IL-17与登革病毒感染致病关系的研究进展

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Abstract Dengue virus is transmitted by Aedes mosquito and causes dengue fever, dengue hemorrhagic fever and dengue shock syndrome. Early studies have found that dengue virus infection causes cytokines to be oversecreted, leading to cytokine storms. Different cytokines play different roles in dengue virus infection, aggravate or inhibit the progression of disease, and affect the outcome of the disease. As an important pro-inflammatory cytokine, interleukin-17 (IL-17), secreted by Th17 cells, can induce the aggregation and proliferation of neutrophils, thus effectively mediating the inflammatory response of tissues, which is related to the pathogenesis of various viral infections. The immune mechanism of dengue virus infection and cytokine storm IL-17 and the relationship between IL-17 and dengue virus infection were reviewed.

Key words： Dengue virus Dengue fever Cytokine Interleukin-17

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	ZHENG Yuanfei LIU Fenghui CHEN Weifeng WU Huiwen ZHANG Yunqin ZHOU Bingxua ZHENG Biying

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ZHENG Yuanfei LIU Fenghui CHEN Weifeng WU Huiwen ZHANG Yunqin ZHOU Bingxua ZHENG Biying. Research progress on the IL-17 and pathogenesis of dengue virus infection[J]. 中国医药导报, 2018, 15(21): 31-34.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I21/31

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