 (21): 8-13 [Abstract] ( 198 ) HTML (1 KB)  PDF (1583 KB)  ( 120 )
14 Study of effect and potential mechanism of Callicarpa nudiflora extract against psoriasis
BA Li′na
Objective To determine the anti-psoriasis effect of Callicarpa nudiflora extract. Methods Sixty KM mouses were randomly divided into 5 groups by random number table (n = 12), including model group, Callicarpa nudiflora low-dose group, Callicarpa nudiflora middle-dose group, Callicarpa nudiflora high-dose group and positive control group. They were given to normal saline, Callicarpa nudiflora extract (0.6 g/kg or 1.2 g/kg or 2.4 g/kg) and 1 mg/kg methotrexate by gastric perfusion for seven days respectively. Lateral line scales of granular layer were detected by HE method. The expression of Caspase3, Cleaved-Caspase3, Bax and BCL-2 mRNA and protein were detected by Real-time PCR and Western blot. Results Lateral line scales of granular layer of Callicarpa nudiflora middle-dose and high-dose groups was increased than those in the model group (P < 0.05). The expression of the pro-apoptotic proteins Caspase3, Cleaved-Caspase3, Bax mRNA and protein in callicarpa nudiflora middle-dose and high-dose groups were up-regulated than those in the model group (P < 0.05), the expression of the anti-apoptotic protein BCL-2 mRNA and protein was down-regulated (P < 0.05). Conclusion The Callicarpa nudiflora extract can exert anti-psoriatic effect by inducing apoptosis.
2018 Vol. 15 (21): 14-18 [Abstract] ( 336 ) HTML (1 KB)  PDF (1277 KB)  ( 91 )
19 The effect of Yitai Compound on apoptosis of acinous cells in the rats with pancreatic fibrosis
GAO Lijuan1,2 LIU Li3 LIU Huasheng2 WANG Kejun4 ZHENG Nan2
2018 Vol. 15 (21): 19-22 [Abstract] ( 179 ) HTML (1 KB)  PDF (523 KB)  ( 96 )
23 Study advance in the relationship between Parkinson′s disease and melatonin
HU Yingying WANG Xijin
Parkinson′s disease is a chronic progressive neurodegenerative disease. The main clinical manifestations include motor syptoms such as bradykinesia, tremor, rigidity, and postural instability, as well as non-motor symptoms, such as impaired olfaction, sleep disorder, cognitive impairment, and emotional disorder. Melatonin is a hormone synthesized mainly by the pineal gland, regulating the circadian rhythm. Besides it acts as a free-radical scavenger, with neuroprotective, anti-inflammatory, and antioxidant properties. The unbalance of pineal melatonin synthesis disposes the body to a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson′s disease. Parkinson′s disease is due to the impairment of melatonin concentration and the expression of its receptor in the brain. Exogenous melatonin treatment improves its motor symptoms. Besides, it also shows effects on non-motor symptoms, such as sleep disorders, congnitive disorders, anxiety and depression. The aim of this review is to summarize the knowledge about the potential role of the melatoninergic system in the pathogenesis and treatment of Parkinson′s disease.
2018 Vol. 15 (21): 23-26 [Abstract] ( 209 ) HTML (1 KB)  PDF (422 KB)  ( 76 )
27 The research progress of association between Helicobacter pylori and inflammatory bowel disease
CHENG Yi′an TAN Shiyun LI Ming
Inflammatory bowel disease (IBD) is a chronic inflammatory disease affecting intestinal tract. Existing researches suggest that environment, genetics, immunity and infection may be involved in its pathogenesis. Helicobacter pylori (H.pylori) is a common human pathogen, which is associated with a variety of gastric and extra-gastric diseases. In recent years, a lot of data show a negative correlation between them, and studies find that this association may be related to the immune regulation characteristics of H.pylori or other confounding factors such as antibiotics, sulfasalazine and environment. In addition, there are cases of newly diagnosed IBD after the eradication of H.pylori and it may trigger Crohn disease by affecting the balance between Th1 and Th2 immune response. The association between H.pylori and IBD as well as the mechanism are disscussed in this paper, and the article also reviews the development of IBD after the eradication of H.pylori.
2018 Vol. 15 (21): 27-30 [Abstract] ( 287 ) HTML (1 KB)  PDF (472 KB)  ( 148 )
31 Research progress on the IL-17 and pathogenesis of dengue virus infection
ZHENG Yuanfei LIU Fenghui CHEN Weifeng WU Huiwen ZHANG Yunqin ZHOU Bingxua ZHENG Biying
Dengue virus is transmitted by Aedes mosquito and causes dengue fever, dengue hemorrhagic fever and dengue shock syndrome. Early studies have found that dengue virus infection causes cytokines to be oversecreted, leading to cytokine storms. Different cytokines play different roles in dengue virus infection, aggravate or inhibit the progression of disease, and affect the outcome of the disease. As an important pro-inflammatory cytokine, interleukin-17 (IL-17), secreted by Th17 cells, can induce the aggregation and proliferation of neutrophils, thus effectively mediating the inflammatory response of tissues, which is related to the pathogenesis of various viral infections. The immune mechanism of dengue virus infection and cytokine storm IL-17 and the relationship between IL-17 and dengue virus infection were reviewed.
2018 Vol. 15 (21): 31-34 [Abstract] ( 263 ) HTML (1 KB)  PDF (420 KB)  ( 90 )
35 Bibliometrics of scientific papers of 5 Chinese universities of traditional Chinese medicine based on Web of Science in recent ten years
LI Han WANG Liangbin
Objective To analysis the publication of scientific papers of “The five” Chinese medicine universities and reflect the comprehensive scientific research ability of universities in a certain extent. Methods Scientific papers of “The five” included in the Web of Science Database in the last ten years (from January 2007 to May 2017) were used as analysis object, bibliometrics method was used to statistically analysis literatures on the volume of literature, including the publication of sources, the citation of papers, the influencing factors, the H index and the dominant disciplines from natural science and humanistic community. Results The number of scientific papers of “The five” was increased year by year, but the average influence factor and cited quantity were not high. In the scientific papers included in SCIE, Evidence Based Complementary and Alternative Medicine were the most frequent source of publications. In the comparison of dominant subjects, Science of Traditional Chinese Medicine and Integrative & Complementary Medicine was developed well, but Traditional Chinese Medicine was relatively weak. The development of Humanistic community was slow compared with natural science. Conclusion Scientific papers of “The five” should simultaneously guarantee the quality with steady increase in quantity, coordinatively develop disadvantaged subjects and characteristic subjects of Chinese Medicine, further manifest the “The five” comprehensive strength.
2018 Vol. 15 (21): 35-39 [Abstract] ( 272 ) HTML (1 KB)  PDF (788 KB)  ( 122 )
40 Medication use behaviors and demands for community pharmaceutical care among the elderly in Macao
LAO Cheng-kin１ WONG Sok-nei１,２ LAO Keng-kun１,3 CHAN Tak-chio１,3 CHAN Nga-san１ KUOK Chiu-fai１ FONG Pedro１ MENG Li-rong１
Objective To explore the medication use behaviors, their associated factors and the demands for community pharmaceutical care among the elderly in Macao. Methods A survey was conducted by quota sampling in October 2015, which targeted at the residents aged 60 years or older from the districts of Nossa Senhora de Fátima, Santo António, São Lourenáo, islands, São Lázaro and Sé of Macao. Data such as health information, medication use behaviors, basis for purchasing medications, and demands for pharmaceutical care were collected. Results A total of 401 questionnaires were issued. 398 valid questionnaires were collected and the valid rate was 99.3%. Regular use of 5 or more medications was reported by 30.4% of respondents. Based on the results of the Morisky scale, overall medication adherence was found to be unsatisfactory in 60.6% of respondents. 14.1% of respondents had adjusted medication doses and 8.5% had repeated doses. Both types of irrational medication use were associated with polypharmacy. Most respondents were supportive of the implementation of community pharmaceutical care. Conclusion There are strong demands for community pharmaceutical care from the elderly in Macao. These data can serve as references to develop various pharmaceutical care models, so that pharmacists can play a more significant role in promoting rational medication use among the elderly.
2018 Vol. 15 (21): 40-43 [Abstract] ( 301 ) HTML (1 KB)  PDF (440 KB)  ( 100 )
44 Design and application of regional collaborative remote outpatient system based on articulated naturality web
ZHENG Fuzeng1 LI Hongqi2 WANG Haidong1 MA Qiuling1 LIU Yuqiang3 XU Peng1 TIAN Bingbing1 LI Jianping4
Remote video communication technology based on the articulated naturality web provides rich new forms for the development of medicine, and it plays an important role in improving medical technology, rescuing critically ill patients, preventing and controlling sudden diseases. At present, China is actively promoting the new policy of graded diagnosis and treatment reform, that resulting in a large number of patients in the primary hospitals, but there are obvious shortcomings in the management, technology, doctors, equipments and other aspects of the primary hospitals. The primary hospitals cannot vigorously promote the development of medical service to serve the people better. The telemedicine system can make up for these shortcomings to some extent, combining with various current forms of remote consultation, and a regional cooperative remote outpatient system based on the articulated naturality web has been designed. The system has established extensive cooperation with 17 prefecture-level and city-level hospitals in Henan Province. The system can accelerate the sinking of quality medical resources, promote the upward and downward linkage among hospitals, expand the way for basic-level doctors and patients to solve problems, and narrow the gap between basic-level and higher-level hospitals. This artical summarizes in detail to provide references for telemedicine systems in various places.
2018 Vol. 15 (21): 44-47 [Abstract] ( 194 ) HTML (1 KB)  PDF (381 KB)  ( 37 )
48 Atypical manifestations and misdiagnosis analysis of children with hypothyroidism
YU Fei FANG Haining WANG Xiaoxia ZHU Jie SU Hang
Objective To analyze the atypical manifestations of hypothyroidism in children and long term misdiagnosis, in order to improve the children′s hypothyroidism diagnosis level. Methods The clinical data of 23 cases misdiagnosed children with hypothyroidism in Maternal and Child Health Care Hospital of Hubei Province from August 2013 to December 2017 was collected to review and carry on clinical analysis. Results The main symptoms of 7 cases were long-term anorexia, abdominal distension, constipation and other gastrointestinal symptoms. The main symptoms of 3 cases were severe anemia. The main symptoms of 6 cases were growth retardation, mental retardation. The main symptoms of 7 cases were precocious puberty. Conclusion The manifestation of hypothyroidism is complicated and lacks specificity. Thyroid function test and comprehensive analysis should be carried out in time, that may reduce the rate of misdiagnosis.
2018 Vol. 15 (21): 48-50,97 [Abstract] ( 225 ) HTML (1 KB)  PDF (725 KB)  ( 98 )
51 Impact of chronic diseases management on the quality of life of patients with benign prostatic hyperplasia
MA Zhengjun SUN Xiaohong
Objective To explore the effect of chronic diseases management mode on quality of life of the patients with benign prostatic hyperplasia, so as to provide references for effective development of health education of benign prostatic hyperplasia. Methods A total of 200 patients(≥65 years old) were investigated from May 2011 to April 2012 in Beijing Geriatric Hospital, stratified randomly divided into normal mode group(n=100) and management mode group(n=100), the normal group received routine diagnosis and health education, and the chronic diseases management group received the hospital-community-message unify platform. After 5 years, international prostate symptom score (IPSS), quality of life and urinary retention were compared between the two groups after 5 years of follow-up. Results IPSS of chronic diseases management group was better than the normal mode group, and the difference was statistically significant (Z = 2.031, P < 0.05). The QOL scores in the two groups was less than that befores intervention, and the difference was statistically significant (t = 2.283, P < 0.05; t =3.908, P < 0.05), and the QOL scores of the chronic diseases management group was lower than that of the normal model group, the difference was statistically significant (t = 2.587, P < 0.05). The incidence rate of urinary retention in chronic disease management group was 6%, the incidence rate in normal group was 22%, the incidence rate between the two groups was statistically significant (χ2 = 11.368, P ＜ 0.05). Conclusion Chronic disease management mode is especially important for health management of patients with benign prostatic hyperplasia, which not only can effectively control symptoms, but also reduce the incidence of urinary retention and improve the quality of life of patients.
2018 Vol. 15 (21): 51-54 [Abstract] ( 225 ) HTML (1 KB)  PDF (391 KB)  ( 200 )
55 Effect of percutaneous kyphoplasty for treatment of multiple osteoporotic vertebral compression fractures
JIN Zhankui1 XU Cuixiang2 WU Xueyuan1 DONG Xianghui1 CHANG Yanhai1 SUN Zhengming1 CHEN Ming1 LING Ming1
Objective To observe the clinical efficacy of percutaneous kyphoplasty (PKP) in the treatment of osteoporotic multiple segmental thoracolumbar fractures in the elderly. Methods The clinical data of 46 patients with multi-segment senile osteoporotic vertebral fracture treated by PKP from April 2011 to January 2016 in Shaanxi Provincial People′s Hospital were retrospectively analyzed. Visual analogue scale (VAS), Oswestry disability index(ODI) score, vertebral body height, and vertebral Cobb angle were observed preoperatively at 3 days postoperatively and at the last follow-up, and the factors that affect postoperative efficacy were evaluated. Results PKP was performed on 113 vertebral lesions in 46 patients. The average cement injection volume was (4.05±1.20) mL. There was 11 vertebral cement leakages, including 1 nerve compression symptom and 7 cases were new-onset adjacent vertebral compressions fractures. The VAS scores, ODI scores at preoperative 3 d, the last follow-up and were compared, the differences were statistically significant (P < 0.01). The height of anterior vertebral body and vertebral body at the postoperative 3 d was significantly higher than before operation, and the height of the last follow-up was lower than the postoperative 3 d, the differences were statistically significant (P < 0.01). The Cobb angle at the  postoperative 3 d was significantly lower than before opertation, and the Cobb angle of the last follow-up was higher than the postoperative 3 d, the differences were statistically significant (P < 0.01). Multivariate analysis found that bone density, the number of injured vertebrae, and adjacent vertebral fractures were related factors affecting surgical outcomes (P < 0.05). Conclusion PKP is a safe and effective method for the treatment of multi-segment senile osteoporotic thoracolumbar fractures. It can instantly reduce pain and improve quality of life.
2018 Vol. 15 (21): 55-59 [Abstract] ( 210 ) HTML (1 KB)  PDF (1107 KB)  ( 144 )
60 retrospective clinical observation on repair of osteochondral lesions of talus with non-weight bearing area osteochondral columns from patellofemoral joint surface of ipsilateral femoral condyle
LIU Yang JIA Jinling CUI Mingxing LIU Chang ZHAO Bin
Objective To investigate the clinical effect of using autologous osteochondral transplantation with non-weight bearing area osteochondral columns which derived fromthe patellofemoral joint surfaceof ipsilateral femoral condyle for repairing osteochondral lesions of the talus (OLT). Methods From May 2014 to March 2017, in the First Affiliated Hospital of Xinxiang Medical University, 22 OLT patients were retrospectively reviewed, all patients underwent preoperative assessment of the extent of talus lesions by X-ray, CT or MRI. Then the position and area of osteochondral lesions were determined by arthroscopy in all patients, the edge of the defect area and medial malleolus osteotomy was cleared, osteochondral autograft transfer system was used to repair osteochondral lesions of the talus with non-weight bearing area osteochondral columns from the patellofemoral joint surface of ipsilateral femoral condyle. Visual analogue scale (VAS) was used to assess ankle pain preoperatively and during the last follow-up postoperatively. American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score was used to evaluate ankle function preoperativly and the last follow-up postoperatively. X-ray and MRI of ankle joint were observed to understand the recovery of osteochondral lesions area postoperatively. Results A total 21 patients received follow-up, 1 patient lost follow-up. After treatment they received follow-up for 10-20 months, the VAS reduced from (5.95±1.04) points before surgery to (1.50±0.96) points at last follow-up, the difference was statistically significant (P ＜ 0.01). The AOFAS improved from (53.28±14.93) points before surgery to (84.47±9.31) points at last follow-up, the difference was statistically significant (P ＜ 0.01). Conclusion Osteochondral autografts is effective in the treatment of OLT, it can reduce the pain of the ankle and improve the function of the ankle joint.
2018 Vol. 15 (21): 60-63,77 [Abstract] ( 230 ) HTML (1 KB)  PDF (723 KB)  ( 113 )
64 Clinical Observation on treatmentof lumbar disc herniation by Buqihuoxue Decoction combined with percutaneous endoscopic lumbar discectomy
SHANG Rong′an1 YU Hongchao2 WANG Shaofei1 CHAO Jianhu1 LIU Dongqian1 FENG Wanli1
Objeetive To observe clinical effect of Buqihuoxue Decoction and percutaneous endoscopic lumbar discectomy on lumbar disc herniation. Methods From April 2015 to March 2017, in Department of Orthopedics, Baoji Hospital of Chinese Medicine, 50 patients with lumbar intervertebral disc herniation were divided into control group 25 cases (given percutaneous intervertebral endoscopy) and treatment group 25 cases (given Buqihuoxue Decoction and percutaneous intervertebral endoscopy). The visual analogue score (VAS score) and Oswestry disability index (ODI index) were compared the preoperation, 1 week, 1 month, and 6 months after surgery. During treatment, the function of liver and kidney, adverse drug reactions were monitored regularly. Results After treatment, the VAS score and ODI index in two groups were improved than before treatment, the differences were statistically significant (P ＜ 0.05); the VAS score and ODI index in the treatment group were significantly lower than the control group on 1 week, 1 month, and 6 months, the differences were statistically significant (P ＜ 0.05). There was no drug-related gastrointestinal reaction and general discomfort in all patients. Conclusion Buqihuoxue Decoction combined with percutaneous transforaminal endoscope for the treatment of lumbar disc herniation is safe and effective. The combination of Chinese and Western medicine has achieved good results.
2018 Vol. 15 (21): 64-67 [Abstract] ( 244 ) HTML (1 KB)  PDF (616 KB)  ( 154 )
68 study of diagnosis value of three-dimensionalreconstruction on complex tibial plateau fractures
ZHENG Jun1 ZHANG Lei2 WANG Xiaoyang1 GAO Yuantong1 CHEN Ruoqian1
Objective To compare X-ray, three-dimensional CT reconstruction and MRI in the diagnosis of complex tibial plateau fractures. Methods From January 2012 to December 2016, in People′s Hospital of Ruian City, 70 patients with complex tibial plateau fracturesours were select, all the patients were given the conventional X-ray examination, three-dimensional CT reconstruction and MRI, of diagnosis of joint damage of the surface subsidence and rest of the soft structure, diagnostic coincidence rate and classification accuracy were compared. Results Compared with X-ray and MRI, three-dimensional CT reconstruction had a higher diagnosis rate of articular surface subsidence, the differences were statistically significant (P < 0.05). Compared with X ray film and three-dimensional CT reconstruction, MRI had a higher diagnosis rate of the rest of the soft structure damage, the differences were statistically significant (P < 0.05). Compared with X-ray and MRI, three-dimensional CT reconstruction had higher diagnosis accordance rate and classification accuracy rate, the differences were statistically significant (P < 0.05). Conclusion Three-dimensional CT reconstruction can be intuitive and stereo display tibial fracture morphology, for the diagnosis of complex fractures of tibial plateau, helping found around the knee joint and joint of occult injury, improving the accuracy of diagnosis, it has important clinical effect.
2018 Vol. 15 (21): 68-71 [Abstract] ( 248 ) HTML (1 KB)  PDF (940 KB)  ( 50 )
72 Effect of locking compression paediatric hip plate applicated in the treatment of femoral inter and subtrochanteric fractures in children
QIAN Yutao YANG Zheng GAO Lei GUO Yuan
Objective To observe the clinical effect of the lateral reduction of proximal femur and internal fixation with locking compression paediatric hip plate （LCP PHP） for the treatment of femoral inter and subtrochanteric fractures in children. Methods There were 26 cases of femoral inter and subtrochanteric fracture treated with LCP PHP plate in Beijing Jishuitan Hospital from August 2010 to March 2016 were selected as study object. Beaty standard imaging evaluation methods were used for evaluation of imaging data, fracture healing time and complications were recorded, and hip function was evaluated according to Sanders standard. Results A total of 16 patients were followed up satisfactorily with an average follow-up time of 10 （7.25, 13.75） months. All the 16 patients were satisfied with the postoperative imaging data. 14 patients had normal bone healing through X-ray examination results. The average healing time was 11（7.75, 16.00） weeks. No complications occurred during follow-up. One patient with femoral subtrochanteric fracture combined with multiple fractures had internal fixation fracture due to delayed union of fracture, and the proximal humerus lateral plate （Philos system） internal fixation was used laterally to obtain bone healing. One patient of intertrochanteric fracture due to poor healing lead to failure of internal fixation, leading to coxa varus. About hip function, 12 cases were excellent, 3 were good, and 1 was middle of the 16 cases; among the 16 cases, 11 cases of intertrochanteric or simple subtrochanteric fracture were all excellent in hip joint function. Conclusion LCP PHP internal fixation system is used to treat the femoral inter and subtrochanteric fractures in children. The postoperative internal fixation is stable, the fracture healing is fast, and the postoperative complications are less. It can shorten the time of external fixation and facilitate the early functional exercise to restore the hip function, with high clinical value.
2018 Vol. 15 (21): 72-77 [Abstract] ( 298 ) HTML (1 KB)  PDF (1471 KB)  ( 50 )
78 Application of Compound Naproxen Suppository combined with Phloroglucinol during hysteroscopic examination in menopausal bleeding women
REN Wei1 LI Lili1 SHI Huixing1 ZHANG Yongcun1 YUAN Hong1 QIAN Yali1 CUI Fuchun2
Objective To investigate the application value of Compound Naproxen Suppository combined with Phloroglucinol during hysteroscopic examination in menopausal bleeding women. Methods A total of 129 cases of menopausal bleeding patients in General Hospital of Xingtai Mining Group from December 2015 to May 2017 were selected. They were randomly divided into observation group and control group I and control group Ⅱ, 43 cases in each group. Hysteroscopy was performed in the three groups. The control group Ⅰ was given Compound Naproxen Suppository, the control group Ⅱ was given Phloroglucinol for injection, and the observation group was given Compound Naproxen Suppositories combined with Phloroglucinol for Injection. The cervical softening and dilatation, pain grading and incidence of adverse reactions were compared among the three groups. Results The cervical softening and dilatation of the observation group was better than that of the control group Ⅰ and the control group Ⅱ, and the difference was statistically significant (P < 0.05). The effect rate of softening and dilatation in the observation group [69.77% (30/43)] was higher than that in the control group Ⅰ and the control group Ⅱ [34.88% (15/43), 39.53% (17/43)], and the difference was statistically significant (P < 0.05). There was no significant difference in cervical softening and dilatation between control group Ⅰ and control group Ⅱ (P > 0.05). There was no significant difference in effecfive rate between the control group Ⅰ and the control group Ⅱ(P > 0.05). The observation group had better pain classification than the control group, and the difference between the two groups was statistically significant (P < 0.05). There was no significant difference in pain classification between the control group I and the control group Ⅱ (P > 0.05). The incidence of skin rash, urticaria, abdominal pain and fever three groups were compared, the difference was not statistically significant (P > 0.05). Conclusion Compound Naproxen Suppository combined with Phloroglucinol is helpful to improve the effective rate of cervical softening and dilatation in hysteroscopic examination of menopausal bleeding. It can effectively alleviate the pain and has certain safety.
2018 Vol. 15 (21): 78-81 [Abstract] ( 257 ) HTML (1 KB)  PDF (568 KB)  ( 124 )
82 Cholecalciterol cholesterol emulsion supplementation for the prevention of recurrent respiratory infections: a randomized, controlled trial among children
WEN Jing GUO Mei ZHOU Hong ZHAO Jing MENG Yan MA Yue LI Yuhua▲
Objective To study the effect of cholecalciterol cholesterol emulsion (CCE) on the incidence of recurrent respiratory infections (RRI) among children. Methods From July 2015 to July 2016, 100 children with RRI in the Department of Pediatrics at the People's Hospital of Hechuan District of Chongqing City were divided into Vit D group (50 cases) and control group (50 cases) by random number tabel. Children in the Vit D group were given oral CCE, 8 mL each time, one time every two months, for 4 times; children in control group were given Placebo. Children were followed-up for one year, levels of serum Vit D before and one year after treatment were measured, the frequency of respiratory infections, hospitalization, and recovery time were compared. Results There was no statistically significant difference in level of serum Vit D between the two groups before treatment (P > 0.01). One year after treatment, level of serum Vit D in Vit D group were significantly higher than that in control group (P ＜ 0.01). The frequency of respiratory infections post-discharge and hospitalization rate due to RRI was significantly lower in Vit D group compared with control group (P ＜ 0.05 or P ＜ 0.01). The recovery time from RRI in Vit D group was significantly shorter than that of control group (P ＜ 0.05). Multivariate Logistic regression analysis results showed that higher Vit D level was a protective factor for RRI (OR = 0.84, 95%CI: 0.78-0.90, P ＜ 0.01). Conclusion CCE can significantly increase serum Vit D among RRI children, and decrease the frequency of respiratory infections in children with RRI.
2018 Vol. 15 (21): 82-85 [Abstract] ( 233 ) HTML (1 KB)  PDF (639 KB)  ( 55 )
86 Clinical analysis of the relationship between bacterial vaginosis and vaginal microecological changes with high risk human papillomavirus infection
CHEN Yi WU Dan LI Zhu′nan ZHANG Zhengrong XU Ying LIN Jing
Objective To analyze the relationship between bacterial vaginosis (BV) and vaginal microecological changes with high risk human papillomavirus (HR-HPV) infection. Methods The clinical data of 1768 female vaginal secretions screened by HR-HPV from July to December 2016 were analyzed retrospectively. 1768 women were divided into HR-HPV positive group and negative group. Vaginal microecological indicators (pH, sialidase, hydrogen peroxide and leukocyte esterase) and bacterial vaginosis were compared between the two groups. Results Among 1768 subjects, 527(29.80%) were HR-HPV positive and 1241 (70.20%) were HR-HPV negative. BV was found in 114 cases (6.44%). The proportion of BV was 11.57% in HR-HPV positive group and 4.27% in HR-HPV negative group. The proportion of BV was significantly different between the two groups (P < 0.05). All the four indexes of microecology were positive (pH>4.5, sialidase positive, hydrogen peroxide positive, leukocyte esterase positive) in 98 cases (5.54%). In HR-HPV positive group, the composition ratio of all the four indexes of microecology was 8.54%, in HR-HPV negative group, the composition ratio of all the four indexes of microecology was 4.27%, and in vaginal microecology, the composition ratio of all the four indexes of microecology was statistically significant (P < 0.05). Conclusion Bacterial vaginosis and vaginal microecology are closely related to HR-HPV infection. Reducing the occurrence of bacterial vaginosis, maintaining vaginal microecological balance, can reduce the infection rate of HR-HPV.
2018 Vol. 15 (21): 86-89 [Abstract] ( 190 ) HTML (1 KB)  PDF (605 KB)  ( 95 )
90 Effects of the new obstetrics labor standards on operative vaginal delivery, intrapartum cesarean delivery, maternal and neonatal outcomes
LU Mouqing FENG Bibo▲ ZHAI Jianjun ZHENG Han
Objective To explore the effects of the new obstetrics labor standards on rate of using the operative vaginal delivery and of the intrapartum cesarean delivery, and the effect of maternal and neonatal outcomes. Methods The data of 1411 cases with singleton full term pregnancy and primipara gravidas trying to vaginal delivery in Beijing Tongren Hospital, Capital Medical University from January to December, 2016 were retrospectively analyzed. Among these 1411 women, 581 women were assigned into the new partogram group (New group) which were managed under the new labor stage standards. Another 830 cases were selected into the old partogram group (Old group) which were managed according to the old labor stage standards. Intrapartum cesarean delivery, operative vaginal delivery, postpartum hemorrhage and the neonatal asphyxia were compared between the two groups. Results The rate of intrapartum cesarean delivery and operative vaginal delivery in New group was lower than that in Old group (11.36% vs. 15.30%, 1.38% vs. 2.65%), the rate of postpartum hemorrhage and the asphyxia neonatorum in New groups was higher (5.34% vs. 5.30%, 0.86% vs. 0.36%). The difference of cesarean section rate between two groups had statistical significance (P < 0.05), the difference of others data between two groups had no statistical significance (P > 0.05). Conclusion Application of new labor stage standards can significantly decreased the rate of intrapartum cesarean section delivery, but more research will be needed to explain the results about effects on the maternal and neonatal outcomes and operative vaginal delivery.
2018 Vol. 15 (21): 90-93 [Abstract] ( 235 ) HTML (1 KB)  PDF (594 KB)  ( 124 )
94 Analysis on the status and subtypes of HPV infection in 3239 females in Shanghai Pujiang District
XU Ya′nan XIAO Shijin LIU Wei▲
Objective To investigate the infection status and genotype distribution of human papilloma virus (HPV) infection in Shanghai Pujiang District, and to provide a theoretical basis for the prevention of HPV infection and control of cervical lesions. Methods The detection results of cervical cytology screening for 3239 females in South Campus, Renji Hospital, School of Medicine, Shanghai Jiaotong University from May 2015 to October 2017 were collected, and the HPV typing data were analysed. Results 3239 cases of women were collected, 589 cases of women were HPV infected (the positive rate of HPV infection were 18.18%). There were 449 cases (76.23%) with single HPV type infection, 106 cases (18.0%) with double HPV subtypes infection and 34 cases (5.77%) with multiple HPV subtypes infection. >50-60 years women had the highest HPV infection rate and high-risk HPV subtype infection rate, the difference was statistically significant (P < 0.01). The most common subtypes were HPV52, 16, 58. Conclusion The HPV infection rate in Pujiang District is high, which mainly caused by single HPV genotypes and high-risk HPV subtypes. The most common subtype was HPV52, 16, 58. It is necessary to lay emphasis on preventing HPV52, 16, 58 infection for females in this area.
2018 Vol. 15 (21): 94-97 [Abstract] ( 307 ) HTML (1 KB)  PDF (606 KB)  ( 131 )
98 Effects of uterine netlike compression suture combined with tranexamic acid on the clinical efficacy and DSA imaging performance of refractory postpartum hemorrhage
QI Huaizuan
Objective To explore the effects of uterine netlike compression suture combined with tranexamic acid on the clinical efficacy and digital subtraction angiography （DSA） imaging performance of refractory postpartum hemorrhage Methods A total of 90 patients with refractory postpartum hemorrhage from December 2015 to December 2017 were selected and divided into control group and observation group according to the random number table method, with 45 cases in each group. In the control group, uterine anterior and posterior wall sutures was used for the treatment, the observation group was combined with tranexamic acid on the basis of the control group. The hemostasis, postoperative physical signs, hospitalization and postoperative complications were compared between the two groups. DSA was used to check the postoperative bleeding on the 3rd day after operation. Results Compared with control group, the observation group with less total amount of bleeding, shorter time to stop bleeding, and lower rate of hysterectomy, the differences were statistically significant （P < 0.01）. There was no statistically significant difference in systolic pressure, diastolic pressure and heart rate between the two groups after surgery （P > 0.05）. The volume of postoperative fluid input，volume of blood transfusion were less than the control group, getting out-of-bed time and hospitalization time were shorter than the control group, the differences were statistically significant （P < 0.01). DSA examination results in the observation group was significantly better than that in the control group, the post-treatment bleeding rate in the observation group was significantly lower than that in the control group, the differences were statistically significant（P < 0.01）. There was no statistically significant difference in postoperative complications between the two groups （P > 0.05）. Conclusion The uterine anterior and posterior wall sutures combined with tranexamic acid have a better clinical effect on refractory postpartum hemorrhage, and the DSA examination results show that the combination therapy has a lower postoperative bleeding rate.
2018 Vol. 15 (21): 98-101 [Abstract] ( 213 ) HTML (1 KB)  PDF (561 KB)  ( 50 )
102 Effect of glass-fiber post combined with BisCem resin cement on levels of PGE2 and IL-1β in patients with restoration of residue crown and residue root
WU Yuanyuan
Objective To investigate the effect of glass-fiber post combined with BisCem resin cement on levels of prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) of gingival crevicular fluid in patients with restoration of residue crown and residue root. Methods From October 2015 to June 2017, 84 patients with restoration of residue crown and residue root in Department of Stomatology of Nanjing Mingji Hospital were randomly divided into control group (n = 42) and study group (n = 42). The two groups were all repaired with glass-fiber post and resin material. The study group was treated with BisCem resin cement and the control group was treated with PULPDENT dual-curing resin cement. The masticatory efficacy(bite force, chewing efficiency) before treatment and after 1 month of treatment, the level of PGE2 and IL-1β in gingival crevicular fluid before treatment and after 3 d and 5 d of treatment, the satisfaction and the incidence of complications were statistically analyzed between the two groups. Results There was insignificant difference in masticatory efficiency and bite force between the two groups before treatment(P ＞ 0.05). After 1 month of treatment, the masticatory efficiency and bite force of the two groups increased compared with those before treatment, and the study group was larger than the control group(P ＜ 0.05). There was insignificant difference in levels of PGE2 and IL-1β of gingival crevicular fluid between the two groups before treatment (P ＞ 0.05). After treatment, the levels of PGE2 and IL-1β of gingival crevicular fluid of the two groups increased, but those in the study group were lower than those in the control group(P ＜ 0.05). The repair effect, comfort degree, masticatory ability and the satisfaction score of appearance effect of the study group were higher than those of the control group(P ＜ 0.05). The total incidence of complications in the study group (9.52%) was lower than that in the control group (26.19%) (P ＜ 0.05). Conclusion Glass-fiber post combined with BisCem resin cement in treating patients with restoration of residue crown and residue root is beneficial to improve the masticatory efficacy, reduce the degree of trauma, and inhibit the increase of PGE2 and IL-1β levels of gingival crevicular fluid, and improve the satisfaction of the treatment. Besides, the incidence of complications is lower and the safety is higher.
2018 Vol. 15 (21): 102-105 [Abstract] ( 753 ) HTML (1 KB)  PDF (378 KB)  ( 59 )
106 Comparison of EMIT and 2D-HPLC in the quantification of Carbamazepine in serum of patients with epilepsy
LIU Hang WANG Min JIN Lu ZHANG Jinping
Objective To compare the results of Carbamazepine in serum of patients with epilepsy determined by enzyme-multiplied immunoassay technique (EMIT) and two-dimensional liquid phase chromatography(2D-HPLC). Methods The serum concentration of Carbamazepine in 67 epilepsy patients was determined by EMIT and 2D-HPLC, respectively. In 2D-HPLC method, two reversed phase liquid chromatography columns [ASTON-FAQ C8 (4.0 mm×100.0 mm, 3 μm, ANAX) and Diamonsil-C18 (4.6 mm×200.0 mm, 5 μm, Dikma) column] were used as the first and second separation dimensions, respectively. ASTON C18 (4.6 mm×10.0 mm, 3 μm, ANAX) column was used as a connector to transfer the eluent from the first dimensional column to the second column for further separation. The mobile phases of the two dimensions consisted of acetonitrile-H2O (55∶45, v/v) and acetonitrile-20 mmol/L ammonium acetate (20∶80, v/v, pH=7.0), respectively. The first dimensional column flow rate was 1.0 mL/min, the second dimensional column flow rate was 1.2 mL/min. The detection wavelength was 285 nm, and the column temperature was 40℃. Results There were no significant differences in the serum concentrations of Carbamazepine detected by EMIT and 2D-HPLC. A good correlation was obtained between the two methods. The regression equation was y(2D-HPLC)= 0.9876 × x(EMIT)-0.0313. Bland-Altman plots analysis showed the two methods were consistent. Conclusion Both EMIT and 2D-HPLC methods have good consistency and correlation in the quantification of Carbamazepine. The laboratory conditions and staffing should be taken into consideration when a method is chosen for monitoring the concentration of Carbamazepine.
2018 Vol. 15 (21): 106-109 [Abstract] ( 212 ) HTML (1 KB)  PDF (623 KB)  ( 71 )
110 Analysis of related factors of Vancomycin concentration not up to standard in ICU
YIN Yanyan1 ZHU Jing2 JIANG Li3▲
Objective To investigate the influencing factors of Vancomycin concentration not up to standard, optimize clinical use. Methods From January 2016 to December 2017, in Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, the patients who received monitoring of Vancomycin blood concentration, and got creatinine clearance rate examination, hemodynamic monitoring at same time were retrospectivlye analyzed, the patients with drug dose up to standard were selected, according to Vancomycin concentration wheather up to standard or not, they were divided into two groups, blood concentration 10-20 μg/mL was as up to standard group, blood concentration 0～<10 μg/mL as not up to standard group. The basic information, plasma albumin, alanine aminotransferase, creatinine clearance rate (CCr), body mass index (BMI), and liquid balance during using Vancomycin were collected, single factor analysis and Logistic regression analysis were used to find out the factors influencing the serum concentration of Vancomycin. Results There were 55 patients with drug dose up to standard and whole clinical data, 28 cases were in blood concentration up to standard group, 27 cases were in blood concentration not up to standard group, BMI, CCr, CO, liquid balance in two groups were compared, the differences were statistically significant (P < 0.05), Logistic regression analysis result showed that CO, liquid balance during using Vancomycin were influence factors of blood concentration not blood concentration of patients in ICU (P < 0.05). Conclusion The level of CO, liquid balance during using Vancomycin are the factors influencing the serum concentration of vancomyc influence factors of blood concentration not blood concentration of patients in ICU.
2018 Vol. 15 (21): 110-113 [Abstract] ( 272 ) HTML (1 KB)  PDF (475 KB)  ( 142 )
114 Effect of Ligustrazine combined with levamlodipine besylate on BNP, Ang Ⅱ and pregnancy outcomes in patients with hypertensive disorders complicating pregnancy
WANG Xuefang LU Yanqing▲
Objective To investigate the effects of Ligustrazine combined with levamlodipine besylate on plasma brain natriuretic peptide (BNP), angiotensin Ⅱ (Ang Ⅱ) and pregnancy outcome in patients with pregnancy-induced hypertension. Methods From January 2016 to January 2018, in Wuwei People′s Hospital, 87 patients with pregnancy-induced hypertension were selected, they were divided into two groups according to whether they used Ligustrazine or not. The control group was given 25% magnesium sulfate and levamlodipine besylate based on symptomatic treatment such as reasonable diet and sedation. The observation group was treated with Ligustrazine on the basis of the control group. BPN, AngⅡ, mean arterial pressure, 24 h urinary protein level, uterine artery, and umbilical artery systolic period the ratio of maximum blood flow velocity to end-diastolic blood flow velocity (S/D), pulse index (PI), and resistance index (RI) before and after treatment were observed, adverse reactions during treatment, treatment effect after treatment 10 d were observed. Follow-up to delivery, the pregnancy outcomes of two groups were observe. Results After treatment, the levels of BNP and AngⅡ in the observation group were lower than before treatment and the control group, the differences were statistically significant (P < 0.05). After treatment, the S/D, PI and RI of the uterine artery and umbilical artery in the observation group were lower than before treatment and the control group, the differences were statistically significant (P < 0.05). The total effective rate in the observation group was  higher than the control group, the difference was statistically significant (P < 0.05). The incidence rates of premature labor, cesarean section, intrapartum or postpartum hemorrhage, placental abruption, intrauterine distress and neonatal asphyxia in the observation group were lower than the control group, the differences were statistically significant (P < 0.05). No adverse reactions occurred in both groups during treatment. Conclusion Ligustrazine injection combined with levamlodipine besylate has a satisfactory therapeutic effect on gestational hypertension, reducing the expression of BNP and AngⅡ, increasing uterine and placental blood supply, and reducing the adverse outcomes of pregnancy. It is worthy of clinical promotion.
2018 Vol. 15 (21): 114-117,145 [Abstract] ( 226 ) HTML (1 KB)  PDF (862 KB)  ( 92 )
118 Comparison of effect of Rosuvastatin and Atorvastatin on myocardial injury, inflammatory factors and soluble P selectin in patients with unstable angina pectoris after PCI
MOU Ying1 MA Chunhua2▲
Objective To investigate the effect of Rosuvastatin and Atorvastatin on myocardial injury, inflammatory factors and soluble P selectin (sP-S) in patients with unstable angina pectoris after PCI. Methods From December 2015 to October 2017, in Mianyang Central Hospital, 100 patients with UAP undergoing PCI were selected, according to random number table method, they were divided into Atorvastatin group (50 cases) and Rosuvastatin group (50 cases). Two groups were treated with general care one week before surgery, and then, the atorvastatin group was treated with 20 mg/d Atorvastatin for 7 d, the Rosuvastatin group was treated with 10 mg/d rosuvastatin for 7 d. The indexes levels of cardiac injury, inflammatory factors and sP-S in two groups were compared. Results About indexes of cardiac injury, 24 h after operation, the level of cTnI and CK-MB in Atorvastatin group were significantly higher than before medication (P < 0.05), and these were significantly higher than Rosuvastatin group at the same period (P < 0.05). About inflammatory factors, the level of TNF-α, IL-6 and hs-CRP in Atorvastatin group were significantly higher than before medication, and these were significantly higher than Rosuvastatin group at the same period (P < 0.05); the level of IL-10 of two groups were significantly higher than before medication, and that of Rosuvastatin group was much higher than Atorvastatin group (P < 0.05). The level of sP-S of the two groups was significantly increased, and that of Atorvastatin group was much higher than Rosuvastatin group (P < 0.05). Conclusion Before the implementation of PCI, it can more significantly decrease the level of inflammatory factors and improve myocardial injury that UAP patients were given Rosuvastatin than Atorvastatin.
2018 Vol. 15 (21): 118-121 [Abstract] ( 235 ) HTML (1 KB)  PDF (498 KB)  ( 126 )
122 Effect of Jiedu Huayu Ⅱ Decoction on the expression of Th17 and Th1 in peripheral blood of patients with HBV related acute liver failure and its clinical efficacy
SHI Qinglan MAO Dewen CHEN Yueqiao LYU Jianlin
Objective To investigate the effects of Jiedu Huayu Ⅱ Decoction on the expression of Th17 and Th1 in peripheral blood of patients with HBV related acute liver failure and its clinical efficacy. Methods From February 2013 to March 2016, 118 patients with HBV related acute liver failure treated in the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Rukang Hospital affiliated to Guangxi University of Traditional Chinese Medicine and Tiandong Hospital of Traditional Chinese Medicine were divided into control group and observation group according to random number table, with 59 cases in each group. The control group was treated with western medicine dialectical therapy, and the observation group were treated by Jiedu Huayu Ⅱ Decoction and Western medicine dialectical therapy. After 8 weeks of treatment, the clinical efficacy, biochemical indexes and the expression levels of Th17 and Th1 in peripheral blood of two groups were evaluated. Results The total effective rate of the observation group was higher than that of the control group (P < 0.05). After treatment, the AST, ALT and TBiL of the observation group were lower than those of the control group, and PTA was higher than that of the control group, with statistically significant difference (P < 0.05). After treatment, the proportion of Th17 and Th1 cell in the observation group was lower than that of the control group, and the Th1/Th17 value of the observation group was higher than that of the control group, with statistically significant difference (P < 0.05). Conclusion Jiedu Huayu Ⅱ Decoction can effectively improve the liver function of patients with HBV related acute liver failure, decline the Th17 and Th1 expression, which has high clinical value.
2018 Vol. 15 (21): 122-125 [Abstract] ( 236 ) HTML (1 KB)  PDF (588 KB)  ( 45 )
126 Analysis of Gong Tingxian's thought on health preservation
ZHAO Kaiwei ZHANG Yuhui XU Wenjie LIU Lixiang
Gong Tingxian, a famous TCM physician in the Ming Dynasty, and also the ancient person who kept in good health. Whose representative works are Shou Shi Bao Yuan and Wan Bing Hui Chun. He pays attention to “preventive treatment of disease” and old people health care method, his elucidation of the mechanism of aging is unique. This paper researches the nursing thoughts of Gong Tingxian from cultivating the primordial qi, spleen and kidney's recuperative medical care, mental health, food therapy, physical exercise, etc. The thought is mainly embodied in health and disease preventive prevention is to maintain and nursing of primordial qi, spleen and kidney prevention, keeping a pure heart and few desires, having a suitable diet, regulating of breathing to maintain primordial qi, etc. Through the above research, we hope to have some enlightenment to the modern health care cause, especially the old health care.
2018 Vol. 15 (21): 126-128,137 [Abstract] ( 215 ) HTML (1 KB)  PDF (597 KB)  ( 69 )
129 Meta-analysis of Chinese herbal fumigation bath in treating postoperative pain of mixed hemorrhoid
ZHANG Li LIANG Xueming FAN Xiaohua TAN Kanglian
Objective To systematically evaluate the safety and efficacy of Chinese herbal fumigation bath in treating postoperative pain in mixed hemorrhoid. Methods The databases of PubMed, EMbase, CBM, CNKI, Wanfang Data and VIP were searched by computer, and the retrieval period was set as database until January 2018. All of randomized controlled trials (RCTs) of Chinese herbal fumigation bath in treating postoperative pain in mixed hemorrhoid and research literatures included in the RCTs were also traced. The retrieved literature were screened, valid data was extracted, and the quality of the research literature was assessed by two researchers by using RevMan 5.3 software to analyze the data Meta. Results Totally 6 RCTs involving 664 patients were included into the study. The Meta-analysis results showed that compared with the potassium permanganate solution bath treatment Chinese herbal fumigation bath could significantly improve the clinical effective rate [RR = 1.13, 95%CI (1.06, 1.21), P = 0.0001], with statistically significant differences. Conclusion Chinese herbal fumigation bath can effectively relieve the pain of patients with mixed hemorrhoids and improve the clinical efficiency. However, due to the low methodology and quality and small sample size of included RCTs in this study, more randomized, double-blind trials with a large sample size are required to further verify the efficacy and safety of Chinese herbal fumigation bath in treating postoperative pain in mixed hemorrhoid.
2018 Vol. 15 (21): 129-133 [Abstract] ( 234 ) HTML (1 KB)  PDF (1229 KB)  ( 114 )
134 Clinical effect of Tangwei′an Decoction combined with acupuncture in treating diabetic gastro paresis
WANG Zhufeng1 WANG Baojun2 LI Yuxiu1 WU Rui1 LI Aijun1 ZHANG Ying1 XU Xiaoying3 SHI Bai1
Objective To observe the clinical effect of Tangwei′an Decoction combined with acupuncture in treating diabetic gastro paresis (DGP). Methods From January 2016 to December 2017, 60 patients with DGP with syndrome of Spleen deficiency and Qi stagnation treated in South Branch, Guang′anmen Hospital of China Academy of Chinese Medicial Science were selected and divided into treatment group and control group by random number table, with 30 cases in each group. On the basis of conventional treatment, the control group was treated with Tangwei′an Decoction and the treatment group was treated by Acupuncture combined with Tangwei′an Decoction, they were treated for 12 weeks. The levels of FBG, 2h-PPG, HbA1c, TC, TG, gastrin and curative effect of TCM syndromes in the two groups were compared. Results After treatment, the curative effect on TCM symptoms in the treatment group was better than that of the control group (P < 0.05). The levels of FBG, 2h-PPG, HbA1c, TC, TG and gastrin in the two groups were decreased, and those in the treatment group were lower compared with the control group, with statistically significant difference (P < 0.05). Conclusion Tangwei′an Decoction combined with acupuncture can improve the clinical symptoms of patients with DGP, with remarkable curative effect.
2018 Vol. 15 (21): 134-137 [Abstract] ( 231 ) HTML (1 KB)  PDF (618 KB)  ( 103 )
138 Clinical effect of needle knife in the treatment of elbow spasm at the stage of stroke recovery
LIU Xing DENG Huiming
Objective To observe the clinical effect of needle knife in the treatment of elbow spasm at the stage of stroke recovery. Methods The inpatients diagnosed as elbow spasm at the stage of stroke recovery in Department of Acupuncture and Moxibustion Rehabilitation, Guangdong Second Traditional Chinese Medicine Hospital from December 2016 to January 2018 were selected. 90 patients met with the inclusion criteria were randomly divided into two groups by completely random grouping method, with 45 cases in each group. The treatment group was treated with needle knife (once a week), while the control group was treated with acupuncture penetration muscle antagonist therapy (6 times a week, rest on Sunday). The spasm classification conditions of modified Ashworth scales before and after treatment and the clinical efficacy of the two groups were observed. Results After treatment, the spasm classification of modified Ashworth scales of the two groups were all better than those before treatment, the differences were all statistically significant (all P ＜ 0.05). The total effective rate of treatment group was 88.89%, which of control group was 73.33%, the cure rate of treatment group was 26.67%, which of control group was 4.44%, there were all significant differences between the two groups (all P ＜ 0.05). Conclusion The clinical effects of needle knife in the treatment of elbow spasm at the stage of stroke recovery have obvious advantage.
2018 Vol. 15 (21): 138-141 [Abstract] ( 239 ) HTML (1 KB)  PDF (553 KB)  ( 28 )
142 Clinical effect of needle knife in the treatment of patients with atlantoaxial subluxation
SUN Bichen1 HU Guoqiang2 LI Luning3 GAO Chengchao3 HU Kaibin4 CUI Jianmei1
Objective To investigate the clinical effect of needle knife in the treatment of patients with atlantoaxial subluxation. Methods Sixty cases of patients with atlantoaxial subluxation treated in Department of Rehabilitation, TCM Hospital of Shijiazhuang City from October 2016 to January 2018 were selected as research objects and they were divided into two groups through the design of blocking randomization. 30 cases in the needle knife group were given the treatment of little T-shaped piercing with acupotome, once a week, for 3 weeks. 30 patients in the acupuncture group were given the treatment of acupuncture, 5 times a week, for 3 weeks. The visual analogue scale (VAS) was evaluated before treatment and 3 weeks after treatment, and the clinical effect between the two groups was compared. Results After treatment, the VAS score in both groups were significantly lower than those before treatment, and the score of needle knife group was significantly lower than that of acupuncture group, the difference was statistically significant (P ＜ 0.05). After treatment, the total effective rate in needle knife group was 83.3%, which of the acupuncture group was 66.7%, the difference was statistically significant (P ＜ 0.05). Conclusion The clinical effect of needle knife for patients with atlantoaxial subluxation is better than that of traditional acupuncture, and it is suitable for further popularization.
2018 Vol. 15 (21): 142-145 [Abstract] ( 224 ) HTML (1 KB)  PDF (555 KB)  ( 70 )
146 Study on cervical spondylosis of pathological structure based on human bowstring mechanics anatomical system
ZHANG Qiang1 LU Jie1 ZHANG Tianming2
This paper expounds the basic content of the anatomy system of human bowstring mechanics and the pathological structure of the disease, and constructs the model of the bowstring mechanics of the neck segment. On the basis of cervical spondylosis epidemiological studies, in neck section bowstring mechanics model for material foundation, with acupotomology about etiology and pathology of chronic soft tissue injury, bone hyperplasia, this paper analyzes the characteristics of pathological structure of cervical spondylosis, to draw a cervical spondylosis self compensatory: there are two different sets of repair path adhesion, scar and contracture; sclerosis, calcification, and ossification. It is the first time to propose the initial idea of the diagnosis and treatment of cervical spondylosis in acupuncture.
2018 Vol. 15 (21): 146-149 [Abstract] ( 189 ) HTML (1 KB)  PDF (877 KB)  ( 74 )
150 Research on the inheritance and development of traditional health-care sports from the perspective of pedagogy
KANG Meng1 WU Zhikun1 JIAO Jianpeng2 WANG Xiaowei2
This paper discusses the inheritance and development of traditional health-care sports in China from the perspective of pedagogy. The paper first analyzes the problems existing in traditional health-care and the real dilemma in the development status. It suggests that the inheritance and development of traditional health-care sports should take education as the main line, and consider strengthening cultural strategic consciousness as the guidance, and the concepts of people-oriented theme and regional characteristics not being ignored. Based on the concepts above, the paper puts forward the path selection of the inheritance and development of modern traditional health-care sports from the perspective of pedagogy, which mainly starts from the following aspects as improving the education system to realize the public education, standardizing relevant content to highlight regional characteristics, being attached to education system to optimize teaching model, advocating the “people-oriented” education training model and reorienting the teaching cognitive goal of traditional health-care sports.
2018 Vol. 15 (21): 150-154 [Abstract] ( 194 ) HTML (1 KB)  PDF (696 KB)  ( 45 )
155 The distribution and drug resistance of pathogenic bacteria of pulmonary infection with AIDS patients in hospital of traditional Chinese medicine
NI Wei YANG Liu LIU Guangzhong
Objective To investigate the differences between the pathogenic bacteria and drug resistance of AIDS patients with pulmonary infection between Hubei province hospital of traditional Chinese medicine (short for“our hospital”) and western hospitals. To discuss the problems in the prevention and control of hospital infection. Put forward effective measures for reference. Methods The specimens of AIDS patients with pulmonary infection in our hospital from January 2008 to December 2017 were isolated and cultured, bacterial identification and drug susceptibility analysis were performed, and personal data was collected. Results Gram-negative bacilli, gram-positive cocci and fungi accounted for 58.38%, 23.24 % and 18.38% respectively, and it is most common with Pseudomonas aeruginosa, coagulase negative staphylococci and white candidiosis. The antibiotic resistance rate of gram-negative bacilli was lower than 50.00% in Cephalosporin, and the drug resistance rate was close to 0.00%. The drug resistance rate of gram-positive cocci to quinolones was more than 50.00%, while the resistance rate of Cephalosporin antibiotics was close to 100.00%, but the drug resistance rate of Vancomycin was only 0.00%. The drug resistance rate of Candida Albicans was close to 0.00%. Conclusion Compared with western hospitals, the main pathogenic bacteria from AIDS patients with pulmonary infection in our hospital have low resistance to common antibiotics. But the monitoring of multidrug resistant bacteria should be strengthened, the role of combined treatment of traditional Chinese medicine and western medicine treatment in the prevention and control of hospital infection is emphasized.
2018 Vol. 15 (21): 155-158 [Abstract] ( 296 ) HTML (1 KB)  PDF (688 KB)  ( 54 )
159 The construction and demonstration of the innovation evaluation model of the pharmaceutical industry in Jiangsu Province
SUN feng WANG HONGjie JIANG wei
This paper, starting from the current situation of the development of the pharmaceutical industry in Jiangsu Province, proposed that the evaluation index system should follow the principles of science, operability and clarity, and put forward the establishment of an evaluation index system for the innovation potential of the pharmaceutical manufacturing industry, consisting of 5 first grade indicators and 10 two level indicators and 56 three level indicators. From the 5 aspects of the innovation foundation, the innovation resources, the innovation input, the innovation output and the innovation efficiency, this paper analyzes the regional innovation potential index of the pharmaceutical manufacturing industry, and judges the development level of the scale economy, the innovation input, the output results, the social needs and the contribution of the scientific and technological progress in the pharmaceutical manufacturing industry of Jiangsu Province. Yungang pharmaceutical manufacturing industry has shown a rapid development trend, and the overall development advantage is obvious. Jiangsu Province medical manufacturing industry has formed the three major industrial clusters in Lianyungang, Taizhou and the southern Jiangsu, and the development of the pharmaceutical industry in the southern Jiangsu, the Soviet Union and the northern Jiangsu Province is balanced.
2018 Vol. 15 (21): 159-165,173 [Abstract] ( 173 ) HTML (1 KB)  PDF (1611 KB)  ( 60 )
166 Practice and thinking of public hospital propaganda on health care reform policy in the new era
WANG Lei DU Mengkai HU Cheng
Policy publicity is a necessary link in policy implementation and a powerful tool to ensure the realization of public policy objectives. With the gradual deepening of medical and health reform in China, the medical policy reform in public hospitals has attracted wide attention from the public. The publicity of health care policy reform in public hospitals is an inevitable choice to implement public welfare and promote sustainable development. This article takes the Xuanwu Hospital Capital Medical University as an example to introduce the practical path and experience of the publicity of medical reform policy in public hospitals under the challenge of the credibility crisis, the transformation of the communication order and the complex network public opinion.
2018 Vol. 15 (21): 166-169 [Abstract] ( 249 ) HTML (1 KB)  PDF (744 KB)  ( 82 )
170 Relationship of plasma levels of Aβ1-42 and Tau protein with cognitive impairment in patients with severe Parkinson′s disease
DU Jie WEI Liang ZHAO Xi ZHAO Lige LIU Fengbing
Objective To investigate the relationship of plasma levels of β-amyloid 1-42 (Aβ1-42) and Tau protein with cognitive impairment in patients with severe Parkinson′s disease (PD). Methods Sixty-four cases of severe PD that were treated in Department of Neurology , the People′s Hospital of Kaizhou District from April 2016 to April 2018 were enrolled. They were divided into three groups according to the scores of Montreal cognitive assessment scale (MoCA): severe cognitive impairment group (13 cases), mild-to-moderate cognitive impairment group (29 cases) and normal cognitive function group (22 cases). The levels of plasma Aβ1-42 and Tau protein were compared among the groups. Pearson correlation analysis was used to analyze the correlation between levels of plasma Aβ1-42 and Tau protein with the MoCA scores in PD patients. Results There were statistically significant differences in the levels of plasma Aβ1-42 and Tau protein among the three groups (P ＜ 0.05). The level of plasma Aβ1-42 in severe cognitive impairment group was significantly lower than that in mild-to-moderate cognitive impairment group and normal cognitive function group, while the Tau protein level of severe cognitive impairment group was significantly higher than that in mild-to-moderate cognitive impairment group and normal cognitive function group; the plasma Aβ1-42 level in mild-to-moderate cognitive impairment group was significantly lower than that in normal cognitive function group while the Tau protein level was significantly higher than that in normal cognitive function group, the differences were significant (P ＜ 0.05). Pearson correlation analysis showed that plasma Aβ1-42 level was positively correlated with MoCA score (r = 0.345, P ＜ 0.05), and plasma Tau level was negatively correlated with MoCA score (r = -0.416, P ＜ 0.05). Conclusion Level changes of plasma Aβ1-42 and Tau may be associated with cognitive impairment in PD patients, or they may be used as potential early predictors of cognitive impairment in PD patients.
2018 Vol. 15 (21): 170-173 [Abstract] ( 799 ) HTML (1 KB)  PDF (697 KB)  ( 71 )
174 A retrospective analysis of adverse drug reactions in 3 tertiary general hospitals in Hubei Province
LIU Yu1 WEI Wei2 SONG Yongbo3
Objective To explore the characteristics and regularity of adverse drug reaction (ADR), and to provide guidance for promoting clinical rational drug use and improving nursing ADR monitoring. Methods A retrospective analysis method was used to analyze the data of 1070 ADR reports collected in Xiaogan central hospital, Shiyan people′s hospital and Jingzhou first people′s hospital in Hubei province. Results In 1070 ADR cases, patients ≥60 years got more ADR (367, 34.30%); intravenous infusion got the most (689 cases, 64.39%); severe ADR was 48 cases (4.49%); all ADRs involving 205 kinds of drugs and anti-infection drugs caused the most ADR (785, 55.83%), followed by traditional Chinese medicine and Chinese medicine preparations (214, 15.22%); the clinical manifestations in ADR were varied, with the most damage to skin and accessories (563, 46.99%). Conclusion The occurrence of ADR is related to many factors, focusing on ADR susceptible drug and population, choosing the appropriate way to administer the drugs, paying close attention to the patient′s situation, and making full use of nurse ADR monitoring function to continuously promote the quality of ADR monitoring and nursing work.
2018 Vol. 15 (21): 174-177 [Abstract] ( 181 ) HTML (1 KB)  PDF (693 KB)  ( 70 )
178 The research of standardized model for hospital middle-level cadres selection and appointment
ZHANG Datong WANG Kangjie
In order to establish a standardized model for the selection and appointment of middle-level cadres and strengthen the construction of hospital middle-level cadres, the author adopts case study method of qualitative research and takes the actual work of middle-level cadre selection and appointment in Beijing Xiaotangshan hospital in 2017 as an example. Through thorough understanding and observation of the development status of middle-level cadres selection and appointment, work process, the relevant main job duties and difficulties and successful experiences to extract the effective experience and standarding ways of cadres selection and appointment, the author hope to provide further reference for the future selection and appointment of cadres in hospital.
2018 Vol. 15 (21): 178-181 [Abstract] ( 219 ) HTML (1 KB)  PDF (1075 KB)  ( 70 )
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