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| Cholecalciterol cholesterol emulsion supplementation for the prevention of recurrent respiratory infections: a randomized, controlled trial among children |
| WEN Jing GUO Mei ZHOU Hong ZHAO Jing MENG Yan MA Yue LI Yuhua▲ |
| Department of Pediatrics, People′s Hospital of Hechuan District of Chongqing City, Chongqing 401520, China |
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Abstract Objective To study the effect of cholecalciterol cholesterol emulsion (CCE) on the incidence of recurrent respiratory infections (RRI) among children. Methods From July 2015 to July 2016, 100 children with RRI in the Department of Pediatrics at the People's Hospital of Hechuan District of Chongqing City were divided into Vit D group (50 cases) and control group (50 cases) by random number tabel. Children in the Vit D group were given oral CCE, 8 mL each time, one time every two months, for 4 times; children in control group were given Placebo. Children were followed-up for one year, levels of serum Vit D before and one year after treatment were measured, the frequency of respiratory infections, hospitalization, and recovery time were compared. Results There was no statistically significant difference in level of serum Vit D between the two groups before treatment (P > 0.01). One year after treatment, level of serum Vit D in Vit D group were significantly higher than that in control group (P ＜ 0.01). The frequency of respiratory infections post-discharge and hospitalization rate due to RRI was significantly lower in Vit D group compared with control group (P ＜ 0.05 or P ＜ 0.01). The recovery time from RRI in Vit D group was significantly shorter than that of control group (P ＜ 0.05). Multivariate Logistic regression analysis results showed that higher Vit D level was a protective factor for RRI (OR = 0.84, 95%CI: 0.78-0.90, P ＜ 0.01). Conclusion CCE can significantly increase serum Vit D among RRI children, and decrease the frequency of respiratory infections in children with RRI.
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