|
|
Cholecalciterol cholesterol emulsion supplementation for the prevention of recurrent respiratory infections: a randomized, controlled trial among children |
WEN Jing GUO Mei ZHOU Hong ZHAO Jing MENG Yan MA Yue LI Yuhua▲ |
Department of Pediatrics, People′s Hospital of Hechuan District of Chongqing City, Chongqing 401520, China |
|
|
Abstract Objective To study the effect of cholecalciterol cholesterol emulsion (CCE) on the incidence of recurrent respiratory infections (RRI) among children. Methods From July 2015 to July 2016, 100 children with RRI in the Department of Pediatrics at the People's Hospital of Hechuan District of Chongqing City were divided into Vit D group (50 cases) and control group (50 cases) by random number tabel. Children in the Vit D group were given oral CCE, 8 mL each time, one time every two months, for 4 times; children in control group were given Placebo. Children were followed-up for one year, levels of serum Vit D before and one year after treatment were measured, the frequency of respiratory infections, hospitalization, and recovery time were compared. Results There was no statistically significant difference in level of serum Vit D between the two groups before treatment (P > 0.01). One year after treatment, level of serum Vit D in Vit D group were significantly higher than that in control group (P < 0.01). The frequency of respiratory infections post-discharge and hospitalization rate due to RRI was significantly lower in Vit D group compared with control group (P < 0.05 or P < 0.01). The recovery time from RRI in Vit D group was significantly shorter than that of control group (P < 0.05). Multivariate Logistic regression analysis results showed that higher Vit D level was a protective factor for RRI (OR = 0.84, 95%CI: 0.78-0.90, P < 0.01). Conclusion CCE can significantly increase serum Vit D among RRI children, and decrease the frequency of respiratory infections in children with RRI.
|
|
|
|
|
[1] Liu L,Oza S,Hogan D,et al. Global,regional,and national causes of child mortality in 2000-13,with projections to inform post-2015 priorities:an updated systematic analysis [J]. Lancet,2015,385(9966):430-440.
[2] Borella E,Nesher G,Israeli E,et al. Vitamin D:a new anti-infective agent? [J]. Ann N Y Acad Sci,2014,1317(1):76-83.
[3] Monlezun DJ,Bittner EA,Christopher KB,et al. Vitamin D status and acute respiratory infection:cross sectional results from the United States National Health and Nutrition Examination Survey,2001-2006 [J]. Nutrients,2015,7(3):1933-1944.
[4] Urashima M,Segawa T,Okazaki M,et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren [J]. Am J Clin Nutr,2010,91(5):1255-1260.
[5] 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.反复呼吸道感染的临床概念和处理原则[J].中华儿科杂志,2008,46(2):108-110.
[6] Ross AC,Manson JE,Abrams SA,et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine:what clinicians need to know? [J]. J Clin Endocrinol Metab,2011,96(1):53-58.
[7] Pludowski P,Holick MF,Pilz S,et al. Vitamin D effects on musculoskeletal health,immunity,autoimmunity,cardiovascular disease,cancer,fertility,pregnancy,dementia and mortality-A review of recent evidence [J]. Autoimmun Rev,2013,12(10):976-989.
[8] Berry DJ,Hesketh K,Power C,et al. Vitamin D status has a linear association with seasonal infections and lung function in British adults [J]. Br J Nutr,2011,106(9):1433-1440.
[9] Bergman P,Norlin AC,Hansen S,et al. Vitamin D3 supplementation in patients with frequent respiratory tract infections:a randomised and double-blind intervention study [J]. BMJ Open,2012,2(6):231-239.
[10] Sabetta JR,DePetrillo P,Cipriani RJ,et al. Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults [J]. PLoS One,2010,5(6):e11088.
[11] Roth DE,Shah R,Black RE,et al. Vitamin D status and acute lower respiratory infection in early childhood in Sylhet,Bangladesh [J]. Acta Paediatr,2010,99(3):389-393.
[12] Science M,Maguire JL,Russell ML,et al. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents [J]. Clin Infect Dis,2013,57(3):392-397.
[13] Jia KP,Zhao LF,Feng N,et al. Lower level of vitamin D3 is associated with susceptibility to acute lower respiratory tract infection (ALRTI) and severity:a hospital based study in Chinese infants [J]. Int J Clin Exp Med,2017, 10(5):7997-8003.
[14] Manaseki-Holland S,Maroof Z,Bruce J,et al. Effect on the incidence of pneumonia of vitamin D supplementation by quarterly bolus dose to infants in Kabul:a randomized controlled superiority trial [J]. Lancet,2012,379(9824):1419-1427.
[15] Jat KR. Vitamin D deficiency and lower respiratory tract infections in children:a systematic review and meta-analysis of observational studies [J]. Trop Doct,2017,47(1):77-84.
[16] 李亚,聂鑫,崔明明.儿童反复呼吸道感染与血清维生素A、D、E水平的相关性研究[J].中国儿童保健杂志,2017,25(6):634-636.
[17] 王娴,刘华伟,邓彪.成都地区学龄前儿童25羟基维生素D水平调查[J].检验医学与临床,2016,13(5):644-645.
[18] 田谧,李远,王燕,等.重庆市永川区3-6岁留守儿童25-羟维生素D水平及其与维生素D受体基因FOKⅠ位点多态性的相关性研究[J].第三军医大学学报,2017, 39(5):493-498.
[19] 曲辉,康凯,付姝丽,等.血清维生素D水平与儿童反复呼吸道感染的关系[J].实用儿科临床杂志,2012,27(22):1738-1739.
[20] Liu PT,Stenger S,Li H,et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response [J]. Science,2006,311(5768):1770-1773.
[21] Hansdottir S,Monick MM,Lovan N,et al. Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state [J]. J Immunol,2010,184(2):965-974.
[22] Almerighi C,Sinistro A,Cavazza A,et al. 1Alpha,25-dihy-droxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes [J]. Cytokine,2009,45(3):190-197.
[23] 刘晶,刘永明.PCT、CRP对支气管哮喘合并呼吸道感染的诊断价值[J].现代医院,2016,16(3):388-389,391. |
|
|
|