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2020 Vol. 17, No. 7 Published: 2020-03-05

	4	Comparison of two different methods of extracting exosomes from mouse sera
		SUN Youliang WANG Yutong▲
		Objective To compare the effectiveness and practicability of extraction of serum exosomes by ultracentrifugation and purification kit, and to provide references for subsequent exosome studies. Methods Twelve C57BL/6 male mice aged 6-8 weeks were divided into two groups by random table method, with 6 mice in each group, that was the ultracentrifugation extraction group and the purification kit extraction group. Exosomes in mouse serum were isolated by two methods. The particle size and distribution of exosomes in the two groups were detected by Nano particle size and zeta potentiometer(Nano ZS90). The morphological structures of exosomes were extracted by transmission electron microscopy. Western blot was used to detect the expression level of exosome marker proteins. Ribonucleic acid (RNA) was isolated and identified from exosomes extracted by the two methods. Results The outside diameter of the proceeds of two groups was 30-150 nm, and morphology was lipid bilayer vesicle. Western blot results showed that the exosomes in both groups expressed the marker protein cluster of differentiation 63 and tumor susceptibility gene, and the difference was not statistically significant (P ＞ 0.05). Compared with the purification kit extraction group, the ultracentrifugation extraction group had a higher exosomes concentration, the difference was statistically significant (P < 0.05). Moreover, the RNA in the exosomes in the ultracentrifugation extraction group was mainly microRNA, while the RNA in the exosomes in the purification kit extraction group was mainly piRNA. Conclusion The ultracentrifugation and purification kit extraction method can both effectively extract exosomes, but the exosomes obtain different RNA components, which provides a more effective selection method for the study of exosomes.
		2020 Vol. 17 (7): 4-7 [Abstract] ( 170 ) HTML (1 KB) PDF (697 KB) ( 105 )

	8	The assembly mechanism and internal structure of Methotrexate/Poly-ethylenimine nanoparticles were analyzed by computer
		LEI Yuanzheng1 SUN Danyun1 TANG Yue2 CHEN Xiaoyong1 ZHOU Xing2
		Objective The assembly mechanism and characterization of the internal structure of nano-drug are difficult problems in the field of nano-drug research. In this paper, the assembly mechanism and internal structure of Methotrexate/Polyethyleneimine nano-assembly were analyzed by computer simulation technology. Methods Computer simulation techniques such as molecular docking, mixing energy calculation and dissipation dynamics simulation were used to calculate intermolecular forces, mixing energy and mesoscopic simulation structures in the mixture system of Methotrexate/Polyethylenimine nanocomposites. Results The intermolecular force between methotrexate and polyethyleneimine was -12.98 kcal/mol, mainly composed of electrostatic action, hydrogen bond action and hydrophobic action. After 200 ns of dissipation dynamics simulation, methotrexate and polyethyleneimine formed a core-shell structure of nano-aggregate. Conclusion Methotrexate/Polyethyleneimine nanoassembly is core-shell nanoparticles with methotrexate as core and polyethyleneimine as shell. The driving force of the assembly is mainly provided by the strong electrostatic interaction between the two carboxyl groups of methotrexate and the amino group of polyethyleneimine.
		2020 Vol. 17 (7): 8-10,30 [Abstract] ( 113 ) HTML (1 KB) PDF (1128 KB) ( 112 )

	15	Effect of ellagic acid on cell viability and expression of MEP and SUB genes in trichophyton rubrum
		LI Zhijian Amina·Abula MA Li MA Fuchang LUO Fuxiang Silafu·Aibai WANG Chao DOU Qin
		Objective To investigate the effect of ellagic acid on the cell activity and expression of metalloproteinase (MEP) and subtilis proteinase (SUB) genes in trichophyton rubrum. Methods The experiment was divided into 5 groups, including the growth control group, the terbinanol 0.08 μg/mL group, and the ellagic acid 64, 128 g/mL and 256 g/mL dose groups. After 7 days of drug action, CCK-8 was used to determine the cell activity of trichophyton rubrum, and reverse transcription polymerase chain reaction was used to detect the gene expression levels of trichophyton rubrum protease MEP and SUB gene. Results Compared with the growth control group, the tepinecol 0.08 g/mL and the ellagic acid 64, 128 μg/mL and 256 μg/mL dose groups significantly inhibited the cell activity of trichophyton rubrum, and decreased the expression levels of protease MEP and SUB genes in the fungi, with statistically significant differences (P ＜ 0.05 or P ＜ 0.01). Conclusion Ellagic acid has a strong inhibitory effect on trichophyton rubrum, and can exert its antifungal effect by inhibiting the expression of protease MEP and SUB genes in fungi.
		2020 Vol. 17 (7): 15-18 [Abstract] ( 139 ) HTML (1 KB) PDF (561 KB) ( 127 )

	19	Effect of different processing methods on the composition of Polygonatum odoratum (Mill.) Druce
		ZHOU Xiaozhu1 TIAN Qiang2 SHI Kunlian2 LIU Guidi2 YI Yankui2
		Objective To inspect the effect of different processing methods on the composition of Polygonatum odoratum(Mill.) Druce, and to provide experiment basis for the selecting of clinical processed products. Methods The alcohol extract amount, polysaccharide of Polygonatum odoratums(Mill.) Druce, total saponins of Polygonatum odoratums (Mill.)Druce were used as index. After steaming, honey broiling and wine steaming, three batches of processed products of Polygonatum odoratums(Mill.) Druce and Polygonatum odoratums(Mill.) Druce were compared and analyzed. The extraction method was used to determine the amount of alcohol extract. Phenol-sulfuric acid method was used to determine the content of Polygonatum odoratums (Mill.) Druce. Vanillin-glacial acetic acid method was used to determine the content of total saponins. Results The content of alcohol soluble extract of two batches of honey processed products was higher than that of Polygonatum odoratums(Mill.) Druce, and the difference was statistically significant (all P ＜ 0.05).The content of alcohol soluble extract in one batch of wine steaming products was lower than that in Polygonatum odoratums(Mill.) Druce, the difference was statistically significant (P ＜ 0.05). The content of polysaccharides in three batches of steamed food was higher than that in Polygonatum odoratums (Mill.) Druce, and the difference was statistically significant (all P ＜ 0.01). The content of polysaccharides in one batch of processed honey was higher than that in Polygonatum odoratums (Mill.) Druce, and the difference was statistically significant (P ＜ 0.05). The content of polysaccharide in the two batches of wine steaming products decreased than that of Polygonatum odoratums(Mill.) Druce, and the difference was statistically significant (P ＜ 0.05 or P ＜ 0.01). The total saponin content of three batches of steamed products was higher than that of Polygonatum odoratums (Mill.) Druce, and the difference was statistically significant (all P ＜ 0.05). The content of total saponins in three batches of honey processed products was higher than that in Polygonatum odoratums (Mill.) Druce, and the difference was statistically significant (all P ＜ 0.05). The content of total saponins in one batch of wine and steam was higher than that of pure bamboo, and the difference was statistically significant (P ＜ 0.05). Conclusion The effects of processing methods on the components of Polygonatum odoratums (Mill.) Druce are complicated. Steaming after processing of Polygonatum odoratums (Mill.) Druce can increase the content of polysaccharides, and heating processing can increase the content of total saponins.
		2020 Vol. 17 (7): 19-22,34 [Abstract] ( 127 ) HTML (1 KB) PDF (926 KB) ( 238 )

	23	Research progress of vitamin D and its receptor in the pathogenesis of diabetic kidney disease
		FU Jia XU Qi HAN Rui
		Diabetic kidney disease is an abnormal pathological change in the structure and function of the kidney caused by diabetic chronic microangiopathy. It is one of the most common complications in the middle and advanced stages of diabetes. It is also the leading cause of death in diabetic patients. Because of the complex pathogenesis of diabetic nephropathy, there is no effective treatment to prevent or slow the occurrence and development of diabetic nephropathy now. With the deep studies of vitamin D and its receptors in the past years, it has been found that vitamin D can regulate calcium and phosphorus metabolism and maintain bone structure. In many clinical and animal experimental studies, it has been observed that there is a certain correlation between vitamin D deficiency and diabetic kidney disease. Vitamin D can postpone the progression of diabetic kidney disease through related mechanisms such as anti-inflammatory, anti-oxidative stress, inhibition of renin-angiotensin-aldosterone system activity, and protection of podocyte. This article reviews the related effects and research progress of vitamin D and its receptors on the pathogenesis of diabetic kidney disease.
		2020 Vol. 17 (7): 23-26 [Abstract] ( 202 ) HTML (1 KB) PDF (650 KB) ( 48 )

	27	Research progress on inhibiting excessive proliferation of smooth muscle cells after stent implantation
		HU Zhimin LING Wang WU Meiping
		In-stent restenosis (ISR) is a major complication that limits the efficacy of stent implantation and seriously affects patients′ quality of life. The excessive proliferation of smooth muscle cells at the site of vascular injury is the main reason for the formation of early ISR. Although the advent of drug-coated stents and biodegradable stents has reduced the risk of ISR, late complications are still at a high level, and the applicable materials of biodegradable stents are still in the exploration stage. This article mainly summarizes the related mechanisms and treatment methods of smooth muscle cells in the process of ISR from the aspect of inhibiting the excessive proliferation of smooth muscle cells, hoping to provide ideas for clinical treatment and experimental research.
		2020 Vol. 17 (7): 27-30 [Abstract] ( 138 ) HTML (1 KB) PDF (653 KB) ( 40 )

	31	Research progress on clinical application and mechanism of Chinese medicine in the treatment of pancreatic cancer
		WANG Jiangwei1 SU Xiaolin1 ZHAO Wan1 WANG Qiuhong1,2
		Pancreatic cancer is a kind of digestive system malignant tumor with concealed early manifestations, short survival period, high mortality and no radical treatment. When traditional Chinese medicine as a strong and effective adjuvant treatment combined with various conventional treatment of pancreatic cancer, it can achieve good synergistic effect. At the same time, it can reduce adverse reactions, tumor volume, pain and improve quality of life. This paper summarizes the clinical application of traditional Chinese medicine in the treatment of pancreatic cancer and its anti-tumor mechanism. It is expected to provide reference and help for the treatment of pancreatic cancer with traditional Chinese medicine and the research and development of new drugs in the future.
		2020 Vol. 17 (7): 31-34 [Abstract] ( 126 ) HTML (1 KB) PDF (685 KB) ( 53 )

	35	Advances in cranioplasty
		LIU Baiyu1 WANG Zhong2
		This article has reviewed and analyzeed the research progress of cranioplasty from the aspects of necessity, postoperative complications, repair materials, and repair timing. Cranioplasty surgery is necessary for patients with skull defects and can improve their quality of life. Common complications of cranioplasty include epidural hematoma, subcutaneous effusion, scalp incision infection, intracranial infection, exposure of repair materials, and post-cranioplasty seizures. Compared with traditional repair, early skull repair has many benefits, and its timing needs to be selected according to the type of disease and the patient′s condition; the development of repair material-loaded drug technology and the development of hydroxylimestone bone replacement technology has given clinical staff the choice of materials more and better choices; technologies such as computer-aided design and manufacturing (CAD/CAM) allow autologous skulls to demonstrate their unique advantages in their applications. This article provides a reference for the clinical application of cranioplasty.
		2020 Vol. 17 (7): 35-38 [Abstract] ( 197 ) HTML (1 KB) PDF (651 KB) ( 65 )

	39	Discussion on the mechanism of TCM treatment of community-acquired pneumonia based on intestinal microecology
		LIU Xingci1 SU Kelei2 ZHANG Yeqing1,2 ZHU Mengyue1 LIU Qian1 CAO Yakun1 HE Kongqin1
		Community-acquiredpneumonia (CAP) is a common respiratory disease. In recent years, along with the deep research in the pathogenesis of intestinal flora, more and more evidence indicates that the symbiotic relationship between intestinal flora and host is an important guarantee for human health, in which the development of CAP is closely related with the disorders of intestinal microbial ecosystem. Intestinal flora imbalance can cause the release of intestinal endotoxin and inflammatory mediators, on the other hand,acute lung inflammation caused by CAP can also disrupt the intestinal microbiota. The purpose of this paper is to explore the correlation between intestinal microecology and CAP, and to explore the possibility and mechanism of TCM in regulating intestinal tract flora in the treatment of CAP based on TCM theory “integrated concept, interior-exterior relationship between lung and large intestin”, so as to give full play to the advantages of TCM treatment and provide a new idea for the treatment of CAP with the method of integrated Chinese and western medicine.
		2020 Vol. 17 (7): 39-42 [Abstract] ( 174 ) HTML (1 KB) PDF (649 KB) ( 203 )

	43	Treatment of subcutaneous lipoma from the damp-teat constitution
		CHEN Yiyuan ZHANG Maoyun
		This paper discusses the relationship between the damp-heat constitution and subcutaneous lipoma by analyzing the causes, symptoms, disease tendency of the damp-heat constitution, as well as the etiology, symptoms and disease development law of subcutaneous lipoma. This paper puts forward the common manifestation of damp heat syndrome and depression syndrome, as well as the treatment principle of “removing dampness and heat, promoting qi and removing blood stasis”. It is considered that this is the characteristic of traditional Chinese medition treatment of different diseases treated together, and points out that people with the damp-heat constitution are prone to subcutaneous lipoma. In order to provide new ideas and methods for clinical diagnosis and treatment of subcutaneous lipoma, help patients improve their physique, delay the development of disease, even cure, and enrich the diagnosis, treatment and treatment of traditional Chinese medicine characteristics.
		2020 Vol. 17 (7): 43-45,50 [Abstract] ( 176 ) HTML (1 KB) PDF (697 KB) ( 269 )

	46	Application progress of information technology in monitoring nursing-sensitive quality indicators
		DING Xiangyun1 FENG Zhiying2 GUO Liangmei3 CHENG Yanshuang4 MA Yanlan2▲
		Nursing quality management is the core of nursing management. Nursing quality assessment is the focus of nursing quality management, and is the key to improve nursing service level. It is particularly important to use standard and effective nursing elements to evaluate nursing quality. Nursing quality indicators are the measure of nursing quality quantitative evaluation; Nursing-sensitive quality indicators can reflect nursing quality safety sensitively when nursing quality changes. This paper introduces the basic concept of nursing-sensitive quality indicators, summarizes the research progress of nursing-sensitive quality indicators at home and abroad and the development status and effect of nursing quality management informatization, analyzes the difficulties in the development of nursing quality management informatization in China, and prospects the future of nursing quality management informatization. The purpose is to provide a reference for nursing managers to monitor nursing-sensitive quality indicators with information technology.
		2020 Vol. 17 (7): 46-50 [Abstract] ( 164 ) HTML (1 KB) PDF (658 KB) ( 200 )

	51	Research progress of graphene oxide nanocarriers in the treatment of glioma
		LIANG Ying1 XU Yuan2▲
		Glioma is a common primary tumor of the central nervous system, radiotherapy and chemotherapy after surgical resection are commonly used in clinical treatment, but the therapeutic effect is not good. Graphene oxide nanocarriers have excellent physicochemical propertie and play an important role in the treatment of glioma mainly through drug chemotherapy, immunotherapy and photothermal therapy. This paper reviews the recent research progress of graphene oxide nanocarrier in the treatment of glioma in order to provide reference and new ideas for the biological treatment of glioma.
		2020 Vol. 17 (7): 51-54 [Abstract] ( 134 ) HTML (1 KB) PDF (686 KB) ( 269 )

	55	Application and evaluation of case teaching combined with simulation operation in clinical practice teaching of proctology department
		PENG Yunhua YANG Wei QIU Fei
		Objective To explore and evaluate the effect of case-based learning (CBL) and simulation operation teaching mode in clinical practice teaching in the Department of Proctology. Methods A total of 60 clinical students who practiced in the Department of Proctology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from September 2018 to July 2019 were selected as the subjects, and they were divided into the experimental group (30 cases) and the traditional group (30 cases) according to the random number table method. The experimental group was given CBL+ simulated operation teaching mode, while the traditional group was given lecture based learning (LBL) teaching mode. The students of two groups were compared in written test scores, clinical practice, and teaching evaluation. Results The theoretical examination scores, clinical operations, and overall scores of the students in the experimental group were higher than the traditional group, the differences were highly statistically significant (P ＜ 0.01). In terms of teaching evaluation, the experimental group scored higher than the traditional group in teaching method, teaching effect and total score, the differences were highly statistically significant (P ＜ 0.01). Conclusion The application of CBL and simulation operation in clinical practice teaching of the department of proctology can effectively improve the teaching effect, which is worthy of further promotion.
		2020 Vol. 17 (7): 55-58 [Abstract] ( 153 ) HTML (1 KB) PDF (586 KB) ( 113 )

	59	Synthesis experimental design and teaching practice of environmental electromagnetic radiation measurement
		MA Qinlong1,2 GAO Peng1,2 LU Yonghui1,2 ZHANG Lei1,2 CHEN Chunhai1,2
		The rapid development of modern communication technology has made residents′ exposure to electromagnetic radiation more and more complicated. Scientific and accurate measurement and assessment of the characteristics and intensity of electromagnetic radiation are basic skills that preventive medical undergraduates should master. This research design takes the community environmental electromagnetic radiation field measurement as an example, the purpose is to guide students to observe and analyze the characteristics of the measurement object, according to the basic principles and methods of electromagnetic radiation measurement, discuss the formulation of the evaluation plan, and carry out the electromagnetic radiation field measurement. This study finds that field experiment teaching can deepen students′ understanding of theoretical knowledge and cultivate students′ ability of organization, cooperation and practice.
		2020 Vol. 17 (7): 59-62 [Abstract] ( 133 ) HTML (1 KB) PDF (663 KB) ( 72 )

	63	Challenges and management strategies in clinical teaching of neurosurgery
		FAN Cungang LIU Ruen
		Based on the characteristics of neurosurgery, this article discusses the clinical teaching dilemma of neurosurgery from the two aspects of neurosurgery, including basic theory and clinical skills. With regard to the basic theory of neurosurgery, the author focused on the learning dilemmas in neuroanatomy, neurological examination and neuroimaging technology. In terms of clinical skills in neurosurgery, the emerging auxiliary diagnostic technology places higher requirements on the continuous learning ability of beginners; the delicate neural tissue and microsurgical techniques of neurosurgery significantly extend the surgical training period for surgeons; the limited compensatory volume of the cranial cavity and spinal canal may lead to brain hernia and even endanger the life of the patient in the perioperative period due to tens of milliliters of bleeding in surgical field, necessitating higher demands on the responsibility of neurosurgeons; the specialized instruments and equipment designed for microsurgery operations of neurosurgery are significantly different from common tools used in general surgery, thereby require continuous learning and adaptation of operators; the limited surgical field exposed in neurosurgery and the premise of protection of neurological functions results in the resection principle of neural tumors of “initial intra-capsule decompression and then piece meal resection of the tumor capsule” seems to contradict the “en bloc resection” tumor-free principle of traditional oncology. Based on a systematic analysis and in-depth discussion of the above-mentioned difficulties in teaching of neurosurgery, combined with years of teaching experience in neurosurgery of the authors, the corresponding treatment strategies are proposed in order to provide reference for the clinical teaching of neurosurgery.
		2020 Vol. 17 (7): 63-66 [Abstract] ( 182 ) HTML (1 KB) PDF (538 KB) ( 56 )

	67	Investigation on death anxiety of nursing interns with different educational level under the background of aging society
		CHEN Xingqiang CAI Shaolian
		Objective To investigate the death anxiety of nursing interns with different educational level. Methods From January to June 2018, 1053 full-time vocational nursing interns who had completed 6-7 months of internship and volunteered to participate in this study in Zhaoqing Medical College were selected. According to the educational level, they were devided into two groups, including 503 interns in higher vocational group and 550 interns in secondary vocational group. The Chinese Templer death anxiety scale (T-DAS) was used to investigate the death anxiety in two groups. Results The scores of death anxiety of higher vocational group were higher than those of secondary vocational group (P < 0.05). The number of high death anxiety level of higher vocational group were higher than those of secondary vocational group, and the differences were statistically significant (P < 0.05). There was no significant difference between the two groups in the frequency of death from practice exposure (P > 0.05). The death anxiety scores of never or often come into contact with death in higher vocational group were higher than those in secondary vocational group, and the differences were statistically significant (P < 0.05). There was no significant difference in death anxiety scores of occasional come into contact with death between the two groups (P > 0.05). Educational levels and the interaction between different educational levels and death frequency in practice exposure had an impact on the death anxiety level of nursing students (P < 0.05). Conclusion Considering the high score of death anxiety of nursing interns, and the interaction between the frequency of practice contact death and different educational levels on the death anxiety level of nursing students, it is suggested that nursing educators and the clinical teaching teachers should combine the characteristics of nursing students at different levels to carry out targeted death education in different periods of practice as to improve the level of death anxiety of nursing students.
		2020 Vol. 17 (7): 67-70 [Abstract] ( 179 ) HTML (1 KB) PDF (614 KB) ( 64 )

	71	Systematic evaluation and meta-analysis of Cinobufacin Injection in the treatment of malignant pleural and peritoneal effusion
		JIANG Lujian1,2* ZHOU Qin2* ZHENG Junchao1,2 WANG Yitong1,2 TAN Yabin1,2 LI Binbin1,2 JIANG Miao3 ZUO Minghuan1,2
		Objective To evaluate the efficacy and safety of Cinobufacin Injection in the treatment of malignant pleural and peritoneal effusion and to make a meta-analysis. Methods Three Chinese databases (CNKI, WanFang, VIP) and three English databases (PubMed, Cochrane Library, EMbase) were systematically searched by computer from building database to June 2019. The randomized controlled clinical trial of Cinobufacin Injection in the treatment of malignant pleural and peritoneal effusion was screened according to the pre-established screening criteria, and meta-analysis was conducted with RevMan 5.3 software. Results A total of 145 literatures were retrieved and 9 studies were finally included, with a total sample size of 532 cases, 267 cases in experimental group and 265 cases in control group. The overall quality and sample size of the included studies were generally low. Meta analysis showed that total amount reduction of malignant pleural and peritoneal effusion (OR = 4.78, 95%CI: 3.12-7.32, P < 0.000 01), quality of life improvement (OR = 3.56, 95%CI: 2.06-6.18, P < 0.000 01) and myelosuppression (OR = 0.56, 95%CI: 0.33-0.94, P = 0.03) in Cinobufacin + Western medicine treatment group were all better than those in western medicine treatment group. Conclusion Cinobufacin Injection combined with Western medicine can effectively reduce total amount of malignant pleural and peritoneal effusion, improve the quality of life of patients, and reduce the incidence of myelosuppression in adverse reactions.
		2020 Vol. 17 (7): 71-75,93 [Abstract] ( 216 ) HTML (1 KB) PDF (1899 KB) ( 148 )

	76	The relationship between preoperative electrocardiogram examination and the risk of postoperative major adverse cardiac events
		SONG Ruijia1 ZHAO Xueli1 WANG Bojie2 MU Dongliang2
		Objective To explore the predictive value of preoperative electrocardiogram for major adverse cardiac events (MACE) in patients undergoing selective noncardiac surgery. Methods It was a retrospective cohort study. From November 2012 to January 2013, patients undergoing elective noncardiac surgery in the First Hospital of Peking University were selected as the study subjects. The results of preoperative electrocardiogram, perioperative data and MACE during hospitalization were recorded. Results In this study, 2081 patients completed preoperative electrocardiogram examination. Incidence rate of MACE in all patients was 1.5% (32/2081). The incidence rate of postoperative MACE was 1.7% (11/632) in 632 patients (30.4%) with abnormal electrocardiogram. Multivariate logistic regression analysis showed that there was no significant relationship between preoperative electrocardiogram abnormality and postoperative MACE (OR = 0.580, 95%CI: 0.262-1.286, P = 0.180). Conclusion There is no significant relationship between preoperative electrocardiogram abnormality and postoperative MACE.
		2020 Vol. 17 (7): 76-80 [Abstract] ( 164 ) HTML (1 KB) PDF (704 KB) ( 86 )

	81	Meta-analysis of the association between adenosine deaminase and rheumatoid arthritis
		CAI Xintian ZHU Qing WU Ting LI Nanfang
		Objective To systematically evaluate the association between adenosine deaminase (ADA) level and rheumatoid arthritis (RA). Methods Published literatures on the correlation between ADA level and RA in PubMed, Embase, Cochrane Library, Web of Science, China national knowledge infrastructure and wanfang database were searched. The retrieval time was from the database construction to June 1, 2019. Chinese keywords were adenosine deaminase, adenosine amino hydrolase, rheumatoid arthritis, wind–lik. English keywords were ADA, Adenosine Deaminase, Adenosine Aminohydrolase, RA, Rheunatoid Arthritis. Two researchers shall independently conduct literature screening, quality evaluation and data extraction in accordance. In case of any dispute, both parties shall negotiate or a third party shall assist in adjudication and settlement. GetData Graph Digitizer 2.22 software was used to digitally convert and extract the data in the selected literature and Stata 12.0 software was used to merge the data, sensitivity analysis and publication bias evaluation were carried out. Results A total of 16 articles were enrolled, including 784 cases in the case group and 711 cases in the control group. Meta-analysis showed that the levels of ADA in the case group were significantly higher than those in the control group (SMD = 1.37, 95%CI:1.00-1.74, P < 0.05). After the exclusion of 6 literatures with significant influence on the results of meta-analysis, ADA levels in the case group were significantly higher than those in the control group, with statistically significant differences (SMD = 1.14, 95%CI: 0.90-1.38, P < 0.05). The results of Begg test and Egger test showed that there was no significant publication bias between the studies (P = 0.631, 0.629). Conclusion The levels of ADA in synovial fluid and serum of patients with RA are significantly higher these those of normal people. The levels of ADA in serum and synovial fluid are expected to become an important factor for the diagnosis and evaluation of the disease activity of RA.
		2020 Vol. 17 (7): 81-85 [Abstract] ( 152 ) HTML (1 KB) PDF (1011 KB) ( 79 )

	86	Study on the status and influencing factors of cognitive function in patients with lung cancer undergoing chemotherapy
		ZHOU Li1 LIU Yanping2 YAN Wenjing1 DING Rulei1 PENG Lingying1 ZHENG Ya1 ZENG Guqing1▲ NI Xiaoyan1
		Objective To investigate the cognitive function and the influencing factors in patients with lung cancer undergoing chemotherapy, in order to provide reference for the development of reasonable and effective interventions. Methods This study was adopted to “cluster sampling method”. From November 1, 2018 to April 30, 2019, three hurdred cases with lung cancer undergoing chemotherapy in 4 grade of 3A (Class Three/Grade A) hospital in Hengyang were collected. The general information questionnaire and the mini-mental state examination (MMSE) were used. The cognitive ability and cognitive level of lung cancer patients undergoing chemotherapy were analyzed, and the influencing factors were analyzed. Results The average MMSE scores of lung cancer patients undergoing chemotherapy were (25.530±3.283) scores, and 41 (14.4%) patients were low cognitive level. The results of univariate analysis showed that age, marital status, education level, occupation, medical payment form, physical exercise, understanding of the disease, TNM stage, chemotherapy cycle and metastasis had an impact on the cognitive function of lung cancer patients undergoing chemotherapy (P < 0.05). Multivariate linear stepwise regression analysis showed that age, marital status, education level, physical exercise , Karnofsky score and chemotherapy cycle were the main influencing factors of cognitive function in patients with lung cancer undergoing chemotherapy (P < 0.05). Conclusion There are some patients with low cognitive level and their cognitive function is affected by many factors. It will be beneficial for medical staff to understand those patients cognitive function through cognitive evaluation, and do good to formulate effective interventions to help those patients to improve their cognitive function.
		2020 Vol. 17 (7): 86-89 [Abstract] ( 248 ) HTML (1 KB) PDF (687 KB) ( 71 )

	90	Effect of parental accompany anesthesia induction in preschool children during induction period of surgical anesthesia
		ZHAO Feng YIN Ruirui▲ LYU Jie CAO Lu
		Objective To investigate the effect of parental accompanying anesthesia induction in preschool children during induction period of surgical anesthesia. Methods A total of 148 preschool children who underwent elective tracheal intubation and general anesthesia were selected from April 2017 to April 2019 in Children′s Hospital of Xuzhou City. They were divided into observation group and control group according to the random number table method, 74 cases in each group. The control group received routine intervention, and the observation group was accompanied by their parents during the induction period. The heart rate, blood pressure, and oxygen saturation, the children′s recovery period arousal score (PAED), the modified Yale preoperative anxiety scale (mYPAS), and the adverse reactions during anesthesia were compared between the two groups. Results The heart rate, systolic blood pressure and diastolic blood pressure of the two groups after intervention were lower than those before intervention; while the heart rate, systolic blood pressure and diastolic blood pressure in the observation were lower than those in control group, and the differences were statistically significant (P ＜ 0.05). The PAED and mYPAS scores of the two groups after intervention were lower than those before intervention, while the PAED and mYPAS scores of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of severe cough, nausea and vomiting in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Parental accompanying in the preschool age children induction during period of surgical anesthesia can effectively avoid abnormal rises in heart rate and blood pressure, relieve anxiety, reduce agitation, and decrease the incidence of adverse reactions to anesthesia, which is worthy of promotion.
		2020 Vol. 17 (7): 90-93 [Abstract] ( 261 ) HTML (1 KB) PDF (686 KB) ( 76 )

	94	Application effect of high-throughput sequencing in patients with severe pulmonary infection
		REN Di1 LI Ying1 ZENG Jingjing1 TAN Tingting2
		Objective To investigate the effect of high-throughput sequencing technology in patients with severe pulmonary infection. Methods A retrospective analysis of the clinical data of 87 patients with severe pulmonary infection were admitted to the Department of Critical Medicine, Shenzhen Second People′s Hospital from January to December 2018. Random table method was used to divide 43 cases of next generation sequencing (NGS) group and 44 cases of control group. The pathogen detection rate in the NGS group, the intensity of antibiotic use, the number of days in the intensive care unit (ICU), and the 28-day mortality of two groups were compared. Results There was no significant difference in baseline data of patients between the two groups before treatment (P ＞ 0.05). The detection rate of high-throughput pathogens in the NGS group was significantly higher than that of conventional culture, the intensity of antibiotic use in the NGS group was lower than that in the control group, and the ICU hospital stay was shorter than that in the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the 28 days mortality between the two groups (P ＞ 0.05). Conclusion The application of high-throughput sequencing technology can improve the detection rate of alveolar lavage fluid pathogens in patients with severe pulmonary infection, reduce the intensity of antibiotic use and shorten the length of hospitalization.
		2020 Vol. 17 (7): 94-97 [Abstract] ( 232 ) HTML (1 KB) PDF (685 KB) ( 201 )

	98	A meta-analysis of the effects of blood transfusion on the prognosis of patients undergoing gastric cancer surgery
		KELIMU·Gulipari1 ZHANG Lei▲
		Objective To evaluate affects about perioperative allogenenic blood transfusion (ABT) on the prognosis of patients with gastric cancer surgery. Methods PubMed, Cochrane Library, EMBASE, and Highwire biomedical databases were retrieved by computer, and clinical controlled trials from January 2000 to January 2019 to study the effect of perioperative ABT on the prognosis of patients with gastric cancer surgery were collected. A meta-analysis was performed using Stata version 12.0 software to systematically evaluate the effects of perioperative ABT on 5-year survival, tumor recurrence, and postoperative complications. Results A total of 20 high-quality related literatures were included. Compared with the non-transfusion group, the 5-year survival rate of patients in the ABT group was reduced (OR = 0.47, 95%CI: 0.39-0.56, P = 0.005), while the tumor recurrence rates (OR = 2.09, 95%CI: 1.35-3.25, P = 0.000) and the incidence of postoperative complications were increased (OR = 2.40, 95%CI: 1.81-3.19, P = 0.000), and the differences were statistically significant. Conclusion Perioperative ABT can adversely affect the prognosis of patients with gastric cancer surgery.
		2020 Vol. 17 (7): 98-101,105 [Abstract] ( 197 ) HTML (1 KB) PDF (997 KB) ( 25 )

	102	Effect of different increasing infusion rates of enteral nutrition on patients with severe acute pancreatitis
		LIU Juan1 FENG Xiu1 BAI Jingying2▲
		Objective To investigate the effect of different increasing infusion rates of enteral nutrition on patients with severe acute pancreatitis. Methods Sixty patients with severe acute pancreatitis admitted to Yan′an People′s Hospital from February 2016 to February 2019 were divided into the low-speed group (30 cases) and the high-speed group (30 cases) according to the random paper method. The initial infusion rate was set to 30 mL/h. The enteral nutrition in the low-speed group began to increase at a rate of 10 mL/h, and gradually increased to 80 mL/h after 20 h. The enteral nutrition in the high-speed group increased at a rate of 20 mL/h, and gradually increased to 80 mL/h after 12 h. The intra-abdominal pressures were compared between the two groups before, at 8, 16 h and 20 h after the intervention. The micronutrient nutrition assessment scores form (MNA-SF), serum albumin (ALB), serum prealbumin (PB) levels at 10 days after the intervention, and the incidence of enteral nutritional intolerance of two groups were measured. Results There was no significant difference in the intra-abdominal pressure before intervention between the two groups (P ＞ 0.05). The intra-abdominal pressure at 8, 16 h and 20 h after the intervention were lower in the two groups than before the intervention, and the differences were statistically significant (P ＜ 0.05). The abdominal pressure after intervention in the high-speed group was significantly higher than that in the low-speed group, and the difference was statistically significant (P ＜ 0.05). In addition, there was an interaction between groups and time (P ＜ 0.05). There was no significant difference in MNA-SF, ALB, and PA between the two groups of patients before and 10 days after the intervention (P ＞ 0.05). The ALB and PA at 10 days after the intervention were higher in the two groups than those before the intervention, and the differences were statistically significant (P ＜ 0.05). The incidence of enteral nutrition intolerance in patients with low-speed group was lower than that in high-speed group, and the difference was statistically significant (P ＜ 0.05). Conclusion Severe acute pancreatitis with low infusion rate enteral nutrition has less intra-abdominal pressure and better feeding tolerance, which is worthy of clinical application.
		2020 Vol. 17 (7): 102-105 [Abstract] ( 120 ) HTML (1 KB) PDF (695 KB) ( 34 )

	106	Effect of ultrasound-guided quadratus lumborum block combined with general anesthesia on early postoperative cognitive function and stress response in elderly patients with colorectal cancer
		MOU Junying1 LIU Tao2 YE Gang1 ZHU Xianlin1
		Objective To evaluate the effect of ultrasound-guided quadratus lumborum block (QLB) combined with general anesthesia on early postoperative cognitive function and stress response in elderly patients with colorectal cancer. Methods From July 2018 to July 2019, 60 cases with open colorectal cancer surgery in the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture were collected. They were divided into ultrasound-guided QLB combined with general anesthesia group (group T) and general anesthesia group (group C) according to the radom number table method, with 30 cases in each group. Group T patients were guided by ultrasound to bilateral QLB before surgery, and anesthesia induction began after block for 20 min. Group C was injected with the same normal saline. Mean arterial pressure (MAP), heart rate (HR), blood glucose (Glu) and C-reaction protein (CRP) levels were recorded and compared at 10 min after the patient entered the operating room (T1), 5 min after anesthesia induction (T2), 5 min after incision (T3), 2 h after incision (T4), and at the end of surgery (T5). BIS was measured at 8 o′clock on the night of operation and 6 o′clock in the morning of the next day. Deep sleep time (BIS<80) and effective sleep index (SEI) were recorded and compared between the two groups. Visual analogue scores (VAS) 24 and 48 h after surgery, postoperative cognitive dysfunction (POCD) cases on the first and third day after surgery, dosages of Sufentanil and cases of nausea and vomiting were recorded and compared. Mini-mental state examination (MMSE) and montreal cognitive assessment scale (MoCA) were recorded and compared at preoperative 1 d (Ta), postoperative 1 d (Tb), postoperative 3 d (Tc) and postoperative 5 d (Td). Results The number of cases of POCD on the first day after surgery, nausea and vomiting, postoperative Sufentanil dosages and 24 h VAS scores after surgery in group T were lower than those in group C, with statistically significant differences (all P < 0.05). There were no significant differences between the two groups in the number of cases of POCD on the third day after surgery and 48 h VAS scores after surgery (P > 0.05). BIS values in group T were lower than those in group C at 8 o′clock in the evening and 6 o′clock in the morning of the next day and SEI values in group T were higher than those in group C, the deep sleep time was longer than that in group C, with statistically significant differences (all P < 0.05). Tb MMSE and MoCA scores in group T were lower than those in group C, and Tc MMSE scores were lower than those in group C, with statistically significant differences (all P < 0.05). T3-T5 MAP in group T were lower than those in group C, and T3, T5 HR were lower than those in group C, with statistically significant differences (all P < 0.05). The levels of T3-T5 Glu in group T were lower than those in group C, and the levels of T2 CRP were lower than those in group C, with statistically significant differences (all P < 0.05). Conclusion Ultrasound-guided QLB combined with general anesthesia can reduce perioperative stress response, and decrease the incidence of early POCD in elderly patients with colorectal cancer.
		2020 Vol. 17 (7): 106-110 [Abstract] ( 237 ) HTML (1 KB) PDF (496 KB) ( 140 )

	111	Effect of Sevoflurane combined with Propofol on immune function and liver and kidney function in patients with liver cirrhosis after operation
		ZHANG Kun1 KE Shan2
		Objective To investigate the effect of Sevoflurane combined with Propofol on immune function and liver and kidney function in patients with liver cirrhosis after operation. Methods From August 2016 to July 2019, 102 patients with liver cirrhosis who were to undergo splenectomy in West District of Beijing Chaoyang Hospital, Capital Medical University were selected. The patients were randomly divided into study group (n = 51, Sevoflurane combined with Propofol anesthesia) and control group (n = 51, Sevoflurane anesthesia) according to the randorm number table method. The recovery time of spontaneous respiration, orientation, speech response, eye opening and extubation, CD3+, CD4+, CD8+, CD4+/CD8+, glutamate amino transferase (ALT), total bilirubin (TBil), blood urea nitrogen (BUN), creatinine (CR) and adverse reactions were recorded and compared between the two groups. Results There was no significant difference in preoperative CD3+, CD4+/CD8+, CD8+ and CD4+ between the two groups (P > 0.05). In the third day after operation, CD3+, CD4+/CD8+ and CD4+ in both groups were lower than those before operation, and study group was higher than control group, the differences were statistically significant (all P < 0.05); CD8+ was higher than that before operation, and study group was lower than control group, the differences were statistically significant (all P < 0.05). The recovery time of spontaneous respiration, orientation, speech response, eye opening and extubation in study group were shorter than those in control group, the differences were statistically significant (all P < 0.05). There were no significant differences in serum levels of ALT, TBil, BUN and Cr between the two groups (P > 0.05). The serum levels of ALT, TBil, BUN and Cr in study group were higher than those in control group on the third day after operation, study group was lower than control group, the differences were statistically significant (all P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Sevoflurane combined with Propofol can effectively improve the perioperative indexes, reduce the damage of liver and kidney function, reduce the immunosuppression, and the drug safety is good, which has high clinical application value.
		2020 Vol. 17 (7): 111-115,119 [Abstract] ( 187 ) HTML (1 KB) PDF (501 KB) ( 129 )

	115	Effect of Dexmedetomidine Hydrochloride on hemodynamics and postoperative complications in patients with intracranial aneurysm undergoing interventional surgery
		SHI Ji1 ZHANG Na′na2 ZHAO Shuai3 LI Weijing4 LIU Ya5 ZHOU Changhao1▲
		Objective To investigate the effect of Dexmedetomidine Hydrochloride on hemodynamics and postoperative neurological adverse reactions caused by intracranial pressure (ICP) change during interventional therapy of intracranial aneurysm. Methods From January 2017 to December 2018, 96 cases diagnosed as intracranial aneurysm and receiving elective interventional treatment in the First Hospital of Hebei Medical University were selected as subjects. They were divided into saline group (group A), low-dose Dexmedetomidine Hydrochloride group (group B1), and high-dose Dexmedetomidine Hydrochloride group (group B2) according to the drugs selected and the dose used, with 32 cases in each group. At the time of 30 minutes before ending surgery , Dexmedetomidine Hydrochloride was injected into B1 and B2 groups at 0.6 μg/kg and 1.2 μg/kg and continued for about 20 minutes, while group A was pumped in saline. ICP, mean arterial pressure (MAP) and heart rate (HR) of the three groups were recorded at the time of the preoperative (T0), administration (T1), ending surgery (T2), recovery (T3), extubation (T4) and post-extubation (T5). Postoperative recovery indicators (recovery time, postoperative extubation time and Ramsay sedation score) and incidence of neurological adverse reactions of three groups were compared. Results ICP of group B1 was lower than that of group A at T2-T4, MAP and HR of group B1 were lower than those of group A at T2-T5, and the differences were statistically significant (all P < 0.05). At T2-T4, ICP of group B2 were lower than those of group A and B1, MAP of group B2 were lower than those of group A and B1 at T2-T5, HR of group B2 was lower than that of group A and B1 at T1-T5, and the differences were statistically significant (all P < 0.05). Compared with group A, group B1 showed no statistically significant difference in the recovery time and postoperative extubation time (P > 0.05). Ramsay sedation score in group B1 was higher than that in group A, with statistically significant difference (P < 0.05). The recovery time and postoperative extubation time of group B2 were longer than those of group A and group B1, Ramsay sedation score of group B2 was higher than that of group A and group B1, and the differences were statistically significant (P < 0.05). The incidence of postoperative adverse reactions in the nervous system of three groups were significantly differences (P < 0.05). The incidence of adverse nervous system reactions in group B1 and B2 were significantly lower than those in group A, with statistically significant differences (all P < 0.05). There was no significant difference in the incidence of neurological adverse reactions between group B1 and group B2 (P > 0.05). Conclusion Small doses of Dexmedetomidine Hydrochloride before ending surgery can effectively stabilize the hemodynamics of patients, improve cerebral perfusion, reduce intracranial pressure and the incidence of postoperative neurological adverse reactions. Early intervention with Dexmedetomidine Hydrochloride produces beneficial application value in patients with intracranial aneurysm undergoing interventional surgery.
		2020 Vol. 17 (7): 115-119 [Abstract] ( 174 ) HTML (1 KB) PDF (522 KB) ( 104 )

	120	A case of Hashimoto thyroiditis with thyroid nodules treated by professor Ding Zhiguo
		FU Jinxiang1 QI Shuo2 CHEN Xiaoheng2 LI Huilong2 HUANG Sheng1 LI Xin′ai1 ZHANG Lei1 DING Zhiguo2
		Hashimoto thyroiditis and thyroid nodules both belong to the category of “ying disease” in traditional Chinese medicine, which are in a high trend in recent years and seriously damaged human health. However, there is no effective treatment deal with these diseases. Traditional Chinese medicine has unique advantages in treating thyroid diseases. Professor Ding Zhiguo has been engaged in the therapy of thyroid diseases for many years and has significant effect. He proposed the concept of “window period” in thyroid diseases and the theory of “Ye(thyroid)-Ben(body) corresponding”. Here is a case of Hashimoto thyroiditis with thyroid nodules treated by Professor Ding Zhiguo.
		2020 Vol. 17 (7): 120-123 [Abstract] ( 389 ) HTML (1 KB) PDF (717 KB) ( 216 )

	124	Professor Shi Guanqing′s three cases of miscellaneous diseases in internal medicine
		WANG Xueke1 HUANG Lin2 CUI Yinglin2
		Professor Shi Guanqing is one of the first batch of state-level famous old traditional Chinese medicine doctors. He is skilled in classics, medical theories, differentiation of symptoms and signs, fine prescription and simple medicine, and his effect is as good as a drum. The author has the honor of sorting out professor Shiˊs manuscripts and medical records before his death. He only got a claw and could not see the whole leopard. Therefore, he chose three medical miscellaneous medical records. The following is a brief introduction. I hope you can give me your advice. Case 1: the patient suffered from systemic edema for 2 years, and many western medicines were used to treat it, but the effect was not good. Professor Shi explored the cause of the disease according to his condition, and chose the method of invigorating spleen and warming the spleen to eliminate edema. Case 2: the patient got up in the morning with severe diarrhea and obvious abdominal drop. The blame lies in spleen weakness. Using the method of invigorating yang and spleen, the classic formula Buzhong Yiqi Decoction was chosen, and the curative effect was very good. Case 3: the patient suffered epilepsy due to accumulation of phlegm fire in liver and gallbladder. Both the symptoms and root causes were taken into consideration, eliminating phlegm and relieving convulsion to treat the symptoms, strengthening spleen and calming heart to treat the root causes. Chaihu plus Longgu Muli Decoction was selected for treatment, and the effect was very good.
		2020 Vol. 17 (7): 124-126,134 [Abstract] ( 257 ) HTML (1 KB) PDF (737 KB) ( 161 )

	127	Experience on application of Ziwan Decoction in the treatment of spontaneous sweating based on five evolutive phases and six climatic factors theory
		YANG Ruilan1 LAO Yingrong2
		Clinical syndrome differentiation pattern combined with five evolutive phases and six climatic factors theory is another way of thinking, which pays more attention to the role of traditional Chinese medicine pathogenesis. Spontaneous sweating is a common clinical disease. The deficiency of lung qi causing spontaneous sweating has the basic pathogenesis in the perspective of five evolutive phases and six climatic factors theory. Ziwan Decoction is the prescription of Chen Wuze established in Treatise on Three Categories of Pathogenic Factors, which is pointed at Liu Yi years inferior to metal. Ziwan Decoction treating the spontaneous sweating produces satisfied clinical efficacy under the guidance of five evolutive phases and six climatic factors theory and the thinking of professor Gu Zhishan. Using the theory of five evolutive phases and six climatic factors, this paper analyzes two cases to introduce the traditional Chinese medicine pathogenesis characteristics and clinical syndrome differentiation pattern combined with five evolutive phases and six climatic factors, to provide a new idea and the theoretical basis for spontaneous sweating.
		2020 Vol. 17 (7): 127-130 [Abstract] ( 178 ) HTML (1 KB) PDF (720 KB) ( 239 )

	131	Clinical effect of professor Zheng Rixin′s empirical prescription combined with acupuncture in the treatment of sinusitis with lung channel wind-heat type
		ZHOU Sudi1 ZHENG Rixin2
		Objective To observe clinical effect of professor Zheng Rixin′s empirical prescription combined with acupuncture in the treatment of sinusitis with lung channel wind-heat type. Methods From January to June 2019, 60 patients with lung channel wind-heat type sinusitis in the Second Affiliated Hospital of Anhui University of Chinese Medicine were selected. They were divided into control group and observation group by random number table method, with 34 cases in each group. The control group was given the Huodan Tablets orally. The observation group was treated with professor Zheng Rixin′s empirical prescription combined with acupuncture. Two groups were treated with 1 course of treatment for 10 days. The score and total scores of symptoms and signs before and after treatment between two groups were compared. Clinical effects between two groups were observed. Results Clinical effect of observation group was better than that of control group, the difference was statistically significant (P < 0.05). After treatment, the score and total scores of nasal obstruction, flowing spiss snot, dizziness and headache, dysosmia, swollen turbinate, local tenderness in two groups were lower than those before treatment, and the scores in observation group were lower than those in control group, the differences were statistically significant (P < 0.05). There was no serious adverse reaction in two groups. Conclusion Zheng Rixin′s empirical prescription combined with acupuncture in the treatment of sinusitis with lung channel wind-heat type has a better clinical effect. It can effectively relieve the symptoms and swollen turbinate and local tenderness, and produce no serious adverse reactions. Therefore, it is safe, effective and worthy of clinical promotion.
		2020 Vol. 17 (7): 131-134 [Abstract] ( 270 ) HTML (1 KB) PDF (719 KB) ( 64 )

	135	Mining regularity of professor Ba Yuanming′s prescription in the treatment of chronic renal failure based on the auxiliary platform of traditional Chinese medicine inheritance
		LIU Shi1 GAO Yue1 CHEN Shuhe1 HUANG Zhengde1 LI Chengyin2
		Objective To provide the comprehensive basis for prevention and treatment for chronic renal failure (CRF) through analyzing the herbal administration experience for treating CRF of professor Ba Yuanming by utilizing traditional Chinese medicine inheritance support platform software. Methods From January 2016 to January 2017, the prescriptions for treating CRF applied by professor Ba Yuanming in Hubei Provincial Hospital of Traditional Chinese Medicine were collected, and the database of relevant traditional Chinese medicine prescriptions were constructed based on traditional Chinese medicine inheritance support platform software. Additionally, the frequency statistics, association rules and composing formulas of herbs and prescriptions via the approaches of Apriori algorithm and entropy clustering. Results Totally, 298 prescriptions were enrolled in current research, involving 123 different kinds of herbs. The frequently adopted herbs were Radix Astragali seu Hedysari, Poria, Radix Codonopsis, Rhizoma Dioscoreae, Fructus Corni, and so on. Besides, the medicinal properties were mainly sweet, bitter in the five flavors, cold and flat were appeared most in four qi, while in meridians, they were mainly kidney, liver, spleen, liver meridians. It could be preliminarily concluded that professor Ba was good at using Zhibai Dihuang Pills and Shenqi Dihuang Decoction. And the results emerged 6 new traditional Chinese medicine prescriptions. Conclusion Therapeutic principle and method of professor Ba Yuanming for treating CRF mainly including regulating spleen and stomach, strengthening kidneys, promoting blood circulation to remove blood stasis. Also, professor Ba pays attention to regulate triple warmer, strengthening and restoring effects.
		2020 Vol. 17 (7): 135-138 [Abstract] ( 193 ) HTML (1 KB) PDF (824 KB) ( 52 )

	139	Discussion on professor Zhang Fuli′s experience in the treatment of impaired glucose tolerance from the theory of triple energizer gasification
		LI Yanlin1 LIU Lujia2 TIAN Miao1 MA Boyan1 LIU Chunhong1 GAO Enyu1 ZHANG Fuli1
		Impaired glucose tolerance (IGT) is the early stage of diabetes. At this stage, if not treated in time, the incidence of type 2 diabetes will increase with time, and it will also increase the risk of cardiovascular disease. However, this stage is highly reversible, so active intervention can effectively prevent the development of diabetes mellitus. According to professor Zhang Fuli′s many years of clinical experience, IGT belongs to the category of triple energizer disease in traditional Chinese medicine. Professor Zhang claimes that IGT is characterized by pathogenesis based on the “loss of sanjiao” and “phlegm dampness and blood stasis heat”. Based on this innovative proposal, under the guidance of the theory of triple energizer gasification, the treatment principle is the method of separation, elimination and drainage. And with Wendan Decoction as the core, to add and subtract. Then create the Huayu Wendan Decoction. It has the effect of dispersing and benefiting sanjiao, treating both dampness and heat qi and blood, taking into account both the specimen and the specimen, with excellent curative effect. In addition, the medical record is attached in the article, which provides a new idea for the treatment of impaired glucose tolerance.
		2020 Vol. 17 (7): 139-142 [Abstract] ( 208 ) HTML (1 KB) PDF (717 KB) ( 142 )

	143	Effect of adjuvant treatment with modified Shaoyao Gancao Decoction on pain mediators and inflammatory factors in patients with cancer pain
		CAO Di1 ZHANG Yami2
		Objective To investigate the effects of adjuvant treatment with modified Shaoyao Gancao Decoction on pain mediators and inflammatory factors in patients with cancer pain. Methods One hundred and twenty-three patients with cancer pain admitted to Affiliated Hospital of Shaanxi University of Chinese Medicine from October 2017 to March 2019 were selected and divided into control group (n = 61) and study group (n = 62) according to random number table method. The patients in control group were treated with Morphine Sulfate Sustained-Release Tablets. The patients in study group were treated with modified Shaoyao Gancao Decoction on the basis of control group. The course of treatment was 4 weeks. Clinical efficacy, pain mediators (5-HT, PGE2, SP, ET-1) and inflammatory factors (IL-1β, IL-6, TNF-α) were compared between two groups. Adverse reactions during treatment were recorded in two groups. Results Total clinical effective rate of study group after treatment was significantly higher than that of control group (P < 0.05). After treatment, the levels of 5-HT, PGE2, SP and ET-1 in two groups were lower than those before treatment, and the levels in study group were lower than those in control group (P < 0.05). After treatment, the levels of IL-1β, IL-6 and TNF-α in two groups were lower than those before treatment, and the levels in study group were lower than those in control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Modified Shaoyao Gancao Decoction can effectively improve the level of pain mediators and inflammatory factors in patients with cancer pain. It has definite curative effect and does not increase the incidence of adverse reactions. It has certain clinical application value.
		2020 Vol. 17 (7): 143-146 [Abstract] ( 192 ) HTML (1 KB) PDF (722 KB) ( 114 )

	147	Discussion on application of ultrasonic multimodal combined technique in the evaluation of femoral rectus in rabbits with knee osteoarthritis
		LIU Jing1 LIN Qiaoxuan2 GONG Yurong1 LIU Hong1,3 ZHANG Liangzhi1,3 XIU Zhongbiao1,3,4
		Objective To provide a method and objective basis for the evaluation of chronic injury of skeletal muscles of knee osteoarthritis (KOA), the morphological, blood perfusion and tissue hardness changes of rectus femoris muscle in rabbits with KOA were observed by using ultrasound multimodal combined technique. Methods Sixteen New Zealand white rabbits were divided into the normal group and the model group by random number table method, with 8 rabbits in each group. The normal group was fed routinely. The modified Videman method was used to construct the KOA rabbit model in the model group. After 6 weeks of modeling, 2 cm above the iliac at the rectus femoris, the muscle pennation angle, muscle thickness, perimeter and cross-sectional area of KOA rabbit femoral rectus muscle were measured using a Philips EPIQ107 ultrasound machine to evaluate the morphology of rectus femoris; ACUSON S2000 ultrasound machine was used for imaging, and peak time and transit time were analyzed and compared to evaluate the perfusion of rectus femoris; Vivid E80 ultrasound machine was used for strain elastography, and elastic strain rate ratio of rectus femoris was measured to evaluate tissue hardness of rectus femoris. Results Compared with the normal group, muscle thickness, cross-sectional area, perimeter and pennation angle in the model group were significantly decreased, the ratio of ultrasonic elastic strain rate was significantly increased, and the peak time and transit time were significantly shortened in the model group, the differences were highly statistically significant (all P ＜ 0.01). Conclusion Ultrasonic multimodal combined technique, complements each other's advantages, it can objectively evaluate the condition of KOA rabbit femoral rectus muscle from the aspects of morphology, blood perfusion, and tissue hardness change, which is worthy of clinical application.
		2020 Vol. 17 (7): 147-151 [Abstract] ( 150 ) HTML (1 KB) PDF (699 KB) ( 139 )

	152	Clinical study of Jiawei Yanghe Decoction in the treatment of peripheral arterial disease
		DAI Dandan1 SUI Wenlin1 LI Meiyu2
		Objective To investigate the clinical effect of Jiawei Yanghe Decoction treating peripheral arterial disease(PAD). Methods A total of 133 PAD patients in Liaoyang Hospital of Traditional Chinese Medicine were selected from March 2017 to March 2019 and they were divided into the study group (67 cases, conventional western medicine combined with Jiawei Yanghe Decoction) and the control group (66 cases, conventional western medicine) according to the random number table method. The clinical efficacy, adverse reactions, traditional Chinese medition syndrome score, hemorheology indexes and ankle brachial index (ABI), blood flow of dorsalis pedis artery and intermittent claudication distance of patients in the two groups were compared. Results After treatment the total clinical effective rate of the study group was higher than that of the control group (P ＜ 0.05). After 1 month of treatment, the traditional Chinese medition syndrome scores and high blood viscosity, plasma viscosity, hematocrit, red cell assembling index in the two groups were all lower than before treatment, and the study group was lower than the control group (P ＜ 0.05). After 1 month of treatment, the ABI, blood flow of dorsalis pedis artery, intermittent claudication distance were increased in the two groups, and the study group was higher than the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Jiawei Yanghe Decoction can rapidly improve the clinical symptoms of patients with PAD, with definite curative effect, and also can improve the blood circulation of the body, with good drug safety.
		2020 Vol. 17 (7): 152-155 [Abstract] ( 135 ) HTML (1 KB) PDF (498 KB) ( 117 )

	156	Effect of Shexiang Baoxin Pills and Low Molecular Weight Heparin Calcium in the treatment of acute ST segment elevation myocardial infarction
		MA Cong XU Zhiwei ZHAO Sheng GAO Lin WANG Guizhong SHI Binhao CHENG Wei
		Objective To investigate the effect of Shexiang Baoxin Pills combined with Low Molecular Weight Heparin Calcium in the treatment of acute ST-segment elevation myocardial infarction (STEMI). Methods A total of 90 STEMI patients who admitted to Anhui No.2 Provincial People′s Hospital from January 2017 to July 2019 were selected, they were divided into the control group (45 cases) and the study group (45 cases) according to the random number table method. The control group was treated with Low Molecular Weight Heparin Calcium. The study group was treated with Shexiang Baoxin Pills on the basis of the control group. The clinical efficacy, cardiac function and serological indexes of the two groups were compared, the adverse reactions and the occurrence of early adverse cardiac events during the treatment were recorded. Results After two courses of treatment, the total effective rate of the study group was significantly higher than that of the control group (P ＜ 0.05). After 2 courses of treatment, left ventricular ejection fraction and nitric oxide increased in the two groups were increased, and the study group was higher than the control group (P ＜ 0.05). After 2 courses of treatment, the diameters of left ventricular end systolic period, left ventricular end diastolic period, endothelin and hypersensitive c-reactive protein of the two groups were decreased, and the study group was lower than those in the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). However, the total incidence of adverse cardiac events in the study group was lower than that in the control group (P ＜ 0.05). Conclusion Shexiang Baoxin Pills combines with Low Molecular Weight Heparin Calcium is effective in treating STEMI, which can effectively improve cardiac function and vascular endothelial function, alleviate inflammatory reaction of the body, and has good safety, which can reduce the total incidence of adverse cardiac events, and has a high clinical application value.
		2020 Vol. 17 (7): 156-159,171 [Abstract] ( 177 ) HTML (1 KB) PDF (778 KB) ( 90 )

	160	Clinical effect of Sacubitril/Valsartan in the treatment of chronic heart failure patients with different etiology
		TANG Bi ZHU Lei ZHU Mingli XIE Caixia XU Qingmei KANG Pinfang XUAN Ling ZHANG Heng
		Objective To observe the clinical effect of Sacubitril/Valsartan in the treatment of patients with chronic heart failure caused by different etiologies. Methods Seventy-four cases with chronic heart failure of left ventricular ejection fraction (LVEF) ≤ 40% who admitted to the First Affiliated Hospital of Bengbu Medical College from January 2018 to April 2019 were selected as the study objects. According to cardiac function grade, they were divided into Ⅱ grade subgroups (7 cases), Ⅲ grade group (33 cases), Ⅳ grade subgroups (34 cases). According to the etiology, they were divided into coronary heart disease subgroup (42 cases), hypertensive heart disease subgroup (7 cases), dilated cardiomyopathy subgroup (25 cases). All patients were routine anti-heart failure treatment，and angiotensin converting enzyme inhibitor (ACEI)/angiotensin Ⅱ receptor antagonist (ARB) were replaced by Sacubitril/Valsartan. Qualitative treatment lasted for 3 months. The clinical efficacy of different patients were observed. The indexes of ventricular and cardiac function before and after treatment were compared, and the incidence of cardiovascular end-point events were recorded. Results There was no significant difference in clinical efficacy rate in different etiological subgroups and different cardiac function grades subgroups (P > 0.05). There was no significant difference in ventricular and LVEF of different cardiac function grades subgroups and different etiological subgroups before and after treatment (P > 0.05). Compared with before treatment, left ventricular end-diastolic diameter (LVd) significantly reduced, LVEF increased significantly after treatment in Ⅱ-Ⅳ grade subgroups, and the differences were statistical significance (all P < 0.05); LVd significantly reduced, LVEF increased significantly in after treatment coronary heart disease subgroup, hypertensive heart disease subgroup and dilated cardiomyopathy subgroup, and the differences were statistical significance (all P < 0.05). The incidence of cardiovascular end-point events was 9.45%. Conclusion Sacubitril/Valsartan can significantly improve the cardiac function of patients with chronic heart failure, and the clinical efficacy of patients with heart failure caused by different etiology and cardiac function grade is basically the same.
		2020 Vol. 17 (7): 160-163 [Abstract] ( 258 ) HTML (1 KB) PDF (500 KB) ( 131 )

	164	Changes of serum 25-hydroxyvitamin D levels in patients with obstructive sleep apnea hypopnea syndrome and its clinical significance
		DAI Hongmei1 ZHU Yifang2
		Objective To investigate the changes and clinical significance of serum 25-hydroxyvitamin D[25-(OH)D] in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods A total of 100 OSAHS patients admitted to the Third People′s Hospital of Chengdu (hereinafter referred to as “our hospital”) from July 2017 to January 2019 were selected as the observation group. According to the apnea hypopnea index (AHI) level, they were divided into 23 cases with mild (5 times/h＜AHI≤15 times/h), 48 cases with moderate (15 times/h＜AHI≤30 times/h), and 29 cases with severe (AHI＞30 times/h). A total of 90 healthy patients in our hospital during the same period were selected as the control group. After enrollment, all patients were examined by polysomnography, and the lowest blood oxygen saturation (L-SpO2) was recorded. Serum levels of 25-(OH)D and vitamin D (VitD) deficiency were measured. The L-SpO2 and serum 25-(OH)D levels of patients with different severity of OSAHS were evaluated. The correlation between AHI, L-SpO2 and 25-(OH)D of patients with OSAHS was analyzed. Results Serum L-SpO2 and 25-(OH)D levels in the observation group were lower than those in the control group, with statistically significant differences (all P ＜ 0.05); the degree of serum VitD deficiency in the observation group was significantly higher than that in the control group, with statistically significant difference (P ＜ 0.05); L-SpO2 and 25-(OH)D in severe and moderate OSAHS patients were lower than those in mild patients, and L-SpO2 and 25-(OH)D in severe OSAHS patients were lower than those in moderate patients, with statistically significant differences (all P ＜ 0.05). Pearson correlation analysis showed that serum 25-(OH)D level was negatively correlated with AHI in OSAHS patients (r = -0.634, P = 0.003) and positively correlated with L-SpO2 (r = 0.660, P = 0.002). Conclusion The serum level of 25-(OH)D in OSAHS patients is significantly decreased, and 25-(OH)D is negatively correlated with the severity of OSAHS. VitD may be involved in the occurrence and development of OSAHS.
		2020 Vol. 17 (7): 164-167 [Abstract] ( 143 ) HTML (1 KB) PDF (473 KB) ( 94 )

	168	Diagnostic value of serum amyloid A in Mycoplasma pneumoniae pneumonia
		XIAN Xiaoying DING Yanling▲
		Objective To investigate the diagnostic value of serum amyloid A protein (SAA) in Mycoplasma pneumoniae pneumonia (MPP). Methods A total of 130 children with MPP who came to the pediatric inpatient department of Liuzhou Maternal and Child Healthcare Hospital (hereinafter referred to as “our hospital”) from march to June 2019 were collected as the MPP group, and 100 healthy children who underwent physical examination in the child healthcare department of our hospital during the same period were selected as the control group. The levels of SAA, C-reactive protein (CRP), white blood cell (WBC) in whole blood and serum creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (HBDH) were compared between the two groups. The correlation between SAA and other indicators in MPP group was analyzed, and the diagnostic efficacy of SAA, CRP and WBC on MPP was analyzed by ROC curve. Results The levels of SAA, CRP and WBC in MPP group were higher than those in control group, with statistically significant differences (all P ＜ 0.05). SAA was positively correlated with CRP and WBC (r = 0.760, 0.369, P ＜ 0.05). There was no correlation between SAA, CK, CK-MB, LDH and HBDH (P ＞ 0.05). The ROC curve of MPP was drawn with SAA, CRP and WBC as variables. The area under the ROC curve was 0.942, 0.689 and 0.618, respectively. The sensitivity of MPP was 81.2%, 75.4% and 56.2%, and the specificity was 90.3%, 93.0% and 63.0%, respectively. Conclusion SAA level detection can be used as the monitoring index of MPP and is of great significance to the auxiliary diagnosis of MPP.
		2020 Vol. 17 (7): 168-171 [Abstract] ( 133 ) HTML (1 KB) PDF (499 KB) ( 112 )

	172	Data analysis of implementating national centralized drug procurement reform in a tertiary hospital in Beijing
		ZHANG Xu XU Xinyue TANG Jiaji ZHANG Tongyan
		Objective To analyze the impact on outpatient expenses and medical insurance fund payment of Beijing Tongren Hospital, Capital Medical University (hereinafter referred to as “our hospital”) after implementing the pilot program of centralized drug procurement and use organized by the state, so as to provide data support for policy promotion. Methods The information of patients who used the national drugs to purchase drugs intensively and the drugs with the same generic name but not winning the bid from April to June in both 2018 and 2019 were collected. The data of the average cost before and after department reform was used. The changes of average cost before and after the reform and the use of medical insurance fund were compared and analyzed. Results After the implementation of the national centralized drug procurement and use pilot work, the increase of outpatient and sub average drug costs slowed down, and the proportion of outpatient and emergency drugs decreased from 33.21% to 32.42%. Among the drugs purchased by the state, the number of drugs used in outpatient service ranked the top 10, and the second average cost was significantly lower than that before the reform, with a maximum decrease of 72.41%, saving 2 183 600 yuan of medical insurance fund. Conclusion The pilot program implementation of the national centralized drug procurement plays an important role in controlling the unreasonable growing of outpatient drug costs, can effectively reduce the burden of patients, improve the efficiency of using medical insurance funds.
		2020 Vol. 17 (7): 172-175 [Abstract] ( 129 ) HTML (1 KB) PDF (361 KB) ( 215 )

	176	Research on reliability and validity of constructing hemodialysis center quality evaluation scale based on Servqual model
		LI Xue1,2 ZHOU Yixia1▲ LI Haiyang1,3
		Objective To test its reliability and validity,the service quality evaluation scale of hemodialysis center was constructed based on Servqual model. Methods From October 2018 to March 2019, the evaluation scale of nursing service quality in hemodialysis center was constructed by 15 experts from 13 hospitals in 5 provinces and cities through Delphi method. From January to March 2019, 342 hemodialysis patients in Guizhou Provincial People′s Hospital, Qingzhen First People′s Hospital and Guiyang Huaxi District People′s Hospital were investigated by convenient sampling. The reliability and validity were tested by item analysis, content validity, structure validity and Cronbach′s α coefficient. Results The scale contains 37 indicators of seven dimensions, and the results of item analysis show that the indicators have good discrimination. The content validity index of the total scale was 0.971, and the content validity index of each index ranged from 0.800 to 1.000. Stratified factor analysis results showed that the explanatory variance of each dimension was ＞ 60%, and the factor load value was ＞ 0.60. Cronbach′s α coefficient was 0.975, and the retest reliability was 0.981. The results showed that the scale had good reliability and validity. Conclusion The service quality evaluation scale of hemodialysis center based on Servqual model has good reliability and validity and can be used as a tool to evaluate the service quality of hemodialysis center.
		2020 Vol. 17 (7): 176-180 [Abstract] ( 205 ) HTML (1 KB) PDF (636 KB) ( 124 )

	181	Effect of the early rehabilitation exercise based on behavior change wheel theory on rehabilitation effect of the aged patients after total hip replacement
		XIE Qianqian1 ZHANG Yongmei1 SONG Lingxia2 LIU Hanmei1
		Objective To investigate the effect of early rehabilitation exercise based on behavior change wheel (BCW) theory on the rehabilitation effect of elderly patients after total hip replacement. Methods From March 2018 to February 2019, a total of 86 elderly patients underwent total hip replacement in the Department of Joint Surgery, Affiliated Hospital of Zunyi Medical University were selected, the patients were divided into experimental group and control group by random number table method, 43 cases in group. The control group received routine rehabilitation exercise in joint surgery. On the basis of routine exercise, the experimental group implemented early rehabilitation exercise intervention measures based on BCW model. Results Both groups had higher Harris function scores 1 month after surgery than before surgery, and the Harris functional score of the experimental group was higher than that of the control group, with statistically significant differences (P ＜ 0.05). There were no significant differences between the two groups in the compliance rate of early rehabilitation exercise 1 and 5 days after surgery (all P ＞ 0.05). The compliance rate of early rehabilitation exercise 1 and 5 days after surgery were higher in the experimental group than those in the control group, with statistically significant differences (all P ＜ 0.05). The incidence of postoperative complications in the experimental group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Early rehabilitation exercise based on BCW theory can improve the exercise compliance of elderly patients after total hip replacement, reduce the incidence of complications, and promote the recovery of hip function.
		2020 Vol. 17 (7): 181-184 [Abstract] ( 162 ) HTML (1 KB) PDF (624 KB) ( 385 )

	185	Effect of psycho-cardiologic nursing combined with Chinese press needle embedding on psychological distress in patients with coronary atherosclerotic heart disease
		HOU Chunyan1 TAN Juan1 ZHANG Wenjiang2 YANG Ze1
		Objective To observe the effect of psycho-cardiologic nursing combined with stirrup on psychological distress of patients with coronary atherosclerotic heart disease. Methods From April 2017 to April 2019, a total of 96 patients with coronary heart disease with psychological pain were admitted to The Third Department of Cardiovascular Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine. According to the random number table method, the patients were divided into observation group 48 cases and control group 48 cases. The observation group received psycho-cardiologic nursing and pressneedle therapy, while the control group received routine nursing. The changes of distress thermometer (DT), anxiety self-rating scale (SAS), depression self-rating scale (SDS) and TCM symptom score were observed. Results After intervention, the scores of DT, SAS and SDS in both groups were lower than before intervention (all P ＜ 0.05). The scores of DT, SAS and SDS in the observation group were significantly lower than those in the control group (P ＜ 0.05). After intervention, the scores of chest pain, chest tightness, chest side fullness, restless mood, irritability and palpitations in the observation group were all lower than those before treatment (P ＜ 0.05). In the control group, chest pain, chest tightness, restless mood and palpitations were all lower than those before treatment (P ＜ 0.05). In the observation group, the scores of chest tightness, chest swelling and irritability were significantly lower than those in the control group (P ＜ 0.05). Conclusion Psycho-cardiologic nursing combined with acupuncture can reduce the psychological pain of patients with coronary atherosclerotic heart disease, improve the clinical symptoms of patients.
		2020 Vol. 17 (7): 185-188 [Abstract] ( 212 ) HTML (1 KB) PDF (621 KB) ( 28 )

	189	Application effect of constrained decision-making wheel and grade assessment in patients with consciousness disorder in ICU
		QIAN Xiaoli ZHOU Linghua WANG Min GUAN Yixiang
		Objective To explore the application effect of constraint decision-making wheel and grade evaluation in ICU patients with disturbance of consciousness. Methods From February 2018 to February 2019, a total of 120 ICU patients with consciousness disorder admitted to Hai′an People′s Hospital in Jiangsu Province were selected, while divided into control group and observation group according to the random number table method, with 60 cases in each group. The control group was given conventional constraints, while the observation group was given constraints constraint decision and grade evaluation. The utilization rate of physical restraint, incidence of adverse events and clinical satisfaction were compared between the two groups. Results The use rate of physical constraints after intervention in the observation group was lower than that in the control group, the incidence of adverse events after intervention was lower in the observation group than in the control group, and the clinical satisfaction after intervention in the observation group was higher than that in the control group (P ＜ 0.05). Conclusion In the clinical intervention of ICU patients with consciousness disorder, the constraint decision-making wheel and grade assessment can effectively reduce the utilization rate of physical restraint and the incidence of adverse events, and improve clinical satisfaction, which is worthy of promotion.
		2020 Vol. 17 (7): 189-192 [Abstract] ( 170 ) HTML (1 KB) PDF (618 KB) ( 235 )

	193	Application effect of quantitative activity intervention in clinical nursing of gastric cancer patients undergoing enhanced recovery after surgery
		LIN Chunyan BAO Chuanqing XU Binghua YANG Zenghui▲
		Objective To explore the effect of application activity intervention in clinical nursing of gastric cancer patients undergoing enhanced recovery after surgery (ERAS). Methods A total of 150 patients who underwent gastric cancer surgery in the Affiliated Hospital of Jiangnan University (Formerly the Third People′s Hospital of Wuxi City) from January 2017 to January 2019 were selected. According to the random number table method, they were divided into control group (75 cases) and observation group (75 cases). Both groups received ERAS care, the control group received routine activities, and the observation group receiveded quantitative activity intervention; Physical recovery, activity, pain score, postoperative complications and sleep were compared between the two groups. Results The postoperative out-of-bed activity time, normal diet recovery and anal exhaust time of the observation group were shorter than that of the control group, with statistically significant differences (P ＜ 0.05). There was no significant difference between the two groups immediately after surgery (P ＞ 0.05). The pain scores of the two groups were compared with the immediate scores at 24, 48 h and 72 h after surgery, and the differences were statistically significant (P ＜ 0.05). Immediate postoperative, 24, 48 h and 72 h after surgery patients in the two groups were compared, the differences were statistically significant (P ＜ 0.05). The differences of time and interaction between the two groups were statistically significant (P ＜ 0.05). At 24, 48 and 72 h after surgery, the number of active steps, distance of active distance and duration of sleep in the two groups were compared, and the difference was statistically significant (P ＜ 0.05), and the number of active steps, distance of active steps and night sleep in the observation group were more than that in the control group (P ＜ 0.05). The probability of postoperative complications in the observation group was lower than that in the control group (P ＜ 0.05). Conclusion Quantitative activity intervention has a significant effect on the clinical nursing of ERAS in patients with gastric cancer surgery. Quantitative activity intervention measures can reduce postoperative pain and postoperative complications, improve sleep quality and postoperative recovery of patients.
		2020 Vol. 17 (7): 193-196 [Abstract] ( 153 ) HTML (1 KB) PDF (631 KB) ( 117 )

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