细菌性阴道病和阴道微生态改变与高危型人乳头瘤病毒感染的临床分析

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Abstract Objective To analyze the relationship between bacterial vaginosis (BV) and vaginal microecological changes with high risk human papillomavirus (HR-HPV) infection. Methods The clinical data of 1768 female vaginal secretions screened by HR-HPV from July to December 2016 were analyzed retrospectively. 1768 women were divided into HR-HPV positive group and negative group. Vaginal microecological indicators (pH, sialidase, hydrogen peroxide and leukocyte esterase) and bacterial vaginosis were compared between the two groups. Results Among 1768 subjects, 527(29.80%) were HR-HPV positive and 1241 (70.20%) were HR-HPV negative. BV was found in 114 cases (6.44%). The proportion of BV was 11.57% in HR-HPV positive group and 4.27% in HR-HPV negative group. The proportion of BV was significantly different between the two groups (P < 0.05). All the four indexes of microecology were positive (pH>4.5, sialidase positive, hydrogen peroxide positive, leukocyte esterase positive) in 98 cases (5.54%). In HR-HPV positive group, the composition ratio of all the four indexes of microecology was 8.54%, in HR-HPV negative group, the composition ratio of all the four indexes of microecology was 4.27%, and in vaginal microecology, the composition ratio of all the four indexes of microecology was statistically significant (P < 0.05). Conclusion Bacterial vaginosis and vaginal microecology are closely related to HR-HPV infection. Reducing the occurrence of bacterial vaginosis, maintaining vaginal microecological balance, can reduce the infection rate of HR-HPV.

Key words： Papillomavirus infections Vaginosis bacterial Uterine cervical neoplasms Precancerous lesions Microenvironment

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	CHEN Yi WU Dan LI Zhu′nan ZHANG Zhengrong XU Ying LIN Jing

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CHEN Yi WU Dan LI Zhu′nan ZHANG Zhengrong XU Ying LIN Jing. Clinical analysis of the relationship between bacterial vaginosis and vaginal microecological changes with high risk human papillomavirus infection[J]. 中国医药导报, 2018, 15(21): 86-89.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I21/86

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